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| Product | Description | |
|---|---|---|
| thymidine phosphorylase | The enzyme in some tissues also catalyses deoxyribosyltransferase reactions of the type catalysed by EC 2.4.2.6, nucleoside deoxyribosyltransferase. Group: Enzymes. Synonyms: pyrimidine phosphorylase; thymidine-orthophosphate deoxyribosyltransferase; animal growth regulators, blood platelet-derived endothelial cell growth factors; blood platelet-derived endothelial cell growth factor; deoxythymidine phosphorylase; gliostatins; pyrimidine deoxynucleoside phosphorylase; thymidine:phosphate deoxy-D-ribosyltransferase. Enzyme Commission Number: EC 2.4.2.4. CAS No. 9030-23-3. Thymidine Phosphorylase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2668; thymidine phosphorylase; EC 2.4.2.4; 9030-23-3; pyrimidine phosphorylase; thymidine-orthophosphate deoxyribosyltransferase; animal growth regulators, blood platelet-derived endothelial cell growth factors; blood platelet-derived endothelial cell growth factor; deoxythymidine phosphorylase; gliostatins; pyrimidine deoxynucleoside phosphorylase; thymidine:phosphate deoxy-D-ribosyltransferase. Cat No: EXWM-2668. |  |
| Thymidine Phosphorylase from Escherichia coli, Recombinant | An enzyme that catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the pyrimidine nucleoside salvage pathway. This pathway allows pyrimidine bases to be recycled for nucleotide biosynthesis, while the pentose 1-phosphates are converted to intermediates of the pentose phosphate shunt and glycolysis. The E. coli thymidine phosphorylase shares 40% sequence homology with the human sequence, which has been found to be identical to the angiogenic agent platelet-derived endothelial growth factor. The purified E. coli enzyme has been shown to stimulate blood vessel growth in chick chorioallantoic membrane assays. Applications: ...hosphate deoxy-D-ribosyltransferase; EC 2.4.2.4; 9030-23-3. Enzyme Commission Number: EC 2.4.2.4. CAS No. 9030-23-3. Thymidine Phosphorylase. Activity: Type I, > 900 units/mL, aseptically filled; Type II, > 500 units/mL. Storage: 2-8°C. Form: buffered aqueous solution, Solution in 0.5 M potassium phosphate containing 2 mM uracil, 0.02% sodium azide and bovine serum albumin. Source: E. coli. Species: Escherichia coli. thymidine phosphorylase; pyrimidine phosphorylase; thymidine-orthophosphate deoxyribosyltransferase; animal growth regulators, blood platelet-derived endothelial cell growth factors; blood platelet-derived endothelial cell growth factor; deoxythymidi | |
| 3'-β-Thymidine | As an intermediate in the production of fluorothymidine and phosphorylase derivatives 3'-β-Thymidine (Stavudine EP Impurity B) is used as an antiviral agent. Reverse transcriptase inhibitor. Synonyms: 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-methyluricil; 1-(2-Deoxy-b-D-xylofuranosyl)-5-methyluracil; 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-β-D-threo-pentofuranosyl)-thymine; NSC 526738; Stavudine EP Impurity B; 1-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione. Grades: ≥95%. CAS No. 16053-52-4. Molecular formula: C10H14N2O5. Mole weight: 242.23. |  |
| 5-(2-Furanyl)-2-deoxyuridine | Several novel 5-substituted 2'-deoxyuridine (dUrd) analogs were evaluated as substrates for highly purified herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK) derived from HSV-1 TK gene-transfected murine mammary carcinoma FM3A cells, and human platelet thymidine (dThd) phosphorylase. Group: Biochemicals. Alternative Names: 2'-Deoxy-5-(2-furanyl)uridine. Grades: Highly Purified. CAS No. 92233-50-6. Pack Sizes: 50mg. US Biological Life Sciences. |  Worldwide |
| 5-Chloro-6-[(2-Oxo-1-Pyrrolidinyl)Methyl]-2,4(1H,3H)-Pyrimidinedione | One of the impurities of Tipiracil, which is a thymidine phosphorylase (TPase) inhibitor and has been found to be a potential drug candidate for metastatic colorectal cancer. Synonyms: Tipiracil Impurity C. Grades: ≥95%. CAS No. 2101241-71-6. Molecular formula: C9H12ClN3O3. Mole weight: 245.66. | |
| 5-Iodouracil | 5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones. Group: Biochemicals. Alternative Names: 5-Iodo-2,4(1H,3H)-pyrimidinedione; 5-Iodo-2,4-dihydroxypyrimidine; 5-Iodo-2,4-pyrimidinedione; 5-Iodopyrimidine-2,4-diol; 5-Iodouracil; NSC 57848. Grades: Highly Purified. CAS No. 696-07-1. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
| 5'-O-Tritylinosine | KIN59 is a purine riboside derivative that suppresses thymidine phosphorylase (TPase). TPase is an enzyme catalyzing the reversible phosphorolysis of pyrimidine deoxynucleosides to 2-deoxy-d-ribose-1-phosphate and their respective pyrimidine bases. KIN59 noncompetitively inhibits TPase-induced angiogenesis in the chorioallantoic membrane assay. Synonyms: 5'-Trt-rI; (2R,3R,4S,5R)-9-(3,4-Dihydroxy-5-trityloxymethyl-tetrahydrofuran-2-yl)-1,9-dihydropurin-6-one; KIN-59; Inosine, 5'-O-(triphenylmethyl)-; 5'-O-(triphenylmethyl)-inosine. Grades: ≥98% by HPLC. CAS No. 4152-77-6. Molecular formula: C29H26N4O5. Mole weight: 510.55. | |
| 5-(Trimethylstannyl)-2'-deoxyuridine | Several novel 5-substituted 2'-deoxyuridine analogs were evaluated as substrates for highly purified herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK), which derived from HSV-1 TK gene-transfected murine mammary carcinoma FM3A cells, and human platelet thymidine (dThd) phosphorylase. Uses: Several novel 5-substituted 2'-deoxyuridine (durd) analogs were evaluated as substrates for highly purified herpes simplex virus type 1 (hsv-1)-encoded thymidine kinase (tk) derived from hsv-1 tk gene-transfected murine mammary carcinoma fm3a cells, and h. Synonyms: 2'-Deoxy-5-(trimethylstannyl)uridine. Grades: 97%. CAS No. 146629-34-7. Molecular formula: C12H20N2O5Sn. Mole weight: 391.01. | |
| 6-[(2-Imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione | One of the impurities of Tipiracil, which is a thymidine phosphorylase (TPase) inhibitor and has been found to be a potential drug candidate for metastatic colorectal cancer. Synonyms: Tipiracil Impurity des Cl. Grades: ≥95%. CAS No. 2069937-25-1. Molecular formula: C9H12N4O2. Mole weight: 208.22. | |
| 7-Deazaxanthine | 7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase ( TPase ). 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC 50 value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 7DX. CAS No. 39929-79-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-77537. |  |
| Capecitabine | Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-DEOXY-5-FLUOROCYTISINE;5-DEOXY-5-FLUORO-N-[(PENTYLOXY)CARBONYL]CYTIDINE;CAPECITABINE;RO-9-1978;pentyl [1-(3,4-dihydroxy-5-methyl-oxolan-2-yl)-5-fluoro-2-oxo-pyrimidin-4-yl]aminoformate;XELODA;Cpecitabine;5Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine, Ro-9-1978, Xeloda. Product Category: Inhibitors. Appearance: Solid. CAS No. 154361-50-9. Molecular formula: C15H22FN3O6. Mole weight: 359.35. Purity: 0.9987. Canonical SMILES: O[C@H]1[C@@H](O)[C@H](N2C=C(C(NC(OCCCCC)=O)=NC2=O)F)O[C@@H]1C. Product ID: ACM154361509. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Capecitabine | Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase. Uses: Scientific research. Group: Signaling pathways. CAS No. 154361-50-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0016. | |
| Capecitabine-d11 | Capecitabine-d11 is the deuterium labeled Capecitabine. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5'-DEOXY-5-FLUORO-N-[(PENTYLOXY)CARBONYL]CYTIDINE-D11;CAPECITABINE-D11. Product Category: Inhibitors. Appearance: Off-White Solid. CAS No. 1132662-08-8. Molecular formula: C15H11D11FN3O6. Mole weight: 372.43. Canonical SMILES: C[C@@H]1[C@H]([C@H]([C@H](N2C(N=C(C(F)=C2)NC(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=O)O1)O)O. Product ID: ACM1132662088. Alfa Chemistry ISO 9001:2015 Certified. | |
| Idoxuridine | Idoxuridine (5-Iodo-2-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC 50 value of 4.3 μM [1]. Idoxuridine shows anti-orthopoxvirus activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5-Iodo-2-deoxyuridine; 5-IUdR; IdUrd. CAS No. 54-42-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0307. | |
| pyrimidine-nucleoside phosphorylase | Unlike EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine. The reaction is reversible, and the enzyme does not distinguish between α-D-ribose 1-phosphate and 2-deoxy-α-D-ribose 1-phosphate in the synthetic direction. Group: Enzymes. Synonyms: Py-NPase; pdp (gene name). Enzyme Commission Number: EC 2.4.2.2. CAS No. 9055-35-0. PyNPase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2647; pyrimidine-nucleoside phosphorylase; EC 2.4.2.2; 9055-35-0; Py-NPase; pdp (gene name). Cat No: EXWM-2647. | |
| TAS-102 | TAS-102 is a combination drug composed of the cytotoxic pyrimidine analog Trifluridine (5-trifluoro-2'-deoxythymidine or TFT) and a thymidine phosphorylase inhibitor (TPI) tipiracil hydrochloride, in a molar ratio of 1.0:0.5 (TFT:TPI). TAS-102 is used as a third- or fourth-line treatment of metastatic colorectal cancer. Synonyms: Tipiracil / Trifluridine; Viroptic mixture with 5-CIMU; TAS 102; EX-A1755; Tipiracil hydrochloride / Trifluridine. CAS No. 733030-01-8. Molecular formula: C9H11ClN4O2·HCl·C10H11F3N2O5. Mole weight: 575.328. | |
| Tipiracil | Tipiracil, a thymidine phosphorylase (TPase) inhibitor, has been found to be a potential drug candidate for metastatic colorectal cancer. Synonyms: TAS-102; TAS102. CAS No. 183204-74-2. Molecular formula: C9H11ClN4O2. Mole weight: 242.67. | |
| Tipiracil | Tipiracil is a thymidine phosphorylase ( TPase ) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 183204-74-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-A0063A. | |
| Tipiracil HCl | Tipiralacil, also known as TPI, is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials. TAS-102 consists of the cytotoxin Trifluridine and the thymidine phosphorylase inhibitor (TPI) tipiracil. Trifluridine is incorporated into DNA during DNA synthesis and inhibits tumor cell growth. Tipiracil protects trifluridine from being broken down when taken orally. Synonyms: Tipiracil, TPI. Grades: 0.99. CAS No. 183204-72-0. Molecular formula: C9H12Cl2N4O2. Mole weight: 279.121. | |
| Tipiracil hydrochloride | Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research. Uses: Scientific research. Group: Signaling pathways. CAS No. 183204-72-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-A0063. | |
| Tipiracil Impurity 1 | One of the impurities of Tipiracil, which is a thymidine phosphorylase (TPase) inhibitor and has been found to be a potential drug candidate for metastatic colorectal cancer. Molecular formula: C9H10ClN3O3. Mole weight: 243.65. | |
| Tipiracil Impurity 2 | One of the impurities of Tipiracil, which is a thymidine phosphorylase (TPase) inhibitor and has been found to be a potential drug candidate for metastatic colorectal cancer. Molecular formula: C6H7ClN2O3. Mole weight: 190.59. | |
| Trifluridine | Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA. Synonyms: 5-Trifluoromethyl-2'-deoxyuridine; Trifluorothymidine; FTD; 5-Trifluorothymidine; NSC 529182; NSC 75520; Viroptic; α,α,α-Trifluorothymidine; 2'-Deoxy-5-(trifluoromethyl)uridine; Trifluoromethyldeoxyuridine; Trifluridina; Virophta; TFDU. Grades: ≥95%. CAS No. 70-00-8. Molecular formula: C10H11F3N2O5. Mole weight: 296.20. | |
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