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| Product | Description | |
|---|---|---|
| Ubiquinone | Heterocyclic Organic Compound. CAS No. 10303-98-0. Purity: 0.96. Catalog: ACM10303980. |  |
| Ubiquinone-10 | Ubiquinone-10 acts as an inhibitor of the mitochondrial permeability transition pore (MPTP). This inhibitory effect can be counteracted by ubiquinone-5. Applications: An inhibitor of the mitochondrial permeability transition pore. Group: Coenzymes. Synonyms: Coenzyme Q2; 2,3-Dimethoxy-5-methyl-6-geranyl-1,4-benzoquinone. CAS No. 606-06-4. Purity: ≥90%. Mole weight: 318.4. Form: Liquid. Coenzyme Q2; 2,3-Dimethoxy-5-methyl-6-geranyl-1,4-benzoquinone; Ubiquinone-10; 606-06-4. Cat No: COEC-062. |  |
| Ubiquinone-5 | Ubiquinone-5 is a coenzyme Q10 (CoQ10) (sc-205262) analog that counteracts the inhibitory effects on mitochondrial permeability transition pore (MPTP) of decylubiquinone and ubiquinone-10. Applications: A coq10 analog that counteracts the inhibitory effects on mptp. Group: Coenzymes. Synonyms: Coenzyme Q1. CAS No. 727-81-1. Mole weight: 250.29. Form: Liquid. Coenzyme Q1; Ubiquinone-5; 727-81-1. Cat No: COEC-012. | |
| Decylubiquinone | Decylubiquinone is an analog of ubiquinone (coenzyme Q 10 ). Decylubiquinone blocks reactive oxygen species (ROS) production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 55486-00-5. Pack Sizes: 5 mg (77.53 mM * 200 μL in Ethanol); 10 mg (77.53 mM * 400 μL in Ethanol). Product ID: HY-121134. |  |
| NADH:ubiquinone reductase (H+-translocating) | A flavoprotein (FMN) containing iron-sulfur clusters. The complex is present in mitochondria and aerobic bacteria. Breakdown of the complex can release EC 1.6.99.3, NADH dehydrogenase. In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD+ to NADH. Group: Enzymes. Synonyms: ubiquinone reductase (ambiguous); type 1 dehydrogenase; complex 1 dehydrogenase; coenzyme Q reductase (ambiguous); complex I (electron transport chain); complex I (mitochondrial electron transport); complex I (NADH:Q1 oxidoreductase); dihydronicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous); DPNH-coenzyme Q reductase (. Enzyme Commission Number: EC 7.1.1.2 (Formerly EC 1.6.5.3). CAS No. 9028-04-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1592; NADH:ubiquinone reductase (H+-translocating); EC 1.6.5.3; 9028-04-0; ubiquinone reductase (ambiguous); type 1 dehydrogenase; complex 1 dehydrogenase; coenzyme Q reductase (ambiguous); complex I (electron transport chain); complex I (mitochondrial electron transport); complex I (NADH:Q1 oxidoreductase); dihydronicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous); DPNH-coenzyme Q reductase (ambiguous); DPNH-ubiquinone reductase (ambiguous); mitochondrial electron transp | |
| NADH:ubiquinone reductase (Na+-transporting) | An iron-sulfur flavoprotein, containing two covalently bound molecules of FMN, one noncovalently bound FAD, one riboflavin, and one [2Fe-2S] cluster. Group: Enzymes. Synonyms: Na+-translocating NADH-quinone reductase; (Na+-NQR). Enzyme Commission Number: EC 7.2.1.1 (Formerly EC 1.6.5.8). Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1597; NADH:ubiquinone reductase (Na+-transporting); EC 1.6.5.8; Na+-translocating NADH-quinone reductase; (Na+-NQR). Cat No: EXWM-1597. | |
| NADH:ubiquinone reductase (non-electrogenic) | A flavoprotein (FAD). Occurs in mitochondria of yeast and plants, and in aerobic bacteria. Has low activity with NADPH. Group: Enzymes. Synonyms: ubiquinone reductase (ambiguous); coenzyme Q reductase (ambiguous); dihydronicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous); DPNH-coenzyme Q reductase (ambiguous); DPNH-ubiquinone reductase (ambiguous); NADH-coenzyme Q oxidoreductase (ambiguous); NADH-coenzyme Q reductase (ambiguous); NADH-C. Enzyme Commission Number: EC 1.6.5.9. CAS No. 9028-04-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1598; NADH:ubiquinone reductase (non-electrogenic); EC 1.6.5.9; 9028-04-0; ubiquinone reductase (ambiguous); coenzyme Q reductase (ambiguous); dihydronicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous); DPNH-coenzyme Q reductase (ambiguous); DPNH-ubiquinone reductase (ambiguous); NADH-coenzyme Q oxidoreductase (ambiguous); NADH-coenzyme Q reductase (ambiguous); NADH-CoQ oxidoreductase (ambiguous); NADH-CoQ reductase (ambiguous); NADH-ubiquinone reductase (ambiguous); NADH-ubiquinone oxidoreductase (ambiguous); reduced nicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous); NADH-Q6 oxidoreductase (ambiguous); NADH2 dehydrogenase (ubiquinone) (ambiguous). Cat No: EXWM-1598. | |
| (1S, 4S)-2, 5-Diazabicyclo[2. 2. 1]heptane Dihydrobromide | (1S, 4S)-2, 5-Diazabicyclo[2. 2. 1]heptane Dihydrobromide acts as a reagent for the synthesis and characterization of new piperazine-type inhibitors for mitochondrial ubiquinone reductase, preparation of heterocyclic compounds as chemokine receptor inhibitors useful in treatment of CXCR4-mediated diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 132747-20-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C5H10N2; 2HBr, Molecular Weight: 98.1516182. US Biological Life Sciences. |  Worldwide |
| 2,3-Dimethoxy-5-methyl-6-[all trans]farnesylfarnesyl-1,4-benzoquinone | Heterocyclic Organic Compound. Alternative Names: COENZYME Q6;2,3-DIMETHOXY-5-METHYL-6-[ALL TRANS]FARNESYLFARNESYL-1,4-BENZOQUINONE;UBIQUINONE-30;coenzyme Q6 from saccharomyces*cerevisiae;2,3-dimethoxy-5-methyl-6-(farnesylfarnesyl)-1,4-benzoquinone;ubiquinone 6;2,3-Dimethoxy-5-methyl-6-(farnesylfarnesyl)-1,4-benzoquinone,Ubiquinone-30;2-[(2E,6E,10E,14E,18E)-3,7,11,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexenyl]-3-methyl-5,6-dimethoxy-1,4-benzoquinone. CAS No. 1065-31-2. Molecular formula: C39H58O4. Mole weight: 590.88. Catalog: ACM1065312. | |
| 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase | This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, when the COQ5 gene from Saccharomyces cerevisiae is introduced into Escherichia coli, it complements the respiratory deficiency of an ubiE mutant. The bifunctional enzyme from Escherichia coli also catalyses the methylation of demethylmenaquinol-8 (this activity is classified as EC 2.1.1.163). Group: Enzymes. Synonyms: ubiE (gene name, ambiguous). Enzyme Commission Number: EC 2.1.1.201. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1802; 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase; EC 2.1.1.201; ubiE (gene name, ambiguous). Cat No: EXWM-1802. | |
| 2-polyprenyl-6-hydroxyphenol methylase | UbiG catalyses both methylation steps in ubiquinone biosynthesis in Escherichia coli. The second methylation is classified as EC 2.1.1.64 (3-demethylubiquinol 3-O-methyltransferase). In eukaryotes Coq3 catalyses the two methylation steps in ubiquinone biosynthesis. However, while the second methylation is common to both enzymes, the first methylation by Coq3 occurs at a different position within the pathway, and thus involves a different substrate and is classified as EC 2.1.1.114 (polyprenyldihydroxybenzoate methyltransferase). The substrate of the eukaryotic enzyme (3,4-dihydroxy-5-all-trans-polyprenylbenzoate) differs by an additional carboxylate moiety. Group: Enzymes. Synonyms: ubiG (gene name, ambiguous); ubiG methyltransferase (ambiguous); 2-octaprenyl-6-hydroxyphenol methylase. Enzyme Commission Number: EC 2.1.1.222. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1825; 2-polyprenyl-6-hydroxyphenol methylase; EC 2.1.1.222; ubiG (gene name, ambiguous); ubiG methyltransferase (ambiguous); 2-octaprenyl-6-hydroxyphenol methylase. Cat No: EXWM-1825. | |
| 2-Thenoyltri fluoroacetone | 2-Thenoyltri fluoroacetone is an inhibitor of respiration in animals and bacteria. TTFA binds at the quinone reduction site of succinate ubiquinone oxidoreductase. Group: Biochemicals. Grades: Highly Purified. CAS No. 326-91-0. Pack Sizes: 10g, 25g. Molecular Formula: C8H5F3O2S, Molecular Weight: 222.18. US Biological Life Sciences. | Worldwide |
| 3-demethylubiquinol 3-O-methyltransferase | This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast.The enzymes from yeast, Escherichia coli and rat also catalyse the methylation of 3,4-dihydroxy-5-all-trans-polyprenylbenzoate (a reac...COQ3 (gene name); Coq3 O-methyltransferase; ubiG (gene name, ambiguous). Enzyme Commission Number: EC 2.1.1.64. CAS No. 63774-48-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1966; 3-demethylubiquinol 3-O-methyltransferase; EC 2.1.1.64; 63774-48-1; 5-demethylubiquinone-9 methyltransferase; OMHMB-methyltransferase; 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase; S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase; COQ3 (gene name); Coq3 O-methyltransferase; ubiG (gene name, ambiguous). Cat No: EXWM-1966. | |
| 4-hydroxy-3-polyprenylbenzoate decarboxylase | The enzyme catalyses a step in prokaryotic ubiquinone biosynthesis, as well as in plastoquinone biosynthesis in cyanobacteria. The enzyme can accept substrates with different polyprenyl tail lengths in vitro, but uses a specific length in vivo, which is determined by the polyprenyl diphosphate synthase that exists in the specific organism. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase. Group: Enzymes. Synonyms: ubiD (gene name); 4-hydroxy-3-solanesylbenzoate decarboxylase; 3-octaprenyl-4-hydroxybenzoate decarboxylase. Enzyme Commission Number: EC 4.1.1.98. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4848; 4-hydroxy-3-polyprenylbenzoate decarboxylase; EC 4.1.1.98; ubiD (gene name); 4-hydroxy-3-solanesylbenzoate decarboxylase; 3-octaprenyl-4-hydroxybenzoate decarboxylase. Cat No: EXWM-4848. | |
| 4-hydroxybenzoate polyprenyltransferase | This enzyme, involved in the biosynthesis of ubiquinone, attaches a polyprenyl side chain to a 4-hydroxybenzoate ring, producing the first ubiquinone intermediate that is membrane bound. The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency. Group: Enzymes. Synonyms: nonaprenyl-4-hydroxybenzoate transferase; 4-hydroxybenzoate transferase; p-hydroxybenzoate dimethylallyltransferase; p-hydroxybenzoate polyprenyltransferase; p-hydroxybenzoic acid-polyprenyl transferase; p-hydroxybenzoic-polyprenyl transferase; 4-hydroxybenzoate nonaprenyltransferase. Enzyme Commission Number: EC 2.5.1.39. CAS No. 9030-77-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2775; 4-hydroxybenzoate polyprenyltransferase; EC 2.5.1.39; 9030-77-7; nonaprenyl-4-hydroxybenzoate transferase; 4-hydroxybenzoate transferase; p-hydroxybenzoate dimethylallyltransferase; p-hydroxybenzoate polyprenyltransferase; p-hydroxybenzoic acid-polyprenyl transferase; p-hydroxybenzoic-polyprenyl transferase; 4-hydroxybenzoate nonaprenyltransferase. Cat No: EXWM-2775. | |
| 7-Doxyl Stearic Acid | A spin-labeled fatty acid. The reduction of doxylstearates takes place at the level of the ubiquinone in the respiratory chain in mitochondria in these cells. Group: Biochemicals. Alternative Names: 2-(5-Carboxypentyl)-4,4-dimethyl-2-undecyl-. Grades: Highly Purified. CAS No. 40951-82-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| alcohol dehydrogenase (quinone) | Only described in acetic acid bacteria where it is involved in acetic acid production. Associated with membrane. Electron acceptor is membrane ubiquinone. A model structure suggests that, like all other quinoprotein alcohol dehydrogenases, the catalytic subunit has an 8-bladed propeller structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ; the catalytic subunit also has a heme c in the C-terminal domain. The enzyme has two additional subunits, one of which contains three molecules of heme c. It does not require amines for activation. It has a restricted substrate specificity, oxidizing a few primary alcohols (C2 to C6), but not methanol, secondary alcohols and some aldehydes. It is assayed with phenazine methosulfate or with ferricyanide. Group: Enzymes. Synonyms: type III ADH; membrane associated quinohaemoprotein alcohol dehydrogenase. Enzyme Commission Number: EC 1.1.5.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0433; alcohol dehydrogenase (quinone); EC 1.1.5.5; type III ADH; membrane associated quinohaemoprotein alcohol dehydrogenase. Cat No: EXWM-0433. | |
| all-trans-decaprenyl-diphosphate synthase | This enzyme catalyses the condensation reactions resulting in the formation of all-trans-decaprenyl diphosphate, the isoprenoid side chain of ubiquinone-10 and menaquinone-10. The enzyme adds seven isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. Group: Enzymes. Synonyms: decaprenyl-diphosphate synthase; decaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-prenyltransferase. Enzyme Commission Number: EC 2.5.1.91. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2830; all-trans-decaprenyl-diphosphate synthase; EC 2.5.1.91; decaprenyl-diphosphate synthase; decaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-prenyltransferase. Cat No: EXWM-2830. | |
| all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] | Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate. The plant Arabidopsis thaliana has two different enzymes that catalyse this reaction. SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains. Group: Enzymes. Synonyms: nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); At-SPS2; At-SPS1; SPS1; SPS2. Enzyme Commission Number: EC 2.5.1.85. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2823; all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]; EC 2.5.1.85; nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); At-SPS2; At-SPS1; SPS1; SPS2. Cat No: EXWM-2823. | |
| all-trans-octaprenyl-diphosphate synthase | This enzyme catalyses the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate, the isoprenoid side chain of ubiquinone-8 and menaquinone-8. The enzyme adds five isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. Group: Enzymes. Synonyms: octaprenyl-diphosphate synthase; octaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-heptaprenyltranstransferase; trans-prenyltransferase. Enzyme Commission Number: EC 2.5.1.90. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2829; all-trans-octaprenyl-diphosphate synthase; EC 2.5.1.90; octaprenyl-diphosphate synthase; octaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-heptaprenyltranstransferase; trans-prenyltransferase. Cat No: EXWM-2829. | |
| Antroquinonol | Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata , has hepatoprotective, anti-inflammatory, and anti-cancer effects [1]. Antroquinonol can be used for the research of colon cancer [2]. Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (+)-Antroquinonol. CAS No. 1010081-09-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19893. | |
| Atpenin A5 | Antibiotic. Antifungal. Potent and specific mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor. Mitochondrial ATP-sensitive potassium (mK(ATP)) channel activator. Cardioprotective. Modulates mitochondrial ROS generation during cardioprotection.The IC50 value against bovine heart complex II is 3.6nM (which is ~300-fold lower than the IC50 value of carboxin (1.1uM)). It also inhibits fumarate reductase of Ascaris suum (IC50 = 12nM). Inhibition of E. coli succinate dehydrogenase is less potent (IC50 = 5uM). By co-crystallization studies of atpenin A5 and complex II, the binding site of atpenin A5 was found to be the quinone-binding site of complex II. Additionally, atpenin A5 has been shown to have a protective action against ischemia-reperfusion via the activation of mitochondrial KATP channels. Group: Biochemicals. Alternative Names: 3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone. Grades: Highly Purified. CAS No. 119509-24-9. Pack Sizes: 250ug, 1mg. Molecular Formula: C15H21Cl2NO5. US Biological Life Sciences. | Worldwide |
| Atpenin A5 | Atpenin A5 is an inhibitor of SDHB, SDHC and SDHD. It is an antifungal antibiotic produced by Penicillium sp. and an ubiquinone-binding site inhibitor of succinate dehydrogenase with IC50s of 12 nM for nematode and IC50s of 3.7 nM for mammalian mitochondria. Atpenin A5 is the most effective inhibitor against complex II from all the atpenins and has been shown to protect against cardiac-reperfusion injury in rat studies through the stimulation of mitochondrial KATP channels. Synonyms: Antibiotic FO-125A5. Grades: ≥95%. CAS No. 119509-24-9. Molecular formula: C15H21Cl2NO5. Mole weight: 366.2. |  |
| Atpenin A5 (3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone) | Synthetic. Originally isolated from Penicillium sp. strain. An antibiotic and antifungal agent. Potent and specific mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor and mitochondrial ATP-sensitive potassium (mK(ATP)) channel activator. Modulates mitochondrial ROS generation during cardioprotection. Group: Biochemicals. Grades: Highly Purified. CAS No. 119509-24-9. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| caffeine dehydrogenase | This enzyme, characterized from the soil bacterium Pseudomonas sp. CBB1, catalyses the incorporation of an oxygen atom originating from a water molecule into position C-8 of caffeine. The enzyme utilizes short-tail ubiquinones as the preferred electron acceptor. Group: Enzymes. Enzyme Commission Number: EC 1.17.5.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1095; caffeine dehydrogenase; EC 1.17.5.2. Cat No: EXWM-1095. | |
| chorismate lyase | This enzyme catalyses the first step in the biosynthesis of ubiquinone in Escherichia coli and other Gram-negative bacteria. The yeast Saccharomyces cerevisiae can synthesize ubiquinone from either chorismate or tyrosine. Group: Enzymes. Synonyms: CL; CPL; UbiC. Enzyme Commission Number: EC 4.1.3.40. CAS No. 157482-18-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4917; chorismate lyase; EC 4.1.3.40; 157482-18-3; CL; CPL; UbiC. Cat No: EXWM-4917. | |
| Cochlioquinone A (Luteoleersin) | Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has been recently shown to be an antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). It is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase. Group: Biochemicals. Alternative Names: Luteoleersin. Grades: Highly Purified. CAS No. 32450-25-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Cochlioquinone B | Cochlioquinone B, the minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH-ubiquinone reductase inhibitor and a phytotoxic agent inhibiting root growth. It is closely related to Cochlioquinone A that inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. Cochlioquinones have been recently shown to be antagonists of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Group: Biochemicals. Grades: Highly Purified. CAS No. 32450-26-3. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Cochlioquinone B | It is the minor component of a bioactive pigment isolated from Bipolaris cynodontis and Cochliobolus miyabeanus. It is an NADH-ubiquinone reductase inhibitor. It is also a phytotoxic agent inhibiting root growth. It is closely related to cochlioquinone A which inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. It is an antagonist of the human chemokine receptor, CCR5, in HIV-1. Synonyms: 20-De(acetyloxy)-11-deoxy-20-oxo-cochlioquinone A; 9-(1, 3-Dimethyl-2-oxopentyl)-1, 2, 3, 4aα, 5, 6, 6a, 12, 12aα, 12b-decahydro-3β-(1-hydroxy-1-methylethyl)-6aβ, 12bβ-dimethyl-pyrano[3, 2-a]xanthene-8, 11-dione Stereoisomer; (3R,4aR,6aR,12aR,12bR)-9-[(1S,3S)-1,3-Dimethyl-2-oxopentyl]-1,2,3,4a,5,6,6a,12,12a,12b-decahydro-3-(1-hydroxy-1-methylethyl)-6a,12b-dimethylpyrano[3,2-a]xanthene-8,11-dione. Grades: >99% by HPLC. CAS No. 32450-26-3. Molecular formula: C28H40O6. Mole weight: 472.61. | |
| Coenzyme Q0 | Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy , suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: CoQ0. CAS No. 605-94-7. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W016412. | |
| Coenzyme Q10 | Coenzyme Q10 is an electron transport chain component of the mitochondria, which assists proton and electron transfer across the inner mitochondrial membrane. Studies indicate that Coenzyme Q10 can protect human endothelial cells from oxidative damage by modulating the nitric oxide pathway. In addition, Coenzyme Q10 inhibits LDL oxidation, a major process in the development of atherosclerosis. Coenzyme Q10 is known to suppress the down regulation of NOS3 (endothelial nitric oxide synthase, eNOS) and up-regulation of NOS2 (inducible nitric oxide synthase, iNOS). As a result of its ability to bind Ca2+, Coenzyme Q10 can transport this cation across artificial biomimetic membranes. Applications: A mitochondrial transporter chain component. Group: Coenzymes. Synonyms: CoQ10; Ubidecarenone; Ubiquinone-10; Q-10. CAS No. 303-98-0. Purity: ≥98%. Mole weight: 863.34. Appearance: Powder. Form: Solid. CoQ10; Ubidecarenone; Ubiquinone-10; Q-10; Coenzyme Q10; 303-98-0. Cat No: COEC-013. | |
| Coenzyme Q10 | Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent. Uses: Scientific research. Group: Natural products. Alternative Names: CoQ10; Ubiquinone-10; Ubidecarenone. CAS No. 303-98-0. Pack Sizes: 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-N0111. | |
| Coenzyme Q10 | Coenzyme Q10. Synonyms: Q-10, Ubiquinone 50, Ubiquinone-10. CAS No. 303-98-0. Pack Sizes: 100, 500 mg in poly bottle. Product ID: CDC10-0087. Molecular formula: C59H90O4. Category: Antioxidant Cosmetic Chemicals. Product Keywords: Cosmetic Ingredients; Antioxidant Cosmetic Chemicals; Coenzyme Q10; CDC10-0087; 303-98-0; C59H90O4; Q-10, Ubiquinone 50, Ubiquinone-10; 206-147-9; MFCD00042919; 303-98-0. Purity: ≥98% (HPLC). Color: Yellow to dark orange. EC Number: 206-147-9. Physical State: Powder. Solubility: Soluble in chloroform. Quality Level: 200. Storage: -20°C. Application: cell analysis. Boiling Point: 715.32°C (rough estimate). Melting Point: 49 °C. Density: 0.9145 g/mL(rough estimate). |  |
| Coenzyme Q10 | Coenzyme Q10 (ubiquinone, ubidecarenone, coenzyme Q) is a component of the electron transport chain and participates in aerobic cellular respiration. Uses: Ingredient of health care products. Synonyms: CoQ10; Ubiquinone-10; Ubidecarenone; COQ10; Vitamin Q; NSC 140665; (all-E)-2-(3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione; Bio-Quinone Q10; Cosmesome Q 10; Ensorb; Kaneka Q10; Kudesan. Grades: ≥98%. CAS No. 303-98-0. Molecular formula: C59H90O4. Mole weight: 863.34. | |
| Coenzyme Q10 (with Vit. E & C) | Vitamin-like molecule (ubiquinone, ubidecarenone) obtained from plant material Q10 is encapsulated in nano-sized liposomes consisting of a phospholipid double nano-emulsion with vitamin E and vitamin C (ascorbyl tetraisopalmitate) to maintain activity, enhance skin penetration and potency. Accompanying vitamin E and vitamin C are needed to activate coenzyme to its active state. The liposomes have an average particle size of about 50nm. Activity 6.8-7.3% Q10 (liposome-encapsulation largely reduces the amount of Q10 required for effectiveness as compared to non-encapsulated pure Q10). Uses: Anti-aging & anti-wrinkle products, hair treatments/hair serums, pre/after sun lotions, hydrating / rejuvenating & moisturizing skin care products. Group: Humectants. CAS No. 8002-43-5 / 303-98-0 / 183476-82-6 / 59-02-9 / 68956-68-3 / 532-32-1 / 56-81-5 / 7732-18-5. Appearance: Orange-opaque liquid, faint odor. Catalog: CI-SC-0037. | |
| Coenzyme Q4 | Coenzyme Q4 increases the fluorescence polarization of perylene incorporated into ubiquinone-depleted bilayer and mitochondrial vesicles prepared from mitochondrial phospholipids. Applications: A compound which increases the fluorescence polarization of perylene. Group: Coenzymes. CAS No. 4370-62-1. Purity: ≥90%. Mole weight: 454.64. Form: Liquid. Coenzyme Q4; 4370-62-1. Cat No: COEC-021. | |
| Coenzyme Q8 | Coenzyme Q8. Group: Biochemicals. Alternative Names: 2, 3-Dimethoxy-5-methyl-6-[(2E, 6E, 10E, 14E, 18E, 22E, 26E)-3, 7, 11, 15, 19, 23, 27, 31-octamethyl-2, 6, 10, 14, 18, 22, 26, 30-dotriacontaoctaenyl]-2, 5-cyclohexadiene-1, 4-dione; 2,3-Dimethoxy-5-methyl-6-(3,7,11,15,19,23,27,31-octamethyl-2,6,10,14,18,22,26,30-dotriacontaoctaenyl)-p-benzoquinone; Ubiquinone 40. Grades: Highly Purified. CAS No. 2394-68-5. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C49H74O4. US Biological Life Sciences. | Worldwide |
| Coenzyme q9 | Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis. Group: Inhibitors. Alternative Names: Coenzyme Q(sub 9); 2,3-dimethoxy-5-methyl-6-[(2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaenyl]cyclohexa-2,5-diene-1,4-dione; Coenzyme Q9; All-Trans Coenzyme Q9; Q-9 Ubiquinone-45 Ubiquinone. CAS No. 303-97-9. Molecular formula: C54H82O4. Mole weight: 795.23. Purity: 0.96. IUPACName: 2,3-dimethoxy-5-methyl-6-[(2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaenyl]cyclohexa-2,5-diene-1,4-dione. Canonical SMILES: CC1=C (C (=O)C (=C (C1=O)OC)OC)CC=C (C)CCC=C (C)CCC=C (C)CCC=C (C)CCC=C (C)CCC=C (C)CCC=C (C)CCC=C (C)CCC=C (C)C. Density: 0.97 g/cm³. Catalog: ACM303979. | |
| Coenzyme Q9 | Coenzyme Q9 is a co-enzyme that is lipid solumbe compononet of cell membranes. It is useful in electron and proton transport of liposome systems. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis. Synonyms: 2,5-cyclohexadiene-1,4-dione, 2,3-dimethoxy-5-methyl-6-((2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaen-1-yl)-; coenzyme Q9; CoQ9; ubiquinone 9; ubiquinone 9, (Z,Z,Z,Z,Z,E,E,E)-isomer; ubiquinone Q-9; ubiquinone-9. Grades: ≥98%. CAS No. 303-97-9. Molecular formula: C54H82O4. Mole weight: 795.23. | |
| Coenzyme Q9 | Coenzyme Q9 is a co-enzyme that is lipid solumbe compononet of cell membranes. It is useful in electron and proton transport of liposome systems. It is also a useful tool in vitro to increase the life span of cells. Applications: A useful tool in vitro to increase the life span of cells. Group: Coenzymes. Synonyms: Ubiquinone-9. CAS No. 303-97-9. Purity: ≥98%. Mole weight: 795.23. Form: Solid. Ubiquinone-9; Coenzyme Q9; 303-97-9. Cat No: COEC-045. | |
| D-2-hydroxyacid dehydrogenase (quinone) | The enzyme from mammalian kidney contains one mole of FAD per mole of enzyme.(R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors. Group: Enzymes. Synonyms: (R)-2-hydroxy acid dehydrogenase; (R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase; D-lactate dehydrogenase (ambiguous). Enzyme Commission Number: EC 1.1.5.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0428; D-2-hydroxyacid dehydrogenase (quinone); EC 1.1.5.10; (R)-2-hydroxy acid dehydrogenase; (R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase; D-lactate dehydrogenase (ambiguous). Cat No: EXWM-0428. | |
| demethylmenaquinone methyltransferase | The enzyme catalyses the last step in menaquinone biosynthesis. It is able to accept substrates with varying polyprenyl side chain length (the chain length is determined by polyprenyl diphosphate synthase). The enzyme from Escherichia coli also catalyses the conversion of 2-methoxy-6-octaprenyl-1,4-benzoquinone to 5-methoxy-2-methyl-3-octaprenyl-1,4-benzoquinone during the biosynthesis of ubiquinone. The enzyme probably acts on menaquinol rather than menaquinone. Group: Enzymes. Synonyms: S-adenosyl-L-methione-DMK methyltransferase; demethylmenaquinone C-methylase; 2-heptaprenyl-1,4-naphthoquinone methyltransferase; 2-demethylmenaquinone methyltransferase; S-adenosyl-L-methione:2-demethylmenaquinone methyltransferase. Enzyme Commission Number: EC 2.1.1.163. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1760; demethylmenaquinone methyltransferase; EC 2.1.1.163; S-adenosyl-L-methione-DMK methyltransferase; demethylmenaquinone C-methylase; 2-heptaprenyl-1,4-naphthoquinone methyltransferase; 2-demethylmenaquinone methyltransferase; S-adenosyl-L-methione:2-demethylmenaquinone methyltransferase. Cat No: EXWM-1760. | |
| dihydroorotate dehydrogenase (quinone) | This Class 2 dihydroorotate dehydrogenase enzyme contains FMN. The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane. The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates. Methyl-, ethyl-, tert-butyl and benzyl (S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not. Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. Group: Enzymes. Synonyms: dihydroorot. Enzyme Commission Number: EC 1.3.5.2. CAS No. 59088-23-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1386; dihydroorotate dehydrogenase (quinone); EC 1.3.5.2; 59088-23-2; dihydroorotate:ubiquinone oxidoreductase; (S)-dihydroorotate:(acceptor) oxidoreductase; (S)-dihydroorotate:acceptor oxidoreductase; DHOdehase (ambiguous); DHOD (ambiguous); DHODase (ambiguous); DHODH. Cat No: EXWM-1386. | |
| electron-transferring-flavoprotein dehydrogenase | An iron-sulfur flavoprotein, forming part of the mitochondrial electron-transfer system. Group: Enzymes. Synonyms: ETF-QO; ETF:ubiquinone oxidoreductase; electron transfer flavoprotein dehydrogenase; electron transfer flavoprotein Q oxidoreductase; electron transfer flavoprotein-ubiquinone oxidoreductase; electron transfer flavoprotein reductase. Enzyme Commission Number: EC 1.5.5.1. CAS No. 86551-03-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1556; electron-transferring-flavoprotein dehydrogenase; EC 1.5.5.1; 86551-03-3; ETF-QO; ETF:ubiquinone oxidoreductase; electron transfer flavoprotein dehydrogenase; electron transfer flavoprotein Q oxidoreductase; electron transfer flavoprotein-ubiquinone oxidoreductase; electron transfer flavoprotein reductase. Cat No: EXWM-1556. | |
| FAD:protein FMN transferase | The enzyme catalyses the transfer of the FMN portion of FAD and its covalent binding to the hydroxyl group of an L-threonine residue in a target flavin-binding protein such as the B and C subunits of EC 1.6.5.8, NADH:ubiquinone reductase (Na+-transporting). Requires Mg2+. Group: Enzymes. Synonyms: flavin transferase; apbE (gene name). Enzyme Commission Number: EC 2.7.1.180. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3012; FAD:protein FMN transferase; EC 2.7.1.180; flavin transferase; apbE (gene name). Cat No: EXWM-3012. | |
| Farnesyl pyrophosphate ammonium | Farnesyl pyrophosphate ammonium salt, a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate ammonium salt is a TRPM2 (TRP Channel) agonist, and activates TRPM2 opening for ion influx. Farnesyl pyrophosphate ammonium salt is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Farnesyl diphosphate ammonium. CAS No. 116057-57-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-113037C. | |
| Ferulenol | Ferulenol, a sesquiterpene prenylated coumarin derivative, specifically inhibits succinate ubiquinone reductase at the level of the ubiquinonecycle. Ferulenol shows good antimycobacterial activity and haemorrhagic action [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 6805-34-1. Pack Sizes: 5 mg. Product ID: HY-129605. | |
| fumarate reductase (CoM/CoB) | The enzyme, isolated from the archaeon Methanobacterium thermoautotrophicum, is very oxygen sensitive. It cannot use reduced flavins, reduced coenzyme F420, or NAD(P)H as an electron donor. Distinct from EC 1.3.1.6 [fumarate reductase (NADH)], EC 1.3.5.1 [succinate dehydrogenase (ubiquinone)], and EC 1.3.5.4 [fumarate reductase (quinol)]. Group: Enzymes. Synonyms: thiol:fumarate reductase; Tfr. Enzyme Commission Number: EC 1.3.4.1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1384; fumarate reductase (CoM/CoB); EC 1.3.4.1; thiol:fumarate reductase; Tfr. Cat No: EXWM-1384. | |
| glucose 1-dehydrogenase (PQQ, quinone) | Integral membrane protein containing PQQ as prosthetic group. It also contains bound ubiquinone and Mg2+ or Ca2+. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses. Group: Enzymes. Synonyms: quinoprotein glucose dehydrogenase; membrane-bound glucose dehydrogenase; mGDH; glucose dehydrogenase (PQQ-dependent); glucose dehydrogenase (pyrroloquinoline-quinone); quinoprotein D-glucose dehydrogenase. Enzyme Commission Number: EC 1.1.5.2. CAS No. 81669-60-5. Glucose Dehyrogenase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0430; glucose 1-dehydrogenase (PQQ, quinone); EC 1.1.5.2; 81669-60-5; quinoprotein glucose dehydrogenase; membrane-bound glucose dehydrogenase; mGDH; glucose dehydrogenase (PQQ-dependent); glucose dehydrogenase (pyrroloquinoline-quinone); quinoprotein D-glucose dehydrogenase. Cat No: EXWM-0430. | |
| Harzianopyridone | Harzianopyridone is a metabolite of Trichoderma harzianum that exhibits antifungal and antibacterial properties. Harzianopyridone acts as an atpenin-like inhibitor of mammalian and nematode mitochondrial complex II (succinate:ubiquinone oxidoreductase; SQR) with IC50 values of 0.017, 0.2, and 2 μM for bovine, rat, and nematode complex II, respectively. It also inhibits nematode quinol-fumarate reductase (QFR; IC50 = 0.36 μM). Synonyms: (-)-Harzianopyridone; 4-Hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexenyl]-2(1H)-pyridinone; 2(1H)-Pyridinone, 4-hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexen-1-yl]-; 2(1H)-Pyridinone, 4-hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexenyl]-; 4-Hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexen-1-yl]-2(1H)-pyridinone; (S,E)-4-hydroxy-5,6-dimethoxy-3-(2-methylhex-4-enoyl)pyridin-2(1H)-one. Grades: ≥95%. CAS No. 137813-88-8. Molecular formula: C14H19NO5. Mole weight: 281.30. | |
| heptaprenyl diphosphate synthase | This enzyme catalyses the condensation reactions resulting in the formation of all-trans-heptaprenyl diphosphate, the isoprenoid side chain of ubiquinone-7 and menaquinone-7. The enzyme adds four isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. Group: Enzymes. Synonyms: all-trans-heptaprenyl-diphosphate synthase; heptaprenyl pyrophosphate synthase; heptaprenyl pyrophosphate synthetase; HepPP synthase; HepPS; heptaprenylpyrophosphate synthetase. Enzyme Commission Number: EC 2.5.1.30. CAS No. 74506-59-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2768; heptaprenyl diphosphate synthase; EC 2.5.1.30; 74506-59-5; all-trans-heptaprenyl-diphosphate synthase; heptaprenyl pyrophosphate synthase; heptaprenyl pyrophosphate synthetase; HepPP synthase; HepPS; heptaprenylpyrophosphate synthetase. Cat No: EXWM-2768. | |
| hydrogen:quinone oxidoreductase | Contains nickel, iron-sulfur clusters and cytochrome b. Also catalyses the reduction of water-soluble quinones (e.g. 2,3-dimethylnaphthoquinone) or viologen dyes (benzyl viologen or methyl viologen). Group: Enzymes. Synonyms: hydrogen-ubiquinone oxidoreductase; hydrogen:menaquinone oxidoreductase; membrane-bound hydrogenase; quinone-reactive Ni/Fe-hydrogenase. Enzyme Commission Number: EC 1.12.5.1. CAS No. 151616-65-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0522; hydrogen:quinone oxidoreductase; EC 1.12.5.1; 151616-65-8; hydrogen-ubiquinone oxidoreductase; hydrogen:menaquinone oxidoreductase; membrane-bound hydrogenase; quinone-reactive Ni/Fe-hydrogenase. Cat No: EXWM-0522. | |
| IACS-010759 | IACS-010759 is an orally bioavailable inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targeting complex I of the electron transport chain (NADH ubiquinone oxidoreductase). Study showed that IACS-010759 induced AMPK activation leading to mTOR suppression which resulted in cell growth inhibition in AML cells. Synonyms: 5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole. Grades: ≥98%. CAS No. 1570496-34-2. Molecular formula: C25H25F3N6O4S. Mole weight: 562.57. | |
| Idebenone | Ubiquinone derivative with protective effects against cerebral ischemia. Nootropic. Group: Biochemicals. Alternative Names: 2-(10-Hydroxydecyl)-5,6-methoxy-3-methyl-2,5-cyclohexadiene-1,4-dione; 2,3-Dimethoxy-6-(10-hydroxydecyl)-5-methyl-1,4-benzoquinone; Avan; CV 2619; Daruma; Idebenone; Mnesis. Grades: Highly Purified. CAS No. 58186-27-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Idebenone Glucuronide | Idebenone Glucuronide is the glucuronoside conjugate of Idebenone, an ubiquinone derivative with protective effects against cerebral ischemia. Synonyms: 2-(10-Hydroxydecyl)-5,6-methoxy-3-methyl-2,5-cyclohexadiene-1,4-dione β-D-Glucopyranosiduronic Acid ; 2,3-Dimethoxy-6-(10-hydroxydecyl)-5-methyl-1,4-benzoquinone β-D-Glucopyranosiduronic Acid ; Avan Glucuronide ; CV 2619 Glucuronide; Daruma Glucuronide; Mnesis Glucuronide. Molecular formula: C25H38O11. Mole weight: 514.56. | |
| NADH dehydrogenase | A flavoprotein containing iron-sulfur centres. After preparations have been subjected to certain treatments, cytochrome c may act as an acceptor. Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment. Present in a mitochondrial complex as EC 1.6.5.3, NADH dehydrogenase (ubiquinone). Group: Enzymes. Synonyms: cytochrome c reductase; type 1 dehydrogenase; β-NADH dehydrogenase dinucleotide; diaphorase; dihydrocodehydrogenase I dehydrogenase; dihydronicotinamide adenine dinucleotide dehydrogenase; diphosphopyridine diaphorase; DPNH diaphorase; NADH diaphorase; NADH hydroge. Enzyme Commission Number: EC 1.6.99.3. CAS No. 9079-67-8. Diaphorase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1601; NADH dehydrogenase; EC 1.6.99.3; 9079-67-8; cytochrome c reductase; type 1 dehydrogenase; β-NADH dehydrogenase dinucleotide; diaphorase; dihydrocodehydrogenase I dehydrogenase; dihydronicotinamide adenine dinucleotide dehydrogenase; diphosphopyridine diaphorase; DPNH diaphorase; NADH diaphorase; NADH hydrogenase; NADH oxidoreductase; NADH-menadione oxidoreductase; reduced diphosphopyridine nucleotide diaphorase; NADH:cytochrome c oxidoreductase; NADH2 dehydrogenase; NADH:(acceptor) oxidoreductase. Cat No: EXWM-1601. | |
| NAD(P)H dehydrogenase (quinone) | A flavoprotein. The enzyme catalyses a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. Group: Enzymes. Synonyms: menadione reductase; phylloquinone reductase; quinone reductase; dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone); DT-diaphorase; f. Enzyme Commission Number: EC 1.6.5.2. CAS No. 9032-20-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1591; NAD(P)H dehydrogenase (quinone); EC 1.6.5.2; 9032-20-6; menadione reductase; phylloquinone reductase; quinone reductase; dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone); DT-diaphorase; flavoprotein NAD(P)H-quinone reductase; menadione oxidoreductase; NAD(P)H dehydrogenase; NAD(P)H menadione reductase; NAD(P)H-quinone dehydrogenase; NAD(P)H-quinone oxidoreductase; NAD(P)H: (quinone-acceptor)oxidoreductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase; naphthoquinone reductase; p-benzoquinone reductase; reduced NAD(P)H dehydrogenase; viologen accepting pyridine nucleotide oxidoreductase; vitamin K reductase; diaphorase; reduced nicotinamide-adenine dinucleotide (phosphate) dehy | |
| Native Microorganism Glucose Dehydrogenase (PQQ-dependent) | In enzymology, a quinoprotein glucose dehydrogenase (EC 1.1.5.2) is an enzyme that catalyzes the chemical reaction: D-glucose + ubiquinone <->D-glucono-1,5-lactone + ubiquinol. Thus, the two substrates of this enzyme are D-glucose and ubiquinone, whereas its two products are D-glucono-1,5-lactone and ubiquinol. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a quinone or similar compound as acceptor. This enzyme participates in pentose phosphate pathway. It employs one cofactor, PQQ. Applications: This enzyme is useful for enzymatic determination of d-glucose. Group: Enzymes. Synonyms: Glucose Dehydrogenase; EC 1.1.5.2; D-glucose:ubiquinone oxidoreductase; D-glucose:(pyrroloquinoline-quinone) 1-oxi. Enzyme Commission Number: EC 1.1.5.2. CAS No. 81669-60-5. Glucose Dehyrogenase. Mole weight: approx. 100 kDa (by gel filtration). Activity: Grade? 500 U/mg-solid or more. Stability: Store at -20°C. Appearance: Purple amorphous powder, lyophilized. Form: Freeze dried powder. Source: Microorganism. Glucose Dehydrogenase; EC 1.1.5.2; D-glucose:ubiquinone oxidoreductase; D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase; glucose dehydrogenase (PQQ-dependent); glucose dehydrogenase (pyrroloquinoline-quinone); quinoprotein D-glucose dehydrogenase. Cat No: DIA-192. | |
| Native Microorganism Glucose Dehyrogenase (PQQ-dependent) | In enzymology, a quinoprotein glucose dehydrogenase (EC 1.1.5.2) is an enzyme that catalyzes the chemical reaction: D-glucose + ubiquinone ?D-glucono-1,5-lactone + ubiquinol. Thus, the two substrates of this enzyme are D-glucose and ubiquinone, whereas its two products are D-glucono-1,5-lactone and ubiquinol. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a quinone or similar compound as acceptor. This enzyme participates in pentose phosphate pathway. It employs one cofactor, PQQ. Applications: This enzyme is useful for enzymatic determination of d-glucose. Group: Enzymes. Synonyms: Glucose Dehyrogenase; EC 1.1.5.2; D-glucose:ubiquinone oxidoreductase; D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase; glucose dehydrogenase (PQQ-dependent); glucose d. Enzyme Commission Number: EC 1.1.5.2. CAS No. 81669-60-5. Mole weight: approx. 100 kDa (by gel filtration). Activity: 500 U/mg-solid or more. Appearance: Purple amorphous powder, lyophilized. Form: Freeze dried powder. Source: Microorganism. Glucose Dehyrogenase; EC 1.1.5.2; D-glucose:ubiquinone oxidoreductase; D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase; glucose dehydrogenase (PQQ-dependent); glucose dehydrogenase (pyrroloquinoline-quinone); quinoprotein D-glucose dehydrogenase. Cat No: DIA-192. | |
| phenylacetyl-CoA dehydrogenase | The enzyme from Thauera aromatica is a membrane-bound molybdenum-iron-sulfur protein. The enzyme is specific for phenylacetyl-CoA as substrate. Phenylacetate, acetyl-CoA, benzoyl-CoA, propanoyl-CoA, crotonyl-CoA, succinyl-CoA and 3-hydroxybenzoyl-CoA cannot act as substrates. The oxygen atom introduced into the product, phenylglyoxylyl-CoA, is derived from water and not molecular oxygen. Duroquinone, menaquinone and 2,6-dichlorophenolindophenol (DCPIP) can act as acceptor, but the likely physiological acceptor is ubiquinone. A second enzyme, EC 3.1.2.25, phenylacetyl-CoA hydrolase, converts the phenylglyoxylyl-CoA formed into phenylglyoxylate. Group: Enzymes. Synonyms: phenylacetyl-CoA:acceptor oxidoreductase. Enzyme Commission Number: EC 1.17.5.1. CAS No. 210756-43-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1094; phenylacetyl-CoA dehydrogenase; EC 1.17.5.1; 210756-43-7; phenylacetyl-CoA:acceptor oxidoreductase. Cat No: EXWM-1094. | |
| Piericidin a | Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity. Group: Inhibitors. Alternative Names: PIERICIDIN A. CAS No. 2738-64-9. Molecular formula: C25H37NO4. Mole weight: 415.57. Appearance: Liquid. Purity: >95%. IUPACName: 2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraenyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one. Canonical SMILES: COC1=C (C (C)=C (N=C1OC)C/C=C (C/C=C/C (C)=C/[C@@H] (C)[C@H] (/C (C)=C/C)O)\C)O. Density: 1.05 g/cm³. Catalog: ACM2738649. | |
| Piericidin A | Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity. Synonyms: Shaoguanmycin B. Grades: >95.0%. CAS No. 2738-64-9. Molecular formula: C25H37NO4. Mole weight: 415.57. | |
| Piericidin A (Shaoguanmycin B, Antibiotic MT 1882-I, Antibiotic SN 198E, Antibiotic IT 143D, Piericidin A1) | Piericidin A is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces sp. It is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds to ubiquinone binding site(s). Piericidin A inhibits both mitochondrial and bacterial NADH-ubiquinone oxidoreductases, binding close to NUOD-NUOB interface. Group: Biochemicals. Alternative Names: Shaoguanmycin B, Antibiotic MT 1882-I, Antibiotic SN 198E, Antibiotic IT 143D, Piericidin A1. Grades: Highly Purified. CAS No. 2738-64-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| polyprenyldihydroxybenzoate methyltransferase | This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast. The enzymes from yeast and rat also catalyse the methylation of 3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively (this activity is classified as EC 2.1.1.64, 3-demethylubiquinol 3-O-methyltransferase). Group: Enzymes. Synonyms: 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; dihydroxyhexaprenylbenzoate methyltransferase; C. Enzyme Commission Number: EC 2.1.1.114. CAS No. 139569-31-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1713; polyprenyldihydroxybenzoate methyltransferase; EC 2.1.1.114; 139569-31-6; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; dihydroxyhexaprenylbenzoate methyltransferase; COQ3 (gene name); Coq3 O-methyltransferase; DHHB O-methyltransferase. Cat No: EXWM-1713. | |
| pyruvate dehydrogenase (quinone) | Flavoprotein (FAD). This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone. Does not accept menaquinone. Activity is greatly enhanced by lipids. Requires thiamine diphosphate. The enzyme can also form acetoin. Group: Enzymes. Synonyms: pyruvate dehydrogenase; pyruvic dehydrogenase; pyruvic (cytochrome b1) dehydrogenase; pyruvate:ubiquinone-8-oxidoreductase; pyruvate oxidase (ambiguous); pyruvate dehydrogenase (cytochrome) (incorrect). Enzyme Commission Number: EC 1.2.5.1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1220; pyruvate dehydrogenase (quinone); EC 1.2.5.1; pyruvate dehydrogenase; pyruvic dehydrogenase; pyruvic (cytochrome b1) dehydrogenase; pyruvate:ubiquinone-8-oxidoreductase; pyruvate oxidase (ambiguous); pyruvate dehydrogenase (cytochrome) (incorrect). Cat No: EXWM-1220. | |
| quinol-cytochrome-c reductase | The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. The mammalian enzyme contains cytochromes b-562, b-566 and c1, and a 2-iron ferredoxin. Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non-cytoplasmic compartment (cf. EC 1.6.99.3, NADH dehydrogenase). Group: Enzymes. Synonyms: ubiquinol-cytochrome-c reductase; coenzyme Q-cytochrome c reductase; dihydrocoenzyme Q-cytochrome c reductase; reduced ubiquinone-cytochrome c reductase; complex III (mitocho. Enzyme Commission Number: EC 1.10.2.2. CAS No. 9027-3-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0474; quinol-cytochrome-c reductase; EC 1.10.2.2; 9027-03-6; ubiquinol-cytochrome-c reductase; coenzyme Q-cytochrome c reductase; dihydrocoenzyme Q-cytochrome c reductase; reduced ubiquinone-cytochrome c reductase; complex III (mitochondrial electron transport); ubiquinone-cytochrome c reductase; ubiquinol-cytochrome c oxidoreductase; reduced coenzyme Q-cytochrome c reductase; ubiquinone-cytochrome c oxidoreductase; reduced ubiquinone-cytochrome c oxido | |
| (S)-mandelate dehydrogenase | This enzyme is a member of the FMN-dependent α-hydroxy-acid oxidase/dehydrogenase family. While all enzymes of this family oxidize the (S)-enantiomer of an α-hydroxy acid to an α-oxo acid, the ultimate oxidant (oxygen, intramolecular heme or some other acceptor) depends on the particular enzyme. This enzyme transfers the electron pair from FMNH2 to a component of the electron transport chain, most probably ubiquinone. It is part of a metabolic pathway in Pseudomonads that allows these organisms to utilize mandelic acid, derivatized from the common soil metabolite amygdalin, as the sole source of carbon and energy. The enzyme has a large active-site pocket and preferentially binds substrates with longer sidechains, e.g. 2-hydroxyoctanoate rather than 2-hydroxybutyrate. It also prefers substrates that, like (S)-mandelate, have β unsaturation, e.g. (indol-3-yl)glycolate compared with (indol-3-yl)lactate. Esters of mandelate, such as methyl (S)-mandelate, are also substrates. Group: Enzymes. Synonyms: MDH. Enzyme Commission Number: EC 1.1.99.31. CAS No. 9067-95-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0460; (S)-mandelate dehydrogenase; EC 1.1.99.31; 9067-95-2; MDH. Cat No: EXWM-0460. | |
| succinate dehydrogenase | A flavoprotein (FAD) complex containing iron-sulfur centres. The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria and archaea. It catalyses succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. cf. EC 1.3.5.4, fumarate reductase (quinone). Group: Enzymes. Synonyms: succinate dehydrogenase (quinone); succinate dehydrogenase (ubiquinone); succinic dehydrogenase; complex II (ambiguous); succinate dehydrogenase complex; SDH; succinate:ubiquinone oxidoreductase. Enzyme Commission Number: EC 1.3.5.1. CAS No. 9028-11-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1385; succinate dehydrogenase; EC 1.3.5.1; 9028-11-9; succinate dehydrogenase (quinone); succinate dehydrogenase (ubiquinone); succinic dehydrogenase; complex II (ambiguous); succinate dehydrogenase complex; SDH; succinate:ubiquinone oxidoreductase. Cat No: EXWM-1385. | |
| sulfide:quinone reductase | Contains FAD. Ubiquinone, plastoquinone or menaquinone can act as acceptor in different species. This enzyme catalyses the formation of sulfur globules. It is also an important step in anoxygenic bacterial photosynthesis. Group: Enzymes. Enzyme Commission Number: EC 1.8.5.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1679; sulfide:quinone reductase; EC 1.8.5.4. Cat No: EXWM-1679. | |
| Ubiquinol | A reduced coenzyme Q for improving nervous system cell functions. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl -2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl]-5,6-dimethoxy-3-methyl- 1,4-benzenediol; Dihydrocoenzyme Q10; Reduced Coenzyme Q10; Reduced Ubiquinone Q10; Ubiquinol 50. CAS No. 992-78-9. Molecular formula: C59H92O4. Mole weight: 865.37. | |
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