Tyrphostin Ag 126 Suppliers USA

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Tyrphostin ag 126 Heterocyclic Organic Compound. Alternative Names: RARECHEM AL BX 0673;TYRPHOSTIN A10;TYRPHOSTIN AG 126;ag127;AG 126; ALPHA-CYANO-(3-HYDROXY-4-NITRO)CINNAMONITRILE; [3-HYDROXY-4-NITROBENZYLIDENE]MALONONITRILE; Tyrphostin 126. CAS No. 118409-62-4. Molecular formula: C10H5N3O3. Mole weight: 215.16. Appearance: Yellow Solid. Catalog: ACM118409624. Alfa Chemistry. 2
AG 126 Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Synonyms: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. Grades: 95%. CAS No. 118409-62-4. Molecular formula: C10H5N3O3. Mole weight: 215.16. BOC Sciences 2
Tyrphostin A51 Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [ 3 H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-183. CAS No. 126433-07-6. Pack Sizes: 1 mg. Product ID: HY-101960A. MedChemExpress MCE

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