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| Product | Description | |
|---|---|---|
| Tissue plasminogen activator from Human, Recombinant | Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine proteasewhich converts the proenzymeplasminogento plasmin, a fibrinolyticenzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migrationand tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysiswhich can result in thrombosisor embolism. Tissue plasminogen activator human recombinant produced in cho cells is a single, glycosylated polypeptide chain containing 527 amino acids and having a mol...0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. tPA. Mole weight: 59008.71 Da. Activity: 580,000 IU/mg. Stability: Lyophilized t-PA although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution tPA should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. Appearance: Sterile Filtered White lyophilized (freeze-dried) powder. Source: CHO. Species: Human. Tissue-type plasminogen activator; EC 3.4.21.68; tPA; t-PA; t-plasminogen activator; TPA; T-PA. Cat No: NATE-0920. |  |
| Immobilized human tissue plasminogen activator, single chain | Useful for controlled plasminogen activation studies. May be used to immuno purify monoclonal and polyclonal antibodies directed against human tPA. May be used repeatedly. Group: Enzymes. Synonyms: Tissue-type plasminogen activator; EC 3. 4. 21. 68; tPA; t-PA; t-plasminogen activator; TPA; T-PA. Enzyme Commission Number: EC 3. 4. 21. 68. Purity: >95% by SDS-PAGE analysis. Mole weight: 70000. Stability: 12 months from delivery. Storage: 4°C. Form: Resin. Source: CHO cells. Species: Human. Tissue-type plasminogen activator; EC 3. 4. 21. 68; tPA; t-PA; t-plasminogen activator; TPA; T-PA; Immobilized tissue plasminogen activator; Immobilized tPA. Cat No: NATE-1758. | |
| 7-Aminoheptanoic acid | 7-Aminoheptanoic Acid is an aliphatic ω-amino acid that acts as a ligand for recombinant kringle 2 domain (residues 180-261) of human tissue-type plasminogen. Synonyms: 7-Ahp-OH; 7-Aminoenanthic acid; omega-Aminoenantic acid; 7-Amino-heptanoic acid; HEPTANOIC ACID, 7-AMINO-; 7-Aminohepentanoic acid; Aminoenanthic acid; Amino-enanthylic acid; omega-Aminoheptanoic acid. Grades: ≥ 99%. CAS No. 929-17-9. Molecular formula: C7H15NO2. Mole weight: 145.20. |  |
| α-Enolase from Human, Recombinant | Alpha-enolase, also known as Enolase 1, is one of three enolase isoenzymes and a glycolytic enzyme expressed in most tissues. This protein plays a key role in anaerobic metabolism under hypoxic conditions and may act as a cell surface plasminogen receptor during tissue invasion. Abnormal expression of alpha-enolase is associated with tumor progression in some cases of breast and lung cancer. It also has been identified as an auto antigen associated with Hashimoto?s encephalopathy and severe asthma. Group: Enzymes. Synonyms: 2-phospho-D-glycerate hydro-lyase; Alpha-enolase; ENO1; Enolase 1; Non-neural enolase. Purity: > 90% (SDS-PAGE). Enolase. Mole weight: 47.1 kDa. Storage: Store at -70°C. Form: Liquid; 1 mg/mL solution in 20 mM Tris-HCl (pH 7.5) containing 10% glycerol and 1 mM MgSO4. Source: E. coli. Species: Human. 2-phospho-D-glycerate hydro-lyase; Alpha-enolase; ENO1; Enolase 1; Non-neural enolase. Cat No: NATE-0940. | |
| Alteplase | Alteplase (Actilyse; Activase), a tissue plasminogen activator prepared by recombination, is a thrombolytic agent that play important roles in acute ischemic stroke, pulmonary embolism, acute myocardial infarction, and occluded catheters [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Actilyse; Activase. CAS No. 105857-23-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108865. |  |
| Bovine Plasminogen | Purified from freshly collected bovine plasma. The protein purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol. No Plasmin activity is detected using chromogenic substrate S-2251. Plasminogen is activated to the serine protease plasmin via urokinase, streptokinase or tissue plasminogen activator. Group: Zymogens. Purity: >94% by SDS-PAGE. Plasminogen. Mole weight: 90,000-94,000. Stability: 30 months. Storage: 2-8°C. Source: Bovine. Bovine Plasminogen; Plasminogen. Pack: 1mg. Cat No: CZY-030. | |
| BSc2118 | BSc2118 is a potent proteasome inhibitor. BSc2118 shows significant antimyeloma activity and may be considered as a promising agent in cancer drug development. BSc2118 is also a promising new candidate for stroke therapy, which may in addition alleviate recombinant tissue-plasminogen activator-induced brain toxicity. Synonyms: BSc-2118; BSc 2118. Grades: 98%. CAS No. 863924-64-5. Molecular formula: C28H43N3O7. Mole weight: 533.66. | |
| DC-009 | DC-009 is a small-molecule thrombolytic that can scavenge the free radical in cells. Studies in vitro and in vivo showed that DC-009 had the similar activity as recombinant tissue plasminogen activator (rt-PA) and dose-dependent activity. Further study of treating ischemic stroke is planned. Uses: The potential treatment of ischemic stroke. Synonyms: DC009; DC 009. | |
| D-Ile-Pro-Arg p-nitroanilide dihydrochloride | D-Ile-Pro-Arg p-nitroanilide dihydrochloride is a chromogenic peptide substrate of tissue plasminogen activator (tPA) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 96323-41-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-137837. | |
| Drospirenone | Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dihydrospirorenone. CAS No. 67392-87-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0111. | |
| Edaravone | Edaravone is a strong novel free radical scavenger, and inhibits MMP -9-related brain hemorrhage in rats treated with tissue plasminogen activator. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MCI-186. CAS No. 89-25-8. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g; 25 g. Product ID: HY-B0099. | |
| Edaravone-d5 | Edaravone-d 5 is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator[1][2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: MCI-186-d5. CAS No. 1228765-67-0. Pack Sizes: 1 mg. Product ID: HY-B0099S. | |
| Edaravone (Standard) | Edaravone (Standard) is the analytical standard of Edaravone. This product is intended for research and analytical applications. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Uses: Scientific research. Group: Signaling pathways. CAS No. 89-25-8. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-B0099R. | |
| GW311616 | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616; GW 311616. Grades: >98%. CAS No. 198062-54-3. Molecular formula: C19H31N3O4S. Mole weight: 397.53. | |
| GW311616 hydrochloride | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616 hydrochloride; GW 311616 hydrochloride; GW311616A. Grades: >98%. CAS No. 197890-44-1. Molecular formula: C19H32ClN3O4S. Mole weight: 433.99. | |
| LCKLSL | LCKLSL is a competitive inhibitor of annexin A2 (AnxA2). It can effectively inhibit the binding of tissue plasminogen activator (tPA) and AnxA2. It can also inhibit the production of plasmin and has an anti-angiogenic effect. Synonyms: LCKLSL; HY-P2333; AKOS040758181; 533902-29-3; CS-0130051. CAS No. 533902-29-3. Molecular formula: C30H57N7O8S. Mole weight: 675.88. | |
| Plasminogen, Human plasma | Plasminogen, Human plasma is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen also is a proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Plasminogen can be used in studies of wound healing, inflammation and hypoplasminogenemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-91-6. Pack Sizes: 1 mg. Product ID: HY-P2821. | |
| Pro-Urokinase from Human, recombinant | Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC 3.4.21.73). It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic activity. The single chain zymogen is converted into the active two chain enzyme (tcuPA) by cleavage of the bond between Lys157 and Ile158. After activation, Urokinase specifically cleaves the proenzyme plasminogen to form the active enzyme plasmin. The active plasmin then catalyzes the breakdown of fibrin polymers of blood clots. Urokinase is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. Additionally, it is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium. Group: Enzymes. Synonyms: Single chain Urokinase-type plasminogen activator; s. Purity: > 90% by SDS-PAGE. Pro-Urokinase. Mole weight: 49.3 kDa. Activity: >1200 mU/mg. Storage: Stable at -80°C for at least 1 year as supplied. Store reconstituted aliquots at -80°C. Avoid repeated freeze and thaw cycles. Form: Lyophilized powder. Source: E. coli. Species: Human. Single chain Urokinase-type plasminogen activator; scuPA; Urokinase-type Plasminogen Activator uPA; PLAU; Pro-Urokinase. Cat No: NATE-1689. | |
| Sulodexide | Sulodexide is an orally active mixture of glycosaminoglycans composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III ( AT III ) and heparin cofactor II ( HC II ), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 57821-29-1. Pack Sizes: 250 LSU. Product ID: HY-100897. | |
| Tenecteplase | Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TNK-tPA. CAS No. 191588-94-0. Pack Sizes: 100 μg. Product ID: HY-108845. | |
| t-plasminogen activator | A peptidase of family S1 (trypsin family) from a wide variety of mammalian tissues, especially endothelial cells. Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Activity is considerably enhanced by fibrin. Formerly included in EC 3.4.21.31 and EC 3.4.99.26. Group: Enzymes. Synonyms: tissue plasminogen activator; plasminogen activator, tissue-type; tissue-type plasminogen activator; tPA; t-PA. Enzyme Commission Number: EC 3.4.21.68. CAS No. 139639-23-9. tPA. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4159; t-plasminogen activator; EC 3.4.21.68; 139639-23-9; tissue plasminogen activator; plasminogen activator, tissue-type; tissue-type plasminogen activator; tPA; t-PA. Cat No: EXWM-4159. | |
| UK122 | UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC 50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC 50 >100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 940290-58-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111056. | |
| Urokinase from Human, recombinant | Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC 3.4.21.73). It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic activity. The single chain zymogen is converted into the active two chain enzyme (tcuPA) by cleavage of the bond between Lys157 and Ile158. After activation, Urokinase specifically cleaves the proenzyme plasminogen to form the active enzyme plasmin. The active plasmin then catalyzes the breakdown of fibrin polymers of blood clots. Urokinase is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. Additionally, it is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium. Group: Enzymes. Synonyms: Two chain urokinase-type plasminogen acti. Enzyme Commission Number: EC 3.4.21.73. Purity: > 90% by SDS-PAGE. uPA. Mole weight: 49.3 kDa. Activity: >1500 mU/mg. Storage: Stable at -80°C for at least 1 year as supplied. Store reconstituted aliquots at -80°C. Avoid repeated freeze and thaw cycles. Form: Lyophilized powder. Source: E. coli. Species: Human. Two chain urokinase-type plasminogen activator; tcuPA; PLAU; ATF; UPA; URK; u-PA; BDPLT5; QPD; Urokinase. Cat No: NATE-1690. | |
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