American Chemical Suppliers
A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
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Product | Description | |
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WWL 123 Quick inquiry Where to buy Suppliers range | WWL 123 is an α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 0.43 μM) with antiepileptic activity. It suppresses PTZ-induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Synonyms: WWL123; WWL-123; WWL 123; N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester. Grades: ≥98% by HPLC. CAS No. 1338574-83-6. Molecular formula: C28H24N2O3. Mole weight: 436.5. | |
WWL123 Quick inquiry Where to buy Suppliers range | WWL123 is a brain-penetrant inhibitor of ABHD6 (IC50 = 0.43 μM) exhibiting >10-fold selectivity for ABHD6 compared to a panel of ~35 other serine hydrolases. WWL123 has been used to decrease seizure incidence in a genetic mouse model of juvenile Huntington's disease as well as in chemically-induced epilepsy models. Synonyms: [3-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-phenylphenyl)methyl]carbamate. Grades: ≥95%. CAS No. 1338575-41-9. Molecular formula: C28H24N2O3. Mole weight: 436.5. | |
WWL229 Quick inquiry Where to buy Suppliers range | WWL229 is a selective inhibitor of Ces3 (carboxylesterase-3). It inhibits the triglyceride hydrolase activity of Ces3, promotes lipid storage in cultured adipocytes and prevents basal lipolysis. Synonyms: (4-Nitrophenyl) 2-(3-methoxypropyl)piperidine-1-carboxylate. Grades: ≥98%. CAS No. 1338575-28-2. Molecular formula: C16H22N2O5. Mole weight: 322.4. | |
WWL 70 Quick inquiry Where to buy Suppliers range | WWL 70. Group: Biochemicals. Grades: Purified. CAS No. 947669-91-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
WWL70 Quick inquiry Where to buy Suppliers range | WWL70 is a potent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM). ABHD6 is a serine hydrolase that is highly expressed in mammalian brain. Synonyms: 4'-carbamoyl-[1,1'-biphenyl]-4-yl methyl(3-(pyridin-4-yl)benzyl)carbamate; WWL 70; WWL70; WWL-70. CAS No. 947669-91-2. Molecular formula: C27H23N3O3. Mole weight: 437.5. | |
WY 14643 Quick inquiry Where to buy Suppliers range | WY 14643. Group: Biochemicals. Grades: Purified. CAS No. 50892-23-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
WY-14643 Quick inquiry Where to buy Suppliers range | WY-14643. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 50892-23-4. Pack Sizes: 10MG, 50MG. Mole weight: 323.80. Catalog: AP50892234. | |
WY-14643 Quick inquiry Where to buy Suppliers range | Potent peroxisome proliferator-activated receptor (PPARalpha) activator. Activates also PPARgamma but not PPARdelta. Potent anti-hypercholesterolemic agent. Hypolipidemic compound. Lipogenesis inducer. Tumor promoter. Causes increased cell proliferation and decreased apoptosis. Anti-inflammatory. Inhibits NF-kappaB transcriptional activity and decreases the inflammatory response by reducing the production of inflammatory cytokines (TNF-alpha, IL1beta). Reduces oxidative stress. Increases fatty acid oxidation. Directly affects insulin signaling. Increases glucose uptake. Group: Biochemicals. Grades: Highly Purified. CAS No. 50892-23-4. Pack Sizes: 10mg, 50mg, 250mg. Molecular Formula: C14H14ClN3O2S. US Biological Life Sciences. | Worldwide |
WY-14643 ( [ [4-Chloro-6- [ (2, 3-dimethylphenyl) -amino] -2-pyrimidinyl] thio] acetic Acid, Pirinixic Acid) Quick inquiry Where to buy Suppliers range | Cell-permeable. A selective PPARa agonist (EC50 values are 0.63, 32 and > 100uM at PPARa, PPARg and PPARd respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 50892-23-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
WY 45233 succinate Quick inquiry Where to buy Suppliers range | WY 45233 succinate is an inhibitor of serotonin and noradrenalin reuptake (SNRI) used in the treatment of major depressive disorder (MDD). WY 45233 succinate inhibits [3H]5-HT and [3H]NE uptake (IC50 = 47.3 and 531.3 nM). Uses: The treatment of major depressive disorder. Synonyms: WY 45233 succinate; WY45233 succinate; WY-45233 succinate; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol succinate; O-Desmethylvenlafaxine succinate; Ventab DXT; Desvenlafaxine succinate anhydrous. Grades: ≥99% by HPLC. CAS No. 448904-47-0. Molecular formula: C16H25NO2.C4H6O4. Mole weight: 381.46. | |
wybutosine Quick inquiry Where to buy Suppliers range | A modified nucleoside of phenylalanine tRNA. Synonyms: 3H-Imidazo[1,2-a]purine-7-butanoic acid, 4,9-dihydro-a-[(methoxycarbonyl)amino]-4,6-dimethyl-9-oxo-3-b-D-ribofuranosyl-, methyl ester, (S)-. Grades: ≥98%. CAS No. 55196-46-8. Molecular formula: C21H28N6O9. Mole weight: 508.49. | |
WYE-125132 Quick inquiry Where to buy Suppliers range | ≥97% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1144068-46-1. Pack Sizes: 5MG, 25MG. Mole weight: 519.60. Catalog: AP1144068461. Assay: ≥97% (HPLC). | |
WYE-125132 Quick inquiry Where to buy Suppliers range | WYE-125132, also known as WYE-132, is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor. WYE-132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly, consistent with genetic ablation of mTORC2, WYE-132 targeted P-AKT(S473) and AKT function without significantly reducing the steady-state level of the PI3K/PDK1 activity biomarker P-AKT(T308), highlighting a prominent and direct regulation of AKT by mTORC2 in cancer cells. Synonyms: WYE 125132, WYE-125132, WYE125132, WYE132, WYE 132, WYE-132. Grades: 0.98. CAS No. 1144068-46-1. Molecular formula: C27H33N7O4. Mole weight: 519.606. | |
WYE-23 Quick inquiry Where to buy Suppliers range | WYE-23 is an inhibitor of mTOR with IC50 value of 0.45 nM. Synonyms: mTOR Inhibitor WYE-23; Methyl 4-[6-[4-(cyclopropylcarbamoylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate. Grades: ≥98%. CAS No. 1062169-46-3. Molecular formula: C26H32N8O4. Mole weight: 520.6. | |
WYE-28 Quick inquiry Where to buy Suppliers range | WYE-23 is an ATP-competitive inhibitor of mTOR with IC50 value of 0.08 nM. Synonyms: Methyl 4-[6-[4-[[4- (hydroxymethyl) phenyl]carbamoylamino]phenyl]-4-morpholin-4-ylpyrazolo[3, 4-d]pyrimidin-1-yl]piperidine-1-carboxylate. Grades: ≥98%. CAS No. 1062172-60-4. Molecular formula: C30H34N8O5. Mole weight: 586.6. | |
WYE-354 Quick inquiry Where to buy Suppliers range | WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. Synonyms: WYE354; WYE-354; WYE 354. Grades: 0.98. CAS No. 1062169-56-5. Molecular formula: C24H29N7O5. Mole weight: 495.54. | |
WYE 672 Quick inquiry Where to buy Suppliers range | WYE 672 is a tissue selective liver X receptor (LXR) agonist selectively binds to LXRα (IC50 >1.0 μM). Synonyms: WYE 672; WYE672; WYE-672; 3-methyl-2-[4-(3-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)quinoxaline. Grades: 99%. CAS No. 1221265-37-7. Molecular formula: C23H17F3N2O2S. Mole weight: 442.45. | |
WYE-687 Quick inquiry Where to buy Suppliers range | WYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to mTorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer. Group: Biochemicals. Alternative Names: Methyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d] pyrimidin-6-yl)phenylcarbamate Acid. Grades: Highly Purified. CAS No. 1062161-90-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
WYE-687 Quick inquiry Where to buy Suppliers range | WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM. Synonyms: WYE687; WYE 687; WYE-687. Grades: 0.98. CAS No. 1062161-90-3. Molecular formula: C28H32N8O3. Mole weight: 528.617. | |
WYE 687 dihydrochloride Quick inquiry Where to buy Suppliers range | WYE 687 is an ATP-competitive inhibitor of mTOR with IC50 value of 7 nM. It was shown to inhibit phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt. It also blocks VEGF secretion and HIF-1α expression. Synonyms: N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1702364-87-1. Molecular formula: C28H32N8O32HCl. Mole weight: 601.53. | |
WYE 687 Dihydrochloride (Potent and Selective mTOR Inhibitor, N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyr idinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyr imidin-6-yl]phenyl]-carbamic acid methyl ester hydrochloride) Quick inquiry Where to buy Suppliers range | Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7nm). Displays selectivity for mTOR over PI 3-Kalpha (~100-fold) and PI 3-Kgamma (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1alpha expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1062161-90-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
wyosine Quick inquiry Where to buy Suppliers range | Wyosine is a compound commonly found in transfer RNA (tRNA) molecules. It plays a significant role in stabilizing the anticodon loop of tRNA aiding in accurate protein synthesis. Wyosine has been studied in various diseases, such as cancer and viral infections, due to its involvement in tRNA function and cellular processes. Synonyms: 9H-Imidazo[1,2-a]purin-9-one, 3,4-dihydro-4,6-dimethyl-3-b-D-ribofuranosyl-; {3H-Diimidazo[1,2-a:4',5'-d]pyrimidin-9-one} 4,9-dihydro-4,6-dimethyl-3-B-D-ribofuranosyl-; 3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4,6-dimethyl-imidazo[1,2-a]purin-9-one. CAS No. 52662-10-9. Molecular formula: C14H17N5O5. Mole weight: 335.32. | |
WZ-3146 Quick inquiry Where to buy Suppliers range | WZ-3146 is an irreversiblely inhibitor against EGFR T790M with potential anticancer activity. Synonyms: WZ3146; WZ 3146. Grades: 0.98. CAS No. 1214265-56-1. Molecular formula: C24H25ClN6O2. Mole weight: 464.954. | |
WZ-4002 Quick inquiry Where to buy Suppliers range | WZ-4002 is an EGFR phosphorylation inhibitor with selectivity for EGFR T790M. It has a framework of pyrimidine compound which is different from other EGFR inhibitors. WZ-4002 exhibits anti-tumor activity. Uses: Protein kinase inhibitors. Synonyms: WZ4002; N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide; WZ 4002. CAS No. 1213269-23-8. Molecular formula: C25H27ClN6O3. Mole weight: 494.98. | |
WZ 4003 Quick inquiry Where to buy Suppliers range | WZ 4003. Group: Biochemicals. Grades: Purified. CAS No. 1214265-58-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
WZ4003 Quick inquiry Where to buy Suppliers range | WZ4003 exhibits a high, specific affinity to the L858R/T790M mutant EGFR, while a significantly reduced cellular IC50 against T790M containing Ba/F3 cells. Synonyms: WZ4003; WZ-4003; WZ 4003. Grades: >98%. CAS No. 1214265-58-3. Molecular formula: C25H29ClN6O3. Mole weight: 496.99. | |
WZ-8040 Quick inquiry Where to buy Suppliers range | WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor with potential anticancer activity. WZ8040 is about 30-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than other quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ-8040 may be clinically more effective and better tolerated than quinazoline-based inhibitors. Synonyms: WZ8040; WZ 8040. Grades: 0.98. CAS No. 1214265-57-2. Molecular formula: C24H25ClN6OS. Mole weight: 481.015. | |
WZ 811 Quick inquiry Where to buy Suppliers range | WZ 811. Group: Biochemicals. Grades: Purified. CAS No. 55778-02-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
WZ 811 Quick inquiry Where to buy Suppliers range | WZ 811 is a potent CXCR2 antagonist. Synonyms: N,N'-di-2-pyridinyl-1,4-benzenedimethanamine; WZ811; WZ-811; WZ 811. CAS No. 55778-02-4. Molecular formula: C18H18N4. Mole weight: 290.36. | |
WZ811 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 55778-02-4. Pack Sizes: 5MG, 25MG. Mole weight: 290.36. Catalog: AP55778024. Assay: ≥98% (HPLC). | |
WZB 117 Quick inquiry Where to buy Suppliers range | WZB 117 is a GLUT inhibitor (Ki(app) = 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively) that inhibits passive glucose transport in human erythrocytes and cancer cell lines. It decreases extracellular lactate and intracellular ATP levels. WZB 117 was shown to attenuate erythrocyte 3-O-metylglucose (3MG) uptake in vitro (Ki = 6 μM) and inhibits tumor growth in a nude mouse model. Synonyms: WZB117; WZB-117; WZB 117; 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate). Grades: ≥98% by HPLC. CAS No. 1223397-11-2. Molecular formula: C20H13FO6. Mole weight: 368.31. |