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1-[2-(Methylsulfonyl)benzyl]-N-([6-(trifluoromethyl)pyridin-3-yl]methyl)piperidin-4-amine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-[2-(METHYLSULFONYL)BENZYL]-N-([6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]METHYL)PIPERIDIN-4-AMINE. Product Category: Heterocyclic Organic Compound. CAS No. 909675-57-6. Molecular formula: C20H24F3N3O2S. Mole weight: 427.4836696. Product ID: ACM909675576. Alfa Chemistry ISO 9001:2015 Certified. Categories: 1-[(2-methylsulfonylphenyl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]piperidin-4-amine.
1-Cyclopropyl-2- ( (dimethylamino) methylene) -3- (2- (methylsulfonyl) -4- (trifluoromethyl) phenyl) propane-1, 3-dione is an intermediate in the synthesis of derivatives of isoxaflutole (I918140), a herbicide used for weed control. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C17H18F3NO4S. US Biological Life Sciences.
1-Cyclopropyl-3-[2- (methylsulfonyl) -4- (trifluoromethyl) phenyl]-1, 3-propanedione is an intermediate in the synthesis of derivatives of isoxaflutole (I918140), a herbicide used for weed control. Group: Biochemicals. Grades: Highly Purified. CAS No. 141112-23-4. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C14H13F3O4S. US Biological Life Sciences.
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2-Methylsulfonyl-4-trifluoromethylbenzoic Acid
2-Methylsulfonyl-4-trifluoromethylbenzoic acid is a Benzoic acid derivative and is also a metabolite of Isoxaflutole, a herbicide used for the control of broadleaf and grass weeds in corn and sugarcane crops. Group: Biochemicals. Grades: Highly Purified. CAS No. 142994-06-7. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H7F3O4S. US Biological Life Sciences.
Acetonitrile,2-[[[3-(trifluoromethyl)phenyl]methyl]sulfonyl]-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(TRIFLUOROMETHYL)BENZYLSULFONYL ACETONITRILE;3-(TRIFLUOROMETHYL)BENZYLSULPHONYL ACETONITRILE;(3-TRIFLUOROMETHYLPHENYLMETHANESULFONYL)ACETONITRILE;3-(Trifluoromethyl)benzylsulphonylacetonitrile97%;2-(3-TRIFLUOROMETHYLPHENYLMETHANESULPHONYL)ACETONITRILE. Product Category: Heterocyclic Organic Compound. CAS No. 175276-81-0. Molecular formula: C10H8F3NO2S. Mole weight: 263.24. Purity: 0.96. IUPACName: 2-[[3-(trifluoromethyl)phenyl]methylsulfonyl]acetonitrile. Canonical SMILES: C1=CC(=CC(=C1)C(F)(F)F)CS(=O)(=O)CC#N. Density: 1.354g/cm³. Product ID: ACM175276810. Alfa Chemistry ISO 9001:2015 Certified.
BAY 85-8501
This active molecular is a highly selective neutrophil elastase inhibitor.IC50 for HNE is 0.065 nM, LipE is 7.2. BAY 85-8501 was being tested in clinical studies for the treatment of pulmonary diseases. In Feb 2013, Phase-II clinical trials in Bronchiectasis in Spain were on going. In Mar 2013, Phase-II clinical trials in Bronchiectasis in France, Germany and Italy were on going. In Jun 2014, Bayer completed a phase IIa trial in Bronchiectasis in United Kingdom, Spain, France, Germany and Italy. Uses: The treatment of pulmonary diseases. Synonyms: BAY 85-8501; BAY85-8501; BAY-85-8501; BAY 858501; BAY858501; BAY-858501. (S)-4-(4-cyano-2-(methylsulfonyl)phenyl)-3,6-dimethyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1161921-82-9. Molecular formula: C22H17F3N4O3S. Mole weight: 474.46.
CAY10404
CAY10404 is a potent, selective COX-2 inhibitor. Synonyms: CAY 10404; CAY-10404; CAY10404; 3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-isoxazole. CAS No. 340267-36-9. Molecular formula: C17H12F3NO3S. Mole weight: 367.4.
Defactinib hydrochloride
Defactinib HCl is a potent FAK phosphorylation inhibitor, overcoming YB-1-mediated paclitaxel resistance by an AKT-dependent pathway. Synonyms: N-Methyl-4-((4-(((3-(methyl(methylsulfonyl)amino)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide monohydrochloride; Defactinib hydrochloride; Defactinib HCl; VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878; PF4554878. Grades: >98%. CAS No. 1073160-26-5. Molecular formula: C20H22ClF3N8O3S. Mole weight: 546.95.
DPC 423
DPC 423. Group: Biochemicals. Alternative Names: 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide hydrochloride; 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide monohydrochloride. Grades: Highly Purified. CAS No. 292135-59-2. Pack Sizes: 10mg. Molecular Formula: C25H21ClF4N4O3S. US Biological Life Sciences.
Worldwide
Esaxerenone
Esaxerenone is a highly potent and selective non-steroidal mineralocorticoid receptor antagonist. Esaxerenone is currently under clinical trials developed by Daiichi Sankyo Company for the treatment of hypertension, essential hypertension, hyperaldosteronism, and diabetic nephropathies. Uses: Potential treatment of hypertension, diabetic nephropathies, etc. Synonyms: Esaxerenone; CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550; 1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide. CAS No. 1632006-28-0. Molecular formula: C22H21F3N2O4S. Mole weight: 466.475.
Fevipiprant
Fevipipran is a reversible competitive CRTh2 antagonist with IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood. Now it is in Phase III clinical trials for the treatment of asthma. Uses: Allergic asthma; atopic dermatitis. Synonyms: NVP-QAW039; NVP-QAW 039; NVP-QAW-039 QAW-039; QAW039; QAW 039; Fevipiprant; 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid. Grades: 98%. CAS No. 872365-14-5. Molecular formula: C19H17F3N2O4S. Mole weight: 426.41.
Flubendiamide
Flubendiamide. Group: Biochemicals. Alternative Names: NNI 0001; RIL 038; Synapse; Synapse (insecticide); Takumi; Belt; Fame; Fame (insecticide); N2-[1, 1-dimethyl-2- (methylsulfonyl) ethyl]-3-iodo-N1-[2-methyl-4-[1, 2, 2, 2-tetrafluoro-1- (trifluoromethyl) ethyl]phenyl]-1, 2-benzenedicarboxamide. Grades: Highly Purified. CAS No. 272451-65-7. Pack Sizes: 100mg. Molecular Formula: C23H22F7IN2O4S, Molecular Weight: 682.39. US Biological Life Sciences.
Worldwide
Fomesafen
Fomesafen is a protoporphyrinogen oxidae (PPO) inhibitor. Synonyms: Fomesafene; 5-(2-Chloro-4-(trifluoromethyl)phenoxy)-N-(methylsulfonyl)-2-nitrobenzamide; Reflex. Grades: 95%. CAS No. 72178-02-0. Molecular formula: C15H10ClF3N2O6S. Mole weight: 438.76.
GSK-2033
GSK-2033 is a potent cell-active LXR antagonist (pIC50 = 7.5). It enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells and is cell permeable. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GSK-2033; GSK2033; GSK 2033. Product Category: Antagonists. Appearance: Solid powder. CAS No. 1221277-90-2. Molecular formula: C29H28F3NO5S2. Mole weight: 591.66. Purity: >98%. IUPACName: 2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide. Canonical SMILES: O=S(C1=C(C)C=C(C)C=C1C)(N(CC2=CC=C(C3=CC=CC(S(=O)(C)=O)=C3)C=C2)CC4=CC=C(C(F)(F)F)O4)=O. Product ID: ACM1221277902. Alfa Chemistry ISO 9001:2015 Certified.
GSK-2033
This active molecular is a cell permeable, potent LXR (liver-X-receptor) antagonist. pIC50 values is 7.0 for LXRα and 7.4 for LXR&beta. GSK2033 enhances T-cell proliferation and Th1/Th2/Th17 differentiation when treatment of murine CD41 T cells. Synonyms: GSK-2033; GSK2033; GSK 2033; CHEMBL1093266;GTPL8690; SCHEMBL13280409;2,4,6-trimethyl-N-[[4-(3-methylsulfonylphenyl)phenyl]methyl]-N-[[5-(trifluoromethyl)furan-2-yl]methyl]benzenesulfonamide. Grades: 98%. CAS No. 1221277-90-2. Molecular formula: C29H28F3NO5S2. Mole weight: 591.66.
GSK-2881078
GSK-2881078, an indole derivative, has been found to be an androgen receptor modulator that could probably be effective against Cachexia. It is still under Phase I trail. Uses: Anabolic agents. Synonyms: GSK 2881078; GSK2881078; CS-5736; (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile. Grades: 98%. CAS No. 1539314-06-1. Molecular formula: C14H13F3N2O2S. Mole weight: 330.33.
IACS-010759
IACS-010759 is an orally bioavailable inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targeting complex I of the electron transport chain (NADH ubiquinone oxidoreductase). Study showed that IACS-010759 induced AMPK activation leading to mTOR suppression which resulted in cell growth inhibition in AML cells. Synonyms: 5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole. Grades: ≥98%. CAS No. 1570496-34-2. Molecular formula: C25H25F3N6O4S. Mole weight: 562.57.
Iclepertin
Iclepertin, a glycine transporter inhibitor, is an antipsychotic drug. Synonyms: [5-(methanesulfonyl)-2-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}phenyl]{(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl}methanone; (5-(methylsulfonyl)-2-(((R)-1,1,1-trifluoropropan-2-yl)oxy)phenyl)((1R,5R)-1-(5-(trifluoromethyl)isoxazol-3-yl)-3-azabicyclo[3.1.0]hexan-3-yl)methanone. CAS No. 1421936-85-7. Molecular formula: C20H18F6N2O5S. Mole weight: 512.42.
JNJ-10329670
JNJ-10329670 represents a novel class of immunosuppressive compounds with a highly potent (Ki ~30 nM). Uses: Immunosuppressant. Synonyms: JNJ-10329670; JNJ 10329670; JNJ10329670. 1-(3-(4-(6-chloro-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)propyl)-4,5,6,7-tetrahydro-5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-1H-Pyrazolo(4,3-C)pyridine. Grades: ≥98%. CAS No. 400797-24-2. Molecular formula: C30H34ClF3N6O3S. Mole weight: 651.14.
MK-0822
MK-0822 is a newly developed bone-targeting dual action pro-drug for osteoporosis and bone metastasis. It is also an inhibitor of cathepsin K, an enzyme involved in bone resorption. Group: Biochemicals. Alternative Names: N- (1-cyanocyclopropyl) -4-fluoro-N2-{ (1S) -2, 2, 2-trifluoro-1-[4'- (methylsulfonyl) biphenyl-4-yl]ethyl}-L-leucinamide, Odanacatib. Grades: Highly Purified. CAS No. 603139-19-1. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
MMV390048
MMV390048 is a novel antimalarial compound and it can competitively inhibit the binding of only a single protein, P. falciparum PI4 kinase, to the beads. MV390048 can become a child-friendly drug candidate for uncomplicated malaria that could be given as one single dose, completing the treatment in just one day. In May 2016, Phase I/II clinical trials in Malaria (In volunteers) in Australia was on-going. Uses: Malaria. Synonyms: UNII-0Z5T00JJ10;5-(4-(methylsulfonyl)phenyl)-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine;MMV390048; MMV-390048; MMV 390048; MMV-048; MMV 048; MMV048. Grades: 98%. CAS No. 1314883-11-8. Molecular formula: C18H14F3N3O2S. Mole weight: 393.38.
PF-573228
A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells. Group: Biochemicals. Alternative Names: 3, 4-Dihydro-6-[[4-[[[3- (methylsulfonyl) phenyl]methyl]amino]-5- (trifluoromethyl) -2-pyrimidinyl]amino]-2 (1H) -quinolinone; 6- [ (4- ( (3- (Methanesulfonyl) benzyl) amino) -5-trifluoro methyl pyrimidin-2-yl) amino] -3, 4-dihydro-1H-quinolin-2-one; PF 573228. Grades: Highly Purified. CAS No. 869288-64-2. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Potassium Tris (trifluoromethanesulfonyl)methanide
Potassium Tris (trifluoromethanesulfonyl)methanide. Group: Electrolytesbattery materials. CAS No. 114395-69-6. Product ID: potassium; bis (trifluoromethylsulfonyl) methylsulfonyl-trifluoromethane. Molecular formula: 450.30. Mole weight: C4F9KO6S3. [C-] (S (=O) (=O)C (F) (F)F) (S (=O) (=O)C (F) (F)F)S (=O) (=O)C (F) (F)F. [K+]. InChI=1S/C4F9O6S3.K/c5-2(6, 7)20(14, 15)1(21(16, 17)3(8, 9)10)22(18, 19)4(11, 12)13;/q-1;+1. RJPWSGDBEHVWPP-UHFFFAOYSA-N. >98.0%(T).
RPA 202248
RPA 202248. Group: Biochemicals. Alternative Names: α-(Cyclopropylcarbonyl)-2-(methylsulfonyl)- β -oxo-4- (trifluoromethyl) benzenepropanenitrile. Grades: Highly Purified. CAS No. 143701-75-1. Pack Sizes: 5mg. Molecular Formula: C15H12F3NO4S, Molecular Weight: 359.32. US Biological Life Sciences.
Worldwide
Sarolaner
Sarolaner is an antiparasitic agent. It is used as veterinary drug. Uses: Antiparasitic agent (veterinary use). Synonyms: PF-6450567; PF 6450567; PF6450567; (S)-1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethan-1-one. Grades: 98%. CAS No. 1398609-39-6. Molecular formula: C23H18Cl2F4N2O5S. Mole weight: 581.37.
SC-58125
SC-58125 is a selective COX-2 inhibitor. Uses: Cyclooxygenase inhibitors. Synonyms: SC-58125; SC 58125; SC58125; 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole. CAS No. 162054-19-5. Molecular formula: C17H12F4N2O2S. Mole weight: 384.3.
SC-58125
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor with anti-inflammatory properties. SC-58125 blocks edema and hyperalgesia without causing gastric mucosal damage. SC-58125 also displays antitumor activity. Group: Biochemicals. Alternative Names: 5-(4-Fluorophenyl)-1-(4-methylsulfonylphenyl)-3-trifluoromethyl-1H-pyrazole; SC 58125. Grades: Highly Purified. CAS No. 162054-19-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C17H12F4N2O2S, Originator: Pfizer. US Biological Life Sciences.
Worldwide
WYE 672
WYE 672 is a tissue selective liver X receptor (LXR) agonist selectively binds to LXRα (IC50 >1.0 μM). Synonyms: WYE 672; WYE672; WYE-672; 3-methyl-2-[4-(3-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)quinoxaline. Grades: 99%. CAS No. 1221265-37-7. Molecular formula: C23H17F3N2O2S. Mole weight: 442.45.
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