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| Product | Description | |
|---|---|---|
| (R)-Methotrexate | Cas No. 51865-79-3. |  |
| (R)-Methotrexate N,N-dimethylamide | (R)-Methotrexate N,N-dimethylamide is one of methotrexate impurities. Methotrexate is a Folic Acid antagonist, used as an antineoplastic and antirheumatic. Molecular formula: C22H27N9O4. Mole weight: 481.51. | |
| R-Methotrexate | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. |  |
| (R/S)-Methotrexate N,N-dimethylamide | (R/S)-Methotrexate N,N-dimethylamide is one of methotrexate impurities. Methotrexate is a Folic Acid antagonist, used as an antineoplastic and antirheumatic. Molecular formula: C22H27N9O4. Mole weight: 481.51. | |
| Methotrexate | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standardspharma & vet compounds & metabolitespharma & vet compounds & metabolitesapi standardseuropean pharmacopoeia (ph. eur.)pharmaceutical toxicologypharmacopoeial standards. Alternative Names: L-Amethopterin, 4-Amino-N10-methylfolic acid, Ledertrexate, 4-Amino-10-methylfolic acid, NSC 740, CL 14377, Antifolan, Methoxtrexate, Methylaminopterin, L-(+)-N-[p-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-glutamic acid, Metatrexan, N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(+)-glutamic acid, Amethopterine, 4-Amino-N10-methylpteroylglutamic acid, Methotrexate, R 9985, Methotrexat-Ebewe, Amethopterin, EMT 25299, MTX, Rheumatrex, Trexall, (+)-Amethopterin, Mexate, Emtexate,N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid, L-Methotrexate. | |
| Methyl 4-(Methylamino)benzoate | Methyl 4-(Methylamino)benzoate is used as a reagent in the synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5. Also used in the preparation of hyaluronic acid-methotrexate conjugates as antiarthritic and antiinflammatory agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 18358-63-9. Pack Sizes: 250mg, 500mg. Molecular Formula: C9H11NO2, Molecular Weight: 165.19. US Biological Life Sciences. |  Worldwide |
| 2-(Bromomethyl)acrylic Acid | 2-(Bromomethyl)acrylic Acid. Uses: Reacts with aldehydes and ketones to form α-methylene-butyrolactones. used in the synthesis of methotrexate analogues. Additional or Alternative Names: 2-(bromomethyl)-2-propenoic acid; 2-(bromomethyl)prop-2-enoic acid. Product Category: Polymer/MacromoleculeAcrylate Monomers. Appearance: Beige Crystalline Solid. CAS No. 72707-66-5. Molecular formula: C4H5BrO2. Mole weight: 164.99 g/mol. Purity: 0.98. Canonical SMILES: OC(=O)C(=C)CBr. ECNumber: 276-774-0. Product ID: ACM-MO-72707665. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 4-Fluoro-DL-glutamic Acid | 4-Fluoro-DL-glutamic acid is used as a reagent to synthesize analogues of Methotrexate, which is a folic acid antagonist used as an antineoplastic and antirheumatic. Synonyms: 4-Fluoroglutamic Acid; 4-Fluoroglutamic Acid; DL-4-Fluoroglutamic Acid; 2-Amino-4-fluoropentane-1,5-dioic acid; 4-Fluoro-Glutamic Acid; threo-4-fluoroglutamic acid; D,L-erythro,threo-4-fluoroglutamic acid. Grades: ≥95%. CAS No. 2708-77-2. Molecular formula: C5H8FNO4. Mole weight: 165.12. | |
| 7-Hydroxymethotrexate | 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5939-37-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-130569. |  |
| CHS-828 | CHS-828 is a synthetic guanidine-based small anticancer molecule. CHS 828 was found to exert potent cytotoxic effects in human breast and lung cancer cell lines, with lesser effects on normal fibroblasts and endothelial cells. In nude mice bearing human tumor xenografts, CHS 828, at doses from 20 to 50 mg/kg/day p.o., inhibited the growth of MCF-7 breast cancer tumors and caused regression of NYH small cell lung cancer tumors. Oral administration of CHS 828 once weekly improved efficacy without increasing toxicity. CHS 828 was found to compare favorably with established chemotherapeutic agents such as cyclophosphamide, etoposide, methotrexate, and paclitaxel. In mice with NYH tumors, long-term survival (>6 months) was observed after treatment with CHS 828 was stopped. CHS 828 is an effective new antitumor agent, with a potentially new mechanism of action. CHS-828 appeared to kill cancer cells by depleting NAD. CHS 828 is presently being tested in Phase I clinical trials in collaboration with the European Organization for Research and Treatment of Cancer. Synonyms: CHS 828; CHS828; CHS-828; GMX-1778; GMX1778; GMX 1778. CAS No. 200484-11-3. Molecular formula: C19H22ClN5O. Mole weight: 371.869. | |
| CI-898 hydrochloride | CI-898 is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). The presence of the cofactor NADPH enhances bind of CI-898 and DHFR. CI-898 inhibits growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also inhibits the growth of S. faecalis and S. aureus when used at concentrations less than 0.25 μg/ml. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine in mice with advanced stage P338 leukemia. Synonyms: Trimetrexate; CI 898 trihydrochloride; Trimetrexate trihydrochloride; TMTX. Grades: ≥98%. CAS No. 1658520-97-8. Molecular formula: C19H23N5O3·3HCl. Mole weight: 478.80. | |
| Diethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate | Diethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CID94528, EINECS 256-127-9, Diethyl N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamate, 43170-88-3. Product Category: Heterocyclic Organic Compound. CAS No. 43170-88-3. Molecular formula: C24H30N8O5. Mole weight: 510.546 g/mol. Purity: 0.96. IUPACName: diethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate. Canonical SMILES: CCOC(=O)CCC(C(=O)OCC)NC(=O)C1=CC=C(C=C1)N(C)CC2=CN=C3C(=N2)C(=NC(=N3)N)N. ECNumber: 256-127-9. Product ID: ACM43170883. Alfa Chemistry ISO 9001:2015 Certified. Categories: Diethyl methotrexate. | |
| Edatrexate | Edatrexate is a polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. Uses: Antineoplastic agents. Synonyms: 10-ethyl-deaza-aminopterin; 10-EDAM; 10 EDAM; 10EDAM; CGP-30694; CGP30694; CGP30694; D 03942; D-03942; D03942. CAS No. 80576-83-6. Molecular formula: C22H25N7O5. Mole weight: 467.49. | |
| Folinic acid | Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate. It is a 5-formyl derivative of tetrahydrofolic acid and readily converted to other reduced folic acid derivatives, thus, has vitamin activity that is equivalent to that of folic acid. Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. Synonyms: leucovorin. Grades: >98%. CAS No. 58-05-9. Molecular formula: C20H23N7O7. Mole weight: 473.44. | |
| Folinic acid | Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: leucovorin. CAS No. 58-05-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17556. | |
| Folinic acid calcium | Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Leucovorin calcium; Calcium folinate. CAS No. 1492-18-8. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-13664. | |
| Folinic Acid, Calcium Salt | Folinic Acid is an intermediate product of the metabolism of folic acid and is used as a tissue culture additive. Folinic acid is an antidote to folic acid antagonists such as methotrexate which block the conversion of folic acid into folinic acid. Group: Biochemicals. Alternative Names: L-N- [p- [ [ (2-amino-5-formyl-5, 6, 7, 8-tetrahydro-4-hydroxy-6-pteridinyl) methyl] amino] benzoyl] glutamic Acid Calcium Salt; Calcium 5-formyltetra hydrofolate; Calcium L-Folinate; Calcium Folinate; Calcium Leucovorin; Folidan; Folinic Acid Calcium Salt; Lederfoline; Leucovorin Calcium; Leucovorin Calcium Salt; NSC 3590; Rescuvolin; Wellcovorin; USP Folic Acid Related Compound A. Grades: Cell Culture Grade. CAS No. 1492-18-8. Pack Sizes: 500mg, 1g, 5g. Molecular Formula: C??H??CaN?O?, Molecular Weight: 511.51. US Biological Life Sciences. | Worldwide |
| Folinic acid calcium salt pentahydrate | Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Leucovorin calcium salt pentahydrate. CAS No. 6035-45-6. Pack Sizes: 100 mg; 500 mg. Product ID: HY-B0080. | |
| Hydroxyethyl disulfide | Hydroxyethyl disulfide blocks the inhibitory effect of showdomycin on methotrexate-resistant thymidylate synthase and is also protected by its substrate deoxyuridylic acid, preventing inactivation of the antibiotic [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1892-29-1. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-W076898A. | |
| L-(+)-Amethopterin hydrate (Methotrexate) | 100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C20H22N8O5. CAS No. 59-05-2. Prepack ID 30186373-100mg. Molecular Weight 454.44. See USA prepack pricing. |  |
| L-Glutamic acid,N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methyl-d3-amino]benzoyl]-(9ci) | L-Glutamic acid,N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methyl-d3-amino]benzoyl]-(9ci). Uses: Designed for use in research and industrial production. Additional or Alternative Names: METHOTREXATE-D3. Product Category: Heterocyclic Organic Compound. CAS No. 432545-63-6. Molecular formula: C20H19D3N8O5. Mole weight: 457.46. Product ID: ACM432545636. Alfa Chemistry ISO 9001:2015 Certified. | |
| Lometrexol | Lometrexol is a folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. Uses: Antimetabolites, antineoplastic. Synonyms: Lometrexol; LMTX; LY 264618; LY-264618; LY264618. CAS No. 106400-81-1. Molecular formula: C21H25N5O6. Mole weight: 443.46. | |
| Methotrexate | Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Amethopterin; CL14377; WR19039. CAS No. 59-05-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-14519. | |
| Methotrexate | Methotrexate(WR19039; CL14377) can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. Uses: Adcs cytotoxin. Synonyms: WR19039; CL14377; WR 19039; WR-19039; CL 14377; CL-14377. Grades: >98%. CAS No. 59-05-2. Molecular formula: C20H22N8O5. Mole weight: 454.44. | |
| Methotrexate | Pharmaceutical Secondary Standard; Certified Reference Material. Group: Pharmacopeia & metrological institutes standards. | |
| Methotrexate-D3 solution | 100 ?g/mL in methanol with 0.01N NaOH, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| Methotrexate Dimethyl Ester | Methotrexate Dimethyl Ester. Uses: For analytical and research use. Group: Impurity standards. CAS No. 34378-65-9. Pack Sizes: 100MG. IUPAC Name: dimethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate. Molecular formula: C22H26N8O5. Mole weight: 482.49. Catalog: APS34378659. SMILES: COC(=O)CC[C@H](NC(=O)c1ccc(cc1)N(C)Cc2cnc3nc(N)nc(N)c3n2)C(=O)OC. Format: Neat. Shipping: Room Temperature. | |
| Methotrexate disodium | Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia). Synonyms: Amethopterin Sodium; Methotrexate Lederle; Metoart; Metotrexato Lederle; Sodium Methotrexate; N-[4-[[ (2, 4-Diamino-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic Acid Disodium Salt; 4-amino-n(sup10)-methyl pteroyl glutamic acid disodium salt; amethopterin sodium. Grades: >98.0%. CAS No. 7413-34-5. Molecular formula: C20H20N8Na2O5. Mole weight: 498.40. | |
| Methotrexate EP Impurity C | An impurity of Methotrexate, an antimetabolite and immunosuppressant used in chemotherapy and auto-immune diseases. Synonyms: Methopterine; N-[4-[[ (2-Amino-3, 4-dihydro-4-oxo-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic Acid; N-[p-[[ (2-Amino-3, 4-dihydro-4-oxo-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic Acid; N-[p-[[ (2-Amino-4-hydroxy-6-pteridinyl) methyl]methylamino]benzoyl]glutamic Acid; N-[4-[[ (2-Amino-1, 4-dihydro-4-oxo-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic Acid; 10-Methylfolic Acid; N10-Methyl Folic Acid; 10-Methylpteroylglutamic Acid; N10-Methylpteroylglutamic Acid; Methotrexate USP Related Compound C; Methotrexate Related Compound C; (4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid. Grades: 96%. CAS No. 2410-93-7. Molecular formula: C20H21N7O6. Mole weight: 455.42. | |
| Methotrexate hydrate | Methotrexate hydrate is a substance that affects cell growth and division. It is commonly used to fight certain diseases, especially cancer and autoimmune diseases. It works by inhibiting the process by which cells synthesize DNA. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate. CAS No. 133073-73-1. Pack Sizes: 1 g; 5 g. Product ID: HY-14519B. | |
| Methotrexate Impurity 25 | Methotrexate Impurity 25. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-methylaminobenzoic acid. CAS No. 10541-83-0. Molecular formula: C8H9NO2. Mole weight: 151.17. Catalog: APB10541830. | |
| Methotrexate impurity 29 | Methotrexate impurity 29. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1004-38-2. Molecular formula: C4H7N5. Mole weight: 125.14. Catalog: APB1004382. | |
| Methotrexate Related Compound B | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Methotrexate Related Compound C | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Methotrexate Related Compound E | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Methotrexate solution | 1.0 mg/mL in methanol with 0.1N NaOH, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| Methotrexate System Suitability Mixture | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Pamapimod | A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate. Synonyms: 6-(2,4-Difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one; R 1503; R-1503; R1503; Ro 4402257; Ro4402257; Ro-4402257. Grades: 99%. CAS No. 449811-01-2. Molecular formula: C19H20F2N4O4. Mole weight: 406.39. | |
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