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| Product | Description | |
|---|---|---|
| Trametinib | A MEK inhibitor that suppresses MEK1 and MEK2 with IC50 of 0.92 and 1.8 nM and no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. It has been approved by FDA, in combination with Tafilnar, for the treatment of metastatic anaplastic thyroid cancer (ATC) with BRAF V600E mutation. Synonyms: GSK-1120212; GSK 1120212; GSK1120212; JTP74057; JTP 74057; JTP-74057; Mekinist. Grades: ≥98%. CAS No. 871700-17-3. Molecular formula: C26H23FIN5O4. Mole weight: 615.39. |  |
| Trametinib | Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC 50 s of about 2 nM. Trametinib activates autophagy and induces apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK1120212; JTP-74057. CAS No. 871700-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10999. |  |
| Trametinib | Trametinib. Uses: For analytical and research use. Group: Impurity standards. CAS No. 871700-17-3. Molecular Formula: C26H23FIN5O4. Mole Weight: 615.4. Catalog: APB871700173. |  |
| Trametinib DMSO solvate | Trametinib is a reversible, selective, allosteric MEK1/MEK2 kinase activity inhibitor with IC50 of 0.7 and 0.9 nM for MEK1 and MEK2. Synonyms: GSK-1120212 DMSO solvate; Trametinib; JTP-74057; GSK-1120212; GSK1120212; GSK 1120212; JTP 74057; JTP74057. Grades: >98%. CAS No. 1187431-43-1. Molecular formula: C28H29FIN5O5S. Mole weight: 693.53. | |
| Trametinib (Standard) | Trametinib (Standard) is the analytical standard of Trametinib. This product is intended for research and analytical applications. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC 50 s of about 2 nM. Trametinib activates autophagy and induces apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 871700-17-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10999R. | |
| N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide | N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide. Group: Biochemicals. Alternative Names: G 02442104; GSK 1120212; JTP 74057; N-[3-[3-Cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethy-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide; Trametinib. Grades: Highly Purified. CAS No. 871700-17-3. Pack Sizes: 10mg, 50mg, 100mg. Molecular Formula: C24H20FIN4O4, Molecular Weight: 574.34. US Biological Life Sciences. |  Worldwide |
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