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| Product | Description | |
|---|---|---|
| Yoda 1 | Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 448947-81-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18723. |  |
| Dooku1 | Dooku1 is an analog of Yoda1 and an antagonist of the endogenous Piezo1 channel. Dooku1 inhibited 2 μM Yoda1-induced Ca2+-entry with IC50s of 1.3 μM (HEK 293 cells) and 1.5 μM (HUVECs). Synonyms: Dooku 1. CAS No. 2253744-54-4. Molecular formula: C13H9Cl2N3OS. Mole weight: 326.20. |  |
| Dooku1 | Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 ?M and 1.5 ?M for 2 ?M Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2253744-54-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126010. | |
| Dooku 1 | Dooku 1 reversibly blocks Yoda1 activity (IC50 = ~1.5 μM) and has no effect on constitutive Piezo1 channel activity, but it can antagonize Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Synonyms: 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole. Grade: ≥98% by HPLC. Molecular formula: C13H9Cl2N3OS. Mole weight: 326.2. | |
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