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| Product | Description | |
|---|---|---|
| UCN-02 | UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture with antineoplastic activity. It inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. Synonyms: Antibiotic UCN 02; UCN02; GNF-Pf-3072; 7-hydroxy-staurosporine; 7-epi-Hydroxystaurosporine; (3S,9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one; [3S-(3α, 9α, 10β, 11β, 13α)]-2, 3, 10, 11, 12, 13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9, 13-epoxy-1H, 9H-diindolo[1, 2, 3-gh:3', 2', 1'-lm]pyrrolo[3, 4-j][1, 7]benzodiazonin-1-one. Grades: >95% by HPLC. CAS No. 121569-61-7. Molecular formula: C28H26N4O4. Mole weight: 482.53. |  |
| Antibiotic UCN-02 (UCN 02) | UCN-02 is isolated as a minor co-metabolite of high producing staurosporine strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms. Group: Biochemicals. Alternative Names: UCN 02. Grades: Highly Purified. CAS No. 121569-61-7. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| 7-Oxostaurosporine | It is the oxidised and highly fluorescent analogue of Antibiotic UCN-01 and UCN-02. It is a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. It inhibits the cell cycle at the G2 stage with the accumulation of 4C DNA cells and possesses comparable activity against tumour cells lines to UCN-01. Synonyms: 7-Oxostaurosporine; BMY 41950; RK 1409; (9S,10R,11R,13R)-10,11,12,13-Tetrahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonine-1,3(2H)-dione; 10, 11, 12, 13-Tetrahydro-10-methoxy-9-methyl-11-(methylamino)-[9S-(9α, 10β, 11β, 13α)]-9, 13-epoxy-1H, 9H-diindolo[1, 2, 3-gh:3', 2', 1'-lm]pyrrolo[3, 4-j][1, 7]benzodiazonine-1, 3(2H)-dione. Grades: >98% by HPLC. CAS No. 141196-69-2. Molecular formula: C28H24N4O4. Mole weight: 480.52. | |
| 7-Oxostaurosporine (Antibiotic BMY 41950, Antibiotic RK 1409) | 7-Oxostaurosporine is the oxidised and highly fluorescent analogue of Antibiotics UCN-01 and UCN-02. 7-Oxostaurosporine is a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. It inhibits the cell cycle at the G2 stage with the accumulation of 4C DNA cells and possesses comparable activity against tumor cells lines to Antibiotic UCN-01. Despite its close relationship to Antibiotic UCN-01 and staurosporine, limited access to the metabolite has restricted a more complete investigation of its properties. Group: Biochemicals. Alternative Names: Antibiotic BMY 41950, Antibiotic RK 1409. Grades: Highly Purified. CAS No. 141196-69-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
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