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| Product | Description | |
|---|---|---|
| 2'-Deoxyuridine-5'-monophosphate | Deoxyuridine monophosphate (dUMP), also known as deoxyuridylic acid or deoxyuridylate in its conjugate acid and conjugate base forms, respectively, is a deoxynucleotide. It is an intermediate in the metabolism of deoxyribonucleotides. DUMP is a pyrimidine 2'-deoxyribonucleoside 5'-monophosphate having uracil as the nucleobase. It has a role as a metabolite, an Escherichia coli metabolite and a mouse metabolite. Synonyms: 2'-Deoxy-5'-uridylic acid; dUMP; Deoxyuridine monophosphate; 2'-deoxyuridylic acid; Deoxyuridylic acid; Uridine, 2'-deoxy-, 5'-(dihydrogen phosphate); 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-; ((2R,3S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate. Grade: ≥95%. CAS No. 964-26-1. Molecular formula: C9H13N2O8P. Mole weight: 308.18. |  |
| 2'-Deoxyuridine-5'-monophosphate disodium salt (2'-dUMP·2Na) | 2'-Deoxyuridine-5'-monophosphate disodium salt (2'-dUMP·2Na). Group: Biochemicals. Alternative Names: 2'-dUMP·2Na; 2'-Deoxyuridine-5'-monophosphoric acid disodium salt. Grades: Highly Purified. CAS No. 42155-08-8. Pack Sizes: 1g. Molecular Formula: C9H11N2O8PNa2, Molecular Weight: 352.15. US Biological Life Sciences. |  Worldwide |
| 5-Bromo-2'-deoxyuridine-5'-monophosphate sodium salt | 5-Bromo-2'-deoxyuridine-5'-monophosphate sodium salt. Group: Biochemicals. Alternative Names: 5-BrdUMP. 2Na. Grades: Highly Purified. CAS No. 51432-32-7. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C9H12BrN2O8PNa2. US Biological Life Sciences. | Worldwide |
| 2'-Deoxyuridine-5'-diphosphate sodium salt | 2'-Deoxyuridine-5'-diphosphate sodium salt is an indispensable compound employed in the realm of compound, assuming a seminal function in the intricate processes of DNA replication and repair, thus rendering it an indispensable constituent within diverse pharmaceutical formulations. It is distinguished by its remarkable chemical stability and solubility attributes. Synonyms: DUDP SODIUM SALT; 2'-DEOXYURIDINE-5'-DIPHOSPHATE SODIUM SALT; 2''-Deoxyuridine-5''-diphosphate disodium salt; 2-DEOXYURIDINE-5-MONOPHOSPHATE SODIUM SALT extrapure. Grade: ≥ 97% (HPLC). CAS No. 102814-06-2. Molecular formula: C9H12N2Na2O11P2. Mole weight: 432.13. | |
| 4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid Methyl Ester | 4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Benzoic acid, 4-[2-(2-amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-, methyl ester; Pemetrexed Impurity 63; Methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate; Methyl 4-(2-(2-imino-4,6-dioxo-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate. Grade: ≥95%. CAS No. 1320346-43-7. Molecular formula: C16H16N4O4. Mole weight: 328.32. | |
| 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid | An impurity of Pemetrexed which binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid. Grade: > 95%. CAS No. 137281-39-1. Molecular formula: C15H14N4O3. Mole weight: 298.3. | |
| 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid methyl ester | 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester is one of pemetrexed intermediates. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid Methyl Ester; 2-Amino-4,7-dihydro-5-[2-[4-(methoxycarbonyl)phenyl]ethyl]-4-oxo-3H-pyrrolo[2,3-d]pyrimidine; Pemetrexed Impurity 9. Grade: ≥95%. CAS No. 155405-80-4. Molecular formula: C16H16N4O3. Mole weight: 312.32. | |
| ANX-510 | ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Synonyms: 5,10-Methylenetetrahydrofolic acid; 5,10-Methylene-tetrahydrofolate; Tetrahydromethylenefolate; N-{4-[3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid. CAS No. 3432-99-3. Molecular formula: C20H23N7O6. Mole weight: 457.44. | |
| D-Pemetrexed Dimethyl Diester | D-Pemetrexed dimethyl diester is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Diester. Grade: 98%. CAS No. 1391068-12-4. Molecular formula: C22H25N5O6. Mole weight: 455.46. | |
| D-Pemetrexed Hydrate | D-Pemetrexed Hydrate is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-D-glutamic Acid Hydrate. Molecular formula: C20H23N5O7. Mole weight: 445.42. | |
| (-)-LY-338979 | (-)-LY-338979 is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: (S)-2-(4-(2-((R)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid; (4-(2-((R)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid; N-(4-{2-[(5R)-2-Amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl}benzoyl)-L-glutamic acid; L-Glutamic acid, N-[4-[2-[(5R)-2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl]benzoyl]-. Molecular formula: C20H21N5O7. Mole weight: 443.41. | |
| (+)-LY-338979 | (+)-LY-338979 is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: (S)-2-(4-(2-((S)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid; (4-(2-((S)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid; N-(4-{2-[(5S)-2-Amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl}benzoyl)-L-glutamic acid; L-Glutamic acid, N-[4-[2-[(5S)-2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl]benzoyl]-. Molecular formula: C20H21N5O7. Mole weight: 443.41. | |
| Pemetrexed | Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: LY231514; Alimta; LY 231514; LY-231514. Grade: >98%. CAS No. 137281-23-3. Molecular formula: C20H21N5O6. Mole weight: 427.41. | |
| (S)-dimethyl 2-(4-(4-oxobutyl)benzamido)pentanedioate | (S)-dimethyl 2-(4-(4-oxobutyl)benzamido)pentanedioate is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Pemetrexed Impurity 10. CAS No. 1081974-98-2. Molecular formula: C18H23NO6. Mole weight: 349.38. | |
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