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| Product | Description | |
|---|---|---|
| Urotensin I | Urotensin I is, 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively. Synonyms: Catostomus urotensin I. CAS No. 83930-33-0. Molecular formula: C210H340N62O67S2. Mole weight: 4869.45. |  |
| Urotensin II (114-124), human | Urotensin II (human) is an endogenous peptide agonist for the urotensin-II receptor (EC50 = 0.1 nM). Urotensin II (human) increases calcium levels in a concentration-dependent manner in HEK293 cells expressing human UTR (EC50 = 0.6 nM), and causes arterio-selective vasoconstriction and vasodilatation in mammals in vitro and in vivo. CAS No. 251293-28-4. Molecular formula: C64H85N13O18S2. Mole weight: 1388.57. | |
| Urotensin II (114-124), human acetate | Urotensin II (human) is an endogenous peptide agonist for the urotensin-II receptor (EC50 = 0.1 nM). Urotensin II (human) increases calcium levels in a concentration-dependent manner in HEK293 cells expressing human UTR (EC50 = 0.6 nM), and causes arterio-selective vasoconstriction and vasodilatation in mammals in vitro and in vivo. Synonyms: L-Valine, L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-, cyclic (5?10)-disulfide acetate; Human UII acetate; Human urotensin II acetate; Urotensin II (human) acetate; H-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH.CH3CO2H (Disulfide bridge: Cys5-Cys10); L-alpha-glutamyl-L-threonyl-L-prolyl-L-alpha-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine (5->10)-disulfide acetic acid. Grades: ≥95%. Molecular formula: C66H89N13O20S2. Mole weight: 1448.63. | |
| Urotensin II (Gillichthys mirabilis) acetate | Urotensin II (Gillichthys mirabilis) acetate is a peptide ligand that is the strongest known vasoconstrictor. Synonyms: Urotensin II, mouse acetate; Gillichthys mirabilis urotensin II acetate; Urotensin II (Gillichthys mirabilis reduced), cyclic (6?11)-disulfide acetate; Urotensin II (goby) acetate; L-Valine, L-alanylglycyl-L-threonyl-L-alanyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-, cyclic (6?11)-disulfide acetate; H-Ala-Gly-Thr-Ala-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH.CH3CO2H (Disulfide bridge: Cys6-Cys11); L-alanyl-glycyl-L-threonyl-L-alanyl-L-alpha-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine (6->11)-disulfide acetate. Grades: ≥95%. Molecular formula: C64H88N14O19S2. Mole weight: 1421.61. | |
| Urotensin II (goby) trifluoroacetate salt | Urotensin II is a potent peptide vasoconstrictor and an agonist of the urotensin (UT) receptor. For its distribution in multiple biological systems such as the cardiovascular, nervous, endocrine, and renal, it has been identified as a potential target for therapies of atherosclerosis, heart failure, hypertension, pre-eclampsia, diabetes, renal disease, as well as brain vascular lesions. Synonyms: U-II; Urotensin II (G. mirabilis). Grades: ≥95%. Molecular formula: C62H84N14O17S2·xCF3COOH. Mole weight: 1361.56. | |
| Urotensin ii(human) | Urotensin ii(human). Uses: Designed for use in research and industrial production. Additional or Alternative Names: UROTENSIN-II;UROTENSIN II (HUMAN) HYDROCHLORIDE;UROTENSIN II (HUMAN);ETPDCFWKYCV, HCL (DISULFIDE BRIDGE: 5-10);GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL;GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL HYDROCHLORIDE;H-GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS. Product Category: Heterocyclic Organic Compound. CAS No. 251293-28-4. Molecular formula: C64H87N13O18S2. Mole weight: 1390.58. Product ID: ACM251293284. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Urotensin II (human) trifluoroacetate salt | Urotensin II is a potent peptide vasoconstrictor and an agonist of the urotensin (UT) receptor. For its distribution in multiple biological systems such as the cardiovascular, nervous, endocrine, and renal, it has been identified as a potential target for therapies of atherosclerosis, heart failure, hypertension, pre-eclampsia, diabetes, renal disease, as well as brain vascular lesions. Synonyms: hU II. Grades: ≥95%. Molecular formula: C64H85N13O18S2·xCF3COOH. Mole weight: 1388.57. | |
| Urotensin II, mouse acetate | Urotensin II, mouse acetate, a potent vasoconstrictor, is an endogenous ligand for the orphan GPR14 or SENR. Synonyms: L-Isoleucine, 5-oxo-L-prolyl-L-histidylglycyl-L-alanyl-L-alanyl-L-prolyl-L-α-glutamyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-, cyclic (8?13)-disulfide, acetate; H-Pyr-His-Gly-Ala-Ala-Pro-Glu-Cys-Phe-Trp-Lys-Tyr-Cys-Ile-OH.CH3CO2H (Disulfide bridge: Cys8-Cys13); L-pyroglutamyl-L-histidyl-glycyl-L-alanyl-L-alanyl-L-prolyl-L-alpha-glutamyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-isoleucine (8->13)-disulfide acetate; Urotensin II (mouse) acetate. Grades: ≥95%. Molecular formula: C78H104N18O21S2. Mole weight: 1693.92. | |
| Urotensin II-related peptide | Urotensin II-related peptide is a human urotensin II anague. Urotensin II-related peptide has high affinity for the UT receptor [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 342878-90-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1165. |  |
| Urotensin I (white sucker) trifluoroacetate salt | Urotensin I is a naturally occurring peptide and a member of the corticotropin-releasing factor (CRF) family. It binds to recombinant human CRF1 and rat CRF2 receptors with Ki values of 0.7 and 22.9 nM, respectively. It has been shown to decrease blood pressure in the rat. Grades: ≥95%. Molecular formula: C210H340N62O67S2·xCF3COOH. Mole weight: 4869.46. | |
| [Orn8]-Urotensin II | [Orn8]-Urotensin II. Group: Biochemicals. Grades: Purified. CAS No. 479065-85-5. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| [Orn8]-Urotensin II (human) trifluoroacetate salt | [Orn8]-Urotensin II is a peptide analog of urotensin II and agonist of the urotensin II receptor. Synonyms: L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (5?10)-disulfide, trifluoroacetate salt. Grades: ≥95%. Molecular formula: C63H83N13O18S2·xCF3COOH. Mole weight: 1374.54. | |
| 2-Fluoro-4-nitrobenzotrifluoride | 2-Fluoro-4-nitrobenzotrifluoride is a reagent in the synthesis of benzylamine and benzylsulfone antagonists of urotensin receptor (UT). Group: Biochemicals. Grades: Highly Purified. CAS No. 69411-67-2. Pack Sizes: 500mg, 1g. Molecular Formula: C7H3F4NO2, Molecular Weight: 209.1. US Biological Life Sciences. | Worldwide |
| (±)-AC 7954 hydrochloride | (±)-AC 7954 hydrochloride is a non-peptide urotensin-II (UT) receptor agonist. Synonyms: (±)-AC 7954 hydrochloride; (±)-AC7954 hydrochloride; (±)-AC-7954 hydrochloride ;(±)-3-(4-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-3,4-dihydro-1H-2-benzopyran-1-one hydrochloride. Grades: ≥98% by HPLC. CAS No. 477313-09-0. Molecular formula: C19H20ClNO2.HCl. Mole weight: 366.28. | |
| GSK-1440115 | GSK-1440115 is an orally active urotensin II receptor antagonist. It is used for the treatment of asthma. Uses: Gsk-1440115 is used for the treatment of asthma. Synonyms: GSK 1440115; GSK-1440115; GSK1440115. 4'-(1-(((6,7-Dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl)(methyl)amino)-2-(4-morpholinyl)ethyl)-4-diphenylcarboxylic acid;4-[4-[(1R)-1-[[2-(6,7-dichloro-3-oxo-1,4-benzoxazin-4-yl)acetyl]-methylamino]-2-morpholin-4-ylethyl]phenyl]benzoic acid. Grades: >98 %. CAS No. 1003878-16-7. Molecular formula: C30H29Cl2N3O6. Mole weight: 598.47. | |
| GSK 1562590 hydrochloride | GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT) , with pK i s of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1003878-07-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-108446. | |
| GSK 1562590 hydrochloride | GSK 1562590 hydrochloride is a high affinity and selective urotensin II (UT) receptor antagonist (pKi = 9.14, 9.28, 9.34, 9.64 and 9.66 at monkey, human, mouse, cat and rat recombinant receptors, respectively). It displays selectivity for UT receptors over a range of GPCRs, ion channels, enzymes and neurotransmitter transporters. GSK 1562590 has been shown to inhibit human urotensin-II (hU-II)-induced contraction of isolated rat aorta in vitro and ex vivo. Synonyms: GSK 1562590 hydrochloride; GSK1562590 hydrochloride; GSK-1562590 hydrochloride; N-[(1R)-1-[3'-(Aminocarbonyl)[1,1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-4H-1,4-benzoxazine-4-acetamide hydrochloride; 3-[4-[(1R)-1-[[2-(6,7-dichloro-3-oxo-1,4-benzoxazin-4-yl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenyl]benzamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1003878-07-6. Molecular formula: C30H30Cl2N4O4.HCl. Mole weight: 617.95. | |
| [Orn5]-URP | [Orn5]-URP is a urotensin-II (UT) receptor pure antagonist (pEC50 = 7.24) that displays no agonist activity unlike other U-II/URP analogs. [Orn5]-URP has been shown to inhibit the action of U-II in the rat aorta ring assay. Grades: >98%. CAS No. 782485-03-4. Molecular formula: C48H62N10O10S2. Mole weight: 1003.2. | |
| Palosuran | Palosuran is a new Urotensin-II receptor antagonist (IC50=3.6±0.2 nM). Uses: Urotensin-ii receptor antagonist. Synonyms: 1-[2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl]-3-(2-methylquinolin-4-yl)urea;ACT-058362; ACT058362; ACT 058362. Grades: ≥95%. CAS No. 540769-28-6. Molecular formula: C25H30N4O2. Mole weight: 418.54. | |
| SB 611812 | SB 611812 is a urotensin-II (UT) antagonist that inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. SB 611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation, and decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling. Synonyms: SB-611812; SB 611812; SB611812. 2,6-Dichloro-N-[4-chloro-3-[2-(dimethylamino)ethoxy]phenyl]-4-(trifluoromethyl)benzenesulfonamide. Grades: ≥99% by HPLC. CAS No. 345892-71-9. Molecular formula: C17H16Cl3F3N2O3S. Mole weight: 491.74. | |
| SB 657510 | SB 657510 is a selective urotensin-II (UT) receptor/GRP14 antagonist (Ki = 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors, respectively). SB 657510 was also shown to inhibit U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonize the contractile action of U-II in isolated mammalian arteries and aortae (EC50 = 50 - 189 nM). Synonyms: SB 657510; SB657510; SB-657510; 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 474960-44-6. Molecular formula: C19H22BrClN2O5S. Mole weight: 505.81. | |
| SB 706375 | SB 706375 is a high affinity and non-peptide antagonist of the mammalian urotensin-II (UT) receptor displaying ≥100-fold selectivity for the human UT receptor over 86 different receptors, ion channels, enzymes, transporters and nuclear hormones. SB 706375 also inhibits binding of radiolabeled urotensin to endogenous human UT receptors (Ki = 5.4 nM in a whole-cell binding assay). Synonyms: SB-706375; SB 706375; SB706375. 2-Bromo-4, 5-dimethoxy-N-[3-[[ (3R) -1-methyl-3-pyrrolidinyl]oxy]-4- (trifluoromethyl) phenyl]benzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 733734-61-7. Molecular formula: C20H22BrF3N2O5S. Mole weight: 539.36. | |
| UFP 803 | UFP 803 is a urotensin-II (UT) receptor ligand that acts as a silent antagonist in most in vitro assays and in vivo. UFP 803 competitively antagonizes U-II induced contractions in the rat aorta (pIC50 = 7.46) and prevents plasma extravasation elicited by U-II in mice in vivo. Synonyms: UFP 803; UFP-803; UFP803. Grades: >98%. CAS No. 879497-82-2. Molecular formula: C50H64N10O12S2. Mole weight: 1061.24. | |
| Urantide | Urantide is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3) that blocks hU-II induced contractions in thoracic aorta ex vivo. Urantide has no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Urantide also exhibits partial agonist activity in a calcium mobilization assay (in CHO cells expressing hUT receptors). Synonyms: L-Valine, L-α-aspartyl-3-mercapto-L-valyl-L-phenylalanyl-D-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-, cyclic (2?7)-disulfide; H-Asp-Pen(1)-Phe-D-Trp-Orn-Tyr-Cys(1)-Val-OH; L-alpha-aspartyl-L-penicillamyl-L-phenylalanyl-D-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-L-valine (2->7)-disulfide acetic acid; (S)-4-(((4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-10-(3-aminopropyl)-16-benzyl-4-(((S)-1-carboxy-2-methylpropyl)carbamoyl)-7-(4-hydroxybenzyl)-20,20-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-19-yl)amino)-3-amino-4-oxobutanoic acid. Grades: ≥95%. CAS No. 669089-53-6. Molecular formula: C51H66N10O12S2. Mole weight: 1075.26. | |
| Urantide acetate | Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3) that blocks hU-II-induced contractions in the thoracic aorta ex vivo. Urantide has no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Urantide also exhibits partial agonist activity in a calcium mobilization assay (in CHO cells expressing hUT receptors). Synonyms: L-Valine, L-α-aspartyl-3-mercapto-L-valyl-L-phenylalanyl-D-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-, cyclic (2?7)-disulfide, acetate salt (1:1); H-Asp-Pen(1)-Phe-D-Trp-Orn-Tyr-Cys(1)-Val-OH.CH3CO2H; L-alpha-aspartyl-L-penicillamyl-L-phenylalanyl-D-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-L-valine (2->7)-disulfide acetic acid; (S)-4-(((4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-10-(3-aminopropyl)-16-benzyl-4-(((S)-1-carboxy-2-methylpropyl)carbamoyl)-7-(4-hydroxybenzyl)-20,20-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-19-yl)amino)-3-amino-4-oxobutanoic acid compound with acetic acid (1:1). Grades: ≥95%. Molecular formula: C53H70N10O14S2. Mole weight: 1135.32. | |
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