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Tuberactinomycin B is a member of the tuberactinomycin family of antibiotics used for the treatment of multidrug-resistant tuberculosis. Tuberactinomycin B inhibits group I intron splicing and prokaryotic protein synthesis, and freezes bacterial ribosomes in either the pre-or post-translational state. Uses: The treatment of multidrug-resistant tuberculosis. Synonyms: Tuberactinomycin B; Celiomycin; Florimycin; Viomicina; Viomycine; Viomycinum. CAS No. 32988-50-4. Molecular formula: C25H43N13O10. Mole weight: 685.69.
viomycin kinase
Acts also on capreomycins. A serine residue in the peptide antibiotics acts as phosphate-acceptor. Group: Enzymes. Synonyms: viomycin phosphotransferase; capreomycin phosphotransferase. Enzyme Commission Number: EC 2.7.1.103. CAS No. 77000-11-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2950; viomycin kinase; EC 2.7.1.103; 77000-11-4; viomycin phosphotransferase; capreomycin phosphotransferase. Cat No: EXWM-2950.
Viomycin sulfate
It is a peptide antibiotic produced by the strain of Str. puniceus 1314-5 and Str. floridae A5014. It has broad-spectrum antibacterial and strong anti-mycobacterium effect. 1-10 μg/mL of Viomycin can inhibit the growth of most tuberculosis bacilli, the main effect is to inhibit the protein synthesis of bacteria, but bacteria are prone to develop drug resistance. In clinical application, it is only used as a second-line drug to treat tuberculosis. Synonyms: Tuberactinomycin B sulfate salt; celicomycin-sulfate; florimycin sulfate; Vinacetin A sulfate; hexanamide, 3,6-diamino-N-[(3S,6Z,9S,12S,15S)-6-[[(aminocarbonyl)amino]methylene]-3-[(4R,6S)-2-amino-3,4,5,6-tetrahydro-6-hydroxy-4-pyrimidinyl]-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaazacyclohexadec-15-yl]-, (3S)-, sulfate (1:1) (salt). CAS No. 37883-00-4. Molecular formula: C25H43N13O10.H2O4S. Mole weight: 783.77.
Viomycin trihydrochloride
It is a peptide antibiotic produced by the strain of Str. puniceus 1314-5 and Str. floridae A5014. It has broad-spectrum antibacterial and strong anti-mycobacterium effect. 1-10 μg/mL of Viomycin can inhibit the growth of most tuberculosis bacilli, the main effect is to inhibit the protein synthesis of bacteria, but bacteria are prone to develop drug resistance. In clinical application, it is only used as a second-line drug to treat tuberculosis. Synonyms: Florimycin trihydrochloride; Viomycinum trihydrochloride; Vinacetin A trihydrochloride; Hexanamide, 3,6-diamino-N-[(3S,6Z,9S,12S,15S)-6-[[(aminocarbonyl)amino]methylene]-3-[(4R,6S)-2-amino-1,4,5,6-tetrahydro-6-hydroxy-4-pyrimidinyl]-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,1 3-pentaazacyclohexadec-15-yl]-, (3S)-, hydrochloride (1:3). CAS No. 39750-31-7. Molecular formula: C25H43N13O10.3HCl. Mole weight: 795.07.
Enviomycin
Enviomycin (Tuberactinomycin N) is a antibacterial antibiotic. Enviomycin has been used to research chronic cavitary pulmonary tuberculosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Enviomycin;1,4,7,10,13-Pentaazacyclohexadecane, cyclic peptide deriv.;enviomucin;Tuberactinomycin N (8CI, 9CI);Viomycin, 1-[(3R,4R)-4-hydroxy-3,6-diaminohexanoic acid]-6-[L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)glycine]-, (R)-;N2-[(4R)-4-Hydroxy-L-. Product Category: Inhibitors. CAS No. 33103-22-9. Molecular formula: C25H43N13O10. Mole weight: 685.696. Purity: 0.96. IUPACName: 3,6-diamino-N-[(6Z)-3-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-6-[(carbamoylamino)methylidene]-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazacyclohexadec-15-yl]-4-hydroxyhexanamide. Density: 1.8g/cm³. Product ID: ACM33103229. Alfa Chemistry ISO 9001:2015 Certified.
23S rRNA (cytidine1920-2'-O)-methyltransferase
The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1920 in helix 69 of 23S rRNA and cytidine1409 in helix 44 of 16S rRNA (cf. EC 2.1.1.227, 16S rRNA (cytidine1409-2'-O)-methyltransferase). These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin. Group: Enzymes. Synonyms: TlyA (ambiguous). Enzyme Commission Number: EC 2.1.1.226. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1829; 23S rRNA (cytidine1920-2'-O)-methyltransferase; EC 2.1.1.226; TlyA (ambiguous). Cat No: EXWM-1829.
capreomycidine synthase
A pyridoxal 5'-phosphate protein. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. Group: Enzymes. Synonyms: VioD (ambiguous). Enzyme Commission Number: EC 4.2.1.145. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4986; capreomycidine synthase; EC 4.2.1.145; VioD (ambiguous). Cat No: EXWM-4986.
L-arginine hydroxylase
Fe2+-dependent enzyme. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. It differs from EC 1.14.11.34, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming), because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine. Group: Enzymes. Synonyms: VioC (ambiguous); L-arginine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating). Enzyme Commission Number: EC 1.14.11.41. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0660; L-arginine hydroxylase; EC 1.14.11.41; VioC (ambiguous); L-arginine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating). Cat No: EXWM-0660.
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