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| Product | Description | |
|---|---|---|
| Trichostatin a | Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC. Group: Inhibitors. Alternative Names: (2E, 4E, 6R)-7-(4-(DIMETHYLAMINO)PHENYL)-N-HYDROXY-4, 6-DIMETHYL-7-OXO-2, 4-HEPTADIENAMIDE; 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4, 6R-DIMETHYL-7-OXO-2E, 4E-HEPTADIENAMIDE; 4, 6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2, 4-DIENOHYDROXAMIC ACID;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID;7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide;TSA;TRICHOSTATIN A;TRICHOSTATIN A, STREPTOMYCES SPECIES. CAS No. 58880-19-6. Molecular formula: C17H22N2O3. Mole weight: 302.37. Purity: 0.9953. Density: 1.139. Catalog: ACM58880196. |  |
| Trichostatin A | Potent, reversible inhibitor of histone deacetylase. Mediates the activation of O6-methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types, induces cell growth arrest at both G1 and G2/M phases. In some cases induces apoptosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 58880-19-6. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Trichostatin A | Trichostatin A, also known as TSA, is an HDAC inhibitor. TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class of histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Uses: Reprogramming. Synonyms: TSA; Antibiotic A-300; 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide. Grades: 98%. CAS No. 58880-19-6. Molecular formula: C17H22N2O3. Mole weight: 302.37. |  |
| Trichostatin A | Trichostatin A Inhibitor. Uses: Scientific use. Product Category: T6270. CAS No. 58880-19-6. |  |
| Trichostatin A | Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II , with an IC 50 value of 1.8 nM for HDAC [1]. Uses: Scientific research. Group: Natural products. Alternative Names: TSA. CAS No. 58880-19-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15144. |  |
| Trichostatin A (TSA, A300, R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide) | Antibiotic. Antifungal. Antiprotozoal. Potent and reversible, cell permeable inhibitor of histone deacetylase (HDAC). Immunosuppressive. Anticancer compound. Antifibrogenic. Apoptosis inducer. Induces cell growth arrest at both G1 and G2/M phases. Enhances the efficacy of anticancer agents that target DNA. Inactivates mitotic spindle checkpoint. Smooth muscle cell proliferation inhibitor. Telomerase inhibitor. Downregulates DNA methyltransferase DNMT1 and affects DNA methylation. Anti-inflammatory. Inhibits osteoclastogenesis and bone resorption. Group: Biochemicals. Alternative Names: TSA, A300, R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide. Grades: Highly Purified. CAS No. 58880-19-6. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H22N2O3, Molecular Weight: 302.4. US Biological Life Sciences. | Worldwide |
| Trichostatin A (TSA) (Histone Deacetylase Inhibitor)89/1/20 | Trichostatin A is an antifungal antibiotic that is a reversible, potent and specific inhibitor of mammalian histone deacetylase (HDAC) both in vivo and in vitro. Histone deacetylase inhibition causes chromatin relaxation and gene expression modulation. May induce apoptosis. TSA inhibits the eukaryotic cell cycle and induces morphological reversion of transformed cells. It blocks cell cycle progression at G1 phase in Hela Cells. TSA causes accumulation of highly acetylated histones in vivo, while inhibiting the activity of partially purified histone deacetylase in vitro. Group: Biochemicals. Alternative Names: 4,6-Dimethyl-7-[p-dimethylaminophenyl]- 7-oxohepta-2, 4-dienohydroxamic acid). Grades: Highly Purified. CAS No. 58880-19-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Trichostatin C | Trichostatin C can protect the more unstable N-OH group of trichostatin A. It has anti-fungal, protozoan and anti-tumor activity. Synonyms: 145-A. Grades: >95% by HPLC. CAS No. 68676-88-0. Molecular formula: C23H32N2O8. Mole weight: 464.51. | |
| Trichostatin C (Antibiotic 145-A) | Trichostatin C is the first example of a glucopyranosyl hydroxamate from nature. The conjugation may act to protect the less stable N-OH group of Trichostatin A. Trichostatin C displays antifungal, antiprotozoan and antitumor activity, albeit less active than trichostatin A. Group: Biochemicals. Alternative Names: Antibiotic 145-A. Grades: Highly Purified. CAS No. 68676-88-0. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Trichostatin D | Trichostatin D is a metamorphosis cell phenotype recovery inducer produced by the strain of Streptomyces violaceusniger. Synonyms: 1-O-({(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxohepta-2,4-dienoyl}amino)-alpha-D-glucopyranose. CAS No. 157479-37-3. Molecular formula: C23H32N2O8. Mole weight: 464.51. | |
| Trichostatin RK | Trichostatin RK is a trigustatine derivative produced by the strain of Streptomyces sp. RK98-A74. It can induce luciferase, but its activity is lower than that of trigustatin. Molecular formula: C18H24N2O2. Mole weight: 300.39. | |
| 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole | Histone deacetylase (HDAC) inhibitors are able to interrupt cell cycle progression in transformed cell lines and may be explored as new clinical agents in cancer therapy. 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole has been shown to suppress the biological effects induced by the HDAC inhibitor, Trichostatin A (T774710). Group: Biochemicals. Grades: Highly Purified. CAS No. 200626-61-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C13H7Cl2N3O, Molecular Weight: 292.12. US Biological Life Sciences. | Worldwide |
| β-Alanine methyl ester hydrochloride | β-Alanine Methyl Ester is an intermediate in the synthesis of Trichostatin A and Trapoxin B as histone deacetylase inhibitors. Synonyms: β-Ala-OMe HCl; Methyl 3-aminopropanoate Hydrochloride; beta-Alanine methyl ester hydrochloride; h-beta-ala-ome hydrochloride; beta-alanine methyl ester HCl; 3-aminopropanoic acid methyl ester hydrochloride; Methyl beta-alaninate hydrochloride; 3-aminopropionic acid methyl ester hydrochloride. Grades: ≥ 98% (HPLC). CAS No. 3196-73-4. Molecular formula: C4H9NO2·HCl. Mole weight: 139.62. | |
| β-Alanine Methyl Ester Hydrochloride | β-Alanine Methyl Ester is an intermediate in the synthesis of Trichostatin A (T774710) and Trapoxin B as histone deacetylase inhibitors. Group: Biochemicals. Alternative Names: (3-Methoxy-3-oxopropyl)ammonium Chloride; 3-Aminopropanoic Acid Methyl Ester Hydrochloride; 3-Aminopropionic Acid Methyl Ester Hydrochloride; 3-Aminopropionic Acid Methyl Ester Monohydrochloride; Methyl 3-Aminopropanoate Hydrochloride; Methyl 3-Aminopropionate Hydrochloride; Methyl β-Alaninate Hydrochloride. Grades: Highly Purified. CAS No. 3196-73-4. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| CAY10591 | Sirtuins (SIRTs) are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. SIRT1 Activator 3 is a member of the sirtuins (SIRTs), which is a distinctive class of trichostatin A-insensitive lysyl-deacetylases. CAY10591 has been shown to increase fluorescence by 233% in a SIRT1 activity assay, and to suppress TNF-α in a dose-dependent manner. It suppresses TNF-α in a dose-dependent manner. Uses: Enzyme activators. Synonyms: SIRT1 Activator 3; Sirtuin 1 Activator 3; CAY 10591; CAY-10591. Grades: ≥98%. CAS No. 839699-72-8. Molecular formula: C20H25N5O2. Mole weight: 367.5. | |
| CAY10721 | Sirtuins (SIRTs) are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. SIRT1 Activator 3 is a member of the sirtuins (SIRTs), which is a distinctive class of trichostatin A-insensitive lysyl-deacetylases. CAY10721 is an inhibitor of SIRT3. It is a class III HDAC (39% SIRT3 inhibition at 200 μM). Synonyms: CAY 10721; CAY-10721. Grades: ≥98%. CAS No. 848688-62-0. Molecular formula: C18H13N3O3S. Mole weight: 351.4. | |
| CAY10722 | Sirtuins (SIRTs) are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. SIRT1 Activator 3 is a member of the sirtuins (SIRTs), which is a distinctive class of trichostatin A-insensitive lysyl-deacetylases. CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). Synonyms: CAY 10722; CAY-10722. Grades: ≥98%. CAS No. 388086-13-3. Molecular formula: C21H14Cl2N2O2. Mole weight: 397.3. | |
| ITSA1 | ITSA1 is a cell-permeable HDAC activator via inhibition of trichostatin A (TSA), which is a reversible inhibitor of HDAC. ITSA1 was showed to specifically counteract TSA-induced cell cycle arrest, histone acetylation, transcriptional activation, and cytoplasmic alpha-tubulin acetylation. Synonyms: ITSA-1; ITSA 1; N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide. Grades: ≥95%. CAS No. 200626-61-5. Molecular formula: C13H7Cl2N3O. Mole weight: 292.1. | |
| ITSA-1 (N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide, ITSA1) | Cell-permeable. ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct acetylation events (histone and tubulin). ITSA-1 specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 reverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 200626-61-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| M344 | An amide analog of Trichostatin A that potently Inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2uM) of murine erythroleukemia cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 251456-60-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-Hydroxy-7- (4-dimethylaminobenzoyl) aminoheptanamide | Histone deacetylase inhibitor III. A cell-permeable amide analog of Trichostatin A that potently inhibits HDACs. Group: Biochemicals. Alternative Names: 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide. Grades: Highly Purified. CAS No. 251456-60-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Tubacin | Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC50=4nm). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits a-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of a-tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated a-tubulin deacetylation in mammalian cells. Group: Biochemicals. Alternative Names: (N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl- 2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3- dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide). Grades: Highly Purified. CAS No. 537049-40-4. Pack Sizes: 500ug, 1mg, 2.5mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 721.86. US Biological Life Sciences. | Worldwide |
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