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The USP14 Inhibitor, IU1 controls the biological activity of USP14. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy.
A cell-permeable pyrrolylpyrrolidinyl-ethanone compound that directly targets proteasome-associated DUB (deubiquitinating enzyme) USP14 and acts as a potent, active-site-directed and reversible inhibitor of hUSP14 deubiquitinating catalytic activity (IC50=4.7uM for Ub-AMC hydrolysis) with excellent selectivity over proteasome-free USP14 and 8-other hDUBs including IsoT (IC50=100uM), UCH37, BAP1, UCH-L1, UCH-L3, USP15, USP2 and USP7 (IC50>700uM). Shown to enhance proteolysis in cells and induce degradation of misfolded toxic proteins like tau, TDP-43 and GFAP (glial fibrillary acidic protein) in coexpressed-wtMEFs at 50uM and offer protection against oxidative stress-induced cytotoxicity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
USP15-IN-1
USP15-IN-1 is a potent USP15 inhibitor with an IC50 value of 3.76 ?M. USP15-IN-1 can be used for researching anticancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2260826-16-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148046.
USP1-IN-7
USP1-IN-7 (Compound 3) is an inhibitor for ubiquitin specific peptidase 1 ( USP1 ) and its cofactor UAF1 , with IC 50 ≤50 nM. USP1-IN-7 inhibits proliferation of MDA-MB-436 with IC 50 ≤50 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3033480-42-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161446.
USP25/28 inhibitor AZ1
USP25/28 inhibitor AZ1 (AZ1) is an orally active, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC50s of 0.7 ?M and 0.6 ?M, respectively. USP25/28 inhibitor AZ1 attenuates colitis and tumorigenesis in the mice model[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZ1. CAS No. 2165322-94-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117370.
USP28-IN-4
USP28-IN-4 is a USP28 inhibitor (IC50=0.04 ?M) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2931509-15-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149230.
USP5-IN-1
USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 ?M). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers. Uses: Scientific research. Group: Signaling pathways. CAS No. 2851040-81-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139979.
USP7-797
USP7-797 (USP7-IN-7) is an orally available, selective USP7 inhibitor (IC50=0.5 nmol/L) with antitumor activity. USP7-797 reduces the level of MDM2, thereby increasing the stability and activity of p53, leading to cell cycle arrest and apoptosis. USP7-797 has low nanomolar cytotoxicity against p53 mutant cancer cell lines, p53 wild-type hematological tumors, and neuroblastoma cell lines[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: USP7-IN-7. CAS No. 2413944-70-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136910.
USP7-IN-13
USP7-IN-13 (Compound 101) is a USP7 inhibitor with an IC 50 value of 0.2-1 μM, which can be used for the study of multiple myeloma [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2305046-93-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160515.
USP7/USP47 inhibitor
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 ?M and 1.0 ?M, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1247825-37-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13487.
1,2-Propanediol 99.5+% (GC) USP/EP
1,2-Propanediol 99.5+% (GC) USP/EP. Group: Biochemicals. Grades: USP. Pack Sizes: 1L, 4L, 18L. US Biological Life Sciences.
Albuterol USP Related Compound F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(2-(tert-butylamino)-1-ethoxyethyl)-2-(hydroxymethyl)phenol. CAS No. 1221742-55-7. Molecular formula: C15H25NO3. Mole weight: 267.36. Catalog: APB1221742557.
Ammonium Sulfate USP. CAS No. 7783-20-2. Molecular formula: (NH4)2SO4.
Amphotericin B, USP
Amphotericin B is a polyene antifungal agent for yeast, mold and mycoplasma. It was first isolated by Gold, et a., from Streptomyces nodosus in 1955. It is an amphoteric compound composed of a hydrophilic polyhydroxyl chain along one side and a lipophilic polyene hydrocarbon chain on the other. Amphotericin B is poorly soluble in water. Amphotericin B binds to sterols, preferentially to the primary fungal cell membrane sterol, ergosterol. This binding disrupts osmotic integrity of the fungal membrane, resulting in leakage of intracellular potassium, magnesium, sugars, and metabolites and then cellular death.Used in the preparation of baculoviral stocks. Group: Biochemicals. Alternative Names: Abelcet; Abelecet; AmBisome; Ampho-Moronal; Amphocin; Amphozone; Apothecon; Fungilin; Fungizona; Fungizone; Halizon; LNS-AmB; NS 718; NSC 527017. Grades: USP. CAS No. 1397-89-3. Pack Sizes: 1g, 10g, 25g, 100g. Molecular Formula: C47H73NO17, Molecular Weight: 924.09. US Biological Life Sciences.
An impurity of Anagrelide, a medication used to treat essential thrombocytosis or overproduction of blood platelets. Synonyms: Ethyl 2-(6-amino-2,3-dichlorobenzylamino)acetate; Anagrelide hydrochloride USP Related Compound A; Glycine, N-[(6-amino-2,3-dichlorophenyl)methyl]-, ethyl ester; Anagrelide Related Compound A; N-[(6-Amino-2,3-dichlorophenyl)methyl]glycine ethyl ester; USP Anagrelide Related Impurity A; Ethyl N-(2,3-dichloro-6-aminobenzyl)glcycine; Ethyl (2-amino-5,6-dichlorobenzyl)aminoacetate; Ethyl N-(6-amino-2,3-dichlorobenzyl)glycine; N-(6-Amino-2,3-dichlorobenzyl)glycine ethyl ester. Grade: ≥95%. CAS No. 70406-92-7. Molecular formula: C11H14Cl2N2O2. Mole weight: 277.15.
Anagrelide USP Related Compound A hydrochloride
An impurity of Anagrelide, a medication used to treat essential thrombocytosis or overproduction of blood platelets. Synonyms: Ethyl 2-(6-amino-2,3-dichlorobenzylamino)acetate hydrochloride; Anagrelide hydrochloride USP Related Compound A hydrochloride; Glycine, N-[(6-amino-2,3-dichlorophenyl)methyl]-, ethyl ester, hydrochloride (1:x); Anagrelide Related Compound A hydrochloride; Anagrelide Related Compound A HCl; N-[(6-Amino-2,3-dichlorophenyl)methyl]glycine Ethyl Ester Hydrochloride; USP Anagrelide Related Impurity A hydrochloride. Grade: ≥95%. CAS No. 85325-12-8. Molecular formula: C11H14Cl2N2O2.xHCl. Mole weight: 277.15 (free base).
Anagrelide USP Related Compound C
An impurity of Anagrelide, a medication used to treat essential thrombocytosis or overproduction of blood platelets. Synonyms: Anagrelide related compound C; Ethyl 2-(5,6-dichloro-2-imino-1,2-dihydroquinazolin-3(4H)-yl)acetate hydrobromide; 3(4H)-Quinazolineacetic acid, 2-amino-5,6-dichloro-, ethyl ester, monohydrobromide; 3(4H)-Quinazolineacetic acid, 2-amino-5,6-dichloro-, ethyl ester, hydrobromide (1:1); Ethyl 5,6-dichloro-3,4-dihydro-2(1H)-iminoquinazoline-3-acetate hydrobromide; 2-Amino-5,6-dichloro-3(4H)-quinazoline acetic acid ethyl ester hydrobromide; USP Anagrelide Related Impurity C; Anagrelide hydrochloride USP Related Compound C. Grade: 95%. CAS No. 70381-75-8. Molecular formula: C12H13Cl2N3O2.HBr. Mole weight: 383.07.
Anagrelide USP Related Impurity B
Anagrelide USP Related Impurity B is an impurity of Anagrelide, a medication used to treat essential thrombocytosis or overproduction of blood platelets. Synonyms: 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid; Anagrelide Impurity B. Grade: 95%. CAS No. 1159977-03-3. Molecular formula: C10H9Cl2N3O2. Mole weight: 274.10.