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| Product | Description | |
|---|---|---|
| Yoda 1 | Yoda 1 is a glycine transporters GLYT2 inhibitor as a novel agonist of the mechanotransduction channel Piezo1. Uses: Piezo1 channel activator. Synonyms: GlyT2-IN-1; Yoda1; Yoda-1; Yoda 1;2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine;2-[(2,6-dichlorophenyl)methylsulfanyl]-5-pyrazin-2-yl-1,3,4-thiadiazole. Grades: ≥98 %. CAS No. 448947-81-7. Molecular formula: C13H8Cl2N4S2. Mole weight: 355.27. |  |
| Yoda 1 | Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 448947-81-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18723. |  |
| Dooku 1 | Dooku 1 reversibly blocks Yoda1 activity (IC50 = ~1.5 μM) and has no effect on constitutive Piezo1 channel activity, but it can antagonize Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Synonyms: 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole. Grades: ≥98% by HPLC. Molecular formula: C13H9Cl2N3OS. Mole weight: 326.2. | |
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