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| Product | Description | |
|---|---|---|
| (R)-CR8 | Molecular glue; brings about ubiquination and degradation of cyclin K. Synonyms: (R)-CR8; (R)-CR-8; (R)-CR 8; CR8; CR-8; CR 8; CR8 CDK inhibitor; CR8 CDK inhibitor HCl; CR8 CDK inhibitor hydrochloride; (R)-CR8 trihydrochloride. Grade: ≥99% (HPLC). CAS No. 1786438-30-9. Molecular formula: C24H29N7O.3HCl. Mole weight: 540.92. |  |
| (R)-CR8 | (R)-CR8, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC50=0.09 ?M), CDK2/cyclin A (0.072 ?M), CDK2/cyclin E (0.041 ?M), CDK5/p25 (0.11 ?M), CDK7/cyclin H (1.1 ?M), CDK9/cyclin T (0.18 ?M) and CK1?/? (0.4 ?M). (R)-CR8 induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K[3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CR8, (R)-Isomer. CAS No. 294646-77-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18340. (R)?-?CR8 |  |
| (R)-CR8 (2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine) | Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Group: Biochemicals. Alternative Names: 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine. Grades: Highly Purified. CAS No. 294646-77-8. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| CR8 | CR8 is a potent and selective inhibitor of CDK. CR8 is a more potent pyridyl analogue of roscovitine. In comparison to roscovirtine, the compound gains in potency toward CK1, which is involved in amyloid-β formation. The R-CR8 enantiomer is slightly more potent than S. CR8 is around 30 times more potent at cellular assay then roscovitine. (R)?-CR8 induces apoptosis and has neuroprotective effect. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K. Synonyms: (R)-CR8; CR 8; CR-8. Grade: 98%. CAS No. 294646-77-8. Molecular formula: C24H29N7O. Mole weight: 431.544. | |
| Difelikefalin acetate | Difelikefalin is an analgesic opioid peptide acting as a peripherally specific, highly selective agonist of the κ-opioid receptor (KOR). Synonyms: CR845 acetate; CR-845 acetate. CAS No. 1024829-44-4. Molecular formula: C38H57N7O8. Mole weight: 739.90. | |
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