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| Product | Description | |
|---|---|---|
| 3-Amino-6-morpholinopyridine+A376:B386 | 3-Amino-6-morpholinopyridine+A376:B386. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-Amino-2-morpholinopyridine. Product Category: Pyridines. CAS No. 52023-68-4. Molecular formula: C9H13N3O. Mole weight: 179.2. Product ID: ACM52023684. Alfa Chemistry ISO 9001:2015 Certified. Categories: 6-morpholinopyridin-3-amine. |  |
| A37 | A37 is an aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor (IC50 = 4.6 μM; Ki = 300 nM). It competitively binds to the aldehyde binding pocket of ALDH1A1, resulting in the disruption of spheroid formation and a decrease of cell viability in ovarian cancer cells in vitro. Synonyms: Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl][1]benzothieno[3,2-d]pyrimidin-2-yl]thio]acetate; CM037; CM-037; CM 037; A37; A-37; A 37. Grade: ≥97% by HPLC. CAS No. 896795-60-1. Molecular formula: C21H25N3O3S2. Mole weight: 431.57. |  |
| 2-methylthio-N6-threonyl carbamoyladenosine | 2-Methylthio-N6-threonylcarbamoyladenosine is a hypermodified form of Adenosine found in bacterial and eukaryotic tRNAs at the A37 position adjacent to the 3'-end of the anticodon, which is essential for efficient and highly accurate protein translation by the ribosome. Synonyms: L-Threonine, N-[[[2-(methylthio)-9-b-D-ribofuranosyl-9H-purin-6-yl]amino]carbonyl]-; n-[(9-beta-d-ribofuranosyl-2-methylthiopurin-6-yl)carbamoyl]threonine; N-((9-beta-D-Ribofuranosyl-2-methylthiopurine-6-yl)carbamoyl)threonine. CAS No. 70333-82-3. Molecular formula: C16H22N6O8S. Mole weight: 458.45. | |
| 3- (4-Methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) benzoic Acid | 3- (4-Methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) benzoic Acid acts as a synthetic reagent used in the preparation and in antitumor activity of pyrrolo[2,3-d]pyrimidine derivatives against A375 human melanoma cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 641571-13-3. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H9F3N2O2, Molecular Weight: 270.209999999999. US Biological Life Sciences. |  Worldwide |
| ARN14988 | ARN14988 can normalize ceramide levels and concomitantly sensitize proliferative melanoma cells to the cytotoxic actions of various antitumoral agents. ARN14988 is a potent inhibitor of acid ceramidase with IC50 of 12.8 nM for the human enzyme. ARN14988 also reduces growth of A375 with EC50s of 41.8 μM and G361 with EC50s of 67.7 μM. Synonyms: ARN 14988; ARN-14988. Grade: ≥98%. CAS No. 1502027-70-4. Molecular formula: C16H24ClN3O5. Mole weight: 373.83. | |
| Atractylenolide I | Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4 -antagonizing agent. Uses: Scientific research. Group: Natural products. CAS No. 73069-13-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-N0201. |  |
| AZD0364 | AZD-0364 is a potent and selective ERK2 inhibitor, which has an IC50 value of 0.6 nM. AZD-0364 is measured in the A375 phospho-p90RSK assays with IC50s of 5.7 nM. AZD-0364 can inhibit the growth of a panel of cancer cell lines. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growth. Synonyms: AZD-0364; AZD 0364; tizaterkib. Grade: ≥98%. CAS No. 2097416-76-5. Molecular formula: C24H24F2N8O2. Mole weight: 494.50. | |
| Bmi1-Ring1A E3 Ligase Inhibitor, PRT4165 (2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione) | A cell-permeable indandione compound that inhibits the Bmi1-Ring1A E3 complex ubiquitin ligase activity both in cell-free assays (by 100% against self- and Top2alpha ubiquitination at 25 and 50uM, respectively) and in HeLa cells (by 100% against Bmi1 ubiquitination at 50uM). Shown to greatly potentiate Teniposide (VM26) cancer cytotoxicity (by 10-fold in A375 and A549 cultures at 5.5 and 33uM, respectively) by preventing Top2alpha degradation following VM26 treatment (100% inhibition at 50uM in HeLa cells). Group: Biochemicals. Grades: Highly Purified. CAS No. 31083-55-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| B-Raf inhibitor 1 | B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 μM and 2 nM for A375 proliferation and A375 p-ERK respectively. Synonyms: B-Raf Inhibitor 1; B-Raf-Inhibitor 1; B-Raf-Inhibitor-1; MDK0403; MDK-0403; MDK 0403. Grade: >98%. CAS No. 1093100-40-3. Molecular formula: C26H19ClN8. Mole weight: 478.94. | |
| B-Raf inhibitor 1 dihydrochloride | B-Raf inhibitor 1 is an inhibitor of B-Raf kinase with IC50 values of 0.31μM and 0.72μM for cell proliferation, respectively in A375 and HCT116. B-Raf is important in signal transduction and some mutant B-Raf occurs in cancer cells. The most common mutation of these is V600E, which makes B-Raf kinase constitutively active. B-Raf inhibitor 1 belongs to the type IIA inhibitors and binds to the DFG-out ATP-binding site of B-Raf. The selectivity of B-Raf inhibitor 1 is less than of other type inhibitors. Besides mutant B-Raf, it can also inhibit wild type B-Raf and other tyrosine kinase. In cells with wild type B-Raf, B-Raf inhibitor 1 can activate the RAF-MEK-ERK signaling pathway via Raf dimerization. The preclinical toxicity test shows B-Raf inhibitor 1 can induce hyperplasia in a mouse model. Synonyms: 1,5-Isoquinolinediamine, N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, hydrochloride (1:2). Grade: >98%. CAS No. 1191385-19-9. Molecular formula: C26H21Cl3N8. Mole weight: 551.86. | |
| Cdk1/2 Inhibitor III | Cdk1/2 Inhibitor III is a selective inhibitor of Cdk1/2 with an IC50 of 2.1 μM for CDK1/cyclin B. It is a cell-permeable triazolo-diamine compound with anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa and A375 cells, respectively). Synonyms: Cyclin-dependent Kinase 1/2 Inhibitor III; 1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-; 3-Amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide; 3-amino-N-(2,6-difluorophenyl)-5-((4-sulfamoylphenyl)amino)-1H-1,2,4-triazole-1-carbothioamide. Grade: >95%. CAS No. 443798-55-8. Molecular formula: C15H13F2N7O2S2. Mole weight: 425.44. | |
| (-)-Cryptopleurine | ( - )-Cryptopleurine is an alkaloid that has been found in Lauraceae and has diverse biological activities. It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells ( IC 50 =3 nM for all).2 ( - )-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay ( IC 50 =8.7 nM).3 ( - )-Cryptopleurine (500 μg/mL) prevents lesion formation in tobacco (N. tabacum) plants infected with tobacco mosaic virus (TMV). It also inhibits protein synthesis by yeast and mammalian ribosomes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-Cryptopleurine; NSC 19912. CAS No. 482-22-4. Pack Sizes: 1 mg. Product ID: HY-121255. | |
| CX-5461 | CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1138549-36-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13323. | |
| CX-5461 dihydrochloride | CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ?25 ?M). Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13323A. | |
| CX-5461 dihydrochloride | CX-5461 dihydrochloride is a potent and orally bioavailable Pol I-mediated rRNA synthesis inhibitor, with IC50s of 142, 113 and 54 nM in HCT-116, A375 and MIA PaCa-2 cells, respectively. It shows little or no effect on Pol II (IC50 ≥25 μM). Synonyms: 5H-Benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-, hydrochloride (1:2). Grade: ≥98%. Molecular formula: C27H29Cl2N7O2S. Mole weight: 586.54. | |
| GDC-0623 | GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG 7421; MEK inhibitor 1. CAS No. 1168091-68-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15610. | |
| HLM006474 | HLM006474 is a pan E2F inhibitor, which inhibits E2F4 DNA-binding with an IC50 of 29.8 ?M in A375 cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 353519-63-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16667. | |
| JNK Inhibitor XVI, JNK-IN-8 ( (E) -3- (4- (dimethylamino) but-2-enamido) -N- (3-methyl-4- ( (4- (pyridin-3-yl) pyrimidin-2-yl) amino) phenyl) benzamide) | A cell-permeable, selective, and irreversible type 2 inhibitor of c-Jun N-terminal kinases (JNK) (IC50=4.67nM, 18.7nM, 980pM for JNK1, JNK2, and JNK3, respectively). Forms a covalent adduct with the conserved cysteine residue (Cys116 in JNK1) and binds to JNK in an extended type 2 conformation. Blocks the phosphorylation of c-Jun in cells (EC50=486nM in HeLa cells; 338nM in A375 cells). Exhibits greater cellular specificity for JNK when compared to 40 other kinases screened using a cell-based assay. Shows weaker binding to KIT mutants (IC50=92nM for V559D and 56nM for T670I) and RIOK2 (120nM). Does not show any significant inhibitory activity against various other kinases, including ERK, p38, Akt, MSK, and RSK. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MC-031 | MC-031, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 10.6×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: O-Demethylchlorothricin. CAS No. 134637-04-0. Molecular formula: C49H61ClO16. Mole weight: 941.45. | |
| MC-032 | MC-032, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 10.5×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: O-Demethylhydroxychlorothricin. CAS No. 134615-17-1. Molecular formula: C49H61ClO17. Mole weight: 957.45. | |
| MC-033 | MC-033, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 1.06×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: MC 033; Chlorothricin, 3B-O-de(3-chloro-6-methoxy-2-methylbenzoyl)-, 4B-(3-chloro-6-methoxy-2-methylbenzoate). CAS No. 134615-15-9. Molecular formula: C49H61ClO16. Mole weight: 941.45. | |
| MC-034 | MC-034, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 18.3×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: MC 034; Chlorothricin, 3B-O-de(3-chloro-6-methoxy-2-methylbenzoyl)-2A-hydroxy-, 4B-(3-chloro-6-methoxy-2-methylbenzoate). CAS No. 134615-16-0. Molecular formula: C49H61ClO17. Mole weight: 957.45. | |
| N-Methylstreptothricin F | N-Methylstreptothricin F is a streptomycin antibiotic produced by Actinomyces sp. A37812. It has good antibacterial activity against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. Synonyms: A 37812. Grade: >98%. CAS No. 99237-10-2. Molecular formula: C20H36N8O8. Mole weight: 516.55. | |
| Rho/SRF Pathway Inhibitor, CCG-1423 (N- (2- (4-Chloroanilino) -1-methyl-2-oxoethoxy) -3, 5-bis (trifluoromethyl) benzamide) | A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Ga12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50≤300nM) and block RhoC/ Ga12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 285986-88-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Sartorypyrone A | Sartorypyrone A is a meroditerpene metabolite produced by Neosartorya fungal species, displaying antibacterial and antibiofilm activities. It shows inhibitory effects against various Gram-positive bacteria. It also suppresses the growth of MCF-7 breast, NCI-H460 lung and A375-C5 melanoma cancer cell lines. Synonyms: 20-O-Acetyl Sartorypyrone D; rel-(+)-3-[(2E,6E)-9-[(1R,3S)-3-(acetyloxy)-2,2-dimethyl-6-methylenecyclohexyl]-3,7-dimethyl-2,6-nonadien-1-yl]-4-hydroxy-6-methyl-2H-pyran-2-one. Grade: ≥95%. CAS No. 1452396-10-9. Molecular formula: C28H40O5. Mole weight: 456.61. | |
| SR-3029 | SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with potent antiproliferative properties SR-3029 shoed IC50:= 97 nM in MTT assays against the human A375 melanoma cell line and have physical, in vitro and in vivo PK properties suitable for use in proof of principle animal xenograft studies against human cancer cell lines. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR-3029; SR 3029; SR3029. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1454585-06-8. Molecular formula: C23H19F3N8O. Mole weight: 480.46. Purity: >98%. IUPACName: (6,7-Difluoro-1H-benzoimidazol-2-ylmethyl)-[9-(3-fluoro-phenyl)-2-morpholin-4-yl-9H-purin-6-yl]-amine. Canonical SMILES: FC1=CC(N2C=NC3=C(NCC4=NC5=CC=C(F)C(F)=C5N4)N=C(N6CCOCC6)N=C23)=CC=C1. Product ID: ACM1454585068. Alfa Chemistry ISO 9001:2015 Certified. Categories: SR 302 (VA). | |
| Tagarafdeg | Tagarafdeg (CFT1946) is an orally active, CRBN-based and mutant-selective bifunctional degradation activating compound (BiDAC) degrader of BRAFV600E with a DC50 of 14 nM in A375 cells. Tagarafdeg is capable of degrading BRAF V600E (Class I), G469A (Class II), G466V (Class III) mutations, and the p61-BRAFV600E splice variant. Tagarafdeg can be used in tumor research[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CFT1946. CAS No. 2882165-79-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-153341. | |
| TMC-2A | TMC-2A is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 A. Molecular formula: C28H34N4O9. Mole weight: 570.6. | |
| TMC-2B | TMC-2B is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 B. Molecular formula: C28H34N4O8. Mole weight: 554.6. | |
| TMC-2C | TMC-2C is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 C. Molecular formula: C28H34N4O8. Mole weight: 554.6. | |
| Ulixertinib | Ulixertinib (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC 50 of <0.3 nM against ERK2. Ulixertinib (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BVD-523; VRT752271. CAS No. 869886-67-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15816. | |
| Ulixertinib hydrochloride | Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC 50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BVD-523 hydrochloride; VRT752271 hydrochloride. CAS No. 1956366-10-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15816A. | |
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