Tunicamycin Suppliers USA
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Product | Description | |
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tunicamycin Quick inquiry Where to buy Suppliers range | Tunicamycin, a mixture of homologous nucleoside antibiotics, has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells. Tunicamycin blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Synonyms: A nucleoside antibiotic. Grades: >99% by HPLC. CAS No. 11089-65-9. Molecular formula: C39H64N4O16 (n=10). Mole weight: 844.94 (n=10). | |
Tunicamycin Quick inquiry Where to buy Suppliers range | N-linked glycosylation is a highly regulated post-translational modification that is involved in protein folding and conformation, oligomerization, sorting, cell-cell interactions, and targeting of proteins to sub- or extra-cellular locations. It is initiated in the endoplastic reticulum with the transfer of a carbohydrate moiety to an asparagine residue within a specific amino acid consensus sequence and then further processed in the Golgi whereupon a mature glycoprotein is exported through the secretory machinery to the plasma membrane. Tunicamycin, a mixture of nucleoside antibiotics, is a specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis thereby inducing protein unfolding. At 500 nM, it can impair the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, and IGF-IR.1 Also at 500 nM, it radiosensitizes U251 glioma and BXPC3 pancreatic adenocarcinoma cells to chemotherapy.1 Tunicamycin impairs ALK phosphorylation Group: Biochemicals. Alternative Names: Streptomyces Iysosuperficus. Grades: Molecular Biology Grade. CAS No. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C39H64N4O16, Molecular Weight: 844.4. US Biological Life Sciences. | Worldwide |
Tunicamycin Quick inquiry Where to buy Suppliers range | White to off-white powder. Group: Main Products. Alternative Names: tunicamycin, Tunicamycin A1, CID5607, 11089-65-9. Grades: 98%+. CAS No. 11089-65-9. Molecular formula: C37H60N4O16. Mole weight: 816.89. IUPAC Name: N-[2-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[2-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4,5-dihydroxyoxan-3-yl]-12-methyltridec-2-enamide. Exact Mass: 816.40000. Melting Point: 234 - 235ÂșC. Density: 1.57g/cm3. SMILES: CC (C)CCCCCCCCC=CC (=O)NC1C (C (C (OC1OC2C (C (C (C (O2)CO)O)O)NC (=O)C)CC (C3C (C (C (O3)N4C=CC (=O)NC4=O)O)O)O)O)O. InChIKey: YJQCOFNZVFGCAF-UHFFFAOYSA-N. H-Bond Donor: 11. H-Bond Acceptor: 16. Safty Description: 28-37/39-45. Hazard statements: T+: Very toxic. | |
Tunicamycin Quick inquiry Where to buy Suppliers range | Tunicamycin is a competitive cell cycle inhibitor exhibiting antiungal properties and is widely used in the study of glycoprotein synthesis. Uses: Microbial Fermentation Products. CAS No. 11089-65-9. Product ID: MFP-054. | |
Tunicamycin Quick inquiry Where to buy Suppliers range | Tunicamycin Inhibitor. Uses: Scientific use. Product Category: T13229. CAS No. 11089-65-9. | |
Tunicamycin Ready Made Solution Quick inquiry Where to buy Suppliers range | 5 mg/mL in DMSO, from Streptomyces sp. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 11089-65-9. Pack Sizes: 1ML. Mole weight: 816.89. EC Number: 200-664-3. Catalog: AP11089659. | |
(D-Glycero-a-D-manno-heptopyranosyl)-dihydrogenphosphate cyclohexylammonium salt Quick inquiry Where to buy Suppliers range | (D-Glycero-a-D-manno-heptopyranosyl)-dihydrogenphosphate cyclohexylammonium salt, a notable compound within the biomedical sector for its extensive utilization in research based studies, can be employed in examining aspects related to the biosynthesis of heptose-containing antibiotics, for example, tunicamycin. Molecular formula: C7H15O10P.C6H13N. Mole weight: 389.34. | |
IRE1 Inhibitor III, 4u8C (8-Formyl-7-hydroxy-4-methylcoumarin, 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde, ER-to-Nucleus Signaling 1 Inhibitor III, Inositol-Reguiring Protein 1 Inhibitor III) Quick inquiry Where to buy Suppliers range | A cell-permeable coumarin o-hydroxyaldehyde that inhibits IRE1 RNase activity in a time- and dose-dependent manner (IC50=550 and 45nM, respectively, with 0 and 16min drug preincubation in RNA cleavage assays) by covalently targeting IRE1 Lys907 via Schiff base formation, effectively preventing ER stress-induced site-specific mRNA splicing as well as RIDD (Regulated IRE1-Dependent Degradation) mRNA degradation (IC50=6.9 and 4.1uM, respectively, against Xbp1 splicing and Scara3 degradation) in MEF cultures following Tunicamycin treatment. Comparing to STF083010, 4u8C is also shown to inhibit IRE1 autophosphorylation in cell-free assays via Schiff base formation with IRE1 Lys599 in the absence of ADP, however cellular nucleotide prevents 4u8C from targeting IRE1 Lys599 intracellularly. Group: Biochemicals. Grades: Highly Purified. CAS No. 14003-96-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |