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| Product | Description | |
|---|---|---|
| Verruculogen | Verruculogen is a tremorgenic mycotoxin first isolated from Penicillium verruculosum in 1972 and the structure resolved as an indole alkaloid in 1974. Subsequent investigations have shown that verruculogen is produced by several species of Penicillium and Aspergillus and its presence is a useful taxonomic phenotypic marker. The tremorgenic action of verruculogen is complex but is associated with increases in spontaneous glutamate and aspartate release, decreases in GABA levels and, at toxic doses, an increase in the number and decrease in the affinity of DHP receptors in rat cortex. In in vitro guinea pig ileum preparations, verruculogen causes an increase in contractile responses due to electrical field stimulation, attributed to enhancement of acetylcholine from presynaptic nerve terminals. Verruculogen also inhibits Ca2+-activated K+ channels and is a cell cycle inhibitor blocking division at the M phase. Group: Biochemicals. Grades: Highly Purified. CAS No. 12771-72-1. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Verruculogen | Verruculogen is a tremorgenic mycotoxin isolated from penicillium verruculosu. It can inhibit the K+ channel activated by ca2+, and is a cell cycle inhibitor that prevents M phase division. Synonyms: TR 1 toxin. Grades: >95% by HPLC. CAS No. 12771-72-1. Molecular formula: C27H33N3O7. Mole weight: 511.57. |  |
| Verruculogen (NA 209A, TR 1) | Fumitremorgin-type alkaloid. Tremorgenic neurotoxic mycotoxin. Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+; BK; maxi-K) channels. Decreases GABA levels in CNS. Increases spontaneous glutamate and aspartate release. At toxic doses, increases the number and decreases the affinity of DHP receptors in rat cortex. Cell cycle inhibitor at the M phase. Inhibits calmodulin and PKC activity. Has apoptotic effects on human T lymphocytes. Stimulates the growth of seedling roots of buckwheat. Group: Biochemicals. Alternative Names: (5R, 10S, 10aR) -1, 10, 10a, 14, 14aS, 15bS-hexahydro-10, 10a-dihydroxy-7-methoxy-2, 2-dimethyl-5- (2-methyl-1-propen-1-yl) -5H, 12H-3, 4-dioxa-5a, 11a, 15a-triazacyclooct [lm]indeno [5, 6-b]fluorene-11, 15 (2H, 13H) -dione. Grades: Highly Purified. CAS No. 12771-72-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C27H33N3O7. US Biological Life Sciences. | Worldwide |
| verruculogen prenyltransferase | Found in a number of fungi. Catalyses the last step in the biosynthetic pathway of the indole alkaloid fumitremorgin A. The enzyme from the fungus Neosartorya fischeri is also active with fumitremorgin B and 12α,13α-dihydroxyfumitremorgin C. Group: Enzymes. Synonyms: FtmPT3. Enzyme Commission Number: EC 2.5.1.107. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2723; verruculogen prenyltransferase; EC 2.5.1.107; FtmPT3. Cat No: EXWM-2723. |  |
| verruculogen synthase | Requires Fe2+ and ascorbate. Found in the fungus Aspergillus fumigatus. Both atoms of a dioxygen molecule are incorporated into verruculogen. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A. Group: Enzymes. Synonyms: fmtF (gene name); FmtOx1. Enzyme Commission Number: EC 1.14.11.38. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0656; verruculogen synthase; EC 1.14.11.38; fmtF (gene name); FmtOx1. Cat No: EXWM-0656. | |
| 12α,13α-dihydroxyfumitremorgin C prenyltransferase | The enzyme from the fungus Aspergillus fumigatus also shows some activity with fumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen. Group: Enzymes. Synonyms: ftmH (gene name); FtmPT2. Enzyme Commission Number: EC 2.5.1.110. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2726; 12α,13α-dihydroxyfumitremorgin C prenyltransferase; EC 2.5.1.110; ftmH (gene name); FtmPT2. Cat No: EXWM-2726. | |
| 5H, 12H-3, 4-Dioxa-5a, 11a, 15a-triazacyclooct[lm]indeno[5, 6-b]fluorene-11, 15(2H, 13H)-dione, 1, 10, 10a, 14, 14a, 15b-hexahydro-10, 10a-dihydroxy-7-methoxy-2, 2-dimethyl-5-(2-methyl-1-propen-1-yl)-, (5r, 10s, 10ar, 1 | Heterocyclic Organic Compound. Alternative Names: VERRUCULOGEN;VERRUCULOGEN, PENICILLIUM VERRUCULOSUM;3h)-dione, 1, 10, 10a, 14, 14a, 15b-hexahydro-10, 10a-dihydroxy-7-methoxy-2, 2-dimeth;5h, 12h-3, 4-dioxa-5a, 11a, 15a-triazacyclooct(lm)indeno(5, 6-b)fluorene-11, 15(2h, 1;tr1;verruculogentr1;yl-5-(2-methyl-1-propenyl. CAS No. 12771-72-1. Molecular formula: C27H33N3O7. Mole weight: 511.5668. Appearance: White to off-white powder. Purity: 0.96. IUPACName: verruculogen. Canonical SMILES: CC (=CC1N2C3C (CC (OO1) (C)C)N4C (=O)C5CCCN5C (=O)C4 (C (C3C6=C2C=C (C=C6)OC)O)O)C. Density: 1.49 g/cm³. Catalog: ACM12771721. |  |
| 6-hydroxytryprostatin B O-methyltransferase | Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen. Group: Enzymes. Synonyms: ftmD (gene name). Enzyme Commission Number: EC 2.1.1.293. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1900; 6-hydroxytryprostatin B O-methyltransferase; EC 2.1.1.293; ftmD (gene name). Cat No: EXWM-1900. | |
| fumitremorgin C monooxygenase | A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of the indole alkaloid verruculogen. Group: Enzymes. Synonyms: ftmG (gene name). Enzyme Commission Number: EC 1.14.13.177. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0775; fumitremorgin C monooxygenase; EC 1.14.13.177; ftmG (gene name). Cat No: EXWM-0775. | |
| fumitremorgin C synthase | A heme-thiolate protein (P-450). The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen. Group: Enzymes. Synonyms: ftmE (gene name). Enzyme Commission Number: EC 1.14.21.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1021; fumitremorgin C synthase; EC 1.14.21.10; ftmE (gene name). Cat No: EXWM-1021. | |
| tryprostatin B 6-hydroxylase | A heme-thiolate protein (P-450). Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen. Group: Enzymes. Synonyms: ftmC (gene name). Enzyme Commission Number: EC 1.14.13.176. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0774; tryprostatin B 6-hydroxylase; EC 1.14.13.176; ftmC (gene name). Cat No: EXWM-0774. | |
| tryprostatin B synthase | The enzyme from the fungus Aspergillus fumigatus can also prenylate other tryptophan-containing cyclic dipeptides. Prenylation occurs mainly at C-2, but also at C-3. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, cyclotryprostatins, spirotryprostatins, fumitremorgins and verruculogen. Group: Enzymes. Synonyms: ftmPT1 (gene name); brevianamide F prenyltransferase (ambiguous). Enzyme Commission Number: EC 2.5.1.106. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2722; tryprostatin B synthase; EC 2.5.1.106; ftmPT1 (gene name); brevianamide F prenyltransferase (ambiguous). Cat No: EXWM-2722. | |
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