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| Product | Description | |
|---|---|---|
| Trametinib | Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC 50 s of about 2 nM. Trametinib activates autophagy and induces apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK1120212; JTP-74057. CAS No. 871700-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10999. |  |
| Trametinib-[d4] | One of the isotopic labelled form of Trametinib, which has been found to be an EGFR kinase inhibitor and could be used against advanced cutaneous melanoma. Synonyms: N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide-d4; G 02442104-d4; GSK 1120212-d4; JTP 74057-d4. Grade: >98%. Molecular formula: C26H19D4FIN5O4. Mole weight: 619.42. |  |
| Trametinib-[d6] | One of the impurities of Trametinib, which has been found to be an EGFR kinase inhibitor and could be used against advanced cutaneous melanoma. Synonyms: N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl-2,4,5,6-d4]-acetamide-2,2-d2. Grade: 95% by HPLC; 98% atom D. Molecular formula: C26H17D6FIN5O4. Mole weight: 621.44. | |
| Trametinib (DMSO solvate) | Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK-1120212 (DMSO solvate); JTP-74057 (DMSO solvate). CAS No. 1187431-43-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10999A. | |
| Trametinib (Standard) | Trametinib (Standard) is the analytical standard of Trametinib. This product is intended for research and analytical applications. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC 50 s of about 2 nM. Trametinib activates autophagy and induces apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 871700-17-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10999R. | |
| Borussertib | Borussertib is a covalent-allosteric Akt inhibitor with IC50 of 0.8 nM. Borussertib displays antitumor activity in combination with the MEK inhibitor trametinib in patient-derived xenograft models and provides a starting point for further pharmacokinetic/dynamic optimization. CAS No. 1800070-77-2. Molecular formula: C36H32N6O3. Mole weight: 596.68. | |
| N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide | N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide. Group: Biochemicals. Alternative Names: G 02442104; GSK 1120212; JTP 74057; N-[3-[3-Cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethy-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide; Trametinib. Grades: Highly Purified. CAS No. 871700-17-3. Pack Sizes: 10mg, 50mg, 100mg. Molecular Formula: C24H20FIN4O4, Molecular Weight: 574.34. US Biological Life Sciences. |  Worldwide |
| Trametiglue | Trametiglue, a derivative of Trametinib (HY-10999), targets both KSR-MEK and RAF-MEK with unprecedented potency and selectivity via unique interfacial binding interactions[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2666940-97-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153181. | |
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