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Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: γ-Vinyl-GABA. CAS No. 68506-86-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15399.
Vigabatrin
Vigabatrin. Group: Biochemicals. Grades: Purified. CAS No. 60643-86-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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Vigabatrin
Vigabatrin is an analogue of gamma-aminobutyric acid(GABA) and is an irreversible inhibitor of 4-aminobutyrate transaminase. It is used in combination with other agents as therapy of refractory complex partial seizures and as monotherapy for infantile spasms. It is an antiepileptic drug that inhibits the breakdown of GABA by acting as a suicide inhibitor of GABA transaminase (GABA-T). It increases brain concentrations of GABA, an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. It is a racemic compound, and its [S]-enantiomer is pharmacologically active. It has been listed. Uses: Vigabatrin is used in combination with other agents as therapy of refractory complex partial seizures and as monotherapy for infantile spasms. it is an antiepileptic drug. Synonyms: γ-Vinyl-GABA; 4-Amino-5-hexenoic Acid; (±)-4-Amino-5-hexenoic Acid; Sabril; Vigabatrine; 4-Aminohexenoic acid; rac-Vigabatrin; (±)-Vigabatrin; (±)-4-Aminohexenoic acid. Grades: ≥98%. CAS No. 68506-86-5. Molecular formula: C6H11NO2. Mole weight: 129.16.
Vigabatrin EP Impurity A
An impurity of Vigabatrin. Vigabatrin is an inhibitor of the enzyme GABA transaminase (GABA-T) used as an antiepileptic drug. Synonyms: 5-Ethenyl-2-pyrrolidinone; 5-Vinyl-2-pyrrolidinone; (±)-5-Vinylpyrrolidin-2-one; 5-Vinyl-2-pyrrolidinone; MDL 17637-03. CAS No. 7529-16-0. Molecular formula: C6H9NO. Mole weight: 111.14.
Vigabatrin EP Impurity A
Vigabatrin EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 7529-16-0. Molecular Formula: C6H9NO. Mole Weight: 111.14. Catalog: APB7529160.
Vigabatrin EP Impurity B
An impurity of Vigabatrin. Vigabatrin is an inhibitor of the enzyme GABA transaminase (GABA-T) used as an antiepileptic drug. Synonyms: UNII-6GON7WT3C8; (2E)-2-(2-Aminoethyl)but-2-enoic acid; 2-(2-Aminoethyl)but-2-enoic acid, (2E)-; 6GON7WT3C8; (E)-2-(2-aminoethyl)but-2-enoic acid. CAS No. 1379504-35-4. Molecular formula: C6H11NO2. Mole weight: 129.16.
Vigabatrin EP Impurity B
Vigabatrin EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1379504-35-4. Molecular Formula: C6H11NO2. Mole Weight: 129.16. Catalog: APB1379504354.
Vigabatrin EP Impurity B HCl
Vigabatrin EP Impurity B HCl. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1379403-11-8. Molecular Formula: C6H12ClNO2. Mole Weight: 165.62. Catalog: APB1379403118.
Vigabatrin EP Impurity C
Vigabatrin EP Impurity C is used in the synthesis of diaminoalkenes through copper-mediated diamination reaction. Synonyms: 2-Oxo-5-vinylpyrrolidine-3-carboxamide; 5-Ethenyl-2-oxo-3-pyrrolidinecarboxamide. Molecular formula: C7H10N2O2. Mole weight: 154.17.
Vigabatrin EP Impurity C
Vigabatrin EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 71107-19-2. Molecular Formula: C7H10N2O2. Mole Weight: 154.17. Catalog: APB71107192.
Vigabatrin EP Impurity D
Vigabatrin EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. CAS No. 56-12-2. Molecular Formula: C4H9NO2. Mole Weight: 103.12. Catalog: APB56122.
Vigabatrin EP Impurity E
Vigabatrin EP Impurity E is a derivative of Vigabatrin. Vigabatrin is an inhibitor of the enzyme GABA transaminase (GABA-T) used as an antiepileptic drug. Synonyms: 2-(2-Aminobut-3-enyl)malonic Acid. CAS No. 1378466-25-1. Molecular formula: C7H11NO4. Mole weight: 173.17.
Vigabatrin EP Impurity E
Vigabatrin EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1378466-25-1. Molecular Formula: C7H11NO4. Mole Weight: 173.17. Catalog: APB1378466251.
Vigabatrin EP Impurity F
An impurity of Vigabatrin. Vigabatrin is an inhibitor of the enzyme GABA transaminase (GABA-T) used as an antiepileptic drug. Synonyms: 4-(4-Amino-hex-5-enoylamino)-hex-5-enoic Acid; 4-[(4-Amino-1-oxo-5-hexenyl)amino]-5-hexenoic Acid; 4-[(4-Amino-1-oxo-5-hexen-1-yl)amino]-5-hexenoic Acid. CAS No. 794466-81-2. Molecular formula: C12H20N2O3. Mole weight: 240.3.
Vigabatrin EP Impurity F
Vigabatrin EP Impurity F. Uses: For analytical and research use. Group: Impurity standards. CAS No. 794466-81-2. Molecular Formula: C12H20N2O3. Mole Weight: 240.3. Catalog: APB794466812.
A selective, irreversible inhibitor of GABA transaminase with antiepileptic properties. Covalently binds to the active site of GABA tansaminase to inactivate it in a dose-dependent manner and increases extracellular GABA levels in the brain. Rapidly absorbed following oral administration and is shown to inhibit [3H]GABA uptake across the apical membrane of Caco-2 cell monolayers in a concentration-dependent manner (IC50 = 2.9mM). Group: Biochemicals. Grades: Highly Purified. CAS No. 68506-86-5. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Vigabatrin hydrochloride
Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: γ-Vinyl-GABA hydrochloride. CAS No. 1391054-02-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0033.
Vigabatrin Hydrochloride. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1391054-02-6. Molecular Formula: C6H12ClNO2. Mole Weight: 165.62. Catalog: APB1391054026.
Vigabatrin Impurity 11
Vigabatrin Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2324151-81-5. Molecular Formula: C8H11NO3. Mole Weight: 169.18. Catalog: APB2324151815.
Vigabatrin Impurity 15
Vigabatrin Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 71107-20-5. Molecular Formula: C7H9NO3. Mole Weight: 155.15. Catalog: APB71107205.
Vigabatrin Impurity 16
Vigabatrin Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 27428-45-1. Molecular Formula: C6H9NO. Mole Weight: 111.14. Catalog: APB27428451.
Vigabatrin Impurity 17
Vigabatrin Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 213758-47-5. Molecular Formula: C8H15NO2. Mole Weight: 157.21. Catalog: APB213758475.
Vigabatrin Impurity 6
Vigabatrin Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1824506-31-1. Molecular Formula: C8H13NO3. Mole Weight: 171.2. Catalog: APB1824506311.
N-Methoxycarbonyl Vigabatrin-13C,d2 Ethyl Ester
Used in the preparation of Vigabatrin. Group: Biochemicals. Alternative Names: 4-[ (Methoxycarbonyl) amino]-5-hexenoic Acid Ethyl Ester-13C,d2. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
N-Methoxycarbonyl Vigabatrin Ethyl Ester
Used in the preparation of Vigabatrin. Group: Biochemicals. Alternative Names: 4-[ (Methoxycarbonyl) amino]-5-hexenoic Acid Ethyl Ester. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
rac-Vigabatrin-13C,d2 (Major)
Labeled Vigabatrin. A novel antiepileptic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
rac-Vigabatrin Hydrochloride
A novel antiepileptic. Group: Biochemicals. Alternative Names: 4-Amino-5-hexenoic Acid Hydrochloride; (±)-4-Amino-5-hexenoic Acid Hydrochloride; (±)-γ-Vinyl GABA Hydrochloride; 4-Amino-5-hexenoic Acid Hydrochloride. Grades: Highly Purified. Pack Sizes: 5mg, 10mg, 25mg, 50mg. US Biological Life Sciences.
Worldwide
(S)-Vigabatrin
(S)-Vigabatrin. Group: Biochemicals. Alternative Names: (4S)-4-Amino-5-hexenoic Acid. Grades: Highly Purified. CAS No. 74046-07-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C6H11NO2. US Biological Life Sciences.
Worldwide
2-(2-Aminobut-3-enyl)malonic Acid
2-(2-Aminobut-3-enyl)malonic Acid. Group: Biochemicals. Alternative Names: Vigabatrin Related Compound E. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C7H11NO4, Molecular Weight: 173.17. US Biological Life Sciences.
2-Ethenyl-5-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester is an intermediate in the preparation of rac-Vigabatrin Hydrochloride (V253010). Group: Biochemicals. Alternative Names: 2-Ethenyl-5-oxo-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 160428-64-8. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
2-Oxo-5-vinylpyrrolidine-3-carboxamide
2-Oxo-5-vinylpyrrolidine-3-carboxamide is obtained from (2E)-1,4-Dibromo-2-butene (D425545) which is used as a reagent in the preparation of diaminoalkenes though copper-mediated diamination reaction. 2-Oxo-5-vinylpyrrolidine-3-carboxamide is also used for vigabatrin separation from, by HPLC, macroporous polymeric column in analytical study. Group: Biochemicals. Grades: Highly Purified. CAS No. 71107-19-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C7H10N2O2, Molecular Weight: 154.169999999999. US Biological Life Sciences.
(2S)-2-[(Ethylthio)carbonyl]-5-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester is an intermediate in the preparation of rac-Vigabatrin Hydrochloride (V253010), (-)-Sessilifoliamide C and (-)-8-Epi-stemoamide. Group: Biochemicals. Alternative Names: (2S)-2-[(Ethylthio)carbonyl]-5-oxo-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 1298023-90-1. Pack Sizes: 250mg. US Biological Life Sciences.
(2S)-2-[(Ethylthio)carbonyl]-5-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester is an intermediate in the preparation of rac-Vigabatrin Hydrochloride (V253010), (-)-Sessilifoliamide C and (-)-8-Epi-stemoamide. Group: Biochemicals. Grades: Highly Purified. CAS No. 1298024-11-9. Pack Sizes: 500mg. US Biological Life Sciences.
Worldwide
5-(Aminomethyl)indole
5-(Aminomethyl)indole is used in the synthesis of Vigabatrin bioisosteres as inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT) inhibitors. Group: Biochemicals. Alternative Names: 1H-Indole-5-methanamine; ((Indol-5-yl)methyl)amine; (1H-Indol-5-ylmethyl)amine; 1-(1H-Indol-5-yl)methanamine; Indole-5-methanamine. Grades: Highly Purified. CAS No. 81881-74-5. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
5-Ethenyl-2-pyrrolidinone
Vigabatrin impurity. Group: Biochemicals. Alternative Names: 5-Vinyl-2-pyrrolidinone; (±)-5-Vinylpyrrolidin-2-one; 5-Vinyl-2-pyrrolidinone; MDL 17637-03. Grades: Highly Purified. CAS No. 7529-16-0. Pack Sizes: 10mg. US Biological Life Sciences.