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| Product | Description | |
|---|---|---|
| tunicamycin | Tunicamycin, a mixture of homologous nucleoside antibiotics, has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells. Tunicamycin blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Synonyms: A nucleoside antibiotic. Grades: >99% by HPLC. CAS No. 11089-65-9. Molecular formula: C39H64N4O16 (n=10). Mole weight: 844.94 (n=10). |  |
| Tunicamycin | N-linked glycosylation is a highly regulated post-translational modification that is involved in protein folding and conformation, oligomerization, sorting, cell-cell interactions, and targeting of proteins to sub- or extra-cellular locations. It is initiated in the endoplastic reticulum with the transfer of a carbohydrate moiety to an asparagine residue within a specific amino acid consensus sequence and then further processed in the Golgi whereupon a mature glycoprotein is exported through the secretory machinery to the plasma membrane. Tunicamycin, a mixture of nucleoside antibiotics, is a specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis thereby inducing protein unfolding. At 500 nM, it can impair the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, and IGF-IR.1 Also at 500 nM, it radiosensitizes U251 glioma and BXPC3 pancreatic adenocarcinoma cells to chemotherapy.1 Tunicamycin impairs ALK phosphorylation Group: Biochemicals. Alternative Names: Streptomyces Iysosuperficus. Grades: Molecular Biology Grade. CAS No. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C39H64N4O16, Molecular Weight: 844.4. US Biological Life Sciences. |  Worldwide |
| Tunicamycin | Tunicamycin Inhibitor. Uses: Scientific use. Product Category: T13229. CAS No. 11089-65-9. |  |
| Tunicamycin | Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity.Tunicamycin increases exosome release in cervical cancer cells. Group: Inhibitors. Alternative Names: tunicamycin, Tunicamycin A1, CID5607, 11089-65-9. CAS No. 11089-65-9. Molecular formula: C37H60N4O16. Mole weight: 816.89. Appearance: White to off-white powder. Purity: 98%+. IUPACName: N-[2-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[2-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4,5-dihydroxyoxan-3-yl]-12-methyltridec-2-enamide. Canonical SMILES: CC (C)CCCCCCCCC=CC (=O)NC1C (C (C (OC1OC2C (C (C (C (O2)CO)O)O)NC (=O)C)CC (C3C (C (C (O3)N4C=CC (=O)NC4=O)O)O)O)O)O. Density: 1.57g/cm³. Catalog: ACM11089659. |  |
| (D-Glycero-a-D-manno-heptopyranosyl)-dihydrogenphosphate cyclohexylammonium salt | (D-Glycero-a-D-manno-heptopyranosyl)-dihydrogenphosphate cyclohexylammonium salt, a notable compound within the biomedical sector for its extensive utilization in research based studies, can be employed in examining aspects related to the biosynthesis of heptose-containing antibiotics, for example, tunicamycin. Molecular formula: C7H15O10P.C6H13N. Mole weight: 389.34. | |
| HtrA2 peptidase | This enzyme is upregulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment. It can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP). Belongs in peptidase family S1C. Group: Enzymes. Synonyms: high temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; serine proteinase OMI; HtrA2 protease; OMI/HtrA2 protease; HtrA2/Omi; Omi/HtrA2. Enzyme Commission Number: EC 3.4.21.108. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4103; HtrA2 peptidase; EC 3.4.21.108; high temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; serine proteinase OMI; HtrA2 protease; OMI/HtrA2 protease; HtrA2/Omi; Omi/HtrA2. Cat No: EXWM-4103. |  |
| IRE1 Inhibitor III, 4u8C (8-Formyl-7-hydroxy-4-methylcoumarin, 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde, ER-to-Nucleus Signaling 1 Inhibitor III, Inositol-Reguiring Protein 1 Inhibitor III) | A cell-permeable coumarin o-hydroxyaldehyde that inhibits IRE1 RNase activity in a time- and dose-dependent manner (IC50=550 and 45nM, respectively, with 0 and 16min drug preincubation in RNA cleavage assays) by covalently targeting IRE1 Lys907 via Schiff base formation, effectively preventing ER stress-induced site-specific mRNA splicing as well as RIDD (Regulated IRE1-Dependent Degradation) mRNA degradation (IC50=6.9 and 4.1uM, respectively, against Xbp1 splicing and Scara3 degradation) in MEF cultures following Tunicamycin treatment. Comparing to STF083010, 4u8C is also shown to inhibit IRE1 autophosphorylation in cell-free assays via Schiff base formation with IRE1 Lys599 in the absence of ADP, however cellular nucleotide prevents 4u8C from targeting IRE1 Lys599 intracellularly. Group: Biochemicals. Grades: Highly Purified. CAS No. 14003-96-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
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