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| Product | Description | |
|---|---|---|
| Venetoclax | Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K i of less than 0.01 nM. Venetoclax induces autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-199; GDC-0199; RG7601. CAS No. 1257044-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15531. |  |
| Venetoclax | Venetoclax Inhibitor. Uses: Scientific use. Product Category: T2119. CAS No. 1257044-40-8. |  |
| Venetoclax | Venetoclax. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide. CAS No. 1257044-40-8. Molecular formula: C45H50ClN7O7S. Mole weight: 868.44. Catalog: APB1257044408. |  |
| Venetoclax-[d8] | An isotope labelled Venetoclax. Venetoclax can be used to treat chronic lymphocytic leukemia. Synonyms: 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[3-nitro-4-({[(2,2,3,3,5,5,6,6-D8)oxan-4-yl]methyl}amino)benzenesulfonyl]-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide. Grade: 95% by HPLC; 98% atom D. CAS No. 1257051-06-1. Molecular formula: C45H42D8ClN7O7S. Mole weight: 876.50. |  |
| Venetoclax Impurity 10 | Venetoclax Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: tert-butyl 4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine-1-carboxylate. CAS No. 1228780-71-9. Molecular formula: C24H35ClN2O2. Mole weight: 419.00. Catalog: APB1228780719. | |
| Venetoclax Impurity 17 | Venetoclax Impurity 17. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate. CAS No. 1235865-75-4. Molecular formula: C15H11FN2O3. Mole weight: 286.26. Catalog: APB1235865754. | |
| Venetoclax Impurity 6 | Venetoclax Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoate. CAS No. 1235865-76-5. Molecular formula: C34H37ClN4O3. Mole weight: 585.14. Catalog: APB1235865765. | |
| Venetoclax Impurity 7 | Venetoclax Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid. CAS No. 1235865-77-6. Molecular formula: C33H35ClN4O3. Mole weight: 571.11. Catalog: APB1235865776. | |
| Venetoclax Impurity 8 | Venetoclax Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde. CAS No. 1228837-05-5. Molecular formula: C15H17ClO. Mole weight: 248.75. Catalog: APB1228837055. | |
| Venetoclax Impurity 9 | Venetoclax Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methanol. CAS No. 1228780-51-5. Molecular formula: C15H19ClO. Mole weight: 250.76. Catalog: APB1228780515. | |
| 2'-Oxo Venetoclax | 2'-Oxo Venetoclax is a minor human metabolite of ABT 199 (A112430), which is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. ItÂ’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C45H48ClN7O8S, Molecular Weight: 882.42. US Biological Life Sciences. |  Worldwide |
| 1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine Dihydrochloride | 1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine Dihydrochloride is an intermediate used in the preparation of Venetoclax (A112430), which is a potent and selective BCL-2 inhibitor with potent antitumour activity while sparing platelets. Venetoclax is used to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 1628047-87-9. Pack Sizes: 50mg, 250mg. Molecular Formula: C19H27ClN2 (HCl)2, Molecular Weight: 318.88. US Biological Life Sciences. | Worldwide |
| 1H-?Pyrrolo[2,?3-?b]?pyridin-?5-?ol | 1H-?Pyrrolo[2,?3-?b]?pyridin-?5-?ol is a reagent used in the synthesis of potent VEGFR-2 inhibitors. 7-Azaindole derivative identified as an intermediate in the synthesis of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. Group: Biochemicals. Grades: Highly Purified. CAS No. 98549-88-3. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H6N2O, Molecular Weight: 134.139999999999. US Biological Life Sciences. | Worldwide |
| ABBV-167 | ABBV-167 is a phosphate prodrug of venetoclax, a Bcl-2 inhibitor. Synonyms: Benzamide, 4-(4-((2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)-2-((7-((phosphonooxy)methyl)-7H-pyrrolo(2,3-b)pyridin-5-yl)oxy)-; (5-{5-(4-{[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl}-1-piperazinyl)-2-[({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)carbamoyl]phenoxy}-7H-pyrrolo[2,3-b]pyridin-7-yl)methyl dihydrogen phosphate. CAS No. 1351456-78-4. Molecular formula: C46H53ClN7O11PS. Mole weight: 978.45. | |
| ABT199 intermediate 3 | ABT199 intermediate 3 (CAS# 1228780-72-0 ) is a useful research chemical. Synonyms: 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methy)piperazine; Venetoclax Intermediate 1; UNII-827EXU9VXN; 827EXU9VXN. CAS No. 1228780-72-0. Molecular formula: C19H27ClN2. Mole weight: 318.88. | |
| AZD5991 | AZD5991 is a potent and selective Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay for treatment of hematologic cancers. AZD5991 has high selectivity and affinity for Mcl-1 and is currently in clinical development. AZD5991 shows potent antitumor activity in vivo with complete tumor regression in several models of multiple myeloma and acute myeloid leukemia after a single tolerated dose as monotherapy or in combination with bortezomib or venetoclax. AZD5991 monotherapy caused apoptosis preferentially in hematological cell lines with 6/22 AML and 7/19 MM cell lines showing caspase EC50 values <100 nM. In solid tumor cell lines single agent activity was seen mostly in NSCLC and BrCa. Uses: Antineoplastic agents. Synonyms: AZD-5991; AZD 5991; AZD-5991 Racemate; 22H-9,4,8-(Metheniminomethyno)-14,20:26,23-dimetheno-10H,20H-pyrazolo[4,3-l][2,15,22,18,19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid, 5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-. Grade: ≥98%. CAS No. 2143010-83-5. Molecular formula: C35H34ClN5O3S2. Mole weight: 672.26. | |
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