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5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C14H9Cl3N2OS. CAS No. 68786-66-3. Prepack ID 65631957-5g. Molecular Weight 359.66. See USA prepack pricing.
Triclabendazole
Triclabendazole(CGA89317) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.Target: Microtubule/TubulinTriclabendazole treatment produces percentage decreases of the fluke egg output by 15.3%, 4.3% and 36.6%, respectively, in sheep, dairy cows and heifers, these results indicate the presence of TCBZ-resistant Fasciola hepatica in sheep and cattle on this farm. Triclabendazole sulphoxide (50 mg/mL) results in extensive damage to the tegument of triclabendazole-susceptible F. hepatica, whereas triclabendazole-resistant flukes shows only localized and relatively minor disruption of the tegument covering the spines.Triclabendazole is metabolized into a number of compounds, depending on the route of administration, plasma levels peak at 18-24 hours (Triclabendazole sulphoxide) and 36-48 hours (Triclabendazole sulphone), neither Triclabendazole nor any toher metabolites can be detected in plasma. Triclabendazole sulphoxide blocks the transport of secretory bodies from the cell body to the tegumental surface, the block occurs at the site of their formation by the Golgi complex in the cell body, in their movement through the cytoplasmic connections to the syncytium, and in their movement from the base to the apex of the syncytium. Triclabendazole binds to the colchicine binding site on the β-tubulin molecule and this has been used at the basis for evaluÂ…
Triclabendazole
Triclabendazole is a benzimidazole, and it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis. It is a new type of imidazole anthelmintic. It is effective for Fasciola hepatica in ruminants such as cattle, sheep, goats, and Fasciola hepatica, Fasciola deer, Fasciola hepatica, Fasciola hepatica, etc. Synonyms: 5-Chloro-6-(2,3-dichlorophenoxy)-2-methylthiobenzimidazole; CGA-89317, Egaten; Fasinex. Grades: >98%. CAS No. 68786-66-3. Molecular formula: C14H9Cl3N2OS. Mole weight: 359.66.
Triclabendazole
Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti- Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CGA89317. CAS No. 68786-66-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0621.
An anthelmintic (fasciola). Group: Biochemicals. Alternative Names: 5-Chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole, CGA-89317, Fasinex. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
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Triclabendazole S-Oxide
Triclabendazole S-Oxide is an impurity of Triclabendazole. Triclabendazole is an anthelmintic used for liver fiukes. Molecular formula: C14H9Cl3N2O2S. Mole weight: 375.66.
Triclabendazole (Standard)
Triclabendazole (Standard) is the analytical standard of Triclabendazole. This product is intended for research and analytical applications. Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti- Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 68786-66-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0621R.
Triclabendazole sulfone
Triclabendazole sulfone is an impurity of Triclabendazole. Triclabendazole is an anthelmintic used for liver fiukes. Synonyms: 5-Chloro-6-(2,3-dichlorophenoxy)-2-methylsulfonyl-1H-benzoimidazole. CAS No. 106791-37-1. Molecular formula: C14H9Cl3N2O3S. Mole weight: 391.647.
Triclabendazole Sulfone
Triclabendazole Sulfone. Group: Biochemicals. Alternative Names: 6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfonyl)-1H-benzimidazol. Grades: Highly Purified. CAS No. 106791-37-1. Pack Sizes: 25mg. Molecular Formula: C14H9Cl3N2O3S, Molecular Weight: 391.66. US Biological Life Sciences.
Worldwide
Triclabendazole sulfoxide
Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TCBZ-SO. CAS No. 100648-13-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136450.
Triclabendazole Sulfoxide
Triclabendazole Sulfoxide. Group: Biochemicals. Alternative Names: 6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfinyl)-1H-benzimidazole. Grades: Highly Purified. CAS No. 100648-13-3. Pack Sizes: 25mg. Molecular Formula: C14H9Cl3N2O2S, Molecular Weight: 375.66. US Biological Life Sciences.
Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.1 In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the ParkinsonÂ’s disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.2,3. Group: Biochemicals. Alternative Names: 5-Chloro-6- (2, 3-dichlorophenoxy) -2- methyl thiobenzimidazole; CGA-89317, egaten; Fasinex; Triclabendazole. Grades: Highly Purified. CAS No. 68786-66-3. Pack Sizes: 25g, 50g, 100g. Molecular Formula: C14H9Cl3N2OS, Molecular Weight: 359.66. US Biological Life Sciences.
Worldwide
Amino Triclabendazole HCl
Amino Triclabendazole HCl is an impurity of Triclabendazole. Triclabendazole is an anthelmintic used for liver fiukes. Molecular formula: C14H10Cl3N3OS HCl. Mole weight: 374.68.
Hydroxy Triclabendazole
Hydroxy Triclabendazole is a metabolite of Triclabendazole. Triclabendazole is an anthelmintic used for liver fiukes. Synonyms: Triclabendazole Sulfoxide; 6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfinyl)-1H-benzimidazole. CAS No. 100648-13-3. Molecular formula: C14H9Cl3N2O2S. Mole weight: 375.66.
5-Chloro-6-(2,3-dichlorophenoxy)-1,3-dihydro-2H-benzimidazol-2-one is a metabolite of Triclabendazole, the only anthelmintic drug, which is active against immature, mature and adult stages of fluke. Group: Biochemicals. Alternative Names: Ketotriclabendazole. Grades: Highly Purified. CAS No. 1201920-88-8. Pack Sizes: 10mg. Molecular Formula: C??H?Cl?N?O?, Molecular Weight: 329.57. US Biological Life Sciences.
Worldwide
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