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It is a depsipeptide antibiotic produced by the strain of Str. virginiae and Str. virginiae var. sp. It has anti-gram-positive bacteria and mycobacterium effects, and the antibacterial activity of component M of Virginiamycin against cocci is stronger than component S, while the activity is stronger than component M. Synonyms: Staphylomycin S; Staphylomycin S1; Antibiotic 1754Z3B; Virginiamycin factor S; NSC177858; Stephylomycin; Eskamicin; Cebin V; Factor S; Glycine, N-[(3-hydroxy-2-pyridinyl)carbonyl]-L-threonyl-D-2-aminobutanoyl-L-prolyl-N-methyl-L-phenylalanyl-4-oxo-L-2-piperidinecarbonyl-L-2-phenyl-, r-lactone. Grades: >99% by HPLC. CAS No. 23152-29-6. Molecular formula: C43H49N7O10. Mole weight: 823.89.
Virginiamycin S1
Virginiamycin S1 is a main component of virginiamycin preparations. Virginiamycin S1 is one of a family of depsipeptide antibiotic co-produced with ostreogrycin A and used as a synergistic mixture. Virginiamycin S1 also known as Staphylomycin S and Factor S, among other synonyms were discovered independently and named by several groups leading to considerable confusion in the literature. Virginiamycin S1 acts a synergist binding to the conformational change induced by ostreogrycin A of the peptidyl transferase centre of the 50S ribosome. Virginiamycin S1 differs from virginiamycin B in lacking the dimethylamino moiety on the phenyl ring. Group: Biochemicals. Alternative Names: Staphylomycin S, PA 114B2, Antibiotic 899, Antibiotic PA 114B2, Antibiotic 1745Z3B, Factor S. Grades: Highly Purified. CAS No. 23152-29-6. Pack Sizes: 5mg. Molecular Formula: C43H49N7O10, Molecular Weight: 823.89. US Biological Life Sciences.
Worldwide
Ostreogrycin B3
It is produced by the strain of Str. ostreogriseus NRRL 2558 (NCIB 8792). It has anti-gram positive bacterial activity, and Ostreogrycin A has stronger antibacterial activity than other components. Ostreogrycin A or G has synergistic antibacterial effect with each component of Ostreogrycin B. The Complex has protective effect on mice infected with bacteria by subcutaneous or oral administration. Synonyms: Virginiamycin-S1; N-(3-Hydroxypicolinoyl)-cyclo[L-Thr*-D-Abu-L-Pro-4-(dimethylamino)-N-methyl-L-Phe-4-oxo-5-hydroxy-L-Hpr-L-phenyl-Gly-]. CAS No. 31508-69-7. Molecular formula: C45H54N8O11. Mole weight: 882.96.
Quinupristin
Quinupristin is an antibiotic and usually used in combination with dalfopristin (The trade name is Synercid). It is active against Gram-positive bacteria through inhibiting protein synthesis of the cells, but not active against Gram-negative bacteria, so it needs to be given in combination with other antibacterials for mixed infections which also involve Gram-negative organisms. Uses: Semisynthetic depsipeptide type i streptogramin. an antibacterial agent. Synonyms: N-((6R, 9S, 10R, 13S, 15aS, 18R, 22S, 24aS)-22-(4-(dimethylamino)benzyl)-6-ethyl-10, 23-dimethyl-5, 8, 12, 15, 17, 21, 24-heptaoxo-13-phenyl-18-((((S)-quinuclidin-3-yl)thio)methyl)docosahydro-12H-pyrido[2, 1-f]pyrrolo[2, 1-l][1]oxa[4, 7, 10, 13, 16]pentaazacyclononadecin-9-yl)-3-hydroxypicolinamide; RP68888; RP57669; Antibiotic RP 57669; 4-[4-(Dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]methyl]-4-oxo-2-piperidine carboxylic acid] Virginiamycin S1. Grades: 95%. CAS No. 120138-50-3. Molecular formula: C53H67N9O10S. Mole weight: 1022.22.
Quinupristin-Dalfopristin complex
Quinupristin-dalfopristin complex is a 70:30 (w/w) complex of two semi-synthetic Streptomycin antibiotic. It is a highly effective antibiotic with activity against resistant strains. Synonyms: Synercid complex; Dalfopristin-Quinupristin complex; RP 59500; 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S)-5-[(1-azabicyclo[2.2.2]oct-3-ylthio)methyl]-4-oxo-2-piperidinecarboxylic acid]-virginiamycin S1 mixture with (3R, 4R, 5E, 10E, 12E, 14S, 26R, 26aS)-26-[[2-(diethylamino)ethyl]sulfonyl]-8, 9, 14, 15, 24, 25, 26, 26a-octahydro-14-hydroxy-4, 12-dimethyl-3-(1-methylethyl)-3H-21, 18-nitrilo-1H, 22H-pyrrolo[2, 1-c][1, 8, 4, 19]dioxadiazacyclotetracosine-1, 7, 16, 22(4H, 17H)-tetrone. Grades: >98% by HPLC. CAS No. 126602-89-9. Molecular formula: C53H67N9O10S.C34H50N4O9S. Mole weight: 1713.09.
Virginiamycin
Virginiamycin complex contains two streptogramin antibiotics, virginiamycin M1 (75%) and virginiamycin S1 (25%). It is an antibiotic used primarily in the treatment of staphylococcal infections, and to a less extent streptococcal infections. Uses: Anti-bacterial agents. Synonyms: Pristinamycin. CAS No. 11006-76-1. Molecular formula: C71H84N10O17. Mole weight: 1349.48.
Virginiamycin Complex
Virginiamycin complex is defined as a mixture of 75% virginamycin M1 (ostreogrycin A) and 25% virginiamycin S1 and the less abundant S analogs. As the two major components have quite different solubilities these proportions are not readily achieved or used. The individual components are isolated and re-combined to provide the defined components of virginiamycin complex. The structure composition of the complex is important as Virginiamycin S1 acts a synergist, binding to the conformational change of the peptidyl transferase center of the 50S ribosome induced by ostreogrycin A. Group: Biochemicals. Alternative Names: Cebin V, Eskalin V, Eskamicin, Stafac, Stephylomycin, Mikamycin, Ostreogrycin, Patricin, Pristinamycin, Streptogramin, Vernamycin. Grades: Highly Purified. CAS No. 11006-76-1. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Virginiamycin S2
It is a depsipeptide antibiotic produced by the strain of Str. virginiae and Str. virginiae var. sp. It has anti-gram-positive bacteria and mycobacterium effects, and the antibacterial activity of component M of Virginiamycin against cocci is stronger than component S, while the activity is stronger than component M. Synonyms: Staphylomycin-S2; 4-L-Phenylalanine-5-(cis-4-hydroxy-L-2-piperidinecarboxylic acid)virginiamycin S1; N-[(3-Hydroxy-2-pyridinyl)carbonyl]cyclo[L-Thr*-D-Abu-L-Pro-L-Phe-[(4R)-4-hydroxy-L-pipecoloyl]-L-phenyl-Gly-]; N-[(3-Hydroxy-2-pyridyl)carbonyl]-cyclo[L-Thr*-D-Abu-L-Pro-L-Phe-4β-hydroxy-L-Hpr-L-phenyl-Gly-]. CAS No. 33477-38-2. Molecular formula: C42H49N7O10. Mole weight: 811.88.
Virginiamycin S3
It is a depsipeptide antibiotic produced by the strain of Str. virginiae and Str. virginiae var. sp. It has anti-gram-positive bacteria and mycobacterium effects, and the antibacterial activity of component M of Virginiamycin against cocci is stronger than component S, while the activity is stronger than component M. Synonyms: Staphylomycin S3; Virginiamycin S1, 5-(5-hydroxy-4-oxo-L-2-piperidinecarboxylic acid)-; N-[(3-Hydroxy-2-pyridinyl)carbonyl]cyclo[L-Thr*-D-Abu-L-Pro-N-methyl-L-Phe-4-oxo-5-hydroxy-L-pipecoloyl-L-phenyl-Gly-]. CAS No. 33477-39-3. Molecular formula: C43H49N7O11. Mole weight: 839.89.
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