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Thyrotropin-ReleasingHormone (TRH), Free Acid (TRH-OH) is a physiological metabolite of Thyrotropin-ReleasingHormone. Uses: Scientific research. Group: Peptides. Alternative Names: TRH-OH. CAS No. 24769-58-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1529.
glutaminyl-peptide cyclotransferase
Involved in the formation of thyrotropin-releasinghormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA. Group: Enzymes. Synonyms: glutaminyl-tRNA cyclotransferase; glutaminyl cyclase; glutaminyl-transfer ribonucleate cyclotransferase. Enzyme Commission Number: EC 2.3.2.5. CAS No. 37257-21-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2305; glutaminyl-peptide cyclotransferase; EC 2.3.2.5; 37257-21-9; glutaminyl-tRNA cyclotransferase; glutaminyl cyclase; glutaminyl-transfer ribonucleate cyclotransferase. Cat No: EXWM-2305.
JKC 363
JKC 363 has been found to be a melanocortin MC4 receptor antagonist and could suppress the release of thyrotropin-releasinghormone (TRH). Synonyms: (Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide; JKC363; JKC-363; 3-Mercaptopropionyl-Glu-His-D-2-Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bond); deamino-Cys-Glu-His-D-2Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asn-OH (Disulfide bridge: Cys1-Cys8); deamino-cysteinyl-L-alpha-glutamyl-L-histidyl-3-(2-naphthyl)-D-alanyl-L-arginyl-L-tryptophyl-glycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-L-asparagine (1->8)-disulfide; beta-MSH (11-12)-amide, mercaptopropionic acid(11)-naphthylalanyl(14)-cysteinyl(18)-aspartyl(22)-; beta-MSH (11-22)-amide, Mrp(11)-Nal(14)-Cys(18)-Asp(22)-; [Deamino-Cys11,β-(2-Naphthyl)-D-Ala14,Cys18]-β-Melanocyte Stimulating Hormone Amide Fragment 11-22. Grades: ≥95% by HPLC. CAS No. 436083-30-6. Molecular formula: C69H91N19O16S2. Mole weight: 1506.72.
L-Pyroglutamyl-L-histidyl-L-prolinamide
L-Pyroglutamyl-L-histidyl-L-prolinamide. Group: Biochemicals. Alternative Names: Protirelin; Thyrotropin-ReleasingHormone. Grades: Highly Purified. CAS No. 24305-27-9. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C16H22N6O4. US Biological Life Sciences.
Worldwide
MK-771
MK-771 is an analog of the ThyrotropinReleasingHormone (TRH). It is a therapeutic agent. It may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects. Uses: Mk-771 is a therapeutic agent. it may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects. Synonyms: MK771; MK 771; (S)-3-((S)-3-(1H-imidazol-4-yl)-2-((S)-6-oxopiperidine-2-carboxamido)propanoyl)thiazolidine-4-carboxamide. Grades: 98%. CAS No. 66537-55-1. Molecular formula: C16H22N6O4S. Mole weight: 394.45.
Prepro-trh(178-199)
Heterocyclic Organic Compound. Alternative Names: PHE-ILE-ASP-PRO-GLU-LEU-GLN-ARG-SER-TRP-GLU-GLU-LYS-GLU-GLY-GLU-GLY-VAL-LEU-MET-PRO-GLU;PREPRO-THYROTROPIN-RELEASINGHORMONE (178-199);PREPRO-THYROTROPINRELEASINGHORMONE FRAGMENT 178-199;PREPRO-TRH (178-199);CORTICOTROPIN RELEASE-INHIBITING FACTOR;CRIF. CAS No. 122018-92-2. Molecular formula: C116H176N28O39S. Mole weight: 2618.87. Catalog: ACM122018922.
Protirelin
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions. Uses: Scientific research. Group: Peptides. Alternative Names: Thyrotropin-releasing-hormone; TRH. CAS No. 24305-27-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0002.
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions. Uses: Scientific research. Group: Peptides. Alternative Names: Thyrotropin-releasing-hormone acetate; TRH acetate. CAS No. 120876-23-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-P0002A.
pyroglutamyl-peptidase II
Highly specific for thyrotropinreleasinghormone (pyroglutamyl-histidyl-prolylamide). Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormonereleasinghormone. Found in serum and brain. Inhibited by metal chelators. In peptidase family M1 (membrane alanyl aminopeptidase family). Group: Enzymes. Synonyms: thyroliberinase; pyroglutamyl aminopeptidase II; thyrotropin-releasing factor pyroglutamate aminopeptidase; pyroglutamate aminopeptidase II; pyroglutamyl peptidase II; thyroliberin-hydrolyzing pyroglutamate aminopeptidase; thyrotropin-releasinghormone-degrading pyroglutamate aminopeptidase; thyrotropin-releasinghormone-degrading peptidase; TRH aminopeptidase. Enzyme Commission Number: EC 3.4.19.6. CAS No. 60063-88-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4090; pyroglutamyl-peptidase II; EC 3.4.19.6; 60063-88-9; thyroliberinase; pyroglutamyl aminopeptidase II; thyrotropin-releasing factor pyroglutamate aminopeptidase; pyroglutamate aminopeptidase II; pyroglutamyl peptidase II; thyroliberin-hydrolyzing pyroglutamate aminopeptidase; thyrotropin-releasinghormone-degrading pyroglutamate aminopeptidase; thyrotropin-releasinghormone-degrading peptidase; TRH aminopeptidase. Cat No: EXWM-4090.
Rovatirelin
Rovatirelin, a novel synthetic agent that mimics the actions of thyrotropin-releasinghormone (TRH), binds to the human TRH receptor with higher affinity (Ki=702nM) than taltirelin (Ki=3877nM). Rovatirelin may have an orally effective therapeutic potential in patients with SCD. Synonyms: S-0373; S 0373; S0373. (4S,5S)-5-methyl-N-((S)-1-((R)-2-methylpyrrolidin-1-yl)-1-oxo-4-(thiazol-4-yl)butan-2-yl)-2-oxooxazolidine-4-carboxamide4-Oxazolidinecarboxamide, 5-methyl-N-[2-(2-methyl-1-pyrrolidinyl)-2-oxo-1-(4-thiazolylmethyl)ethyl]-2-oxo-, [4S-[4α[R*(S*)],5α]]-; UNII-9DL0X410PY; Ravatirelin [INN]; RAVATIRELIN; 9DL0X410PY; SCHEMBL14306794; (4S,5S)-5-methyl-N-((2S)-1-((2R)-2-methylpyrrolidin-1-yl)-1-oxo-3-((1,3-thiazol-4-yl)methyl)propan-2-yl)-2-oxo-1,3-oxazolidine-4-carboxamide; 204386-76-5. Grades: >98%. CAS No. 204386-76-5. Molecular formula: C16H22N4O4S. Mole weight: 366.436.
Taltirelin
Taltirelin is a thyrotropin-releasinghormone receptor (TRH-R) superagonist with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release). Synonyms: N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide; (S)-N-[(Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-L-prolinamide; (4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-L-prolinamide; Ceredist; TA 0910; (S)-N-((S)-1-((S)-2-Carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxamide; 1-methyl-(S)-4,5-dihydroorotyl-L-histidyl-L-prolinamide. Grades: >98%. CAS No. 103300-74-9. Molecular formula: C17H23N7O5. Mole weight: 405.41.
Taltirelin
Taltirelin (TA-0910) is an orally effective analogue of thyrotropinreleasinghormone (TRH) and a TRH receptor (TRH-R) superagonist ( IC 50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC 50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TA-0910. CAS No. 103300-74-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0596.
Taltirelin acetate
Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin (TA-0910) is an orally effective analogue of thyrotropinreleasinghormone (TRH) and a TRH receptor (TRH-R) superagonist ( IC 50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC 50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TA-0910 acetate. CAS No. 1549593-23-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0596A.
Taltirelin Hydrate
Taltirelin hydrate is a thyrotropin-releasinghormone receptor (TRH-R) superagonist with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release). Uses: Nootropic agents. Synonyms: N-{[(4S)-1-methyl-2,6-dioxohexahydropyrimidin-4-yl]carbonyl}-L-histidyl-L-prolinamide tetrahydrate; (S)-N-[(Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-L-prolinamide tetrahydrate; Ceredist tetrahydrate; TA 0910 tetrahydrate; (S)-N-((S)-1-((S)-2-Carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxamide tetrahydrate; 1-methyl-(S)-4,5-dihydroorotyl-L-histidyl-L-prolinamide tetrahydrate. Grades: ≥95%. CAS No. 201677-75-0. Molecular formula: C17H31N7O9. Mole weight: 477.46.
Thyroid-stimulating hormone-releasinghormone
Thyroid-stimulating hormone-releasinghormone is a constitution-stimulating hormone produced by hypothalamic neurons. It can stimulate the anterior pituitary to release thyroid-stimulating hormone and prolactin. Uses: Hormones. Synonyms: Protirelin; TSH-RF; pGlu-His-Pro-NH2; {pGLU}HP-NH2; Thyroliberin; L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-; 5-Oxo-L-prolyl-L-histidyl-L-prolinamide; Thyrotropin-releasing factor; (Pyro)-L-glutamic acid-L-histidine-L-proline-NH2; L-Pyroglutamyl-L-histidyl-L-prolinamide; Abbott 38579; Antepan; FDA 1725; Lopremone; Prem; Relefact TRH; Rifathyroin; Rifotironin; Ro 8-6270/9; Stimu TSH; Synthetic thyrotropin-releasing factor; Synthetic thyrotropin-releasinghormone; Synthetic TRF; Synthetic TRH; Thypinone; Thyrefact; Thyroid releasinghormone; Thyroid-stimulating hormone-releasing factor; TRF; TRH; TSH-releasing factor; TSH-releasinghormone. Grades: 95%. CAS No. 24305-27-9. Molecular formula: C16H22N6O4. Mole weight: 362.38.
Thyroliberin acetate salt
Thyroliberin acetate salt is a highly conserved neuropeptide that stimulates the release of thyrotropin and prolactin and plays a hormonal role in controlling thyroid-stimulating hormone (TSH) levels and neuromodulatory functions. Synonyms: Lopremone Acetate; TRH Acetate; Thyroliberin Acetate; TRF Acetate; pGlu-His-Pro-NH2 Acetate; Synthetic thyrotropin-releasinghormone Acetate; Protirelin acetate; Protirelin monoacetate; H-Pyr-His-Pro-NH2.CH3CO2H; Pyr-HP-NH2.CH3CO2H; L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-, acetate (1:1); L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-, monoacetate; Thyrotropin-releasing factor (pig), monoacetate; Pyroglutamylhistidylprolinamide acetate; Thyrotropin-releasinghormone acetate; L-pyroglutamyl-L-histidyl-L-prolinamide acetic acid. Grades: ≥95%. CAS No. 25575-91-1. Molecular formula: C18H26N6O6. Mole weight: 422.44.