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Thiorphan. Group: Biochemicals. Alternative Names: N-[2-(Mercaptomethyl)-1-oxo-3-phenylpropyl]glycine; 2-Mercapto methyl -3-phenyl propionyl aminoacetic acid; D, L-3-Mercapto-2-benzyl propanoyl glycine. Grades: Highly Purified. CAS No. 76721-89-6. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C12H15NO3S. US Biological Life Sciences.
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Thiorphan
Thiorphan is a potent and specific enkephalinase inhibitor with antinociceptive activity. Uses: Protease inhibitors. Synonyms: N-[2-(Mercaptomethyl)-1-oxo-3-phenylpropyl]glycine; 2-Mercaptomethyl-3-phenylpropionylaminoacetic Acid; D,L-3-Mercapto-2-benzylpropanoylglycine; (+/-)-Thiorphan. Grades: > 95%. CAS No. 76721-89-6. Molecular formula: C12H15NO3S. Mole weight: 253.32.
Thiorphan
Thiorphan is a selective NEP (neprilysin) inhibitor with an IC 50 of 6.9 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 76721-89-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-W013375.
An Enkephalinase inhibitor. Group: Biochemicals. Alternative Names: 2-Mercaptomethyl-3-phenyl-propionylamino-acetic Acid, D, L-3-Mercapto-2-benzyl propanoyl glycine. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Thiorphan-methoxyacetophenone
A metabolite of Thiorphan which can be produced in vivo via the metabolism of the prodrug acetorphan. Grades: > 95%. Molecular formula: C21H23NO5S. Mole weight: 401.49.
Thiorphan Methoxyacetophenone Derivative Dicyclohexylamine Salt
Thiorphan derivative. Group: Biochemicals. Alternative Names: N-[2-[[[2-(3-Methoxyphenyl)-2-oxoethyl]thio]methyl]-1-oxo-3-phenylpropyl]glycine Dicyclohexylamine. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
A thiol containing amido-acid that selectively binds to the active site zinc of metalloproteinases and blocks their activity (IC?? = 2.1 nM for neutral endopeptidase-NEP). Group: Fluorescence/luminescence spectroscopy.
dactylysin
An endopeptidase of 100 kDa secreted from the skin of the amphibian, Xenopus laevis (DactylĂȘtre du Cap). Resembles neprilysin in insensitivity to 1 μM captopril, but differs from it in being insensitive to thiorphan (1 μM) and unable to digest [Met5]enkephalin, [Leu5]enkephalin, oxytocin, and substance P-(7-11)-peptide. A similar endopeptidase is found in human neuroblastoma cells. Group: Enzymes. Synonyms: peptide hormone inactivating endopeptidase; PHIE. Enzyme Commission Number: EC 3.4.24.60. CAS No. 139466-40-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4343; dactylysin; EC 3.4.24.60; 139466-40-3; peptide hormone inactivating endopeptidase; PHIE. Cat No: EXWM-4343.
meprin B
A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin β subunits (in contrast to meprin A, which contains both α and β subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family). Group: Enzymes. Synonyms: meprin-b. Enzyme Commission Number: EC 3.4.24.63. CAS No. 150679-52-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4346; meprin B; EC 3.4.24.63; 150679-52-0; meprin-b. Cat No: EXWM-4346.
Intermediate for the synthesis of Thiorphan. Group: Biochemicals. Alternative Names: (+/-)-N-[2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]glycine. Grades: Highly Purified. CAS No. 81110-05-6. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
neprilysin
A membrane-bound glycoprotein widely distributed in animal tissues. Inhibited by phosphoramidon and thiorphan. Common acute lymphoblastic leukemia antigen (CALLA). Type example of peptidase family M13. Group: Enzymes. Synonyms: neutral endopeptidase; endopeptidase 24.11; kidney-brush-border neutral peptidase; enkephalinase (misleading); endopeptidase-2; CALLA (common acute lymphoblastic leukemia-associated) antigens; CALLA antigen; endopeptidase; membrane metallo. Enzyme Commission Number: EC 3.4.24.11. CAS No. 82707-54-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4292; neprilysin; EC 3.4.24.11; 82707-54-8; neutral endopeptidase; endopeptidase 24.11; kidney-brush-border neutral peptidase; enkephalinase (misleading); endopeptidase-2; CALLA (common acute lymphoblastic leukemia-associated) antigens; CALLA antigen; endopeptidase; membrane metalloendopeptidase; kidney-brush-border neutral endopeptidase; kidney-brush-border neutral proteinase; endopeptidase-2; CALLA glycoprotein; CALLA; common acute lymphoblastic leukemia antigen; CALLA glycoproteins; common acute lymphoblastic leukemia-associated antigens; neutral metallendopeptidase; membrane metalloendopeptidase; NEP; neutral endopeptidase 24.11; CD10; neutral endopeptidase; acute lymphoblastic leukemia antigen. Cat No: EXWM-4292.
Racecadotril
Racecadotril (Acetorphan) is a neutral endopeptidase ( NEP ) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with K i s of 4500 and 6.1 nM, , respectively. Antidiarrheal agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Acetorphan. CAS No. 81110-73-8. Pack Sizes: 10 mM * 1 mL; 200 mg; 1 g. Product ID: HY-17399.
Racecadotril Impurity D(Mixture of Diastereomers)
An impurity of Racecadotril.Racecadotril is a peripherally acting enkephalinase inhibitor. It is an antidiarrheal drug. Synonyms: N,N'-[Dithiobis[1-oxo-2-(phenylmethyl)-3,1-propanediyl]]bis-glycine;Thiorphan Disulfide. Grades: > 95%. CAS No. 123658-06-0. Molecular formula: C24H28N2O6S2. Mole weight: 504.63.
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