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8-pCPT-2'-O-Me-Ado is the potential metabolite of 8-pCPT-2'-O-Me-cAMP, a specific Epac activator. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methyladenosine. Grades: ≥ 98% by HPLC. CAS No. 1187179-96-9. Molecular formula: C17H18ClN6O4S. Mole weight: 423.9.
8-pCPT-2'-O-Me-cAMP
8-pCPT-2'-O-Me-cAMP is a PDE-stable activator of the exchange protein activated by cAMP (Epac) or cAMP-GEF, which does not activate protein kinase A. It has high lipophilicity and membrane permeability. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥98% by HPLC. CAS No. 634207-53-7. Molecular formula: C17H16ClN5O6PS · Na. Mole weight: 507.8.
8-pCPT-2'-O-Me-cAMP-AM
8-pCPT-2'-O-Me-cAMP-AM is a precursor of 8-pCPT-2'-O-Me-cAMP, the specific Epac agonist. 8-pCPT-2'-O-Me-cAMP is released after the metabolism of 8-pCPT-2'-O-Me-cAMP-AM by esterases. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grades: ≥ 97% by HPLC for mixture of isomers. CAS No. 1152197-23-3. Molecular formula: C20H21ClN5O8PS. Mole weight: 557.9.
Selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage. Group: Biochemicals. Grades: Highly Purified. CAS No. 1152197-23-3. Pack Sizes: 100ug. US Biological Life Sciences.
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8-pCPT-2'-O-Me-cGMP
8-pCPT-2'-O-Me-cGMP is a PDE-stable, high lipophilic and membrane-permeant analogue. It can be used as a control since it has no activated effect on protein kinase G or Epac. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 625112-42-7. Molecular formula: C17H16ClN5O7PS · Na. Mole weight: 523.8.
8-pCPT-2'-O-Me-cXMP
8-pCPT-2'-O-Me-cXMP can be used as a control since it has no activated effect on protein kinase G or Epac. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methylxanthosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C17H15ClN4O8PS · Na. Mole weight: 524.8.
8-pCPT-2'-O-Me-Guo
8-pCPT-2'-O-Me-Guo is the potential metabolite of the PKG- and Epac-inactive cGMP analogue8-pCPT-2'-O-Me-cGMP. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methylguanosine. Grades: ≥ 97 % by HPLC. CAS No. 966936-60-6. Molecular formula: C17H18ClN6O6S. Mole weight: 439.9.
8-pCPT-5'-AMP
8-pCPT-5'-AMP is a potential metabolite of 8-pCPT-cAMP that inhibits 5'-IMP dehydrogenase. Synonyms: 8-(4-chlorophenylthio)adenosine-5'-O-monophosphate. Grades: ≥ 97 % by HPLC. CAS No. 78710-84-6. Molecular formula: C16H17ClN5O7PS. Mole weight: 489.83.
8-pCPT-Ado
8-pCPT-Ado is the potential metabolite of 8-CPT-cAMP. Synonyms: 8- (4- Chlorophenylthio)adenosine. Grades: ≥ 97 % by HPLC. CAS No. 86362-87-0. Molecular formula: C16H16ClN6O4S. Mole weight: 409.9.
8-pCPT-cGMP
8-pCPT-cGMP is a selective activator of cGMP-dependent protein kinase type I α and type II, as well as of cGMP-gated ion channels. It has higher membrane permeability and stability towards many phosphodiesterases. Synonyms: 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 51239-26-0. Molecular formula: C16H14ClN5O7PS · Na. Mole weight: 509.8.
8-pCPT-cGMP-AM
8-pCPT-cGMP-AM is a precursor of 8-pCPT-cGMP, the PKG activator. 8-pCPT-cGMP is released after the metabolism of 8-pCPT-cGMP-AM by esterases. Synonyms: 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grades: ≥ 97% by HPLC for mixture of isomers. CAS No. 272445-72-4. Molecular formula: C19H19ClN5O9PS. Mole weight: 559.9.
8-Pcpt-cGMP sodium
8-Pcpt-cGMP sodium is the sodium salt form of 8-Pcpt-cGMP (HY-137016). 8-Pcpt-cGMP sodium is an agonist for cyclic nucleotide-gated (CNG) channel with an EC 50 of 0.5 μM. 8-Pcpt-cGMP sodium exhibits good membrane permeability. 8-Pcpt-cGMP sodium can be used in studies about the function of CNG channels in visual signal transduction and olfactory transduction [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 51239-26-0. Pack Sizes: 5 mg. Product ID: HY-137016A.
8-pCPT-Guo
8-pCPT-Guo, a remarkable agonist with potent effects on the adenosine receptors, specifically targeting adenosine A1R and A3R. Scientific research has found it instrumental in exploring the diverse physiological mechanisms of these receptors. Furthermore, the drug holds immense potential as a treatment option for a range of debilitating conditions such as inflammation, cancer, and neurological disorders. With its multidimensional qualities, 8-pCPT-Guo stands as a compelling player in the medical research landscape. Molecular formula: C16H16ClN6O6S. Mole weight: 426.9.
8-pCPT-PET-cGMP
8-pCPT-PET-cGMP is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to 8-Br-PET-cGMP, 8-pCPT-PET-cGMP is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C24H18ClN5O7PS · Na. Mole weight: 609.9.
8-phenyl-1-naphthalenyl boronic acid
8-phenyl-1-naphthalenyl boronic acid. Group: other electronic materials. CAS No. 181135-36-4. Product ID: (8-phenylnaphthalen-1-yl)boronic acid. Molecular formula: 248.1g/mol. Mole weight: C16H13BO2. B (C1=C2C (=CC=C1)C=CC=C2C3=CC=CC=C3) (O)O. InChI=1S/C16H13BO2/c18-17 (19)15-11-5-9-13-8-4-10-14 (16 (13)15)12-6-2-1-3-7-12/h1-11, 18-19H. QBNRXBKYDVJTHS-UHFFFAOYSA-N.
Heterocyclic Organic Compound. CAS No. 120375-41-9. Catalog: ACM120375419.
8-[φ-450]-cAMP
8-[φ-450]-cAMP can be used for studies with intact cells for its excellent lipophilicity and bright green fluorescence. Synonyms: 8-[Pharos-450]-adenosine-3',5'-cyclic monophosphate. Grades: ≥ 98% by HPLC.
8-[φ-450]-cGMP
8-[φ-450]-cGMP can be used for studies with intact cells for its excellent lipophilicity and bright green fluorescence. Synonyms: 8-[Pharos-450]-guanosine-3',5'-cyclic monophosphate. Grades: ≥ 98% by HPLC.
8-[φ-575]-2'-O-Me-cAMP
8-[φ-575]-2'-O-Me-cAMP can be used for studies with intact cells for its excellent lipophilicity and bright red fluorescence. Synonyms: 8-[Pharos-575]-2'-O-methyladenosine-3',5'-cyclic monophosphate. Grades: ≥ 98% by HPLC. Mole weight: 731.
8-[φ-575]-cAMP
8-[φ-575]-cAMP can be used for studies with intact cells for its excellent lipophilicity and bright red fluorescence. A tiny hypsochromic shift would be developed while binding to PKA. Synonyms: 8-[Pharos-575]-adenosine-3',5'-cyclic monophosphate. Grades: ≥ 98% by HPLC.
8-[φ-575]-cGMP
8-[φ-575]-cGMP is a fuorescent analogue of cGMP, which can be used for studies with intact cells on account of its high lipophilicity and bright red fluorescence. Synonyms: 8-[Pharos-575]-guanosine-3',5'-cyclic monophosphate. Grades: ≥ 98% by HPLC. Mole weight: 500.4.
8-pHPT-2'-O-Me-cAMP
8-pHPT-2'-O-Me-cAMP is an activator of the exchange protein activated by cAMP (Epac) or cAMP-GEF, which does not activate protein kinase A. It has superior lipophilicity, membrane permeability and PDE stability. Synonyms: 8- (4- Hydroxyphenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate , sodium salt. Grades: ≥ 98% by HPLC. CAS No. 612513-15-2. Molecular formula: C17H17N5O7PS · Na. Mole weight: 489.4.
8-PIP-cAMP
8-PIP-cAMP is a selective cAMP analogue with a preference for site A of protein kinase A type I and for site B of type II. Compared to cAMP, it has superior stability and membrane permeability. Synonyms: 8- Piperidinoadenosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 31357-06-9. Molecular formula: C15H20N6O6P · Na. Mole weight: 434.3.
8-pMeOPT-2'-O-Me-cAMP is a specific activator of the exchange protein activated by cAMP (Epac) or cAMP-GEF, which does not activate protein kinase A. It is highly lipophilic, membrane-permeant and stable for PDE. Synonyms: 8- (4- Methoxyphenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 612513-16-3. Molecular formula: C18H19N5O7PS · Na. Mole weight: 503.4.
8-pMeOPT-Ado
8-pMeOPT-Ado is a remarkably potent and preferential activator of adenosine receptors, has established itself as an indispensable tool within the realm of biomedical investigation. This exquisite compound serving as an unrivaled agent for deciphering the intricate involvements of adenosine receptors in multifarious pathological states, encompassing cardiac afflictions, inflammatory cascades is as well as neurodegeneration. Synonyms: 8- (4- Methoxyphenylthio)adenosine. Grades: ≥ 97 % by HPLC. CAS No. 696674-66-8. Molecular formula: C17H19N6O6S. Mole weight: 406.4.
8-prenylnaringenin is a prenylflavonoid isolated from hop cones Humulus lupulus , with cytotoxicity. 8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis. 8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 53846-50-7. Pack Sizes: 5 mg. Product ID: HY-N2787.
8-Propyl Etodolac
A derivative of Etodolac. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2. Synonyms: 1-Ethyl-1,3,4,9-tetrahydro-8-propyl-pyrano[3,4-b]indole-1-acetic Acid. Grades: > 95%. CAS No. 57817-27-3. Molecular formula: C18H23NO3. Mole weight: 301.39.
8-Propyl Etodolac
8-Propyl Etodolac. Group: Biochemicals. Alternative Names: 1-Ethyl-1,3,4,9-tetrahydro-8-propyl-pyrano[3,4-b]indole-1-acetic Acid; NSC 282127. Grades: Highly Purified. CAS No. 57817-27-3. Pack Sizes: 2.5mg. Molecular Formula: C18H23NO3, Molecular Weight: 301.38. US Biological Life Sciences.
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8-Propyl Etodolac-d3
8-Propyl Etodolac-d3. Group: Biochemicals. Alternative Names: 1-Ethyl-1,3,4,9-tetrahydro-8-propyl-pyrano[3,4-b]indole-1-acetic Acid-d3; NSC 282127-d3. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C18H20D3NO3, Molecular Weight: 304.399999999999. US Biological Life Sciences.
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8-PT-Ado
8-PT-Ado, a nucleoside analog employed for biomedical research, holds promise as an antiviral and anticancer drug. Notably, potency against leukemia and herpes simplex virus has been found. Engaging apoptosis induction, DNA synthesis inhibition, and DNA methyltransferase interference, 8-PT-Ado has also been seen to suppress the NF-κB pathway. This pathway is critical for the progression of inflammation and cancer. Synonyms: 8- Phenylthioadenosine. Grades: ≥ 97 % by HPLC. Molecular formula: C16H17N6O4S. Mole weight: 376.4.
8-p-Toluidinonaphthalene-1-sulfonic acid
Heterocyclic Organic Compound. Alternative Names: 8-p-toluidinonaphthalene-1-sulphonic acid;8-(P-toluidino)naphthalene-1-sulfonic acid;Tolyl peri acid;8-(4-Aminotoluene)-1-naphthalenesulfonic acid;1-(p-Tolylamino)-8-naphthalenesulfonic acid;N-p-Tolyl-peri acid;8-(4-methylanilino)naphthalene-1-sulfonic a. CAS No. 129-90-8. Molecular formula: C17H15NO3S. Mole weight: 313.37. Catalog: ACM129908.
8R-Brassicasterol is a by-product in the synthesis of Brassicasterol (B676850). Brassicasterol is a phytosterol found in canola oil, rapeseed oil, marine algae and shellfish. This compound has been shown to inhibit sterol Δ24-reductase, an enzyme involved in the mammalian cholesterol biosynthesis pathway. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C28H46O. US Biological Life Sciences.
Fatty Acids and Ester Derivatives. Alternative Names: 8(R)-Hydroxyoctadecanoic acid. CAS No. 1212331-85-5. Molecular formula: C18H36O3. Mole weight: 300.48. Purity: 98%+. Catalog: ACM1212331855.
8S-Cabergoline
8S-Cabergoline. Group: Biochemicals. Alternative Names: (8α)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide. Grades: Highly Purified. CAS No. 856676-33-0. Pack Sizes: 1mg. Molecular Formula: C26H37N5O2, Molecular Weight: 451.6. US Biological Life Sciences.
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8(S)-Hepe
Heterocyclic Organic Compound. Alternative Names: (8)S-HEPE;8S-HYDROXY-5Z,9E,11Z,14Z,17Z-EICOSAPENTAENOIC ACID. CAS No. 118492-81-2. Molecular formula: C20H30O3. Mole weight: 318.5. Canonical SMILES: CC / C=C\\\\C / C=C\\\\C / C=C\\\\C=C\\\\[C@H] (C / C=C\\\\CCCC (=O) O) O. Catalog: ACM118492812.
8(S)-HEPE
8(S)-HEPE is a monohydroxy fatty acid produced by lipoxygenase oxidation of EPA. It acts to promote hatching of barnacle eggs at 10 nM, although it is not clearly identified as the natural egg hatching factor. Uses: Scientific research. Group: Signaling pathways. CAS No. 118492-81-2. Pack Sizes: 25 μg (314.02 μM * 250 μL in Ethanol); 50 μg (314.02 μM * 500 μL in Ethanol). Product ID: HY-126108A.
8(S)-HETE
8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. Synonyms: 8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid. Grades: ≥98%. CAS No. 98462-03-4. Molecular formula: C20H32O3. Mole weight: 320.5.
8-Shogaol
8-Shogaol. Group: Biochemicals. Grades: Plant Grade. CAS No. 36700-45-5. Pack Sizes: 10mg. Molecular Formula: C19H28O3, Molecular Weight: 304.43. US Biological Life Sciences.
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8-Styryl-dG CEP
8-Styryl-dG CEP, an indispensable compound within the realm of biomedicine, assumes a pivotal role. It facilitates the creation of modified nucleosides and oligonucleotides, thus serving as a fundamental constituent. This compound's distinct structural attributes contribute significantly to drug development and therapies associated with DNA alterations, genetic manipulation, and gene suppression. CAS No. 1101864-12-3. Molecular formula: C51H59N8O7P. Mole weight: 927.04.
8-TEMPO-aminoadenosine Cyclic 3',5'-Monophosphate, a spin-labeled cyclic nucleotide used for the mapping of the cAMP site of protein kinase I from rabbit skeletal muscle. Synonyms: 4-[[6-Amino-9-(3,5-O-phosphinico-β-D-ribofuranosyl)-9H-purin-8-yl]amino]-2,2,6,6-tetramethyl-1-piperidinyloxy; 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, 1-Piperidinyloxy Deriv. CAS No. 54606-91-6. Molecular formula: C19H29N7O7P. Mole weight: 498.45.
8-TEMPO-aminoadenosine Cyclic 3,5-Monophosphate
8-TEMPO-aminoadenosine Cyclic 3,5-Monophosphate. Group: Biochemicals. Alternative Names: 4-[[6-Amino-9-(3,5-O-phosphinico- β-D-ribofuranosyl)-9H-purin-8-yl]amino]-2,2,6,6-tetramethyl-1-piperidinyloxy; 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, 1-Piperidinyloxy Deriv. Grades: Highly Purified. CAS No. 54606-91-6. Pack Sizes: 2.5mg. Molecular Formula: C19H29N7O7P, Molecular Weight: 498.45. US Biological Life Sciences.
8- ( (tert-Butyldimethylsilyl) oxy) -5-methyloctan-2-ol is an intermediate in the synthesis of secondary oxidized metabolites of the di (isononyl)cyclohexane-1, 2-dicarboxylate (DINCH) monoester (MINCH) and may be used as biomarkers of DINCH exposure. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 50mg. Molecular Formula: C15H34O2Si. US Biological Life Sciences.
8-Thioguanosine. Group: Biochemicals. Alternative Names: 8-Mercaptoguanosine. Grades: Highly Purified. CAS No. 26001-38-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C10H13N5O5S. US Biological Life Sciences.
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8-Thioguanosine
8-Thioguanosine is a significant compound exhibiting remarkable capabilities in studying viral infections and cancer. By proficiently curtailing viral RNA and DNA replication, it effectively subdues the menace of virulence, while concurrently impeding the enhancement of nucleic acids within cancerous cells. Uses: Adjuvants, immunologic. Synonyms: 8-Mercaptoguanosine; 8-SH-Guo; 2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-mercapto-1H-purin-6(9H)-one; 7,8-Dihydro-8-thioxoguanosine; 8-Mercapto-7,8-dihydroguanosin; 8-Tio-Guanosine. Grades: ≥97% by HPLC. CAS No. 26001-38-7. Molecular formula: C10H13N5O5S. Mole weight: 315.31.
8- (Tributylammonium) octyl Bromide
8- (Tributylammonium) octyl Bromide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences.