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Product | Description | |
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Verruculogen Quick inquiry Where to buy Suppliers range | Verruculogen is a tremorgenic mycotoxin first isolated from Penicillium verruculosum in 1972 and the structure resolved as an indole alkaloid in 1974. Subsequent investigations have shown that verruculogen is produced by several species of Penicillium and Aspergillus and its presence is a useful taxonomic phenotypic marker. The tremorgenic action of verruculogen is complex but is associated with increases in spontaneous glutamate and aspartate release, decreases in GABA levels and, at toxic doses, an increase in the number and decrease in the affinity of DHP receptors in rat cortex. In in vitro guinea pig ileum preparations, verruculogen causes an increase in contractile responses due to electrical field stimulation, attributed to enhancement of acetylcholine from presynaptic nerve terminals. Verruculogen also inhibits Ca2+-activated K+ channels and is a cell cycle inhibitor blocking division at the M phase. Group: Biochemicals. Grades: Highly Purified. CAS No. 12771-72-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Verruculogen Quick inquiry Where to buy Suppliers range | Verruculogen is a tremorgenic mycotoxin isolated from penicillium verruculosu. It can inhibit the K+ channel activated by ca2+, and is a cell cycle inhibitor that prevents M phase division. Synonyms: TR 1 toxin. Grades: >95% by HPLC. CAS No. 12771-72-1. Molecular formula: C27H33N3O7. Mole weight: 511.57. | |
Verruculogen (NA 209A, TR 1) Quick inquiry Where to buy Suppliers range | Fumitremorgin-type alkaloid. Tremorgenic neurotoxic mycotoxin. Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+; BK; maxi-K) channels. Decreases GABA levels in CNS. Increases spontaneous glutamate and aspartate release. At toxic doses, increases the number and decreases the affinity of DHP receptors in rat cortex. Cell cycle inhibitor at the M phase. Inhibits calmodulin and PKC activity. Has apoptotic effects on human T lymphocytes. Stimulates the growth of seedling roots of buckwheat. Group: Biochemicals. Alternative Names: (5R, 10S, 10aR) -1, 10, 10a, 14, 14aS, 15bS-hexahydro-10, 10a-dihydroxy-7-methoxy-2, 2-dimethyl-5- (2-methyl-1-propen-1-yl) -5H, 12H-3, 4-dioxa-5a, 11a, 15a-triazacyclooct [lm]indeno [5, 6-b]fluorene-11, 15 (2H, 13H) -dione. Grades: Highly Purified. CAS No. 12771-72-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C27H33N3O7. US Biological Life Sciences. | Worldwide |