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Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor ( IC 50 =11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: BAY g 5421. CAS No. 56180-94-0. Pack Sizes: 10 mM * 1 mL; 200 mg; 1 g. Product ID: HY-B0089.
Acarbose
Acarbose. Group: Biochemicals. Grades: Purified. CAS No. 56180-94-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Acarbose
Acarbose is an inhibitor of alpha-glucosidase isolated from Actinoplance sp., used to treat type 2 diabetes. Uses: Enzyme inhibitors; hypoglycemic agents. Synonyms: Amylostatin J; Bay g 5421; α-GHI; Glucobay; 4,6-dideoxy-4-{[(1S,4S,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranosyl-(1→4)-alpha-D-glucopyranosyl-(1→4)-beta-D-glucopyranose. Grade: >95% by HPLC. CAS No. 56180-94-0. Molecular formula: C25H43NO18. Mole weight: 645.61.
Acarbose
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standardsapi standardscarbohydrateseuropean pharmacopoeia (ph. eur.)pharmaceutical toxicologypharmacopoeial standards. Alternative Names: Acarbose, O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-enyl]amino]-?-d-glucopyranosyl-(1?4)-O-?-d-glucopyranosyl-(1?4)-d-glucopyranose.
Acarbose-1-phenylthiol
Acarbose-1-phenylthiol is an intermediate formed in the synthesis of α-D-Glucosyl Acarbose Impurity, a homolog of Acarbose for use in the treatment of chronic diseases such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites. Synonyms: (1S,2S,3S,6S)-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6R)-6-(((2R,3S,4R,5R,6S)-4,5-Dihydroxy-2-(hydroxymethyl)-6-(phenylthio)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxy-2-methyltetrahydro-2H-pyran-3-yl)amino)-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol; β-D-Glucopyranoside, phenyl O-4,6-dideoxy-4-[[4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-1-thio-, [1S-(1α,4α,5β,6α)]-. CAS No. 68107-37-9. Molecular formula: C31H47NO17S. Mole weight: 737.77.
Acarbose-1-phenylthiol Dodecaacetate
Acarbose-1-phenylthiol Dodecaacetate is an intermediate formed in the synthesis of α-D-Glucosyl Acarbose Impurity, a homolog of Acarbose for use in the treatment of chronic diseases such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites. Synonyms: (1S,2S,3S,6S)-4-(Acetoxymethyl)-6-(((2R,3R,4S,5R,6R)-4,5-diacetoxy-6-(((2R,3R,4S,5R,6R)-4,5-diacetoxy-2-(acetoxymethyl)-6-(((2R,3R,4S,5R,6S)-4,5-diacetoxy-2-(acetoxymethyl)-6-(phenylthio)tetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)amino)cyclohex-4-ene-1,2,3-triyl Triacetate; β-D-Glucopyranoside, phenyl O-2,3-di-O-acetyl-4,6-dideoxy-4-[[4,5,6-tris(acetyloxy)-3-[(acetyloxy)methyl]-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1→4)-O-2,3,6-tri-O-acetyl-α-D-glucopyranosyl-(1→4)-1-thio-, 2,3,6-triacetate, [1S-(1α,4α,5β,6α)]-. CAS No. 68107-38-0. Molecular formula: C55H71NO29S. Mole weight: 1242.21.
Acarbose-1-phenylthiol Dodeca(p-methoxybenzyl Ether) is an intermediate formed in the synthesis of α-D-Glucosyl Acarbose Impurity, a homolog of Acarbose for use in the treatment of chronic diseases such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites. Synonyms: (2R,3R,4S,5R,6R)-6-(((2R,3R,4S,5R,6R)-6-(((2R,3R,4S,5R,6S)-4,5-bis((4-Methoxybenzyl)oxy)-2-(((4-methoxybenzyl)oxy)methyl)-6-(phenylthio)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis((4-methoxybenzyl)oxy)-2-(((4-methoxybenzyl)oxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis((4-methoxybenzyl)oxy)-2-methyl-N-((1S,4S,5S,6S)-4,5,6-tris((4-methoxybenzyl)oxy)-3-(((4-methoxybenzyl)oxy)methyl)cyclohex-2-en-1-yl)tetrahydro-2H-pyran-3-amine. Molecular formula: C127H143NO29S. Mole weight: 2179.55.
acarbose 7IV-phosphotransferase
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose. Group: Enzymes. Synonyms: acarbose 7-kinase; AcbK. Enzyme Commission Number: EC 2.7.1.187. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3019; acarbose 7IV-phosphotransferase; EC 2.7.1.187; acarbose 7-kinase; AcbK. Cat No: EXWM-3019.
Acarbose D-Fructose 1,6,6',6'''-Tetra-tert-butyldimethylsilyloxy Methyl Ether is a protected intermediate of Acarbose D-Fructose, a derivative of the antibiotic, Acarbose. Synonyms: (7S,8R,9R)-8-(((2R,3R,4R,5S,6R)-6-(((tert-Butyldimethylsilyl)oxy)methyl)-5-(((2R,3R,4S,5S,6R)-5-(((1S,4S,5S,6S)-3-(((tert-butyldimethylsilyl)oxy)methyl)-4,5,6-trihydroxycyclohex-2-en-1-yl)amino)-3,4-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-7,9-dihydroxy-2,2,3,3,12,12,13,13-octamethyl-4,11-dioxa-3,12-disilatetradecan-6-one. Molecular formula: C49H99NO18Si4. Mole weight: 1102.65.
Acarbose D-Fructose Impurity
An analogue of Acarbose, a medication used for the treatment of diabetes mellitus type 2. Synonyms: O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-D-fructose; D-Fructose, O-4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-; Acarbose impurity A [EP]; Acarbose impurity A [USP]. Grade: 90%. CAS No. 1013621-79-8. Molecular formula: C25H43NO18. Mole weight: 645.62.
Acarbose Dodeca-acetate
Acarbose Dodeca-acetate is an intermediate in synthesizing Acarbose, which is used as an anti-diabetic. Synonyms: (1S,2S,3S,6S)-4-(Acetoxymethyl)-6-(((2R,3R,4S,5R,6R)-4,5-diacetoxy-6-(((2R,3R,4S,5R,6R)-4,5-diacetoxy-2-(acetoxymethyl)-6-(((2R,3R,4S,5R,6R)-4,5-diacetoxy-2-(acetoxymethyl)-6-hydroxytetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)amino)cyclohex-4-ene-1,2,3-triyl Triacetate. Molecular formula: C49H67NO30. Mole weight: 1150.04.
Acarbose EP Impurity A
Acarbose EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1013621-79-8. Molecular formula: C25H43NO18. Mole weight: 645.61. Catalog: APB1013621798.
Acarbose EP Impurity A
An impurity of Acarbose, a medication used for the treatment of diabetes mellitus type 2. Synonyms: O-4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-enyl]amino]-α-Dglucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-Darabino-hex-2-ulopyranose; Acarbose Impurity A. Molecular formula: C26H43NO18. Mole weight: 645.60.
Acarbose EP Impurity B
An impurity of Acarbose, a medication used for the treatment of diabetes mellitus type 2. Synonyms: (1R,4R,5S,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)cyclohex-2-enyl 4-O-[4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-enyl]amino]-α-D-glucopyranosyl]-α-D-glucopyranoside; Acarbose Impurity B. Molecular formula: C26H43NO17. Mole weight: 641.62.
Acarbose EP Impurity C
An impurity of Acarbose, a medication used for the treatment of diabetes mellitus type 2. Synonyms: α-D-glucopyranosyl 4-O-[4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-enyl]amino]-α-D-glucopyranosyl]-α-D-glucopyranoside; Acarbose Impurity C. Grade: > 95%. CAS No. 610271-07-3. Molecular formula: C25H43NO18. Mole weight: 645.60.
Acarbose EP Impurity D
An impurity of Acarbose, a medication used for the treatment of diabetes mellitus type 2. Synonyms: 4-O-[4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-enyl]amino]-α-Dglucopyranosyl]-D-glucopyranose; Acarbose Impurity D. Molecular formula: C19H33NO13. Mole weight: 483.46.
Acarbose EP Impurity E
An impurity of Acarbose, a medication used for the treatment of diabetes mellitus type 2. Synonyms: O-4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-enyl]amino]-α-Dglucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-D-arabino-hex-2-ulopyranose; 4-O-α-acarbosyl-D-fructopyranose; Acarbose Impurity E. Molecular formula: C31H53NO23. Mole weight: 807.75.
Acarbose EP Impurity F
An impurity of Acarbose, a medication used for the treatment of diabetes mellitus type 2. Synonyms: O-4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-enyl]amino]-α-Dglucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-D-glucopyranose; 4-O-α-acarbosyl-D-glucopyranose; Acarbose Impurity F. Molecular formula: C31H53NO23. Mole weight: 807.75.
Acarbose EP Impurity G
Acarbose EP Impurity G. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1013621-73-2. Molecular formula: C31H53NO23. Mole weight: 807.75. Catalog: APB1013621732.
Acarbose EP Impurity G
An impurity of Acarbose, a medication used for the treatment of diabetes mellitus type 2. Synonyms: α-D-glucopyranosyl O-4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-enyl]amino]-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranoside; α-D-glucopyranosyl α-acarboside; Acarbose Impurity G. Grade: > 95%. CAS No. 1013621-73-2. Molecular formula: C31H53NO23. Mole weight: 807.75.
Acarbose EP Impurity H
An impurity of Acarbose, a medication used for the treatment of diabetes mellitus type 2. Synonyms: O-4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-enyl]amino]-α-Dglucopyranosyl-(1→4)-O-6-deoxy-α-D-glucopyranosyl-(1→4)-D-glucopyranose; Acarbose Impurity H. Molecular formula: C25H43NO17. Mole weight: 629.61.
Acarbose Impurity B
Acarbose Impurity B. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (1S,2S,3R,6S)-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-4,5-dihydroxy-2-(hydroxymethyl)-6-(((1R,4R,5S,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)cyclohex-2-en-1-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxy-2-methyltetrahydro-2H-pyran-3-yl)amino)-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol. CAS No. 1220983-54-9. Molecular formula: C26H43NO17. Mole weight: 641.62. Catalog: APB1220983549.
Acarbose-N-allyl Formate Tridecaacetate
Acarbose-N-allyl Formate Tridecaacetate is an intermediate formed in the synthesis of α-D-Glucosyl Acarbose Impurity, a homolog of Acarbose (A123500) for use in the treatment of chronic diseases such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites (1,2,3). Acarbose impurity F. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 500mg. Molecular Formula: C55H73NO33. US Biological Life Sciences.
Worldwide
Acarbose-N-allyl Formate Tridecaacetate
Acarbose-N-allyl Formate Tridecaacetate is an intermediate formed in the synthesis of α-D-Glucosyl Acarbose Impurity, a homolog of Acarbose for use in the treatment of chronic diseases such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites. Synonyms: (3R,4S,5R,6R)-6-(Acetoxymethyl)-5-(((2R,3R,4S,5R,6R)-3,4-diacetoxy-6-(acetoxymethyl)-5-(((2R,3R,4S,5R,6R)-3,4-diacetoxy-5-(((allyloxy)carbonyl)((1S,4S,5S,6S)-4,5,6-triacetoxy-3-(acetoxymethyl)cyclohex-2-en-1-yl)amino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triyl triacetate. Molecular formula: C55H73NO33. Mole weight: 1276.16.
Acarbose O-Allyl Ether
Acarbose O-Allyl Ether is an intermediate in synthesizing Acarbose, which is used as an anti-diabetic. Synonyms: (1S,2S,3S,6S)-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6R)-6-(((2R,3S,4R,5R,6R)-6-(Allyloxy)-4,5-dihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxy-2-methyltetrahydro-2H-pyran-3-yl)amino)-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol. Molecular formula: C28H47NO18. Mole weight: 685.67.
Acarbose O-Allyl Ether Bis-O-t-butyldiphenylsilane Ester Deca-acetate is an intermediate in synthesizing Acarbose, which is used as an anti-diabetic. Synonyms: (1S,2S,3S,6S)-4-(((t-Butyldiphenylsilyl)oxy)methyl)-6-(((2R,3R,4S,5R,6R)-4,5-diacetoxy-6-(((2R,3R,4S,5R,6R)-4,5-diacetoxy-2-(acetoxymethyl)-6-(((2R,3R,4S,5R,6R)-4,5-diacetoxy-6-(allyloxy)-2-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)amino)cyclohex-4-ene-1,2,3-triyl Triacetate. Molecular formula: C80H103NO28Si2. Mole weight: 1582.83.
Acarbose O-Allyl Ether Deca-acetate
Acarbose O-Allyl Ether Deca-acetate is an intermediate in synthesizing Acarbose, which is used as an anti-diabetic. Synonyms: (1S,2S,3S,6S)-6-(((2R,3R,4S,5R,6R)-4,5-Diacetoxy-6-(((2R,3R,4S,5R,6R)-4,5-diacetoxy-2-(acetoxymethyl)-6-(((2R,3R,4S,5R)-4,5-diacetoxy-6-(allyloxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)amino)-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triyl triacetate. Molecular formula: C48H67NO28. Mole weight: 1106.04.
Acarbose sulfate
Acarbose sulfate is an anti-diabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes. It is an inhibitor of alpha glucosidase, an enteric enzyme that releases glucose from larger carbohydrates. Acarbose sulfate decreased the Fasting Blood Glucose of DM Rats. The fasting blood glucose (FBG) in the acarbose-treated group decreased significantly at week 2 (P<0.05), week 4 (P<0.05), week 6 (P<0.05), and week 8 (P<0.05) compared to the DM group. Synonyms: Bay-g 5421 sulfate; BAY g 5421 sulfate. Grade:>98%. CAS No. 1221158-13-9. Molecular formula: C25H45NO22S. Mole weight: 743.68.
Acarbose System Suitability Mixture
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Acarbose tridecaacetate
Acarbose tridecaacetate, an alpha-glucosidase inhibitor utilized in managing type 2 diabetes mellitus, enables the delay in carbohydrate digestion and absorption, thus regulating postprandial glucose levels. Synonyms: O-2,3-Di-O-acetyl-4,6-dideoxy-4-[[4,5,6-tris(acetyloxy)-3-[(acetyloxy)methyl]-2-cyclohexen-1-yl]amino]-a-D-glucopyranosyl-(1-4)-O-2,3,6-tri-O-acetyl-a-D-glucopyranosyl-(1-4)-a-D-glucopyranose 1,2,3,6-tetraacetate; α-D-Glucopyranose, O-2,3-di-O-acetyl-4,6-dideoxy-4-[[4,5,6-tris(acetyloxy)-3-[(acetyloxy)methyl]-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1→4)-O-2,3,6-tri-O-acetyl-α-D-glucopyranosyl-(1→4)-, 1,2,3,6-tetraacetate, [1S-(1α,4α,5β,6α)]-. CAS No. 117065-98-2. Molecular formula: C51H69NO31. Mole weight: 1192.08.
[1S-(1α,4α,5 β,6α)]-4,6-Dideoxy-4-[[4,5,6-tris(acetyloxy)-3-[(acetyloxy)methyl]-2-cyclohexen-1-yl]amino]-α-D-glucopyranoside 2,3-Diacetate Methyl Ester is an intermediate in the synthesis of Pseudo Acarbose, an homolog of Acarbose (A123500), used in the treatment of diabetes (1). Group: Biochemicals. Grades: Highly Purified. CAS No. 80943-42-6. Pack Sizes: 100mg, 1g. Molecular Formula: C26H37NO14. US Biological Life Sciences.
[1S-(1α,4α,5β,6α)]-4,6-Dideoxy-4-[[4,5,6-tris(acetyloxy)-3-[(acetyloxy)methyl]-2-cyclohexen-1-yl]amino]-α-D-glucopyranoside 2,3-Diacetate Methyl Ester is an intermediate in the synthesis of Pseudo Acarbose, an homolog of Acarbose, used in the treatment of diabetes. Synonyms: α-D-Glucopyranoside, methyl 4,6-dideoxy-4-[[4,5,6-tris(acetyloxy)-3-[(acetyloxy)methyl]-2-cyclohexen-1-yl]amino]-, 2,3-diacetate, [1S-(1α,4α,5β,6α)]-; (1S,2S,3R,6S)-4-(Acetoxymethyl)-6-(((2R,3R,4S,5R,6S)-4,5-diacetoxy-6-methoxy-2-methyltetrahydro-2H-pyran-3-yl)amino)cyclohex-4-ene-1,2,3-triyl triacetate; Methyl [1S-(1α,4α,5β,6α)]-4,6-dideoxy-4-[[4,5,6-tris(acetyloxy)-3-[(acetyloxy)methyl]-2-cyclohexen-1-yl]amino]-α-D-glucopyranoside 2,3-diacetate. CAS No. 80943-42-6. Molecular formula: C26H37NO14. Mole weight: 587.57.
2-epi-5-epi-valiolone 7-kinase
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is involved in the biosynthesis of the oligosaccharide acarbose. Group: Enzymes. Synonyms: AcbM. Enzyme Commission Number: EC 2.7.1.188. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3020; 2-epi-5-epi-valiolone 7-kinase; EC 2.7.1.188; AcbM. Cat No: EXWM-3020.
2-epi-5-epi-valiolone 7-phosphate 2-epimerase
The enzyme, isolated from the bacterium Actinoplanes sp. SE 50/110, is involved in the biosynthesis of the α-glucosidase inhibitor acarbose. Group: Enzymes. Synonyms: AcbO. Enzyme Commission Number: EC 5.1.3.35. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5422; 2-epi-5-epi-valiolone 7-phosphate 2-epimerase; EC 5.1.3.35; AcbO. Cat No: EXWM-5422.
2-epi-5-epi-valiolone synthase
The enzyme is highly specific for α-D-sedoheptulopyranose 7-phosphate. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. The enzyme is involved in the biosynthesis of C7N-aminocyclitol natural products, such as the valienamine moiety of the antidiabetic drug acarbose and the crop protectant validamycin A. cf. EC 4.2.3.155, 2-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase. Group: Enzymes. Synonyms: AcbC; ValA; CetA; SalQ; C7-cyclitol synthase. Enzyme Commission Number: EC 4.2.3.152. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5167; 2-epi-5-epi-valiolone synthase; EC 4.2.3.152; AcbC; ValA; CetA; SalQ; C7-cyclitol synthase. Cat No: EXWM-5167.
4-O-(2,3,4-Tri-O-acetyl-6-deoxy-6-iodo-α-D-glucopyranosyl)-β-D-glucopyranose 1,2,3,6-Tetraacetate can be used to for electrochemical characterization of 6-iodomaltose, 6'-iodomaltose and 6-iodomaltotriose. It is also an intermediate in the synthesis of homolog of Acarbose for use in the treatment of diabetes. Synonyms: 4-O-(2,3,4-Tri-O-acetyl-6-deoxy-6-iodo-α-D-glucopyranosyl)-β-D-glucopyranose Tetraacetate; β-D-Glucopyranose, 4-O-(2,3,4-tri-O-acetyl-6-deoxy-6-iodo-α-D-glucopyranosyl)-, tetraacetate; β-D-Glucopyranose, 4-O-(2,3,4-tri-O-acetyl-6-deoxy-6-iodo-α-D-glucopyranosyl)-, 1,2,3,6-tetraacetate; (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)-5-(((2S,3R,4S,5S,6S)-3,4,5-triacetoxy-6-(iodomethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triyl triacetate. CAS No. 93528-00-8. Molecular formula: C26H35IO17. Mole weight: 746.45.
4-O-(2,3,4-Tri-O-acetyl-6-deoxy-α-D-glucopyranosyl)-β-D-glucopyranose Triacetate is an intermediate in the synthesis of Pseudo Acarbose, an homolog of Acarbose, used in the treatment of diabetes. Synonyms: 4-O-(2,3,4,6-Tetra-O-acetyl-6-deoxy-α-D-glucopyranosyl-β-D-glucopyranose Triacetate; (2R,3R,4S,5R,6R)-2-(((2R,3R,4S,5R,6R)-4,5-Diacetoxy-2-(acetoxymethyl)-6-hydroxytetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triyl triacetate. Molecular formula: C24H34O16. Mole weight: 578.52.
4-O-[4,6-O-(Phenylmethylene)- β-D-galactopyranosyl]- β-D-glucopyranoside Methyl Ester Hexaacetate is an impurity made in the synthesis of Acarbose (A123500) related compounds (1,2). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 250mg. Molecular Formula: C32H40O16. US Biological Life Sciences.
4-O-[4,6-O-(Phenylmethylene)-β-D-galactopyranosyl]-β-D-glucopyranoside Methyl Ester Pentacetate is an impurity in the synthesis of Acarbose related compounds. Synonyms: (2R,3R,4S,5R,6R)-6-(Acetoxymethyl)-5-(((4aR,6S,7R,8S,8aS)-7,8-diacetoxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-2-methoxytetrahydro-2H-pyran-3,4-diyl diacetate; 4-O-[4,6-O-(Phenylmethylene)-β-D-galactopyranosyl]-β-D-glucopyranoside Methyl Ester Hexaacetate. Molecular formula: C30H38O16. Mole weight: 654.62.
Acarviosine-glucose
An impurity of Acarbose, a medication used for the treatment of diabetes mellitus type 2. Synonyms: Amylostatin XG; Acarviostatin I00. CAS No. 68128-53-0. Molecular formula: C19H33NO13. Mole weight: 483.5.
Acaterin
Acarbose is an acyl-CoA isolated from Pseudomonas species. A92. In the presence of oxidized low-density lipoprotein in macrophages J744, the synthesis of cholesterol enzymes is inhibited, with an IC50 of 45 μmol/L, and the IC50 for inhibiting ACAT in rat liver microsomes is 120 μmol/L. Inhibition of ACAT is non-competitive Sexual. Synonyms: (2R)-4-[(1R)-1-hydroxyoctyl]-2-methyl-2H-furan-5-one; 3-(1-Hydroxyoctyl)-5-methyl-2(5H)-furanone. Grade: >98%. CAS No. 144398-20-9. Molecular formula: C13H22O3. Mole weight: 226.31.
Amylostatin XG 1-Thiophenyl Nonaacetate
Amylostatin XG 1-Thiophenyl Nonaacetate is a protected intermediate of Amylostatin XG, an analogue of an α-glucosidase inhibitor, Acarbose. Molecular formula: C43H55NO21S. Mole weight: 953.96.
Amylostatin XG Octaacetate
Amylostatin XG Octaacetate is a protected intermediate of Amylostatin XG, an analogue of an α-glucosidase inhibitor, Acarbose. Synonyms: [1S-(1α,4α,5β,6α)]-4-O-[2,3-Di-O-acetyl-4,6-dideoxy-4-[[4,5,6-tris(acetyloxy)-3-[(acetyloxy)methyl]-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl]-D-glucopyranose; D-Glucopyranose, 4-O-[2,3-di-O-acetyl-4,6-dideoxy-4-[[4,5,6-tris(acetyloxy)-3-[(acetyloxy)methyl]-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl]-, 1,2,3,6-tetraacetate, [1S-(1α,4α,5β,6α)]-. CAS No. 85747-82-6. Molecular formula: C39H53NO23. Mole weight: 903.83.
Amylostatin XG Octamethoxybenzyl Ether
Amylostatin XG Octamethoxybenzyl Ether is a protected intermediate of Amylostatin XG, an analogue of an α-glucosidase inhibitor, Acarbose. Molecular formula: C97H109NO21S. Mole weight: 1656.96.
CKD-711
It is produced by the strain of Streptomyces sp. CK-4416. CKD-711 strongly inhibited mammalian α-glucosidase activity, but weakly inhibited mammalian α-amylase from microorganism and mammal, which was similar to acarbose in vivo and in vitro. Synonyms: 4-Deoxy-4-{[(1R,2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)-7-oxabicyclo[4.1.0]hept-2-yl]amino}-α-D-glucopyranosyl-(1->4)-α-D-glucopyranosyl-(1->4)-D-glucopyranose. Molecular formula: C25H43NO20. Mole weight: 677.60.
D-Glucopyranose 1,2,3,6-Tetrabenzoate
D-Glucopyranose 1,2,3,6-Tetrabenzoate is used in theα-D-Glucosyl Acarbose Impurity synthesis, a homolog of Acarbose for use in thechronic diseases treatment such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites. Acarbose impurity F. Synonyms: (3R,4S,5R,6R)-6-((benzoyloxy)methyl)-5-hydroxytetrahydro-2H-pyran-2,3,4-triyl tribenzoate. CAS No. 20226-68-0. Molecular formula: C34H28O10. Mole weight: 596.58.
D-Glucopyranosyl-4-trimethylsilyl Tetrabenzoate
D-Glucopyranosyl-4-trimethylsilyl Tetrabenzoate is used in the synthesis of α-D-Glucosyl Acarbose Impurity, a homolog of Acarbose for use in the treatment of chronic diseases such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites. Acarbose impurity F. Synonyms: (3R,4R,5R,6R)-6-((Benzoyloxy)methyl)-5-((trimethylsilyl)oxy)tetrahydro-2H-pyran-2,3,4-triyl Tribenzoate. Molecular formula: C37H36O10Si. Mole weight: 668.76.
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