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Product | Description | |
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Tyrphostin 23 Quick inquiry Where to buy Suppliers range | Tyrphostin 23. Group: Biochemicals. Alternative Names: (3,4-Dihydroxybenzylidene)-malononitrile, RG-50810. Grades: Highly Purified. CAS No. 118409-57-7. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C10H6N2O2. US Biological Life Sciences. | Worldwide |
TYRPHOSTIN 23 Quick inquiry Where to buy Suppliers range | TYRPHOSTIN 23. CAS No. 118409-57-7. Categories: Tyrphostin 23. | |
Tyrphostin 23 ((3,4-Dihydroxybenzylidene)-malononitrile, RG-50810) Quick inquiry Where to buy Suppliers range | A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM). Group: Biochemicals. Alternative Names: (3,4-Dihydroxybenzylidene)-malononitrile, RG-50810. Grades: Highly Purified. CAS No. 118409-57-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
TYRPHOSTIN 25 Quick inquiry Where to buy Suppliers range | TYRPHOSTIN 25. CAS No. 118409-58-8. Categories: Tyrphostin 25. | |
Tyrphostin 25 ( ( [3, 4, 5-Trihydroxybenzylidene] malononitrile) ) Quick inquiry Where to buy Suppliers range | An inhibitor of epidermal growth factor receptor tyrosine kinase activity and has a reported IC50 of 15 µM for the autophosphorylation of the EGF-receptor. Group: Biochemicals. Alternative Names: ( [3, 4, 5-Trihydroxybenzylidene] malononitrile) . Grades: Highly Purified. CAS No. 118409-58-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Tyrphostin 9 Quick inquiry Where to buy Suppliers range | Tyrphostin 9 is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM. Synonyms: SF 6847, RG 50872; SF6847, RG50872; SF-6847, RG-50872. Grades: >98%. CAS No. 10537-47-0. Molecular formula: C18H22N2O. Mole weight: 282.38. | |
Tyrphostin A1 Quick inquiry Where to buy Suppliers range | Tyrphostin A1, can be as a negative control for inhibition of EGFR (IC50 >1250 μM) and was shown to inhibit the tyrosine phosphorylation of IL-2 stimulated Tyk-2 in plemented with 20% LADMAC supernatant. Uses: Antineoplastic agents. Synonyms: Tyrphostin 1; Tyrphostin-1; Tyrphostin1; 2-[ (4-methoxyphenyl) methylidene]propanedinitrile (3, 4-dihydroxybenzylidene) malononitrile (3, 4-dihydroxyphenyl) methylene propanedinitrile3,4-dihydroxybenzylidenemalononitrileRG 50810; RG50810RG-50810tyrphostin 23tyrphostin A1tyrphostin A23tyrphostin AG18tyr. CAS No. 2826-26-8. Molecular formula: C11H8N2O. Mole weight: 184.197. | |
Tyrphostin A9 Quick inquiry Where to buy Suppliers range | solid. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy; Pharma & Vet Compounds & Metabolites; Pharma & Vet Compounds & Metabolites. Alternative Names: alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)cinnamonitrile, Malonoben,Tyrphostin A9, Tyrphostin 9, 2-(3,5-Di-tert-butyl-4-hydroxybenzylidene)malononitrile, Propanedinitrile, 2-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-. CAS No. 10537-47-0. Pack Sizes: 5MG, 25MG. IUPAC Name: 2-[ (3, 5-ditert-butyl-4-hydroxyphenyl) methylidene]propanedinitrile. Molecular formula: C18H22N2O. Mole weight: 282.38. Catalog: APS10537470. SMILES: CC (C) (C)c1cc (C=C (C#N)C#N)cc (c1O)C (C) (C)C. Format: Neat. Shipping: Room Temperature. | |
Tyrphostin A9 Quick inquiry Where to buy Suppliers range | Tyrphostin A9. CAS No. 10537-47-0. | |
Tyrphostin A9 Quick inquiry Where to buy Suppliers range | Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channels in Jurkat T-cells. Tyrphostin A9 also inhibits ephrin-A1-induced chemotaxis and phosphorylation of both EphA1 and PYK2. Group: Biochemicals. Grades: Highly Purified. CAS No. 10537-47-0. Pack Sizes: 250mg, 2.5g. Molecular Formula: C18H22N2O, Molecular Weight: 282.38. US Biological Life Sciences. | Worldwide |
Tyrphostin AG 1296 Quick inquiry Where to buy Suppliers range | Tyrphostin AG 1296 is an inhibitor of PDGFR with an IC50 of 0.3-0.5 μM, no activity to EGFR. It inhibits FGFR and C-Kit with IC50s of 12.3 and 1.8 μM in Swiss 3T3 cells, respectively. Tyrphostin AG 1296 induces intense apoptosis in A375R cells. Synonyms: AG 1296; AG1296; AG-1296; 2-Phenyl-6,7-dimethoxyquinoxaline. Grades: >98%. CAS No. 146535-11-7. Molecular formula: C16H14N2O2. Mole weight: 266.29. | |
Tyrphostin AG 1296 Quick inquiry Where to buy Suppliers range | Tyrphostin AG 1296. Group: Biochemicals. Alternative Names: 6,7-Dimethoxy-2-phenylquinoxaline; 2-Phenyl-6,7-dimethoxyquinoxaline; AG 1296. Grades: Highly Purified. CAS No. 146535-11-7. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C16H14N2O2, Molecular Weight: 266.29. US Biological Life Sciences. | Worldwide |
Tyrphostin AG-528 Quick inquiry Where to buy Suppliers range | Tyrphostin AG-528, also known as Tyrphostin B66, is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively. Synonyms: Tyrphostin AG-528; Tyrphostin AG 528; Tyrphostin AG528; (E)-1-[2-cyano-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-2,3-dihydro-1H-Indole; (αE)-α-[(3,4-Dihydroxyphenyl)methylene]-2,3-dihydro-β-oxo-1H-indole-1-propanenitrile; AG 528; 1-[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-2,3-dihydro-1H-Indole. CAS No. 133550-49-9. Molecular formula: C18H14N2O3. Mole weight: 306.32. | |
Tyrphostin AG 879 Quick inquiry Where to buy Suppliers range | Tyrphostin AG 879. Group: Biochemicals. Alternative Names: (2E)-3-[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide; AG 879. Grades: Highly Purified. CAS No. 148741-30-4. Pack Sizes: 10mg. Molecular Formula: C18H24N2OS, Molecular Weight: 316.459999999999. US Biological Life Sciences. | Worldwide |
Tyrphostin AG 957 Quick inquiry Where to buy Suppliers range | Tyrphostin AG 957. Uses: For analytical and research use. Group: COVID-19 Research and Reference Materials; Enzyme Activators, Inhibitors & Substrates. Alternative Names: NSC 654705,AG 957. CAS No. 140674-76-6. IUPAC Name: methyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate. Molecular formula: C15H15NO4. Mole weight: 273.28. Catalog: APS140674766. SMILES: COC(=O)c1ccc(NCc2cc(O)ccc2O)cc1. Format: Neat. Product Type: Metabolite. | |
Tyrphostin B44, (+) enantiomer Quick inquiry Where to buy Suppliers range | Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.86 μM). Less active than the (-) enantiomer. Synonyms: (S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide. CAS No. 133550-37-5. Molecular formula: C18H16N2O3. Mole weight: 308.34. | |
Tyrphostin B44, (+) enantiomer Quick inquiry Where to buy Suppliers range | Tyrphostin B44, (+) enantiomer. Group: Biochemicals. Grades: Purified. CAS No. 133550-37-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
Tyrphostin B44, (-) enantiomer Quick inquiry Where to buy Suppliers range | Tyrphostin B44, (-) enantiomer. Group: Biochemicals. Grades: Purified. CAS No. 133550-32-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
Tyrphostin B44, (-) enantiomer Quick inquiry Where to buy Suppliers range | Tyrphostin B44, (-) enantiomer is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.4 μM). More active than the (+) enantiomer. Synonyms: (R)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide. CAS No. 133550-32-0. Molecular formula: C18H16N2O3. Mole weight: 308.34. | |
AG 490 (Tyrphostin B42, N-benzyl-3, 4-dihydroxy-benzylidene cyanoacetamide) Quick inquiry Where to buy Suppliers range | Specific and potent JAK2 protein tyrosine kinase inhibitor. Also, inhibits EGF receptor autophosphorylation, with IC50 of 100nM. Inhibits DNA synthesis and cell growth; induces apoptosis. Blocks growth of leukemic cells in vitro and in vivo. Group: Biochemicals. Alternative Names: Tyrphostin B42. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
1H-?Pyrazole-?3-?carboxaldehyde Quick inquiry Where to buy Suppliers range | 1H-?Pyrazole-?3-?carboxaldehyde is an intermediate used to prepare fused pyrrole carboxylic acids as novel, potent D-?amino acid oxidase (DAO) inhibitors. It is also a building block to synthesize α-?substituted benzylidene malononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2?/neu tyrosine kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 3920-50-1. Pack Sizes: 1g, 5 g. Molecular Formula: C4H4N2O, Molecular Weight: 96.09. US Biological Life Sciences. | Worldwide |
AG-1024 Quick inquiry Where to buy Suppliers range | AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Synonyms: AG1024; AG-1024; AG 1024. Tyrphostin. Grades: >98%. CAS No. 65678-07-1. Molecular formula: C21H27N7O. Mole weight: 393.23. | |
AG 126 Quick inquiry Where to buy Suppliers range | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Synonyms: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. Grades: 95%. CAS No. 118409-62-4. Molecular formula: C10H5N3O3. Mole weight: 215.16. | |
AG-1295 Quick inquiry Where to buy Suppliers range | AG-1295. Group: Biochemicals. Alternative Names: 6,7-Dimethyl-2-phenyl-quinoxaline; 2-Phenyl-6,7-dimethylquinoxaline; 6,7-Dimethyl-2-phenylquinoxaline; AG 1295; NSC 380341; Tyrphostin AG 1295. Grades: Highly Purified. CAS No. 71897-07-9. Pack Sizes: 10mg. Molecular Formula: C16H14N2, Molecular Weight: 234.3. US Biological Life Sciences. | Worldwide |
AG1295 Quick inquiry Where to buy Suppliers range | Tyrphostin AG 1295 is a selective inhibitor of PDGFR (platelet-derived growth factor receptor) protein tyrosine kinase (PDGF-receptor PTK)(IC50 = 500 nM) and PDGF-dependent DNA synthesis (IC50 = 2.5 μM) in Swiss/3T3 cells. Synonyms: AG1295; AG 1295; AG 1295; NSC 380341; NSC380341; NSC-380341; Tyrphostin AG 1295. Grades: >98%. CAS No. 71897-07-9. Molecular formula: C16H14N2. Mole weight: 234.30. | |
AG-1478 Quick inquiry Where to buy Suppliers range | AG-1478 (NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM; almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. Uses: Enzyme inhibitors. Synonyms: Tyrphostin AG-1478; AG-1478; AG1478; AG 1478. Grades: >98%. CAS No. 153436-53-4. Molecular formula: C16H14ClN3O2. Mole weight: 315.75. | |
AG-18 Quick inquiry Where to buy Suppliers range | AG 18 (10 μM) inhibits EGF-induced proliferation of GH3 cells. Synonyms: RG-50810; RG 50810; RG50810; Tyrphostin A23; AG-18; AG 18; AG18; TX 825; Tyrphostin A23; Tyrphostin AG-18. Grades: >98%. CAS No. 118409-57-7. Molecular formula: C10H6N2O2. Mole weight: 186.17. | |
AG-183 Quick inquiry Where to buy Suppliers range | AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 0.8 μM in the human epidermoid carcinoma cell line A431. Synonyms: Tyrphostin 51; Tyrphostin AG 183. Grades: ≥98%. CAS No. 122520-90-5. Molecular formula: C13H8N4O3. Mole weight: 268.2. | |
AG-213 Quick inquiry Where to buy Suppliers range | AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 2.4 μM in the human epidermoid carcinoma cell line A431. Uses: Enzyme inhibitors. Synonyms: Tyrphostin AG-213; Tyrphostin 47; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide. Grades: ≥97%. CAS No. 122520-86-9. Molecular formula: C10H8N2O2S. Mole weight: 220.2. | |
AG-490 Quick inquiry Where to buy Suppliers range | Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. Uses: Antineoplastic agents. Synonyms: Tyrphostin AG 490; AG-490; AG490. Grades: 0.98. CAS No. 133550-30-8. Molecular formula: C17H14N2O3. Mole weight: 294.31. | |
AG-490 Quick inquiry Where to buy Suppliers range | AG-490. Group: Biochemicals. Alternative Names: 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; Tyrphostin B 42. Grades: Highly Purified. CAS No. 134036-52-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C17H14N2O3. US Biological Life Sciences. | Worldwide |
AG 494 Quick inquiry Where to buy Suppliers range | AG-494 is a EGFR (epidermal growth factor receptor) kinase inhibitor with IC50 value of 0.7 μM. It is selective over ErbB2, PDGFR and insulin receptor kinase (IC50 values are 42, 6 and > 100 μM respectively). AG-494 tyrphostin also can block Cdk2 activation. Synonyms: alpha-Cyano-(3,4-dihydroxy)-N-phenylcinnamide; Tyrphostin AG-494; Tyrphostin B48. Grades: 98%. CAS No. 139087-53-9. Molecular formula: C16H12N2O3. Mole weight: 280.28. | |
AG 555 Quick inquiry Where to buy Suppliers range | AG 555 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC50 = 0.7 μM) with 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Synonyms: AG 555; AG-555; AG555; (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide; AG 555; AG-555; alpha-cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide; N-(3'-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide; N-(3-phenylpropyl)-3,4-dihydroxybenzylidene cyanoacetamide; tyrphostin AG 555; tyrphostin AG-555; tyrphostin B46. Grades: ≥98% (HPLC). CAS No. 133550-34-2. Molecular formula: C19H18N2O3. Mole weight: 322.36. | |
AG-82 Quick inquiry Where to buy Suppliers range | AG-82 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 3 μM in the human epidermoid carcinoma cell line A431. Uses: Antineoplastic agents. Synonyms: NSC 676484; RG-50875; Tyrphostin 25; Tyrphostin AG-82. Grades: ≥95%. CAS No. 118409-58-8. Molecular formula: C10H6N2O3. Mole weight: 202.2. | |
AG-879 Quick inquiry Where to buy Suppliers range | AG-879, a tyrphostin compound, is a dual EGFR/HER2 inhibitor that was administered together with androgen withdrawal therapy. It inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM). Synonyms: α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide. CAS No. 148741-30-4. Molecular formula: C18H24N2OS. Mole weight: 316.5. | |
AG957 Quick inquiry Where to buy Suppliers range | AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line. AG957 is also used to study signaling through c-Abl. Synonyms: NSC 654705; Tyrphostin AG957; Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, methyl ester. Grades: ≥95%. CAS No. 140674-76-6. Molecular formula: C15H15NO4. Mole weight: 273.3. | |
Entacapone EP Impurity F Quick inquiry Where to buy Suppliers range | An impurity of Entacapone. Entacapone is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: Entacapone acid; (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid; 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-, (2E)-; (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenoic acid; 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-, (E)-; AG 1290; Tyrphostin AG 1290. Grades: ≥95%. CAS No. 160391-70-8. Molecular formula: C10H6N2O6. Mole weight: 250.17. | |
RG13022 Quick inquiry Where to buy Suppliers range | RG13022, a non-phenolic tyrphostin analog, is an epidermal growth factor (EGF) receptor tyrosine kinase inhibitor with potential antiproliferative effect. Synonyms: RG13022; RG 13022; RG-13022; 3-(3,4-dimethoxyphenyl)-2-pyridin-3-ylprop-2-enenitrile; RG 13022; RG-13022. CAS No. 136831-48-6. Molecular formula: C16H14N2O2. Mole weight: 266.29. | |
RG14620 Quick inquiry Where to buy Suppliers range | RG14620 is a non-phenolic tyrphostin-class epidermal growth factor receptor (EGFR) inhibitor (IC50= 3 μM for HER 14 colony formation, and IC50= 1 pM for HER 14 DNA synthesis), with anti-proliferative effects on renal and bladder carcinoma cell lines. Synonyms: (E)-3-(3,5-dichlorophenyl)-2-pyridin-3-ylprop-2-enenitrile; RG 14620; RG14620; RG-14620; TYRPHOSTIN RG 14620. CAS No. 136831-49-7. Molecular formula: C14H8Cl2N2. Mole weight: 275.13. | |
SU1498 Quick inquiry Where to buy Suppliers range | SU1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), and inhibits Flk-1 with an IC50 of value of 700 nM. Synonyms: (E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-N-(3-phenylpropyl)prop-2-enamide; SU-1498; SU 1498; SU1498; AG-1498; AG 1498; AG1498; Tyrphostin SU 1498. CAS No. 168835-82-3. Molecular formula: C25H30N2O2. Mole weight: 390.52. | |
TX-1918 - CAS 503473-32-3 Quick inquiry Where to buy Suppliers range | A cell-permeable arylidene-cyclopentenedione derived tyrphostin that acts as a potent inhibitor for eEF2-K, while it inhibits other kinases at much higher concentrations. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 503473-32-3. Pack Sizes: 10MG. Mole weight: 228.24. Catalog: AP503473323. Assay: ≥95% (HPLC). | |
WP1130 Quick inquiry Where to buy Suppliers range | A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 10MG. Mole weight: 384.27. Catalog: IAR42410931. Assay: ≥97% (HPLC). | |
WP1130 (Degrasyn) Quick inquiry Where to buy Suppliers range | A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-kB activities (IC50 < 1uM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2uM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5uM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 in xenograft mouse models of CML and melanoma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |