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Product
(R)-CR8 Molecular glue; brings about ubiquination and degradation of cyclin K. Synonyms: (R)-CR8; (R)-CR-8; (R)-CR 8; CR8; CR-8; CR 8; CR8 CDK inhibitor; CR8 CDK inhibitor HCl; CR8 CDK inhibitor hydrochloride; (R)-CR8 trihydrochloride. Grades: ≥99% (HPLC). CAS No. 1786438-30-9. Molecular formula: C24H29N7O.3HCl. Mole weight: 540.92. BOC Sciences 10
(R)-CR8 (2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine) Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Group: Biochemicals. Alternative Names: 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine. Grades: Highly Purified. CAS No. 294646-77-8. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 3
Worldwide
CR8 CR8 is a potent and selective inhibitor of CDK. CR8 is a more potent pyridyl analogue of roscovitine. In comparison to roscovirtine, the compound gains in potency toward CK1, which is involved in amyloid-β formation. The R-CR8 enantiomer is slightly more potent than S. CR8 is around 30 times more potent at cellular assay then roscovitine. (R)?-CR8 induces apoptosis and has neuroprotective effect. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K. Synonyms: (R)-CR8; CR 8; CR-8. Grades: 98%. CAS No. 294646-77-8. Molecular formula: C24H29N7O. Mole weight: 431.544. BOC Sciences 11

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