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| Product | Description | |
|---|---|---|
| Tyrphostin 23 | Tyrphostin 23. Group: Biochemicals. Alternative Names: (3,4-Dihydroxybenzylidene)-malononitrile, RG-50810. Grades: Highly Purified. CAS No. 118409-57-7. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C10H6N2O2. US Biological Life Sciences. |  Worldwide |
| Tyrphostin 23 ((3,4-Dihydroxybenzylidene)-malononitrile, RG-50810) | A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM). Group: Biochemicals. Alternative Names: (3,4-Dihydroxybenzylidene)-malononitrile, RG-50810. Grades: Highly Purified. CAS No. 118409-57-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Tyrphostin 25 ( ( [3, 4, 5-Trihydroxybenzylidene] malononitrile) ) | An inhibitor of epidermal growth factor receptor tyrosine kinase activity and has a reported IC50 of 15 µM for the autophosphorylation of the EGF-receptor. Group: Biochemicals. Alternative Names: ( [3, 4, 5-Trihydroxybenzylidene] malononitrile) . Grades: Highly Purified. CAS No. 118409-58-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Tyrphostin 51 | Heterocyclic Organic Compound. CAS No. 126433-07-6. Molecular formula: C13H8N4O3. Mole weight: 268.23. Purity: 0.96. IUPACName: (3Z)-2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile. Canonical SMILES: C1=C (C=C (C (=C1O)O)O)C=C (C#N)C (=C (C#N)C#N)N. Catalog: ACM126433076. |  |
| Tyrphostin 9 | Tyrphostin 9 is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM. Synonyms: SF 6847, RG 50872; SF6847, RG50872; SF-6847, RG-50872. Grades: >98%. CAS No. 10537-47-0. Molecular formula: C18H22N2O. Mole weight: 282.38. |  |
| Tyrphostin A1 | Tyrphostin A1, can be as a negative control for inhibition of EGFR (IC50 >1250 μM) and was shown to inhibit the tyrosine phosphorylation of IL-2 stimulated Tyk-2 in plemented with 20% LADMAC supernatant. Uses: Antineoplastic agents. Synonyms: Tyrphostin 1; Tyrphostin-1; Tyrphostin1; 2-[ (4-methoxyphenyl) methylidene]propanedinitrile (3, 4-dihydroxybenzylidene) malononitrile (3, 4-dihydroxyphenyl) methylene propanedinitrile3,4-dihydroxybenzylidenemalononitrileRG 50810; RG50810RG-50810tyrphostin 23tyrphostin A1tyrphostin A23tyrphostin AG18tyr. CAS No. 2826-26-8. Molecular formula: C11H8N2O. Mole weight: 184.197. | |
| Tyrphostin a51 | Heterocyclic Organic Compound. Alternative Names: 2-AMINO-1, 1, 3-TRICYANO-4-[3', 4', 5'-TRIHYDROXYPHENYL]BUTADIENE;2-AMINO-4-(3', 4', 5'-TRIHYDROXYPHENYL)-1, 1, 3-TRICYANOBUTA-1, 3-DIENE;AG 183;3-AMINO-2,4-DICYANO-5-(3',4',5'-TRIHYDROXYPHENYL)PENTA-2,4-DIENONITRILE;TYRPHOSTIN AG 183;TYRPHOSTIN A51;TYRPHOSTIN 51. CAS No. 122520-90-5. Molecular formula: C13H8N4O3. Mole weight: 268.23. Appearance: Brown solid. Purity: 0.96. IUPACName: (3Z)-2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile. Density: 1.591 g/cm³. Catalog: ACM122520905. | |
| Tyrphostin A51 | Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [ 3 H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-183. CAS No. 126433-07-6. Pack Sizes: 1 mg. Product ID: HY-101960A. |  |
| Tyrphostin A9 | Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channels in Jurkat T-cells. Tyrphostin A9 also inhibits ephrin-A1-induced chemotaxis and phosphorylation of both EphA1 and PYK2. Group: Biochemicals. Grades: Highly Purified. CAS No. 10537-47-0. Pack Sizes: 250mg, 2.5g. Molecular Formula: C18H22N2O, Molecular Weight: 282.38. US Biological Life Sciences. | Worldwide |
| Tyrphostin ag 126 | Heterocyclic Organic Compound. Alternative Names: RARECHEM AL BX 0673;TYRPHOSTIN A10;TYRPHOSTIN AG 126;ag127;AG 126; ALPHA-CYANO-(3-HYDROXY-4-NITRO)CINNAMONITRILE; [3-HYDROXY-4-NITROBENZYLIDENE]MALONONITRILE; Tyrphostin 126. CAS No. 118409-62-4. Molecular formula: C10H5N3O3. Mole weight: 215.16. Appearance: Yellow Solid. Catalog: ACM118409624. | |
| Tyrphostin AG 1296 | Tyrphostin AG 1296. Group: Biochemicals. Alternative Names: 6,7-Dimethoxy-2-phenylquinoxaline; 2-Phenyl-6,7-dimethoxyquinoxaline; AG 1296. Grades: Highly Purified. CAS No. 146535-11-7. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C16H14N2O2, Molecular Weight: 266.29. US Biological Life Sciences. | Worldwide |
| Tyrphostin AG 1296 | Tyrphostin AG 1296 is an inhibitor of PDGFR with an IC50 of 0.3-0.5 μM, no activity to EGFR. It inhibits FGFR and C-Kit with IC50s of 12.3 and 1.8 μM in Swiss 3T3 cells, respectively. Tyrphostin AG 1296 induces intense apoptosis in A375R cells. Synonyms: AG 1296; AG1296; AG-1296; 2-Phenyl-6,7-dimethoxyquinoxaline. Grades: >98%. CAS No. 146535-11-7. Molecular formula: C16H14N2O2. Mole weight: 266.29. | |
| Tyrphostin AG-528 | Tyrphostin AG-528, also known as Tyrphostin B66, is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively. Synonyms: Tyrphostin AG-528; Tyrphostin AG 528; Tyrphostin AG528; (E)-1-[2-cyano-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-2,3-dihydro-1H-Indole; (αE)-α-[(3,4-Dihydroxyphenyl)methylene]-2,3-dihydro-β-oxo-1H-indole-1-propanenitrile; AG 528; 1-[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-2,3-dihydro-1H-Indole. CAS No. 133550-49-9. Molecular formula: C18H14N2O3. Mole weight: 306.32. | |
| Tyrphostin AG 879 | Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation ( IC 50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC 50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG 879. CAS No. 148741-30-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-20878. | |
| Tyrphostin AG 879 | Tyrphostin AG 879. Group: Biochemicals. Alternative Names: (2E)-3-[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide; AG 879. Grades: Highly Purified. CAS No. 148741-30-4. Pack Sizes: 10mg. Molecular Formula: C18H24N2OS, Molecular Weight: 316.459999999999. US Biological Life Sciences. | Worldwide |
| Tyrphostin ag 99 | Heterocyclic Organic Compound. Alternative Names: TYRPHOSTIN A46;TYRPHOSTIN AG 99;TYRPHOSTIN B40;TYRPHOSTIN 46;AG 99;ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMIDE;3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE;(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-2-PROPENAMIDE. CAS No. 118409-59-9. Molecular formula: C10H8N2O3. Mole weight: 204.1821. Appearance: A crystalline solid. Purity: >98%. IUPACName: (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide. Canonical SMILES: C1=CC(=C(C=C1C=C(C#N)C(=O)N)O)O. Density: 1.482 g/cm³. Catalog: ACM118409599. | |
| Tyrphostin B44, (-) enantiomer | Tyrphostin B44, (-) enantiomer. Group: Biochemicals. Grades: Purified. CAS No. 133550-32-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Tyrphostin B44, (-) enantiomer | Tyrphostin B44, (-) enantiomer is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.4 μM). More active than the (+) enantiomer. Synonyms: (R)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide. CAS No. 133550-32-0. Molecular formula: C18H16N2O3. Mole weight: 308.34. | |
| Tyrphostin B44, (+) enantiomer | Tyrphostin B44, (+) enantiomer. Group: Biochemicals. Grades: Purified. CAS No. 133550-37-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Tyrphostin B44, (+) enantiomer | Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.86 μM). Less active than the (-) enantiomer. Synonyms: (S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide. CAS No. 133550-37-5. Molecular formula: C18H16N2O3. Mole weight: 308.34. | |
| AG 490 (Tyrphostin B42, N-benzyl-3, 4-dihydroxy-benzylidene cyanoacetamide) | Specific and potent JAK2 protein tyrosine kinase inhibitor. Also, inhibits EGF receptor autophosphorylation, with IC50 of 100nM. Inhibits DNA synthesis and cell growth; induces apoptosis. Blocks growth of leukemic cells in vitro and in vivo. Group: Biochemicals. Alternative Names: Tyrphostin B42. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| I-OMe-Tyrphostin AG 538 | I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα) , with an IC 50 of 1 μM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: I-OMe-AG 538. CAS No. 1094048-77-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135680. | |
| 1H-?Pyrazole-?3-?carboxaldehyde | 1H-?Pyrazole-?3-?carboxaldehyde is an intermediate used to prepare fused pyrrole carboxylic acids as novel, potent D-?amino acid oxidase (DAO) inhibitors. It is also a building block to synthesize α-?substituted benzylidene malononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2?/neu tyrosine kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 3920-50-1. Pack Sizes: 1g, 5 g. Molecular Formula: C4H4N2O, Molecular Weight: 96.09. US Biological Life Sciences. | Worldwide |
| 2-Propenethioamide,2-cyano-3-(3,4-dihydroxyphenyl)-,(2E)- | Heterocyclic Organic Compound. Alternative Names: Tyrphostin 47, AC1OASLQ, AGN-PC-001RMR, CTK8E9304, IN1038, ZINC03871430, LP01221, Tyrphostin 47 (RG-50864, AG-213), (Z)-3-amino-2-[(E)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile, 122520-86-9, 3-amino-2-[(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile. CAS No. 122520-86-9. Molecular formula: C10H8N2O2S. Mole weight: 220.2477. Appearance: White solid. Purity: >97%. IUPACName: 3-amino-2-[(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile. Density: 1.583 g/cm³. Catalog: ACM122520869. | |
| AG-1024 | AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Synonyms: AG1024; AG-1024; AG 1024. Tyrphostin. Grades: >98%. CAS No. 65678-07-1. Molecular formula: C21H27N7O. Mole weight: 393.23. | |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Synonyms: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. Grades: 95%. CAS No. 118409-62-4. Molecular formula: C10H5N3O3. Mole weight: 215.16. | |
| Ag-1288 | Heterocyclic Organic Compound. Alternative Names: AG-1288;alpha-Cyano-(3,4-dihydroxy-5-nitro)cinnamonitrile;Tyrphostin AG 1288. CAS No. 116313-73-6. Molecular formula: C10H5N3O4. Mole weight: 231.16. Appearance: Pale orange solid. Catalog: ACM116313736. | |
| AG1295 | Tyrphostin AG 1295 is a selective inhibitor of PDGFR (platelet-derived growth factor receptor) protein tyrosine kinase (PDGF-receptor PTK)(IC50 = 500 nM) and PDGF-dependent DNA synthesis (IC50 = 2.5 μM) in Swiss/3T3 cells. Synonyms: AG1295; AG 1295; AG 1295; NSC 380341; NSC380341; NSC-380341; Tyrphostin AG 1295. Grades: >98%. CAS No. 71897-07-9. Molecular formula: C16H14N2. Mole weight: 234.30. | |
| AG-1295 | AG-1295. Group: Biochemicals. Alternative Names: 6,7-Dimethyl-2-phenyl-quinoxaline; 2-Phenyl-6,7-dimethylquinoxaline; 6,7-Dimethyl-2-phenylquinoxaline; AG 1295; NSC 380341; Tyrphostin AG 1295. Grades: Highly Purified. CAS No. 71897-07-9. Pack Sizes: 10mg. Molecular Formula: C16H14N2, Molecular Weight: 234.3. US Biological Life Sciences. | Worldwide |
| AG-1478 | AG-1478 (NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM; almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. Uses: Enzyme inhibitors. Synonyms: Tyrphostin AG-1478; AG-1478; AG1478; AG 1478. Grades: >98%. CAS No. 153436-53-4. Molecular formula: C16H14ClN3O2. Mole weight: 315.75. | |
| AG-1478 | AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC 50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tyrphostin AG-1478; NSC 693255. CAS No. 153436-53-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13524. | |
| AG-18 | AG 18 (10 μM) inhibits EGF-induced proliferation of GH3 cells. Synonyms: RG-50810; RG 50810; RG50810; Tyrphostin A23; AG-18; AG 18; AG18; TX 825; Tyrphostin A23; Tyrphostin AG-18. Grades: >98%. CAS No. 118409-57-7. Molecular formula: C10H6N2O2. Mole weight: 186.17. | |
| AG-183 | AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 0.8 μM in the human epidermoid carcinoma cell line A431. Synonyms: Tyrphostin 51; Tyrphostin AG 183. Grades: ≥98%. CAS No. 122520-90-5. Molecular formula: C13H8N4O3. Mole weight: 268.2. | |
| Ag 213 | Heterocyclic Organic Compound. Alternative Names: Tyrphostin 47, Tyrphostin A47, Tyrphostin AG-213, tyrphostin AG213, Tyrphostin RG50864, Tocris-0503, Lopac-T-7540, C9H9NO2S, RG 50864, (E)-isomer, 3,4-Dihydroxybenzylidenethioacetamide, AG 213, MolPort-003-939-811, AG213, RG 50864, 3,4-Dihydroxy-alpha-cyanothiocinnamide, AG-213, alpha-Cyano-3,4-dihydroxythiocinnamamide, RG-50864, CID5485187, RG50864. CAS No. 118409-60-2. Molecular formula: C10H8N2O2S. Mole weight: 220.25. Purity: 0.96. IUPACName: (E)-3-amino-2-[(Z)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile. Density: 1.583g/cm³. Catalog: ACM118409602. | |
| AG-213 | AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 2.4 μM in the human epidermoid carcinoma cell line A431. Uses: Enzyme inhibitors. Synonyms: Tyrphostin AG-213; Tyrphostin 47; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide. Grades: ≥97%. CAS No. 122520-86-9. Molecular formula: C10H8N2O2S. Mole weight: 220.2. | |
| AG-490 | AG-490. Group: Biochemicals. Alternative Names: 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; Tyrphostin B 42. Grades: Highly Purified. CAS No. 134036-52-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C17H14N2O3. US Biological Life Sciences. | Worldwide |
| AG-490 | Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. Uses: Antineoplastic agents. Synonyms: Tyrphostin AG 490; AG-490; AG490. Grades: 0.98. CAS No. 133550-30-8. Molecular formula: C17H14N2O3. Mole weight: 294.31. | |
| AG 494 | AG-494 is a EGFR (epidermal growth factor receptor) kinase inhibitor with IC50 value of 0.7 μM. It is selective over ErbB2, PDGFR and insulin receptor kinase (IC50 values are 42, 6 and > 100 μM respectively). AG-494 tyrphostin also can block Cdk2 activation. Synonyms: alpha-Cyano-(3,4-dihydroxy)-N-phenylcinnamide; Tyrphostin AG-494; Tyrphostin B48. Grades: 98%. CAS No. 139087-53-9. Molecular formula: C16H12N2O3. Mole weight: 280.28. | |
| AG 555 | AG 555 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC50 = 0.7 μM) with 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Synonyms: AG 555; AG-555; AG555; (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide; AG 555; AG-555; alpha-cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide; N-(3'-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide; N-(3-phenylpropyl)-3,4-dihydroxybenzylidene cyanoacetamide; tyrphostin AG 555; tyrphostin AG-555; tyrphostin B46. Grades: ≥98% (HPLC). CAS No. 133550-34-2. Molecular formula: C19H18N2O3. Mole weight: 322.36. | |
| AG-82 | AG-82 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 3 μM in the human epidermoid carcinoma cell line A431. Uses: Antineoplastic agents. Synonyms: NSC 676484; RG-50875; Tyrphostin 25; Tyrphostin AG-82. Grades: ≥95%. CAS No. 118409-58-8. Molecular formula: C10H6N2O3. Mole weight: 202.2. | |
| AG-879 | AG-879, a tyrphostin compound, is a dual EGFR/HER2 inhibitor that was administered together with androgen withdrawal therapy. It inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM). Synonyms: α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide. CAS No. 148741-30-4. Molecular formula: C18H24N2OS. Mole weight: 316.5. | |
| AG957 | AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line. AG957 is also used to study signaling through c-Abl. Synonyms: NSC 654705; Tyrphostin AG957; Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, methyl ester. Grades: ≥95%. CAS No. 140674-76-6. Molecular formula: C15H15NO4. Mole weight: 273.3. | |
| Ag 99 | Heterocyclic Organic Compound. Alternative Names: Tyrphostin A46, CID2065, 3,4-Dihydroxy-alpha-cyanocinnamide, IN1036, NSC125402, NCI60_012686, 122520-85-8. CAS No. 122520-85-8. Molecular formula: C10H8N2O3. Mole weight: 204.18. Purity: >99 %. IUPACName: 2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide. Density: 1.482g/cm³. Catalog: ACM122520858. | |
| (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid | Heterocyclic Organic Compound. Alternative Names: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid;Tyrphostin AG 30. CAS No. 122520-79-0. Molecular formula: C10H7NO4. Mole weight: 205.17. Appearance: Yellow solid. Catalog: ACM122520790. | |
| (E)-AG 556 | (E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (E)-Tyrphostin AG 556. CAS No. 133550-41-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101041. | |
| Entacapone EP Impurity F | An impurity of Entacapone. Entacapone is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: Entacapone acid; (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid; 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-, (2E)-; (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenoic acid; 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-, (E)-; AG 1290; Tyrphostin AG 1290. Grades: ≥95%. CAS No. 160391-70-8. Molecular formula: C10H6N2O6. Mole weight: 250.17. | |
| Propanedinitrile,2-[(3,4,5-trihydroxyphenyl)methylene]- | Heterocyclic Organic Compound. Alternative Names: [3, 4, 5-TRIHYDROXYBENZYLIDENE]MALONONITRILE; AG 82;ALPHA-CYANO-(3,4,5-TRIHYDROXY)CINNAMONITRILE;RG-50875;RARECHEM AL BX 0070;TYRPHOSTIN 25;TYRPHOSTIN RG 50875;TYRPHOSTIN AG 82. CAS No. 118409-58-8. Molecular formula: C10H6N2O3. Mole weight: 202.17. Appearance: Yellow Green Powder. Purity: ≥95%. IUPACName: 2-[ (3, 4, 5-trihydroxyphenyl) methylidene]propanedinitrile. Canonical SMILES: C1=C(C=C(C(=C1O)O)O)C=C(C#N)C#N. Density: 1.569 g/cm³. Catalog: ACM118409588. | |
| RG13022 | RG13022, a non-phenolic tyrphostin analog, is an epidermal growth factor (EGF) receptor tyrosine kinase inhibitor with potential antiproliferative effect. Synonyms: RG13022; RG 13022; RG-13022; 3-(3,4-dimethoxyphenyl)-2-pyridin-3-ylprop-2-enenitrile; RG 13022; RG-13022. CAS No. 136831-48-6. Molecular formula: C16H14N2O2. Mole weight: 266.29. | |
| RG14620 | RG14620 is a non-phenolic tyrphostin-class epidermal growth factor receptor (EGFR) inhibitor (IC50= 3 μM for HER 14 colony formation, and IC50= 1 pM for HER 14 DNA synthesis), with anti-proliferative effects on renal and bladder carcinoma cell lines. Synonyms: (E)-3-(3,5-dichlorophenyl)-2-pyridin-3-ylprop-2-enenitrile; RG 14620; RG14620; RG-14620; TYRPHOSTIN RG 14620. CAS No. 136831-49-7. Molecular formula: C14H8Cl2N2. Mole weight: 275.13. | |
| SU1498 | SU1498 (AG 1498) is a selective inhibitor of the VEGFR2 ; inhibits Flk-1 with an IC 50 of value of 700 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG 1498; Tyrphostin SU 1498. CAS No. 168835-82-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19326. | |
| SU1498 | SU1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), and inhibits Flk-1 with an IC50 of value of 700 nM. Synonyms: (E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-N-(3-phenylpropyl)prop-2-enamide; SU-1498; SU 1498; SU1498; AG-1498; AG 1498; AG1498; Tyrphostin SU 1498. CAS No. 168835-82-3. Molecular formula: C25H30N2O2. Mole weight: 390.52. | |
| WP1130 (Degrasyn) | A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-kB activities (IC50 < 1uM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2uM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5uM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 in xenograft mouse models of CML and melanoma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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