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A thiamine-diphosphate protein. Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO2 and R-CHOH-CO-CH2OH. The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor. Group: Enzymes. Synonyms: glycolaldehydetransferase. Enzyme Commission Number: EC 2.2.1.1. CAS No. 9014-48-6. Transketolase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2025; transketolase; EC 2.2.1.1; 9014-48-6; glycolaldehydetransferase. Cat No: EXWM-2025.
Transketolase-IN-3
Transketolase-IN-3 is a potent transketolase (TK) inhibitor. Transketolase-IN-3 has herbicidal activity and has inhibitory effects against Digitaria sanguinalis (DS) and Amaranthus retroflexus (AR). Transketolase-IN-3 can be used for the research of herbicides [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2757552-03-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151604.
Transketolase-IN-4
Transketolase-IN-4 is a potent transketolase inhibitor ( IC 50 =3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 419547-73-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153090.
formaldehyde transketolase
A thiamine-diphosphate protein. Not identical with EC 2.2.1.1 transketolase. Also converts hydroxypyruvate and formaldehyde into glycerone and CO2. Group: Enzymes. Synonyms: dihydroxyacetone synthase. Enzyme Commission Number: EC 2.2.1.3. CAS No. 124566-23-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2030; formaldehyde transketolase; EC 2.2.1.3; 124566-23-0; dihydroxyacetone synthase. Cat No: EXWM-2030.
Native E. coli Transketolase
Transketolase is highly specific for ketol donor substrates and is stereospecific and enantioselective to hydroxyaldehyde substrates with an (R) configuration. It specifically catalyzes the irreversible transfer of one ketol unit from α-hydroxypyruvic acid to an aldehyde to produce a D-threo (3S,4R)ketose. Applications: Transketolase is widely used in organic synthesis. Group: Enzymes. Synonyms: Transketolase; EC 2.2.1.1; 9014-48-6; glycolaldehydetransferase; Glycolaldehyde Transferase. Enzyme Commission Number: EC 2.2.1.1. CAS No. 9014-48-6. Transketolase. Activity: > 0.1 units/mg. Storage: -20°C. Source: E. coli. Transketolase; EC 2.2.1.1; 9014-48-6; glycolaldehydetransferase; Glycolaldehyde Transferase. Cat No: NATE-0716.
Native Transketolase from Thermophillic bacteria
Transketolase is highly specific for ketol donor substrates and is stereospecific and enantioselective to hydroxyaldehyde substrates with an (R) configuration. It specifically catalyzes the irreversible transfer of one ketol unit from α-hydroxypyruvic acid to an aldehyde to produce a D-threo (3S,4R)ketose. Applications: This enzyme is a potential candidate for biocatalysis, suitable for pharmaceutical development / manufacturing. asymmetric c-c bond formation, ketol donor d-xylulose-5-phosphate may be substituted by hydroxypyruvate; preparation of ketose sugars such as fructose analogs, azasugars and fluorogenic substrates. Group: Enzymes. Synonyms: Transketolase; EC 2.2.1.1; 9014-48-6; glycolaldehydetransferase; Glycolaldehyde Transferase. Enzyme Commission Number: EC 2.2.1.1. CAS No. 9014-48-6. Transketolase. Storage: Store at -20°C. Form: Frozen Liquid. Source: Thermophillic bacteria. Transketolase; EC 2.2.1.1; 9014-48-6; glycolaldehydetransferase; Glycolaldehyde Transferase. Cat No: NATE-1162.
2-Amino-6-chloronicotinic Acid
2-Amino-6-chloronicotinic Acid is a useful synthetic intermediate. It is used in the synthesis of thiamine antagonist transketolase inhibitors. It is also used to prepare 2-aminonicotinic acid 1-oxides as inhibitors of quinolinic acid synthesis in the mammalian brain. Group: Biochemicals. Grades: Highly Purified. CAS No. 58584-92-2. Pack Sizes: 1g, 2.5g. Molecular Formula: C6H5ClN2O2, Molecular Weight: 172.57. US Biological Life Sciences.
Worldwide
3,4-Dihydroxy-3-cyclobutene-1,2-dione
3,4-dihydroxy-3-cyclobutene-1,2 dione, commonly known as squaric acid, is widely used in bioorganic and medicinal chemistry. It is an inhibitor of glyoxylase, semiqauric acid, pyruvate dehrogenase, and transketolase. It is used as a replacement for phosphate in a peptide-based ligand for an SH2 domain. Its derivatives are high-affinity ligands for excitatory amino acid receptors. These derivatives are also used as dyes for fluorescence detection of small biological molecules. Uses: 3,4-dihydroxy-3-cyclobutene-1,2-dione can be used: in fluorescence detection in immunoassays, hybridization assays, enzymatic reactions, and other analytical procedures. to form diffraction quality crystals. to synthesize a squarate dianion, which is used as a building block to create uncharged polymeric networks. these ordered structures are used in catalysis, nonlinear optics, electrical conductivity, molecular recognition, and molecular sieves. Group: Organic & printed electronics. Alternative Names: Squaric acid. CAS No. 2892-51-5. Molecular formula: (HO)2C4(=O)2. Mole weight: 114.06. Appearance: Gray crystalline solid. Purity: 95%+. IUPACName: 3,4-Dihydroxycyclobut-3-ene-1,2-dione. Canonical SMILES: C1(=C(C(=O)C1=O)O)O. Density: 1.82 g/cm³. ECNumber: 220-761-4. Catalog: ACM2892515-1.
3,4-Dihydroxy-3-cyclobutene-1,2-dione
3,4-dihydroxy-3-cyclobutene-1,2 dione, commonly known as squaric acid, is widely used in bioorganic and medicinal chemistry. It is an inhibitor of glyoxylase, semiqauric acid, pyruvate dehrogenase, and transketolase. It is used as a replacement for phosphate in a peptide-based ligand for an SH2 domain. Its derivatives are high-affinity ligands for excitatory amino acid receptors. These derivatives are also used as dyes for fluorescence detection of small biological molecules. Uses: 3,4-dihydroxy-3-cyclobutene-1,2-dione can be used: in fluorescence detection in immunoassays, hybridization assays, enzymatic reactions, and other analytical procedures. to form diffraction quality crystals. to synthesize a squarate dianion, which is used as a building block to create uncharged polymeric networks. these ordered structures are used in catalysis, nonlinear optics, electrical conductivity, molecular recognition, and molecular sieves. Group: Synthetic tools and reagents. Alternative Names: Squaric acid. CAS No. 2892-51-5. Pack Sizes: Packaging 5 g in glass bottle 25, 100 g in poly bottle. Product ID: 3,4-Dihydroxycyclobut-3-ene-1,2-dione. Molecular formula: 114.06. Mole weight: (HO)2C4(=O)2. C1(=C(C(=O)C1=O)O)O. InChI=1S/C4H2O4/c5-1-2 (6)4 (8)3 (1)7/h5-6H. PWEBUXCTKOWPCW-UHFFFAOYSA-N. 95%+.
N3PT
N3PT inhibits transketolase activity in a cell based assay. Competitive inhibition of TK by N3PT in cells treated with increasing doses of thiamine, expressed as percentage enzymatic activity (the slope of initial linear range) of controls not treated with compounds. Tumors were induced in mice at day 0 and mice were then treated at day 7 with vehicle alone or with N3PT [2]. Low-thiamine diet enhances the sensitivity to N3PT inhibition of TK in spleen. Animals were switched to diets containing 16.5 mg/kg (unchanged), 5 mg/kg, 1 mg/kg, or 0 mg/kg thiamine, from a normal chow containing 16.5mg/kg thiamine. Synonyms: N3-pyridyl thiamine. Grades: >98%. CAS No. 13860-66-7. Molecular formula: C13H19Cl2N3OS. Mole weight: 336.28.
Native Baker's yeast (S. cerevisiae) Transaldolase
Transaldolase is an enzyme (EC 2.2.1.2) of the non-oxidative phase of the pentose phosphate pathway. In humans, transaldolase is encoded by the TALDO1 gene. The following chemical reaction is catalyzed by transaldolase:sedoheptulose 7-phosphate + glyceraldehyde 3-phosphate<-> erythrose 4-phosphate + fructose 6-phosphate. Applications: Useful in systems requiring low sulfate concentrations. Group: Enzymes. Synonyms: Transaldolase; EC 2.2.1.2; 9014-46-4; dihydroxyacetonetransferase; dihydroxyacetone synthase; formaldehyde transketolase; D-Sedoheptulose-7-phosphate:D-Glyceraldehyde-3-phosphate dihydroxyacetonetransferase. Enzyme Commission Number: EC 2.2.1.2. CAS No. 9014-46-4. Transaldolase. Activity: 10-30 units/mg protein (biuret). Storage: -20°C. Form: Lyophilized, essentially sulfate-free; contains approx. 5% Citrate buffer salts. Source: Baker's yeast (S. cerevisiae). Transaldolase; EC 2.2.1.2; 9014-46-4; dihydroxyacetonetransferase; dihydroxyacetone synthase; formaldehyde transketolase; D-Sedoheptulose-7-phosphate:D-Glyceraldehyde-3-phosphate dihydroxyacetonetransferase. Cat No: NATE-0714.
Thiamine pyrophosphate
Thiamine pyrophosphate is a vitamin B-1 derivative that acts as a coenzyme of transketolase. Thiamine pyrophosphate is used in studies to assess decarboxylation mechanisms in biological systems. Applications: A vitamin and transketolase coenzyme. Group: Coenzymes. Synonyms: Aneurinepyrophosphoric acid; Cocarboxylase; Thiamine pyrophosphate chloride. CAS No. 154-87-0. Purity: ≥96%. Mole weight: 460.77. Appearance: Powder or crystalline. Form: Solid. Aneurinepyrophosphoric acid; Cocarboxylase; Thiamine pyrophosphate chloride; Thiamine pyrophosphate; 154-87-0. Cat No: COEC-046.
transaldolase
Transaldolase is an enzyme (EC 2.2.1.2) of the non-oxidative phase of the pentose phosphate pathway. In humans, transaldolase is encoded by the TALDO1 gene. Group: Enzymes. Synonyms: dihydroxyacetonetransferase; dihydroxyacetone synthase; formaldehyde transketolase. Enzyme Commission Number: EC 2.2.1.2. CAS No. 9014-46-4. Transaldolase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2029; transaldolase; EC 2.2.1.2; 9014-46-4; dihydroxyacetonetransferase; dihydroxyacetone synthase; formaldehyde transketolase. Cat No: EXWM-2029.
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