A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
N(6)-Carboxymethyllysine (CML), also known as N(epsilon)-(carboxymethyl)lysine, is an advanced glycation endproduct(AGE). CML has been the most used marker for AGEs in food analysis. Uses: Cel and cml are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions. Synonyms: Lys(Cm); 2-Amino-6-(carboxymethyl-amino)-hexanoic Acid; N6-(Carboxymethyl)lysine; N6-(Carboxymethyl)-L-lysine; CML; Nε-(1-Carboxymethyl)-L-lysine; Ne-Carboxymethyl-L-lysine; NECML; N(epsilon)-(Carboxymethyl)lysine; (S)-2-Amino-6-(carboxymethylamino)hexanoic acid; (2S)-2-amino-6-(carboxymethylamino)hexanoic acid; n'-(carboxymethyl)lysine. Grades: ≥ 97% (Assay by titration). CAS No. 5746-4-3. Molecular formula: C8H16N2O4. Mole weight: 204.22.
Nε-Crotonyl-L-lysine
A reagent used in peptide synthesis and drug screening. Synonyms: L-Lys(crotonyl)-OH; (S)-2-Amino-6-(but-2-enamido)hexanoic acid; N6-(1-Oxo-2-buten-1-yl)-L-lysine. Grades: ≥ 99% (HPLC). CAS No. 1338823-35-0. Molecular formula: C10H18N2O3. Mole weight: 214.20.
N-ε-Isopropyl-L-lysine is an alkylated version of Lysine. H-Lysine(Isopropyl)-OH was found in the plasma and urine of rats fed with isopropylated casein. Synonyms: H-Lys(Isopropyl)-OH. CAS No. 5977-9-3. Molecular formula: C9H20N2O2. Mole weight: 188.27.
Used for the preparation of sugar specific antibodies using liposomes. Uses: Used for the preparation of sugar specific antibodies using liposomes. Synonyms: [6-(β-D-Galactopyranosylamino)-6-oxohexyl]carbamic Acid Phenylmethyl Ester; N-N-Benzyloxycarbonyl-ε-aminocaproyl-β-D-galactopyranosylamine. CAS No. 38822-58-1. Molecular formula: C20H30N2O8. Mole weight: 426.46.
Used in the preparation of lipophilic human glucagon-like peptide-1 derivatives with protracted action profiles. Group: Biochemicals. Alternative Names: Nε-Palmitoyl-Glu-γ-succinimidyl-α-tert-butyl Ester; (2S)-. Grades: Highly Purified. CAS No. 204521-63-1. Pack Sizes: 100mg. US Biological Life Sciences.
NeQuinate. Group: Biochemicals. Grades: Highly Purified. CAS No. 13997-19-8. Pack Sizes: 5mg, 10mg, 25mg. US Biological Life Sciences.
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Neramexane
Neramexane is a drug related to memantine, which acts as an NMDA antagonist and has neuroprotective effects. Synonyms: KRP-209; 1,3,3,5,5-Pentamethylcyclohexanamine. Grades: > 95%. CAS No. 219810-59-0. Molecular formula: C11H23N. Mole weight: 169.31.
Neramexane mesylate
Neramexane mesylate. Group: Biochemicals. Grades: Highly Purified. CAS No. 457068-92-7. Pack Sizes: 50g, 100g. Molecular Formula: C11H23N·CH4O3S. US Biological Life Sciences.
Worldwide
Nerandomilast
Nerandomilast (BI 1015550) is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. Nerandomilast has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BI 1015550. CAS No. 1423719-30-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153192.
Neratinib
Neratinib. Group: Biochemicals. Alternative Names: (2E) -N-[4-[[3-Chloro-4- (2-pyridinylmethoxy) phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4- (dimethylamino) -2-butenamide; HKI 272. Grades: Highly Purified. CAS No. 698387-09-6. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Neratinib
Neratinib (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC 50 s of 59 nM and 92 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HKI-272. CAS No. 698387-09-6. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-32721.
Neratinib
Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells. Synonyms: HKI-272; HKI 272; HKI272; PB-272; PB 272; PB 272. Grades: >98%. CAS No. 698387-09-6. Molecular formula: C30H29ClN6O3. Mole weight: 557.051.
Neratinib Dimethylamine-N-oxide (M7)
An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: 2-Butenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethyloxidoamino)-, (2E)-. Grades: ≥95%. CAS No. 1376615-55-2. Molecular formula: C30H29ClN6O4. Mole weight: 573.04.
Neratinib Impurity 1
An impurity of Neratinib, which is irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: N,3-bis(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxy-3-methylquinolin-6-yl)-2-oxopropanamide. Grades: > 95%. Molecular formula: C50H38Cl2N10O6. Mole weight: 945.83.
Neratinib Impurity 10
An impurity of Neratinib, which is irreversible inhibitor of the HER-11 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxy-6-(2-hydroxy-5-oxopyrrolidin-1-yl)quinoline-3-carbonitrile. Grades: > 95%. Molecular formula: C28H24ClN5O4. Mole weight: 529.99.
Neratinib Impurity 11
An impurity of Neratinib, which is irreversible inhibitor of the HER-12 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: N1-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-N2,N2-dimethyloxalamide. Grades: > 95%. Molecular formula: C28H25ClN6O4. Mole weight: 545.
Neratinib Impurity 12
An impurity of Neratinib, which is irreversible inhibitor of the HER-13 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-methyl-2,3-dioxopiperidine-4-carboxamide. Grades: > 95%. Molecular formula: C31H27ClN6O5. Mole weight: 599.05.
Neratinib Impurity 13
An impurity of Neratinib, which is irreversible inhibitor of the HER-14 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: N1-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)oxalamide. Grades: > 95%. Molecular formula: C26H21ClN6O4. Mole weight: 516.95.
Neratinib Impurity 2
An impurity of Neratinib, which is irreversible inhibitor of the HER-3 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)formamide. Grades: > 95%. Molecular formula: C25H20ClN5O3. Mole weight: 473.92.
Neratinib Impurity 3
An impurity of Neratinib, which is irreversible inhibitor of the HER-4 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: (E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide. Grades: > 95%. Molecular formula: C30H29ClN6O4. Mole weight: 573.06.
Neratinib Impurity 33
Neratinib Impurity 33. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1222172-49-7. Molecular formula: C12H16N2O4. Mole weight: 252.27. Catalog: APB1222172497.
Neratinib Impurity 34
Neratinib Impurity 34. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1222172-50-0. Molecular formula: C15H17N3O4. Mole weight: 303.32. Catalog: APB1222172500.
Neratinib Impurity 4
An impurity of Neratinib, which is irreversible inhibitor of the HER-5 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: (E)-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-6-(4-(dimethylamino)but-2-enamido)-7-ethoxyquinoline 1-oxide. Grades: > 95%. Molecular formula: C30H29ClN6O4. Mole weight: 573.06.
Neratinib Impurity 5
An impurity of Neratinib, which is irreversible inhibitor of the HER-6 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: 2-((4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)amino)-2-oxoacetic acid. Grades: > 95%. Molecular formula: C26H20ClN5O5. Mole weight: 517.93.
Neratinib Impurity 6
Neratinib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 102137-46-2. Molecular formula: C12H12N2O. Mole weight: 200.24. Catalog: APB102137462.
Neratinib Impurity 6
An impurity of Neratinib, which is irreversible inhibitor of the HER-7 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-((dimethylamino)methyl)oxirane-2-carboxamide. Grades: > 95%. Molecular formula: C30H29ClN6O4. Mole weight: 573.06.
Neratinib Impurity 7
An impurity of Neratinib, which is irreversible inhibitor of the HER-8 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3,4-bis(dimethylamino)butanamide. Grades: > 95%. Molecular formula: C32H36ClN7O3. Mole weight: 602.14.
Neratinib Impurity 8
An impurity of Neratinib, which is irreversible inhibitor of the HER-9 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: (E)-4-((4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)amino)-N,N,N-trimethyl-4-oxobut-2-en-1-aminium. Grades: > 95%. Molecular formula: C31H32ClN6O3. Mole weight: 572.09.
Neratinib Impurity 8
Neratinib Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 105326-69-0. Molecular formula: C12H11ClN2O. Mole weight: 234.68. Catalog: APB105326690.
Neratinib Impurity 9
An impurity of Neratinib, which is irreversible inhibitor of the HER-10 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: (E)-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxy-6-((1-methylpyrrolidin-2-ylidene)amino)quinoline-3-carbonitrile. Grades: > 95%. Molecular formula: C29H27ClN6O2. Mole weight: 527.03.
Neratinib Impurity QL
An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: Neratinib Impurity QL. Grades: ≥95%. CAS No. 1469746-91-5. Molecular formula: C30H30N6O3. Mole weight: 522.60.
Neratinib Impurity QLAJ
An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C24H21N5O2. Mole weight: 411.47.
Neratinib Impurity SMQA
An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C12H11ClN2O2. Mole weight: 250.68.
Neratinib Impurity SMYXJ
An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C12H9ClN2O2. Mole weight: 248.67.
Neratinib Impurity XA
An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: (E)-4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-(4-(dimethylamino)but-2-enamido)-7-ethoxyquinoline-3-carboxamide; 1376619-98-5. Grades: ≥95%. CAS No. 1376619-98-5. Molecular formula: C30H31ClN6O4. Mole weight: 575.06.
Neratinib Impurity XAAJ
An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C24H22ClN5O3. Mole weight: 463.92.
Neratinib maleate
Neratinib (HKI-272) maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC 50 s of 59 nM and 92 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HKI-272 maleate. CAS No. 915942-22-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32721B.
Neridronic acid is a Bone resorption factor inhibitor and it can be used to treat Osteogenesis imperfecta and Paget's disease of bone. Uses: Osteogenesis imperfecta;paget's disease of bone. Synonyms: Neridronate; Neridronic acid; Nerixia;(6-Amino-1-hydroxyhexylidene)diphosphonic acid;80729-79-9(Sodium salt). Grades: 97%. CAS No. 79778-41-9. Molecular formula: C6H17NO7P2. Mole weight: 277.15.
Neridronate
Neridronate is an aminobisphosphonate, licensed in Italy for the treatment of osteogenesis imperfecta (OI) and Pagets disease of bone (PDB). Neridronate is effective also in other skeletal diseases such as osteoporosis, algodystrophy, hypercalcemia of malignancy, and bone metastases [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 79778-41-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119443.
Neridronate
Neridronate. Group: Biochemicals. Alternative Names: 6-Amino-1-hydroxyhexylidene bisphosphonic acid. Grades: Highly Purified. CAS No. 79778-41-9. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C6H17NO7P2. US Biological Life Sciences.