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| Product | Description | |
|---|---|---|
| 2-?Aminoindan-?2-?carboxylic Acid | 2-?Aminoindan-?2-?carboxylic Acid can be used as a potential tyrosine hydroxylase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 27473-62-7. Pack Sizes: 250mg, 1g. Molecular Formula: C10H11NO2. US Biological Life Sciences. |  Worldwide |
| 2-Aminoindane-2-carboxylic acid | 2-Aminoindane-2-carboxylic acid can be used as a potential tyrosine hydroxylase inhibitor. Synonyms: Aic-OH; 2-Amino-2-indancarboxylic acid; 2-amino-2,3-dihydro-1H-indene-2-carboxylic acid; 2-Aminoindan-2-carboxylic acid; 2-Amino-indan-2-carboxylic acid; 1H-Indene-2-carboxylic acid, 2-amino-2,3-dihydro-; (+/-)-2-Aminoindane-2-carboxylic acid; 2-azanyl-1,3-dihydroindene-2-carboxylic acid; Aic OH. Grades: ≥ 99 % (HPLC). CAS No. 27473-62-7. Molecular formula: C10H11NO2. Mole weight: 177.20. |  |
| 3,4-Dihydroxy-L-phenylalanine | Precursor of catecholamine neurotransmitters; anti-parkinsonian therapy. Natural isomer of the immediate precursor of dopamine; product of tyrsine hydroxylase. Group: Biochemicals. Alternative Names: Levodopa; L-3-Hydroxytyrosine; 3-Hydroxy-L-tyrosine; (-)-3-(3,4-Dihydroxyphenyl)-L-alanine; Bendopa; Deadopa; Dopaflex; Dopal; Dopaidan; Dopalina; Dopar. Grades: Highly Purified. CAS No. 59-92-7. Pack Sizes: 50g, 100g, 250g, 500g, 1Kg. Molecular Formula: C9H11NO4, Molecular Weight: 197.19. US Biological Life Sciences. | Worldwide |
| 3,4-Dihydroxystyrene | It is produced by the strain of Fomes tasmanicus. It inhibits the activity of Hydroxylases including tyrosine, tryptophan and phenylalanine. Uses: A metabolite of styrene (s687790). Synonyms: 4-Vinylbenzene-1,2-diol; 4-Vinylcatechol; 2-hydroxy-4-vinylphenol; 3,4-Dihydroxy Styrene; Vinylcatechol. Grades: ≥95%. CAS No. 6053-2-7. Molecular formula: C8H8O2. Mole weight: 136.15. | |
| 3-Iodo-L-tyrosine (3-Monoiodo-L-tyrosine) | A Tyrosine Hydroxylase Inhibitor. Group: Biochemicals. Alternative Names: 3-Monoiodo-L-tyrosine. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 3-Iodotyrosine | 3-Iodotyrosine is an inhibitor of tyrosine hydroxylase (Ki = 0.39 μM) and an intermediate in the synthesis of thyroid hormones. Synonyms: Monoiodotyrosine; NSC 210787; L-Tyrosine, 3-iodo-. Grades: ≥95%. CAS No. 70-78-0. Molecular formula: C9H10INO3. Mole weight: 307.09. | |
| 6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride | 6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride is a synthetic reduced pterin cofactor for nitric oxide synthetase, and for phenylalanine, tyrosine, and tryptophan hydroxylases; less active than the natural cofactor, tetrahydrobiopterin (BH4). Applications: A synthetic reduced pterin cofactor. Group: Coenzymes. Synonyms: DMPH4; 2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine. CAS No. 945-43-7. Purity: ≥95%. Mole weight: 231.68. Appearance: Powder. Form: Solid. DMPH4; 2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine; 6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride; 945-43-7. Cat No: COEC-094. |  |
| (±)-6-Methyl-5,6,7,8-tetrahydropterine dihydrochloride | (±)-6-Methyl-5,6,7,8-tetrahydropterine dihydrochloride is a synthetic cofactor for tyrosine hydrolase, phenylalanine and tryptophan hydroxylases. (±)-6-Methyl-5,6,7,8-tetrahydropterine dihydrochloride has less activity than the natural cofactor, BH4. Applications: A synthetic cofactor for tyrosine hydrolase. Group: Coenzymes. CAS No. 69113-63-9. Mole weight: 254.12. Appearance: Powder. Form: Solid. (±)-6-Methyl-5,6,7,8-tetrahydropterine dihydrochloride; 69113-63-9. Cat No: COEC-081. | |
| 6-Methyltetrahydropterin dihydrochloride | 6-Methyltetrahydropterin (dihydrochloride) is a biochemical detection reagent that can be used in tyrosine hydroxylase activity assay [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 69113-63-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W071686. |  |
| (6R)-Tetrahydro-L-biopterin-d3 Sulfate(Mixture of Diastereomers) | (6R)-Tetrahydro-L-biopterin-d3 Sulfate(Mixture of Diastereomers) is the labeled R-enantiomer of Tetrahydro-L-biopterin. It is a natural cofactor for phenylalanine hydroxylase, tryptophan hydroxylase, tyrosine hydroxylase, and nitric oxide synthase. An essential cofactor for the production of neurotransmitters such as catecholamines, serotonin, and nitric oxide. Increasing BH4 levels boosts sensitivity to pain. Applications: A natural cofactor for phenylalanine hydroxylase. Group: Coenzymes. CAS No. 103130-44-5 (unlabeled). Mole weight: 342.34. (6R)-Tetrahydro-L-biopterin-d3 Sulfate(Mixture of Diastereomers); 103130-44-5 (unlabeled). Cat No: COEC-090. | |
| (6R)-Tetrahydro-L-biopterin Sulfate | (6R)-Tetrahydro-L-biopterin Sulfate is a natural cofactor for tyrosine hydroxylase, phenylalanine hydroxylase, tryptophan hydroxylase, and nitric oxide synthase. It is also an essential cofactor in the the production of neurotransmitters such as catecholamines, serotonin, and nitric oxide. Applications: An essential cofactor in the the production of neurotransmitters. Group: Coenzymes. CAS No. 103130-44-5. Mole weight: 339.33. Form: Solid. (6R)-Tetrahydro-L-biopterin Sulfate; 103130-44-5. Cat No: COEC-074. | |
| 7,8-Dihydro-L-biopterin-d3 | 7,8-Dihydro-L-biopterin-d3 is a labeled reduced form of Biopterin. An oxidation product of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase, is involved in the synthesis of tyrosine and neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM. Applications: Noncompetitive inhibitor of gtp cyclohydrolase i. Group: Coenzymes. Synonyms: 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydro-4(3H)-pteridinone; 7,8-Dihydrobiopterin. CAS No. 6779-87-9 (unlabeled). Mole weight: 242.25. Form: Solid. 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydro-4(3H)-pteridinone; 7,8-Dihydrobiopterin; 7,8-Dihydro-L-biopterin-d3; 6779-87-9 (unlabeled). Cat No: COEC-091. | |
| a-Methyl-D,L-tyrosine | A tyrosine hydroxylase inhibitor. An antihypertensive in pheochromocytoma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| a-Methyl-L-p-tyrosine (AMPT, Metyrosine,) | A tyrosine hydroxylase inhibitor. An antihypertensive in pheochromocytoma. Group: Biochemicals. Alternative Names: AMPT, Metyrosine. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Aquayamycin | Aquayamycin is a quinone antibiotic produced by Streptomyces misawanensis MA944-A5. Aquayamycin has weak antibacterial activity, prolongs the life of mice inoculated with Ehrlich ascites cancer, and inhibits tyrosine hydroxylase and monoamine oxidase. Synonyms: Urdamycinone A; 9-(2,6-Dideoxy-beta-D-arabino-hexopyranosyl)-3,4,4a,12b-tetrahydro-3,4a,8,12b-tetrahydroxy-3-methylbenz(a)anthracene-1,7,12(2H)-trione (3R-(3alpha,4aalpha,12balpha))-. Grades: >98%. CAS No. 26055-63-0. Molecular formula: C25H26O10. Mole weight: 486.47. | |
| HA-1004 | HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium , that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 91742-10-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-123468. | |
| Harmane | Harmane is a benzodiazepine receptor inhibitor ( IC 50 =7 μM), with IC 50 values for mACh , Opioid Receptor , MAO-A/B , and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor ( IC 50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 486-84-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-101392. | |
| L-α-Methyltyrosine | L-α-Methyltyrosine is a tyrosine hydroxylase inhibitor. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. It reduces the elevated levels of catecholamines associated with pheochromocytoma, thus preventing hypertension. It significantly inhibits COX-2 activity and has anti-inflammatory and anti-ulcer effects. Uses: L-α-methyltyrosine is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. Synonyms: α-Methyl-L-tyrosine; (S)-2-(4-Hydroxybenzyl)-2-aminopropanoic Acid; (S)-α-Methyltyrosine; Demser; L(-)-Metyrosine; L-α-MT; Metirosine; Racemetirosine; L-α-Methyl-p-tyrosine; Metyrosine. Grades: 98%. CAS No. 672-87-7. Molecular formula: C10H13NO3. Mole weight: 195.21. | |
| L-DOPA-2,5,6-d3 (Levodopd3, L-3-Hydroxytyrosine-d3, 3-Hydroxy-L-tyrosine-d3, (-)-3-(3,4-Dihydroxyphenyl-2,5,6-d3)-L-alanine, Bendopa-d3, Deadopa-d3, Dopaflex-d3, Dopal-d3, Dopaidan-d3, Dopalina-d3, Dopar-d3) | Natural isomer of the immediate precursor of dopamine; product of tyrsine hydroxylase. Group: Biochemicals. Alternative Names: Levodopd3; L-3-Hydroxytyrosine-d3; 3-Hydroxy-L-tyrosine-d3; (-)-3-(3,4-Dihydroxyphenyl-2,5,6-d3)-L-alanine; Bendopa-d3; Deadopa-d3; Dopaflex-d3; Dopal-d3; Dopaidan-d3; Dopalina-d3; Dopar-d3. Grades: Highly Purified. CAS No. 53587-29-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Metyrosine | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity [1]. Metyrosine is a very effective agent for blood pressure control [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 672-87-7. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W015007. | |
| MK-351 hydrochloride | MK-351 hydrochloride is an alpha-adrenergic agonist selective for α2-adrenergic receptors. It is a psychoactive drug used as a sympatholytic or antihypertensive. It plays a role in treating hypertension and gestational hypertension. It has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, which converts L-DOPA into dopamine. It is converted to α-methylnorepinephrine by dopamine beta-hydroxylase. Uses: Mk-351 hydrochloride is a psychoactive drug used as a sympatholytic or antihypertensive. it plays a role in treating hypertension and gestational hypertension. Synonyms: MK-351 hydrochloride; MK 351 hydrochloride; MK351 hydrochloride; Alpha-Methyldopa hydrochloride;L-(-)-A-Methyldopa hydrochloride;Alpha-Methyldopa HCl;(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;3-Hydroxy-alpha-methyl-L-tyrosine hydrochloride;L-Tyrosine, 3-hydroxy-alpha-methyl-, hydrochloride;Methyldopa hydrochloride. Grades: >98 %. CAS No. 884-39-9. Molecular formula: C10H14ClNO4. Mole weight: 247.68. | |
| Nifurtimox | Nifurtimox is a 5-nitrofuran and is used to treat diseases caused by trypanosomes including Chagas disease and sleeping sickness. It is given by mouth and not by injection. Nifurtimox is now in a Phase II clinical trial for the treatment of pediatric neuroblastoma and medulloblastoma. Nifurtimox decreased cell viability in a concentration-dependent manner. Nifurtimox also suppressed basal and TrkB-mediated Akt phosphorylation, and the cytotoxicity of nifurtimox was attenuated by a tyrosine hydroxylase inhibitor (alpha-methyl-tyrosine). Nifurtimox killed catecholaminergic, but not cholinergic, autonomic neurons in culture. In vivo xenograft models showed inhibition of tumor growth with a histologic decrease in proliferation and increase in apoptosis. These results suggest that nifurtimox induces cell death in neuroblastoma. Therefore, further studies are warranted to develop nifurtimox as a promising new treatment for neuroblastoma. Uses: Trypanocidal agents. Synonyms: BAY 2502; BAY2502; BAY-2502; Bayer 2502; Bayer2502; Bayer-2502; Lampit. Grades: >98%. CAS No. 23256-30-6. Molecular formula: C10H13N3O5S. Mole weight: 287.29. | |
| N-Methyl-L-tyrosine | A tyrosine hydroxylase inhibitor. An antihypertensive in pheochromocytoma. N-Methyl-L-tyrosine from seeds of Combretum zeyheri. Group: Biochemicals. Alternative Names: Surinamine; (+)-N-Methyltyrosine; Andirine; Andrine; N-Methyl-L-tyrosine; N-Methyltyrosine; Ratanhin; Ratanhine; Surinamin. Grades: Highly Purified. CAS No. 537-49-5. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| N-Methyl-L-tyrosine | A tyrosine hydroxylase inhibitor. An antihypertensive in pheochromocytoma. N-Methyl-L-tyrosine from seeds of Combretum zeyheri. Synonyms: N-Me-L-Tyr-OH; (2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid; (S)-3-(4-Hydroxyphenyl)-2-(methylamino)propionic acid N-Me-Tyr-OH Surinamine. Grades: ≥ 95% (HPLC). CAS No. 537-49-5. Molecular formula: C10H13NO3. Mole weight: 195.22. | |
| N-Methyl-L-tyrosine ≥95% (HPLC) | A tyrosine hydroxylase inhibitor. An antihypertensive in pheochromocytoma. Group: Biochemicals. Alternative Names: N-Me-Tyr-OH. Grades: Highly Purified. CAS No. 537-49-5. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| PACAP-27, Amide, Sheep (Pituitary Adenylate Cyclase Activating Polypeptide, HSDGIFTDSYSRYRKQMAVKKy l AAVL-NH2) | Increases cAMP levels in a dose-dependent manner (EC50=4.7nM). Increases tyrosine hydroxylase expression in chromaffin cells.CAS No:127317-03-7. Group: Biochemicals. Grades: Highly Purified. CAS No. 127317-03-7. Pack Sizes: 0.5mg. Molecular Formula: C???H???N??O??S, Molecular Weight: 3147.7. US Biological Life Sciences. | Worldwide |
| phenylalanine 3-monooxygenase | The enzyme from the bacterium Streptomyces coeruleorubidus forms 3-hydroxy-L-phenylalanine (i.e. m-L-tyrosine), which is one of the building blocks in the biosynthesis of the uridyl peptide antibiotics pacidamycins. Group: Enzymes. Synonyms: PacX; phenylalanine 3-hydroxylase. Enzyme Commission Number: EC 1.14.16.7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0959; phenylalanine 3-monooxygenase; EC 1.14.16.7; PacX; phenylalanine 3-hydroxylase. Cat No: EXWM-0959. | |
| tyrosine 3-monooxygenase | The active centre contains mononuclear iron(II). The enzyme is activated by phosphorylation, catalysed by EC 2.7.11.27, [acetyl-CoA carboxylase] kinase. The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34 (6,7-dihydropteridine reductase), or slowly rearranges into the more stable compound 7,8-dihydrobiopterin. Group: Enzymes. Synonyms: L-tyrosine hydroxylase; tyrosine 3-hydroxylase; tyrosine hydroxylase. Enzyme Commission Number: EC 1.14.16.2. CAS No. 9036-22-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0954; tyrosine 3-monooxygenase; EC 1.14.16.2; 9036-22-0; L-tyrosine hydroxylase; tyrosine 3-hydroxylase; tyrosine hydroxylase. Cat No: EXWM-0954. | |
| [tyrosine 3-monooxygenase] kinase | The enzyme has no activating compound but is specific for its substrate, with which it co-purifies. Requires Mg2+. Activates EC 1.14.16.2, tyrosine 3-monooxygenase, by phosphorylation. Group: Enzymes. Synonyms: pheochromocytoma tyrosine hydroxylase-associated kinase; STK4; tyrosine 3-monooxygenase kinase (phosphorylating). Enzyme Commission Number: EC 2.7.11.6. CAS No. 103537-12-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3157; [tyrosine 3-monooxygenase] kinase; EC 2.7.11.6; 103537-12-8; pheochromocytoma tyrosine hydroxylase-associated kinase; STK4; tyrosine 3-monooxygenase kinase (phosphorylating). Cat No: EXWM-3157. | |
| tyrosine N-monooxygenase | A heme-thiolate protein (P-450). This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.13.68, 4-hydroxyphenylacetaldehyde oxime monooxygenase and EC 2.4.1.85, cyanohydrin β-glucosyltransferase. Some 2-(4-hydroxyphenyl)-1-nitroethane is formed as a side product. Group: Enzymes. Synonyms: tyrosine N-hydroxylase; CYP79A1. Enzyme Commission Number: EC 1.14.13.41. CAS No. 159447-19-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0849; tyrosine N-monooxygenase; EC 1.14.13.41; 159447-19-5; tyrosine N-hydroxylase; CYP79A1. Cat No: EXWM-0849. | |
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