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CP-199330, a chromen derivative, has been found to be a Leukotriene D4 receptor antagonist that was once studied against asthma by Pfizer. Synonyms: CP-199330; CP 199330; CP199330; UNII-V4WYK6T8QA; CHEMBL96206; V4WYK6T8QA; SCHEMBL8890632; BDBM50081532; N-[3-[[(3R,4R)-6-[(7-chloroquinolin-2-yl)methoxy]-4-hydroxy-3,4-dihydro-2H-chromen-3-yl]methyl]-4-methoxyphenyl]-1,1,1-trifluoromethanesulfonamide. Grades: 98%. CAS No. 158102-92-2. Molecular formula: C28H24ClF3N2O6S. Mole weight: 609.01.
MRK 560, under the IUPAC name N-((1r,4r)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamide, is a novel orally bioavailable γ-secretase inhibitor and inhibites the production of Aβ40 and Aβ42 (in vitro: IC50 = 0.65 nM). in vivo: Reduces Aβ in the brain (ED50 = 6 mg/kg) and cerebrospinal fluid (CSF) (ED50 = 10 mg/kg) in the rat markedly. Synonyms: N-((1r,4r)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamide; MRK560; MRK 560; MRK-560; 677772-84-8. CAS No. 677772-84-8. Molecular formula: C19H17ClF5NO4S2. Mole weight: 517.92.
MRK-560
MRK-560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system. Group: Fluorinated apis. Alternative Names: N-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide. CAS No. 677772-84-8. Molecular formula: C19H17ClF5NO4S2. Mole weight: 517.92. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: N-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide. Catalog: OFC677772848.