Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| venetoclax | Venetoclax is a small-molecule inhibitor that has high selectivity for Bcl-2 (Ki < 0.01 nM in cell-free assays) over Mcl-1. It suppresses anti-apoptotic Bcl-2, a protein commonly overexpressed in cancer cells, to induce programmed death of CLL cells. Venetoclax is used as a second-line treatment of chronic lymphocytic leukemia (CLL). Uses: The treatment of chronic lymphocytic leukemia (cll). Synonyms: ABT199; ABT-199; ABT 199; GDC0199; GDC0199; GDC 0199; RG7601; RG7601; RG 7601. Venetoclax. CAS No. 1257044-40-8. Molecular formula: C45H50ClN7O7S. Mole weight: 868.44. |  |
| Venetoclax | Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K i of less than 0.01 nM. Venetoclax induces autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-199; GDC-0199; RG7601. CAS No. 1257044-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15531. |  |
| Venetoclax | Venetoclax Inhibitor. Uses: Scientific use. Product Category: T2119. CAS No. 1257044-40-8. |  |
| Venetoclax | Venetoclax. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2- ( (1H-pyrrolo[2, 3-b]pyridin-5-yl) oxy) -4- (4- ( (4'-chloro-5, 5-dimethyl-3, 4, 5, 6-tetrahydro-[1, 1'-biphenyl]-2-yl) methyl) piperazin-1-yl) -N- ( (3-nitro-4- ( ( (tetrahydro-2H-pyran-4-yl) methyl) amino) phenyl) sulfonyl) benzamide. CAS No. 1257044-40-8. Molecular Formula: C45H50ClN7O7S. Mole Weight: 868.44. Catalog: APB1257044408. |  |
| Venetoclax Impurity 10 | Venetoclax Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: tert-butyl 4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine-1-carboxylate. CAS No. 1228780-71-9. Molecular Formula: C24H35ClN2O2. Mole Weight: 419.00. Catalog: APB1228780719. | |
| Venetoclax Impurity 12 | Venetoclax Impurity 12. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1H-pyrrolo[2,3-b]pyridin-5-ol. CAS No. 98549-88-3. Molecular Formula: C7H6N2O. Mole Weight: 134.14. Catalog: APB98549883. | |
| Venetoclax Impurity 17 | Venetoclax Impurity 17. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate. CAS No. 1235865-75-4. Molecular Formula: C15H11FN2O3. Mole Weight: 286.26. Catalog: APB1235865754. | |
| Venetoclax Impurity 18 | Venetoclax Impurity 18. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 2,4-bis((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)benzoate. CAS No. 2514648-06-5. Molecular Formula: C22H16N4O4. Mole Weight: 400.39. Catalog: APB2514648065. | |
| Venetoclax Impurity 2 | Venetoclax Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2097938-69-5. Molecular Formula: C45H48ClN7O8S. Mole Weight: 882.42. Catalog: APB2097938695. | |
| Venetoclax Impurity 28 | Venetoclax Impurity 28. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoic acid. CAS No. 2142574-09-0. Molecular Formula: C14H9FN2O3. Mole Weight: 272.24. Catalog: APB2142574090. | |
| Venetoclax Impurity 35 | Venetoclax Impurity 35. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2- ( (1H-pyrrolo[2, 3-b]pyridin-5-yl) oxy) -4- (4- ( (5, 5-dimethyl-3, 4, 5, 6-tetrahydro-[1, 1'-biphenyl]-2-yl) methyl) piperazin-1-yl) -N- ( (3-nitro-4- ( ( (tetrahydro-2H-pyran-4-yl) methyl) amino) phenyl) sulfonyl) benzamide. CAS No. 2573767-91-4. Molecular Formula: C45H51N7O7S. Mole Weight: 833.99. Catalog: APB2573767914. | |
| Venetoclax Impurity 4 | Venetoclax Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 93745-74-5. Molecular Formula: C6H5ClN2O4S. Mole Weight: 236.63. Catalog: APB93745745. | |
| Venetoclax Impurity 5 (2-chloro-3-nitrobenzenesulfonamide) | Venetoclax Impurity 5 (2-chloro-3-nitrobenzenesulfonamide). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1261761-91-4. Molecular Formula: C6H5ClN2O4S. Mole Weight: 236.63. Catalog: APB1261761914. | |
| Venetoclax Impurity 6 | Venetoclax Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoate. CAS No. 1235865-76-5. Molecular Formula: C34H37ClN4O3. Mole Weight: 585.14. Catalog: APB1235865765. | |
| Venetoclax Impurity 7 | Venetoclax Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid. CAS No. 1235865-77-6. Molecular Formula: C33H35ClN4O3. Mole Weight: 571.11. Catalog: APB1235865776. | |
| Venetoclax Impurity 8 | Venetoclax Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde. CAS No. 1228837-05-5. Molecular Formula: C15H17ClO. Mole Weight: 248.75. Catalog: APB1228837055. | |
| Venetoclax Impurity 9 | Venetoclax Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methanol. CAS No. 1228780-51-5. Molecular Formula: C15H19ClO. Mole Weight: 250.76. Catalog: APB1228780515. | |
| Venetoclax-N-Oxide | Venetoclax-N-Oxide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4- (3- ( (1H-pyrrolo[2, 3-b]pyridin-5-yl) oxy) -4- ( ( (3-nitro-4- ( ( (tetrahydro-2H-pyran-4-yl) methyl) amino) phenyl) sulfonyl) carbamoyl) phenyl) -1- ( (4'-chloro-5, 5-dimethyl-3, 4, 5, 6-tetrahydro-[1, 1'-biphenyl]-2-yl) methyl) piperazine 1-oxide. CAS No. 2469279-00-1. Molecular Formula: C45H50ClN7O8S. Mole Weight: 884.44. Catalog: APB2469279001. | |
| 2'-Oxo Venetoclax | 2'-Oxo Venetoclax is a minor human metabolite of ABT 199 (A112430), which is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. ItÂ’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C45H48ClN7O8S, Molecular Weight: 882.42. US Biological Life Sciences. |  Worldwide |
| 1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine Dihydrochloride | 1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine Dihydrochloride is an intermediate used in the preparation of Venetoclax (A112430), which is a potent and selective BCL-2 inhibitor with potent antitumour activity while sparing platelets. Venetoclax is used to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 1628047-87-9. Pack Sizes: 50mg, 250mg. Molecular Formula: C19H27ClN2 (HCl)2, Molecular Weight: 318.88. US Biological Life Sciences. | Worldwide |
| 1H-?Pyrrolo[2,?3-?b]?pyridin-?5-?ol | 1H-?Pyrrolo[2,?3-?b]?pyridin-?5-?ol is a reagent used in the synthesis of potent VEGFR-2 inhibitors. 7-Azaindole derivative identified as an intermediate in the synthesis of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. Group: Biochemicals. Grades: Highly Purified. CAS No. 98549-88-3. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H6N2O, Molecular Weight: 134.139999999999. US Biological Life Sciences. | Worldwide |
| AZD5991 | AZD5991 is a potent and selective Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay for treatment of hematologic cancers. AZD5991 has high selectivity and affinity for Mcl-1 and is currently in clinical development. AZD5991 shows potent antitumor activity in vivo with complete tumor regression in several models of multiple myeloma and acute myeloid leukemia after a single tolerated dose as monotherapy or in combination with bortezomib or venetoclax. AZD5991 monotherapy caused apoptosis preferentially in hematological cell lines with 6/22 AML and 7/19 MM cell lines showing caspase EC50 values <100 nM. In solid tumor cell lines single agent activity was seen mostly in NSCLC and BrCa. Uses: Antineoplastic agents. Synonyms: AZD-5991; AZD 5991; AZD-5991 Racemate; 22H-9, 4, 8-(Metheniminomethyno)-14, 20:26, 23-dimetheno-10H, 20H-pyrazolo[4, 3-l][2, 15, 22, 18, 19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid, 5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-. Grades: ≥98%. CAS No. 2143010-83-5. Molecular formula: C35H34ClN5O3S2. Mole weight: 672.26. | |
Our database is helping our users find suppliers everyday.
