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A cell-permeable pyrrolylpyrrolidinyl-ethanone compound that directly targets proteasome-associated DUB (deubiquitinating enzyme) USP14 and acts as a potent, active-site-directed and reversible inhibitor of hUSP14 deubiquitinating catalytic activity (IC50=4.7uM for Ub-AMC hydrolysis) with excellent selectivity over proteasome-free USP14 and 8-other hDUBs including IsoT (IC50=100uM), UCH37, BAP1, UCH-L1, UCH-L3, USP15, USP2 and USP7 (IC50>700uM). Shown to enhance proteolysis in cells and induce degradation of misfolded toxic proteins like tau, TDP-43 and GFAP (glial fibrillary acidic protein) in coexpressed-wtMEFs at 50uM and offer protection against oxidative stress-induced cytotoxicity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
USP1-IN-7
USP1-IN-7 (Compound 3) is an inhibitor for ubiquitin specific peptidase 1 ( USP1 ) and its cofactor UAF1 , with IC 50 ≤50 nM. USP1-IN-7 inhibits proliferation of MDA-MB-436 with IC 50 ≤50 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3033480-42-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161446.
USP7-IN-1
USP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase(IC50>200 uM); HCT116 cell viability GI50 is 67 uM. Synonyms: USP7-IN-1; USP7 IN 1. Grades: >98%. CAS No. 1381291-36-6. Molecular formula: C23H24ClN3O3. Mole weight: 425.91.
USP7-IN-13
USP7-IN-13 (Compound 101) is a USP7 inhibitor with an IC 50 value of 0.2-1 μM, which can be used for the study of multiple myeloma [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2305046-93-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160515.
USP7-USP47 inhibitor
USP7/USP47 inhibitor(compound 14) is a selective USP7 (EC50= 0.42 μM)/USP47 (EC50= 1.0 μM) inhibitor but does not inhibit caspase 3, calpain 1, 20S proteasome, and a panel of representative USPs (USP2, USP5, USP8, USP21, and USP28; EC50 > 31.6 μM Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47. compound 14 exhibits enhanced potency against HCT-116 cells. treatment of cells with compound 14 resulted in an increase in p53 and an appreciable induction of p21 protein over the DMSO control. Thus, compound 14 penetrated the cells and modulated p53 and p21 as expected for a USP7 inhibitor. Synonyms: MDK25371; MDK25371; MDK25371; USP7-USP47 inhibitor; 2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-. Grades: >98%. CAS No. 1247825-37-1. Molecular formula: C18H11Cl2N3O3S3. Mole weight: 484.4.
USP Almotriptan Related Compound A;
A metabolite of Almotriptan. Synonyms: 3-[2-(Dimethylamino)ethyl]-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-1-methanol. Grades: > 95%. CAS No. 1018676-02-2. Molecular formula: C18H27N3O3S. Mole weight: 365.5.
USP Cyclophosphamide Related Compound A
Bis(2-chloroethyl)amine hydrochloride is a cytotoxic metabolite of Cyclophosphamide, which is an alkylating agent of the nitrogen mustard type with antineoplastic and immunosuppressive activities. Synonyms: Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride (1:1); Bis(2-chloroethyl)amine Hydrochloride; 2-Chloro-N-(2-chloroethyl)ethanamine Hydrochloride; Diethylamine, 2,2'-dichloro-, hydrochloride; Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride; 1,5-Dichloro-3-azapentane hydrochloride; 2,2'-Dichlorodiethylamine hydrochloride; Bis(2-chloroethyl)ammonium chloride; Bis(β-chloroethyl)amine hydrochloride; Di(2-chloroethyl)amine hydrochloride; Leo 72a; N,N-Bis(2-chloroethyl)amine hydrochloride; Nornitrogen mustard hydrochloride; NSC 10873; β,β'-Dichlorodiethylamine hydrochloride. Grades: ≥95%. CAS No. 821-48-7. Molecular formula: C4H10Cl3N. Mole weight: 178.49.
USP Triamterene Related Compound C is an impurity of Triamterene. Triamterene is a potassium-sparing diuretic that is used for the treatment of edema caused by some other diseases. Synonyms: Triamterene Impurity C; 2,4-Diamino-6-phenyl-7-pteridinol; 2,4-Diamino-6-phenyl-7(1H)-pteridinone; 2,4-Diamino-7-hydroxy-6-phenylpteridine; NSC 33416; Triamterene Related Compound C. CAS No. 19152-93-3. Molecular formula: C12H10N6O. Mole weight: 254.25.
USP Valacyclovir Related Compound D
Cas No. 1346747-69-0.
1,2-Propanediol 99.5+% (GC) USP/EP
1,2-Propanediol 99.5+% (GC) USP/EP. Group: Biochemicals. Grades: USP. Pack Sizes: 1L, 4L, 18L. US Biological Life Sciences.
Acitretin EP Impurity A (Acitretin USP Related Compound A, 13-cis-Acitretin)
Acitretin EP Impurity A (Acitretin USP Related Compound A, 13-cis-Acitretin). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2Z,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid. CAS No. 69427-46-9. Molecular Formula: C21H26O3. Mole Weight: 326.44. Catalog: APB69427469.
Activated Charcoal, Powder, USP
Activated Charcoal, Powder, USP. CAS No. 7440-44-0. Product ID: 2-08487.
Albuterol USP Related Compound F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(2-(tert-butylamino)-1-ethoxyethyl)-2-(hydroxymethyl)phenol. CAS No. 1221742-55-7. Molecular Formula: C15H25NO3. Mole Weight: 267.36. Catalog: APB1221742557.
Allantoin IP, BP, USP. CAS No. 97-59-6. Molecular formula: C4H6N4O3.
Allopurinol EP Impurity D (Allopurinol USP Related Compound D)
Allopurinol EP Impurity D (Allopurinol USP Related Compound D). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 5-amino-1H-pyrazole-4-carboxylate. CAS No. 6994-25-8. Molecular Formula: C6H9N3O2. Mole Weight: 155.15. Catalog: APB6994258.
Aloe Vera USP
Aloe Vera USP. Grades: USP. CAS No. 85507-69-3. Product ID: 8-04792.
Alpha-lipoic Acid USP
Alpha-lipoic Acid USP. CAS No. 1077-28-7. Molecular formula: C8H14O2S2.
Ammonium Sulfate USP. CAS No. 7783-20-2. Molecular formula: (NH4)2SO4.
Amphotericin B, USP
Amphotericin B is a polyene antifungal agent for yeast, mold and mycoplasma. It was first isolated by Gold, et a., from Streptomyces nodosus in 1955. It is an amphoteric compound composed of a hydrophilic polyhydroxyl chain along one side and a lipophilic polyene hydrocarbon chain on the other. Amphotericin B is poorly soluble in water. Amphotericin B binds to sterols, preferentially to the primary fungal cell membrane sterol, ergosterol. This binding disrupts osmotic integrity of the fungal membrane, resulting in leakage of intracellular potassium, magnesium, sugars, and metabolites and then cellular death.Used in the preparation of baculoviral stocks. Group: Biochemicals. Alternative Names: Abelcet; Abelecet; AmBisome; Ampho-Moronal; Amphocin; Amphozone; Apothecon; Fungilin; Fungizona; Fungizone; Halizon; LNS-AmB; NS 718; NSC 527017. Grades: USP. CAS No. 1397-89-3. Pack Sizes: 1g, 10g, 25g, 100g. Molecular Formula: C47H73NO17, Molecular Weight: 924.09. US Biological Life Sciences.