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It is produced by the strain of Myrothecium verrucaria NRRL 3003. Verrucarin A has the effect of anti-Gram-negative bacteria and fungi, inhibiting Newcastle disease virus, tobacco Mosaic virus, and S-37 sarcoma and Yoshida sarcoma in animals. Synonyms: Muconomycin A; Antibiotic 379Y; VER A; (4S, 5R, 10E, 12Z, 16R, 16aS, 17S, 18R, 19aR, 23aR)-4-hydroxy-5, 16a, 21-trimethyl-4, 5, 6, 7, 16, 16a, 22, 23-octahydro-3H, 18H, 19aH-spiro[16, 18-methano[1, 6, 12]trioxacyclooctadecino[3, 4-d]chromene-17, 2'-oxirane]-3, 9, 14-trione; NSC 126728. Grades: 95%. CAS No. 3148-9-2. Molecular formula: C27H34O9. Mole weight: 502.55.
Verrucarin A
Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria , is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53 [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Muconomycin A. CAS No. 3148-9-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107426.
It is produced by the strain of Myrothecium verrucaria NRRL 3003. Verrucarin B has an effect on Ascites carcinoma, also has a weak inhibitory effect on fungi. Synonyms: (2'S,3'R)-2'-Deoxy-2',3'-oxyverrucarin A. CAS No. 2290-11-1. Molecular formula: C27H32O9. Mole weight: 500.54.
Verrucarin J
Verrucarin J is produced by the strain of Myrothecium verrucaria NRRL 3003. The ED50 of Verrucarin J on giant cell tumor P-815 cells was about 0.001 μg/mL. Uses: For research used only. Synonyms: Muconomycin B; 2',3'-Didehydro-2'-deoxyverrucarin A; Verrucarin A, 2',?3'-didehydro-2'-deoxy-, (2'E)?-; Verrucrin J; Verrucosporin J. Grades: ≥98%. CAS No. 4643-58-7. Molecular formula: C27H32O8. Mole weight: 484.54.
Verrucarin J
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Muconomycin B. Product Category: Inhibitors. Appearance: Solid. CAS No. 4643-58-7. Molecular formula: C27H32O8. Mole weight: 484.5. Purity: 95%+. IUPACName: (1R,3R,8R,12E,18E,20Z,24R,25S,26S)-5,13,25-Trimethylspiro[2,10,16,23-tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa-4,12,18,20-tetraene-26,2'-oxirane]-11,17,22-trione. Canonical SMILES: CC1=C[C@@H]2[C@]3(COC(/C=C(C)/CCOC(/C=C/C=C\C(OC4[C@]3(C)[C@@]5([C@H](O2)C4)CO5)=O)=O)=O)CC1. Product ID: ACM4643587-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: Verrucarin A.
Verrucarin K
Verrucarin K is produced by the strain of Myrothecium verrucaria NRRL 3003. The ED50 of Verrucarin K on giant cell tumor P-815 cells was about 0.001 μg/mL. Synonyms: BRN 1276841; Verrucarin A, 12,13-deepoxy-12,13-didehydro-. CAS No. 63739-93-5. Molecular formula: C27H34O8. Mole weight: 486.55.
Roridin A
It has antifungal effect, and it can inhibit 50% of mast cell tumor P815 cells at 0.001 μg/mL in vitro. Synonyms: Roridine A; Roridan A; NSC 200737; Antibiotic 379X; Verrucarin A, 7'-deoxo-7'-(1-hydroxyethyl)-. Grades: ≥98%. CAS No. 14729-29-4. Molecular formula: C29H40O9. Mole weight: 532.62.
Roridin D
Roridin D is originally isolated from Myrothecium roridum S-1135 (NRRL 3005). Synonyms: Roridin-D; 7'-Deoxo-2'-deoxy-2',3'-epoxy-7'-(1-hydroxyethyl)verrucarin A; Verrucarin A, 7'-deoxo-2'-deoxy-2',3'-epoxy-7'-(1-hydroxyethyl)-; NSC-374338. CAS No. 14682-29-2. Molecular formula: C29H38O9. Mole weight: 530.61.
Roridin E
Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria. It exhibits anticancer activity against various cancer cell lines. Synonyms: Verrucarin A, 2',3'-didehydro-7'-deoxo-2'-deoxy-7'-((1R)-1-hydroxyethyl)-, (2'E,7'R)-. Grades: ≥95% by HPLC. CAS No. 16891-85-3. Molecular formula: C29H38O8. Mole weight: 514.61.
Roridine H
Roridin E is originally isolated from Myrothecium roridum S-1135 (NRRL 3005). Synonyms: CL-72-VB-s; CL-72-VB-2; NSC 274540; Verrucarin A, 2',3'-didehydro-7'-deoxo-2'-deoxy-7',5'-(ethylideneoxy)-. CAS No. 29953-50-2. Molecular formula: C29H36O8. Mole weight: 512.59.
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