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5,6-Dimethoxy-1-indanone. Group: Biochemicals. Grades: Highly Purified. CAS No. 2107-69-9. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C11H12O3. US Biological Life Sciences.
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5,6-Dimethoxy-1-indanone
An intermediate useful in the preparation of Donepezil. Uses: An intermediate useful in the preparation of donepezil. Synonyms: 5,6-dimethoxy-2,3-dihydroinden-1-one; 5,6-dimethoxy-2,3-dihydroinden-1-one. Grade: > 95 %. CAS No. 2107-69-9. Molecular formula: C11H12O3. Mole weight: 192.21.
2,3-Dihydro-5,6-dimethoxy-2-[(1-oxido-4-pyridinyl)methyl]-1H-inden-1-one is used in the preparation of Donepezil, which is a highly specific reversible acetylcholinesterase (AChE) inhibitor used to treat moderate to severe Alzheimer's disease. Synonyms: 5,6-Dimethoxy-2(4-pyridylmethyl)-1-indanone N-Oxide; Donepezil Pyridine N-Oxide; Donepezil alkene pyridine N-oxide; 4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)pyridine 1-oxide; 4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]pyridine N-oxide; Donepezil impurity 34. Grade: ≥95%. CAS No. 896134-07-9. Molecular formula: C17H17NO4. Mole weight: 299.32.
Donepezil
Donepezil, also called Aricept, a centrally acting reversible acetyl cholinesterase inhibitor that the FDA has also approved for the treatment of moderate to severe Alzheimer's disease. It readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. Synonyms: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one; (±)-E 2020; 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine; Neuripezil; Tonizep; 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; Aricept; HSDB 7743; HSDB7743; HSDB-7743; 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride; 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; Eranz; Aricept ODT; donepezilo; donepezilum; CHEMBL502; donepezil hydrochloride; donepezilium oxalate trihydrate; E 2020; E-2020; E2020; 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one; (RS)-2-[(1-BENZYL-PIPERIDIN-4-YL)METHYL]-5,6-DIMETHOXYINDAN-1-ONE. Grade: > 98%. CAS No. 120014-06-4. Molecular formula: C24H29NO3. Mole weight: 379.49.
Donepezil Alkene Pyridine N-Oxide
Donepezil Alkene Pyridine N-Oxide is an impurity of Donepezil, a medication for the treatment of Alzheimer's disease. Synonyms: 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[(1-oxido-4-pyridinyl)methylene]-; 2,3-Dihydro-5,6-dimethoxy-2-[(1-oxido-4-pyridinyl)methylene]-1H-inden-1-one; 4-[(5,6-dimethoxy-1-indanon-2-ylidene)methyl]pyridine N-oxide; 4-((5,6-Dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)pyridine 1-oxide. Grade: ≥95%. CAS No. 896134-06-8. Molecular formula: C17H15NO4. Mole weight: 297.31.
Donepezil hydrochloride
Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. Uses: Cholinesterase inhibitors. Synonyms: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-oneHydrochloride; Aricept; Aricept D; BNAG; Donepezil HCl; BNAG; donepezilium oxalate trihydrate; 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride. Grade: ≥ 95%. CAS No. 120011-70-3. Molecular formula: C24H30ClNO3. Mole weight: 415.95.
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