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(-)-Nebivolol. Group: Biochemicals. Alternative Names: (a-S, a'S, 2R, 2'S)-a, a'-[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol]; [2S-[2R*[R*[R* (S*)]]]]-a, a'-[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol. Grades: Highly Purified. CAS No. 118457-16-2. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C22H25F2NO4. US Biological Life Sciences.
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(-)-Nebivolol-d4 Hydrochloride
Labeled (-)-Nebivolol. A β1-Adrenergic blocker. Used as an antihypertensive. Group: Biochemicals. Alternative Names: (α S, α S, 2R, 2S)-α , α -[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol]-d4 Hydrochloride; [2S-[2R*[R*[R* (S*)]]]]-α , α '-[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol-d4 Hydrochloride. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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(2S*,2'S*)-Nebivolol Impurity C
An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.15 nM. Grade: > 95%. CAS No. 876514-31-7. Molecular formula: C11H11FO2. Mole weight: 194.21.
N-Benzyl (-)-Nebivolol
(-)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (α S, α 'S, 2R, 2'S) -α , α '-[[ (Phenylmethyl) imino]bis (methylene) ]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol. Grades: Highly Purified. CAS No. 1199945-26-0. Pack Sizes: 5mg. US Biological Life Sciences.
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(+)-Nebivolol
Dexnebivolol is an enantiomer of Nebivolol which is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and left ventricular failure in Europe. It is highly cardioselective under certain circumstances. Uses: Treatment of hypertension and left ventricular failure. Synonyms: R67138; R-67138; R 67138; Dexnebivolol; (S,R,R,R)-nebivolol; Bystolic; D-Nebivolol; (αR,α'R,2R,2'S)-α,α'-[IMinobis(Methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-Methanol]. Grade: 95%. CAS No. 118457-15-1. Molecular formula: C22H25F2NO4. Mole weight: 405.44.
(±)-Nebivolol-d4 hydrochloride
(±)-Nebivolol-d4 is intended for use as an internal standard for the quantification of nebivolol by GC- or LC-MS. Nebivolol is a potent and selective β1-adrenergic receptor (β1-AR) antagonist (IC50s = 7.41 and 251 nM for β1- and β2-ARs, respectively, in a radioligand binding assay using rabbit lung membrane preparations). It is also selective for β1-ARs over serotonin 5-HT1A and 5-HT2, α1- and α2-adrenergic, histamine H1, and dopamine D2 receptors (IC50s = 27.5 and 2,239, 3,162 and >10,000, 5,623, and 10,000 nM, respectively). Nebivolol inhibits cAMP accumulation induced by norepinephrine in primary rat cardiac cells (IC50 = 22 nM) and induces vasodilation in mouse renal arteries via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 μM). It decreases contraction of isolated human left ventricular trabeculae induced by isoproterenol (IC50 = 7.0 μM) but does not exert intrinsic sympathomimetic activity (ISA). Nebivolol inhibits proliferation of human coronary artery smooth muscle cells (HCASMCs) in the presence and absence of growth factors (IC50s = 6.1, 6.8, 6.4, and 7.7 μM for HCASMCs grown in media containing no growth factor, PDGFBB, basic FGF, and TGF-β1, respectively). Formulations containing nebivolol have been used to treat hypertension. Synonyms: (S,R,R,R)-Nebivolol-d4 Hydrochloride; (1R)-2,2-dideuterio-2-[[(2R)-1,1-dideuterio-2-[(2S)-6-fluo
(+)-Nebivolol-d4 Hydrochloride
Labeled (+)-Nebivolol. A β1-Adrenergic blocker. Used as an antihypertensive. Group: Biochemicals. Alternative Names: (α R, α R, 2R, 2S)-α , α -[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol]-d4; [2R-[2R*[R*[R* (S*)]]]]-α , α '-[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol-d4 Hydrochloride; (S,R,R,R)-Nebivolol-d4 Hydrochloride; Dexnebivolol-d4 Hydrochloride; R 67138-d4; d-Nebivolol-d4 Hydrochloride. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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(Rac)-Nebivolol
(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC 50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (Rac)-R 065824. CAS No. 99200-09-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B0203B.
(1R)-1-((2S)-6-Fluoro-4-Hydroxychroman-2-yl)ethane-1,2-diol is an intermediate in the synthesis of (S,R,R,S)-Nebivolol (N387910), a metabolite in vitro which acts as a β-adrenergic blocker. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 250mg. Molecular Formula: C11H13FO4. US Biological Life Sciences.
(+)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (1R)-1-[(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol. Grades: Highly Purified. CAS No. 303176-45-6. Pack Sizes: 100mg. US Biological Life Sciences.
(+)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (2R)-2-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydro-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 797054-18-3. Pack Sizes: 250mg. US Biological Life Sciences.
(+)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (1R)-1-[(2S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol. Grades: Highly Purified. CAS No. 303176-39-8. Pack Sizes: 100mg. US Biological Life Sciences.
(+)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (2S)-2-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydro-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 797054-19-4. Pack Sizes: 100mg. US Biological Life Sciences.
(-)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (1S)-1-[(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol. Grades: Highly Purified. CAS No. 303176-43-4. Pack Sizes: 100mg. US Biological Life Sciences.
(-)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (2R)-2-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydro-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 797054-21-8. Pack Sizes: 100mg. US Biological Life Sciences.
(-)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (1S)-1-[(2S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol. Grades: Highly Purified. CAS No. 905454-57-1. Pack Sizes: 100mg. US Biological Life Sciences.
(-)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (2S)-2-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydro-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 797054-20-7. Pack Sizes: 250mg. US Biological Life Sciences.
(+)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (2S,αR)-α-(Aminomethyl)-6-fluoro-chroman-2-methanol. Grades: Highly Purified. CAS No. 303176-42-3. Pack Sizes: 25mg. US Biological Life Sciences.
(-)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (2E)-3-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-1-(5-fluoro-2-hydroxyphenyl)-2-propen-1-one. Grades: Highly Purified. CAS No. 797054-17-2. Pack Sizes: 500mg. US Biological Life Sciences.
(+)-Nebivolol intermediate. Group: Biochemicals. Alternative Names: (2E)-3-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-1-(5-fluoro-2-hydroxyphenyl)-2-propen-1-one. Grades: Highly Purified. CAS No. 797054-16-1. Pack Sizes: 500mg. US Biological Life Sciences.
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Nebivolol
Nebivolol. Uses: Designed for use in research and industrial production. Additional or Alternative Names: NEBIVOLOL;dl-Nebivolol;[2R*[R*[R*(S*)]]]-alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol;Unii-030Y90569u. Product Category: Heterocyclic Organic Compound. CAS No. 118457-14-0. Molecular formula: C22H25F2NO4. Mole weight: 405.43. Density: 1.309. Product ID: ACM118457140. Alfa Chemistry ISO 9001:2015 Certified.
1,2:5,6-Di-O-isopropylidene-D-mannitol
Nebivolol intermediate. Group: Biochemicals. Alternative Names: 1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol; D- ( + ) -1, 2: 5, 6-Di-O-isopropyl idenemannitol; D-Mannitol 1,2:5,6-Bis-acetonide; Mannitol Diacetonide; NSC 47987; NSC 67545; NSC 89874. Grades: Highly Purified. CAS No. 1707-77-3. Pack Sizes: 10g. US Biological Life Sciences.
An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.12 nM. Synonyms: 1-(3,4-dihydro-2H-chromen-2-yl)-2-(methylamino)ethanol. Grade: > 95%. Molecular formula: C12H17NO2. Mole weight: 207.27.
An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.13 nM. Synonyms: 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone] HCl. Grade: > 95%. Molecular formula: C22H21F2NO4. HCl. Mole weight: 401.41 36.46.
(2R,2R)-6-Fluoro-2-(2-oxiranyl)chromane
(2R,2R)-6-Fluoro-2-(2-oxiranyl)chromane is an intermediate to synthesize Nebivolol (rac, HCl salt, N387900) which is a β1-Adrenergic blocker. Group: Biochemicals. Grades: Highly Purified. CAS No. 197706-50-6. Pack Sizes: 25mg, 250mg. Molecular Formula: C11H11FO2, Molecular Weight: 194.2. US Biological Life Sciences.
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(2S, 2R)-6-Fluoro-2-(2-oxiranyl)chromane
(2S,2R)-6-Fluoro-2-(2-oxiranyl)chromane is an intermediate to synthesize Nebivolol (rac, HCl salt, N387900) which is a β1-Adrenergic blocker. Group: Biochemicals. Grades: Highly Purified. CAS No. 197706-51-7. Pack Sizes: 10mg, 100mg. Molecular Formula: C11H11FO2, Molecular Weight: 194.2. US Biological Life Sciences.
Worldwide
4-Hydroxy Nebivolol
An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.11 nM. Synonyms: 4-Hydroxy nebivolol hydrochloride; 6-fluoro-2-[2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]-1-hydroxyethyl]-3,4-dihydro-2H-chromen-4-ol; hydrate; hydrochloride. Grade: > 95%. CAS No. 178383-76-1. Molecular formula: C22H25F2NO5. Mole weight: 421.45.
4-Hydroxy Nebivolol, Hydrochloride Hydrate (Mixture of Diastereomers)
A metabolite of Nebivolol. Group: Biochemicals. Alternative Names: 6-Fluoro-α - [ [ [2- (6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-yl) -2-hydroxyethyl] amino] methyl] -3, 4-dihydro-4-hydroxy-2H-1-benzopyran-2-methanol Hydrochloride Hydrate. Grades: Highly Purified. CAS No. 178383-76-1. Pack Sizes: 500ug. US Biological Life Sciences.
Worldwide
6-Fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran-d2 (Mixture of Diastereomers)
Intermediate in the production of labeled Nebivolol. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
6-Fluoro-3, 4-dihydro-α -[[ (benzyl)amino]methyl]-2H-1-benzopyran-2-methanol-d2 (Mixture of Diastereomers)
Intermediate in the production of labeled Nebivolol. Group: Biochemicals. Alternative Names: 6-Fluoro-3, 4-dihydro-α -[[ (phenylmethyl) amino]methyl]-2H-1-benzopyran-2-methanol-d2. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
α-(Aminomethyl)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol (Mixture of Diastereomers)
Intermediate in the preparation of hydroxylated Nebivolol metabolites. Group: Biochemicals. Alternative Names: α-(Aminomethyl)-6-fluoro-chroman-2-methanol. Grades: Highly Purified. CAS No. 897661-66-4. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Desfluoro Nebivolol
An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.18 nM. Synonyms: Defluoro Nebivolol; α-[[[2-(3,4-Dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino]methyl]-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol; 1-(Chroman-2-yl)-2-[2-(6-fluorochroman-2-yl)]- 2-hydroxyethylamino)ethanol. Grade: > 95%. CAS No. 129101-34-4. Molecular formula: C22H26FNO4. Mole weight: 387.46.
Nebivolol
Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 065824. CAS No. 118457-14-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B0203.
Nebivolol EP Impurity A
Nebivolol EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1696472-15-7. Molecular formula: C22H26FNO4. Mole weight: 387.45. Catalog: APB1696472157.
Nebivolol EP Impurity C
Nebivolol EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1224567-85-4. Molecular formula: C29H32ClF2NO4. Mole weight: 532.02. Catalog: APB1224567854.
Nebivolol HCl
Nebivolol HCl. Group: Biochemicals. Grades: Highly Purified. CAS No. 152520-56-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C22H25F2NO4·HCl. US Biological Life Sciences.
Worldwide
Nebivolol hydrochloride
An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.23 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1). Grade: > 95%. CAS No. 169293-50-9. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91.
Nebivolol hydrochloride
Nebivolol hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 152520-56-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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Nebivolol hydrochloride
Nebivolol (R 065824) hydrochloride is an orally active beta receptor blocker and has the high beta(1)-receptor affinity.Nebivolol hydrochloride has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol hydrochloride can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 065824 hydrochloride. CAS No. 152520-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0203A.
A competitive, highly selective beta-1-adrenoceptor antagonist (more than 40-fold selective for beta-1 than beta-2; Ki1 and beta-2, respectively). The most beta-1-selective chemical of the beta-blockers tested so far. Used for treatment of essential hypertension and highly cardioselective. Induces mild vasodialation via a nitric oxide- and cGMP-depedent pathways (EC50 = 11.36uM in renal arteries). Group: Biochemicals. Grades: Highly Purified. CAS No. 152520-56-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Nebivolol Impurity 15
Nebivolol Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1315508-93-0. Molecular formula: C11H12ClFO2. Mole weight: 230.66. Catalog: APB1315508930.
Nebivolol Impurity 16
Nebivolol Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1315508-96-3. Molecular formula: C11H12ClFO2. Mole weight: 230.66. Catalog: APB1315508963.
Nebivolol Impurity 17
Nebivolol Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1315508-95-2. Molecular formula: C11H12ClFO2. Mole weight: 230.66. Catalog: APB1315508952.
Nebivolol Impurity 18
Nebivolol Impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1315508-94-1. Molecular formula: C11H12ClFO2. Mole weight: 230.66. Catalog: APB1315508941.
Nebivolol Impurity 36
Nebivolol Impurity 36. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-methyl 6-fluorochroman-2-carboxylate. CAS No. 1219915-01-1. Molecular formula: C11H11FO3. Mole weight: 210.20. Catalog: APB1219915011.
Nebivolol Impurity 37
Nebivolol Impurity 37. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-ethyl 6-fluorochroman-2-carboxylate. CAS No. 1335103-88-2. Molecular formula: C12H13FO3. Mole weight: 224.23. Catalog: APB1335103882.
Nebivolol Impurity 38
Nebivolol Impurity 38. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-ethyl 6-fluorochroman-2-carboxylate. CAS No. 1335103-90-6. Molecular formula: C12H13FO3. Mole weight: 224.23. Catalog: APB1335103906.
Nebivolol Impurity 39
Nebivolol Impurity 39. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2-chloro-1-(6-fluorochroman-2-yl)ethanone. CAS No. 1219914-99-4. Molecular formula: C11H10ClFO2. Mole weight: 228.65. Catalog: APB1219914994.
Nebivolol Impurity 40
Nebivolol Impurity 40. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-2-chloro-1-(6-fluorochroman-2-yl)ethanone. CAS No. 1219915-00-0. Molecular formula: C11H10ClFO2. Mole weight: 228.65. Catalog: APB1219915000.
Nebivolol Impurity 47
Nebivolol Impurity 47. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2-(benzylamino)-1-((S)-6-fluorochroman-2-yl)ethanol. CAS No. 1030385-16-0. Molecular formula: C18H20FNO2. Mole weight: 301.36. Catalog: APB1030385160.
Nebivolol Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Nebivolol Related Compound B
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
N-Nitroso Nebivolol
Nebivolol derivative, A β1-Adrenergic blocker. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Intermediate in the production of Nebivolol. Group: Biochemicals. Alternative Names: Ethyl 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate. Grades: Highly Purified. CAS No. 99199-61-8. Pack Sizes: 100mg. US Biological Life Sciences.
Intermediate in the production of Nebivolol. Group: Biochemicals. Grades: Highly Purified. CAS No. 99199-62-9. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
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