Acid Dehydrogenase Suppliers USA
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Product | Description | |
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Dihydroorotate Dehydrogenase Inhibitor, Brequinar (6-fluoro-2-(2-fluoro-1,1-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic Acid Sodium Salt, NSC 368390, DuP 785) Quick inquiry Where to buy Suppliers range | A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 96201-88-6. Pack Sizes: 10mg. Molecular Formula: C??H??F?NNaO?, Primary Target: DHODH. US Biological Life Sciences. | Worldwide |
1, 1'-[ (2-Ethyl-1, 3-propanediyl) bis (oxymethylene) ]bisbenzene Quick inquiry Where to buy Suppliers range | 1, 1'-[ (2-Ethyl-1, 3-propanediyl) bis (oxymethylene) ]bisbenzene is an intermediate in the synthesis of 2- (Hydroxymethyl) butanoic Acid (H946455), a substrate used to study the activity of 2-methyl-3hydroxybutyryl-CoA dehydrogenase deficiency in patients and carriers. Group: Biochemicals. Grades: Highly Purified. CAS No. 33498-90-7. Pack Sizes: 1g, 10g. Molecular Formula: C19H24O2. US Biological Life Sciences. | Worldwide |
1-?(2,?3,?5-?Tri-?O-?acetyl-? β-?D-?ribofuranosyl)?-?1,?2,?4-?triazole-?3-?carboxylic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | 1-?(2,?3,?5-?Tri-?O-?acetyl-? β-?D-?ribofuranosyl)?-?1,?2,?4-?triazole-?3-?carboxylic Acid Methyl Ester is a reactant used in the synthesis of azole nucleoside 5'-?MP mimics (P1Ms) as IMP dehydrogenase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 39925-10-5. Pack Sizes: 10mg, 100mg. Molecular Formula: C15H19N3O9, Molecular Weight: 385.33. US Biological Life Sciences. | Worldwide |
1-?(2,?3,?5-?Tri-?O-?acetyl-?β-?D-?ribofuranosyl)?-?1,?2,?4-?triazole-?3-?carboxylic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | As an IMP dehydrogenase inhibitor, 1-(2,?3,?5-Tri-O-acetyl-β-D-ribofuranosyl)?-1,?2,?4-triazole-3-carboxylic Acid Methyl Ester is a reactant used in the synthesis of azole nucleoside 5'-MP mimics (P1Ms). Synonyms: Methyl 1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)?-1,2,4-triazole-3-carboxylate; 1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylic Acid Methyl Ester. Grades: 96%. CAS No. 39925-10-5. Molecular formula: C15H19N3O9. Mole weight: 385.33. | |
1-?(2,?3,?5-?Tri-?O-?acetyl-? β-?D-?ribofuranosyl)?-?1,?2,?4-?triazole-?3-?carboxylic Acid Methyl Ester-13C2 Quick inquiry Where to buy Suppliers range | 1-?(2,?3,?5-?Tri-?O-?acetyl-? β-?D-?ribofuranosyl)?-?1,?2,?4-?triazole-?3-?carboxylic Acid Methyl Ester-13C2 is the labeled analogue of 1-?(2,?3,?5-?Tri-?O-?acetyl-? β-?D-?ribofuranosyl)?-?1,?2,?4-?triazole-?3-?carboxylic Acid Methyl Ester (T767035), a reactant used in the synthesis of azole nucleoside 5'-?MP mimics (P1Ms) as IMP dehydrogenase inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C1313C2H19N3O9, Molecular Weight: 387.31. US Biological Life Sciences. | Worldwide |
1-Bromo-3,4-dimethoxy-2-propylbenzene Quick inquiry Where to buy Suppliers range | 1-Bromo-3,4-dimethoxy-2-propylbenzene is an intermediate formed in the synthesis of 2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid (D453265), which is used in the synthesis of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 142601-49-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C11H15BrO2. US Biological Life Sciences. | Worldwide |
1-Cyclopropane Mycophenolic Acid Quick inquiry Where to buy Suppliers range | 1-Cyclopropane Mycophenolic Acid is a non-active analogue of Mycophenolic Acid (M831500), an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides. Group: Biochemicals. Grades: Highly Purified. CAS No. 125198-40-5. Pack Sizes: 10mg, 100mg. Molecular Formula: C18H22O6. US Biological Life Sciences. | Worldwide |
1H-Indazole-6-boronic Acid Quick inquiry Where to buy Suppliers range | It is commonly used in the preparation of reactants such as dicyclic hydroxybenzophenone derivatives as hydroxysteroid dehydrogenase inhibitors. Synonyms: 6-Indazolyboronic acid; 1H-Indazol-6-yl-6-boronic acid; (1H-indazol-6-yl)boronic acid; Indazole-6-boronic acid; Boronic acid, 1H-indazol-6-yl-; MFCD04972419; J-500188; (2H-indazol-6-yl)boronic acid; AMBA00083; CTK5G0023. Grades: > 97 % (HPLC). CAS No. 885068-10-0. Molecular formula: C7H7BN2O2. Mole weight: 161.95. | |
1-O-D-Sorbitol Mycophenolate Quick inquiry Where to buy Suppliers range | 1-O-D-Sorbitol Mycophenolate is an impurity or sugar conjugate of Mycophenolic Acid (M831500), which is an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. It is a selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C23H32O11, Molecular Weight: 484.49. US Biological Life Sciences. | Worldwide |
(1R, 4R) -4-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | (1R, 4R) -4-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester is an intermediate in synthesizing trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 168958-19-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C12H19NO4. US Biological Life Sciences. | Worldwide |
20-Carboxy arachidonic acid Quick inquiry Where to buy Suppliers range | 20-Carboxy arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Synonyms: 20-carboxy AA; 20-COOH-AA; 5Z,8Z,11Z,14Z-Eicosatetraenedioic acid; Arachidonic acid-20-carboxylic acid. Grades: >98%. CAS No. 79551-84-1. Molecular formula: C20H30O4. Mole weight: 334.5. | |
2-(3,5-Diformyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic Acid Quick inquiry Where to buy Suppliers range | 2-(3,5-Diformyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic Acid s an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C17H17NO5S, Molecular Weight: 347.39. US Biological Life Sciences. | Worldwide |
2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid Quick inquiry Where to buy Suppliers range | This compound is used in the synthesis of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 213971-34-7. Pack Sizes: 500ug, 5mg. Molecular Formula: C22H22O4. US Biological Life Sciences. | Worldwide |
2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid-d5 Quick inquiry Where to buy Suppliers range | 2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid-d5 is the labeled analogue of 2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid (D453265), used in the synthesis of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C22H17D5O4, Molecular Weight: 355.44. US Biological Life Sciences. | Worldwide |
2,3-Dimethoxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid Quick inquiry Where to buy Suppliers range | 2,3-Dimethoxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid is an intermediate formed in the synthesis of 2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid (D453265), which is used in the synthesis of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 213971-47-2. Pack Sizes: 5mg, 25mg. Molecular Formula: C24H26O4. US Biological Life Sciences. | Worldwide |
2,3-Dimethoxy-7-methyl-6-(phenylmethyl)-1-propylnaphthalene Quick inquiry Where to buy Suppliers range | 2,3-Dimethoxy-7-methyl-6-(phenylmethyl)-1-propylnaphthalene is an intermediate formed in the synthesis of 2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid, which is used in the synthesis of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 213971-42-7. Pack Sizes: 5mg, 25mg. Molecular Formula: C23H26O2. US Biological Life Sciences. | Worldwide |
2,3-Xylohydroquinone Quick inquiry Where to buy Suppliers range | 2,3-Xylohydroquinone is a useful synthetic intermediate. It was used in the synthesis of mycophenolic acid analogs with IMP dehydrogenase-inhibiting activities. It is a metabolite of butylamino (dimethylphenoxy) propanol, a new adrenergic β-blocking agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 608-43-5. Pack Sizes: 1g, 2.5g. Molecular Formula: C8H10O2. US Biological Life Sciences. | Worldwide |
2,4-Dichlorobenzeneboronic Acid Quick inquiry Where to buy Suppliers range | 2,4-Dichlorobenzeneboronic Acid is an intermediate used to prepare N-hydroxyindole-2-carboxylates for use as lactate dehydrogenase inhibitors and Non-ATP competitive MK2 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 68716-47-2. Pack Sizes: 1g, 5g. Molecular Formula: C6H5BCl2O2, Molecular Weight: 190.82. US Biological Life Sciences. | Worldwide |
2,6-Dimethylheptanoyl-CoA Sodium Salt Quick inquiry Where to buy Suppliers range | 2,6-Dimethylheptanoyl-CoA Sodium Salt is a sodium salt analog of 2,6-Dimethylheptanoyl-CoA , which is a specific substrate for long-chain acyl-CoA dehydrogenase (LCAD) which plays a major role in branched-chain fatty acid oxidation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C30H52N7O17P3S; x(Na). US Biological Life Sciences. | Worldwide |
2-Aminotetraline-2-carboxylic acid Quick inquiry Where to buy Suppliers range | 2-Aminotetraline-2-carboxylic acid is a potent and selective IDH1 (isocitrate dehydrogenase 1) mutant inhibitor for the treatment of acute myeloid leukemia. Synonyms: Atc-OH; 2-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid; 2-Aminotetralin-2-carboxylic acid; D,L-2-Aminotetralin-2-carboxylic acid; 2-AMINOTETRALINE-2-CARBOXYLIC ACID; 2-Amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylicacid; 2-amino-3,4-dihydro-1H-naphthalene-2-carboxylic acid; (R)-2-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid; (+/-)-2-Amino-1,2,3,4-tetrahydro-2-naphthoic acid; GSK 321; Atc OH. Grades: ≥ 98% (HPLC). CAS No. 6331-63-1. Molecular formula: C11H13NO2. Mole weight: 191.22. | |
2-Bromo-1,6-dimethyl Ester Hexanedioic Acid Quick inquiry Where to buy Suppliers range | 2-Bromo-1,6-dimethyl Ester Hexanedioic Acid is an intermediate in the synthesis of 2-Hydroxyhexanedioic Acid Disodium Salt (H943015). Accumulation and excretion of 2-Hydroxyhexanedioic Acid (with 2-ketoadipic and 2-aminoadipic) in urine can be caused by 2-ketoadipic acidemia, probably without adverse phenotypic effects, due to deficiency of 2-ketoadipic dehydrogenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 3196-19-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H13BrO4. US Biological Life Sciences. | Worldwide |
2-Ethyl-1,3-propanediol-d5 Quick inquiry Where to buy Suppliers range | 2-Ethyl-1,3-propanediol-d5 is a labelled analogue of 2-Ethyl-1,3-propanediol (E678665), which is an intermediate in the synthesis of Peloruside A related compounds, novel anti mitotic agents with Paclitaxel (P132500)-like microtubule-stabilizing activity. 2-Ethyl-1,3-propanediol-d5 is also an intermediate in synthesizing 2- (Hydroxymethyl) butanoic-d5 Acid (H946457), which is used as a substrate to study the activity of 2-methyl-3hydroxybutyryl-CoA dehydrogenase deficiency in patients and carriers. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C5H7D5O2. US Biological Life Sciences. | Worldwide |
2-Fluoro-3-Methoxyphenylboronic acid Quick inquiry Where to buy Suppliers range | 2-Fluoro-3-methoxyphenylboronic acid was used as the reactant to participate in the regional selective suzuki coupling, the preparation of 17 hydroxysteroid dehydrogenase type 1 inhibitors, and the preparation of boron esters. Synonyms: 2-fluoro-3-methoxybenzeneboronic acid; Boronic acid, (2-fluoro-3-methoxyphenyl)-; MFCD02094728; 2-fluoro-3-methoxy-phenyl-boronic acid; AK-34813; BC000799. Grades: 98 % (HPLC). CAS No. 352303-67-4. Molecular formula: C7H8BFO3. Mole weight: 169.95. | |
2-Hydroxyhexanedioic Acid Disodium Salt Quick inquiry Where to buy Suppliers range | Accumulation and excretion of 2-Hydroxyhexanedioic Acid (with 2-ketoadipic and 2-aminoadipic) in urine can be caused by 2-ketoadipic acidemia, probably without adverse phenotypic effects , due to deficiency of 2-ketoadipic dehydrogenase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 500mg. Molecular Formula: C6H8Na2O5. US Biological Life Sciences. | Worldwide |
2-Ketobutyric Acid Quick inquiry Where to buy Suppliers range | A substrate for the determination of lactate dehydrogenase isoenzymes.This compound is suitable for lactate dehydrogenase (LDH) related research. Group: Biochemicals. Alternative Names: 2-Oxobutanoic Acid; 2-Oxobutyric Acid; 2-Ketobutanoic Acid; 2-Ketobutyric Acid; 2-Oxo-n-butyric Acid; 2-Oxobutanoic Acid; 2-Oxobutyric Acid; 3-Methylpyruvic Acid; NSC 60533; Propionylformic Acid; α-Ketobutyric Acid; α-Oxo-n-butyric Acid; α-Oxobutanoic Acid; α-Oxobutyric Acid; α-keto-n-Butyric Acid. Grades: Reagent Grade. CAS No. 600-18-0. Pack Sizes: 5g, 10g, 25g. US Biological Life Sciences. | Worldwide |
2-Ketoglutaric Acid-d2 Cacium Salt (d3 major) Quick inquiry Where to buy Suppliers range | 2-Ketoglutaric Acid-d2 Cacium Salt is a isotope labelled derivative of glutaric acid and is an intermediate in the krebs cycle catalyzed by glutamate dehydrogenase enzyme on glutamate. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. Molecular Formula: C5H2D2CaO5. US Biological Life Sciences. | Worldwide |
2-NH2-6-Cl-5'-PuMP Quick inquiry Where to buy Suppliers range | 2-NH2-6-Cl-5'-PuMP is an analogue of guanosine-5'-O-monophosphate and an inhibitor of IMP dehydrogenase. It is often used as the precursor for 6-modified 5'-GMP derivatives. Synonyms: 2-Amino-6-chloropurine riboside-5'-O-monophosphate, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 16321-98-5. Molecular formula: C10H13ClN5O7P (free acid). Mole weight: 381.67. | |
2-[ (Phenylmethoxy)methyl]-1-butanol Quick inquiry Where to buy Suppliers range | 2-[ (Phenylmethoxy)methyl]-1-butanol is an intermediate in the synthesis of 2- (Hydroxymethyl) butanoic Acid (H946455), a substrate used to study the activity of 2-methyl-3hydroxybutyryl-CoA dehydrogenase deficiency in patients and carriers. Group: Biochemicals. Grades: Highly Purified. CAS No. 14058-59-4. Pack Sizes: 25mg, 250mg. Molecular Formula: C12H18O2. US Biological Life Sciences. | Worldwide |
2-[ (Phenylmethoxy) methyl]butanoic Acid Quick inquiry Where to buy Suppliers range | 2-[ (Phenylmethoxy) methyl]butanoic Acid is an intermediate in the synthesis of 2- (Hydroxymethyl) butanoic Acid (H946455), a substrate used to study the activity of 2-methyl-3hydroxybutyryl-CoA dehydrogenase deficiency in patients and carriers. Group: Biochemicals. Grades: Highly Purified. CAS No. 1598357-06-2. Pack Sizes: 10mg, 100mg. Molecular Formula: C12H16O3. US Biological Life Sciences. | Worldwide |
(2R,3S)-3-Methylmalic Acid Quick inquiry Where to buy Suppliers range | (2R,3S)-3-Methylmalic Acid is used as one of determinants of performance in isocitrate dehydrogenase of Escherichia coli. Group: Biochemicals. Grades: Highly Purified. CAS No. 152204-30-3. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C5H8O5, Molecular Weight: 148.11. US Biological Life Sciences. | Worldwide |
3-[[[3-[4-[ (Methylsulfonyl) amino]phenyl]-4-oxo-4H-chromen-7-yl]oxy]methyl]benzoic Acid Quick inquiry Where to buy Suppliers range | 3-[[[3-[4-[ (Methylsulfonyl) amino]phenyl]-4-oxo-4H-chromen-7-yl]oxy]methyl]benzoic Acid is a highly selective reversible aldehyde dehydrogenase 2 (ALDH-2) inhibitor that reduce alcohol and cocaine intake in rats. It also has anxiolytic properties as well as reduces excessive alcohol drinking. Group: Biochemicals. Grades: Highly Purified. CAS No. 1005334-57-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H19NO7S, Molecular Weight: 465.48. US Biological Life Sciences. | Worldwide |
3-Amino-3-methylbutanoic Acid, 90% Quick inquiry Where to buy Suppliers range | 3-Amino-3-methylbutanoic Acid acts as a reagent in the preparation of arylsulfonyl methylbutanamides of cycloalkylamines, particularly adamantylamines, as selective inhibitors of human and murine 11 β-hydroxysteroid dehydrogenase type 1. Synthesis of acetylcholine and carbamoylcholine analogs as a functionally selective α4 β2 nicotinic acetylcholine receptor agonist. Phenamide preparation by coupling reaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 625-05-8. Pack Sizes: 250mg, 1g. Molecular Formula: C5H11NO2. US Biological Life Sciences. | Worldwide |
3-(Aminocarbonyl)-1-(2,3,5-tri-O-acetyl- β-D-ribofuranosyl)-pyridinium-d4 Triflate Quick inquiry Where to buy Suppliers range | 3-(Aminocarbonyl)-1-(2,3,5-tri-O-acetyl- β-D-ribofuranosyl)-pyridinium-d4 Triflate is an intermediate in the synthesis of β-NADH-d5 (d5-major) Diammonium Salt (N201487). β-NADH-d4 is labelled β-NADH (N201480, Disodium salt). β-NADH is one of the biologically active forms of nicotinic acid. Serves as a coenzyme of hydrogenases and dehydrogenases. NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C17H17D4N2O8+; CF3O3S-. US Biological Life Sciences. | Worldwide |
3-Bicyclo[3.2.1]octanone Quick inquiry Where to buy Suppliers range | 3-Bicyclo[3.2.1]octanone is used as a reactant in the synthesis of polycyclic acid derivatives as selective inhibitors of human 11 β-hydroxysteroid dehydrogenase type 1 (11 β-HSD-1). Group: Biochemicals. Grades: Highly Purified. CAS No. 14252-05-2. Pack Sizes: 250mg, 2.5g. Molecular Formula: C8H12O, Molecular Weight: 124.18. US Biological Life Sciences. | Worldwide |
3-Bromobenzoic Acid Methyl Ester-d4 Quick inquiry Where to buy Suppliers range | 3-Bromobenzoic Acid Methyl Ester-d4, is the labeled analogue of 3-Bromobenzoic Acid Methyl Ester (B680250), an halogenated benzoate derivative used as a reagent in organic synthesis. 3-Bromobenzoic Acid Methyl Ester is used in the synthesis of a novel series of tetra hydrodibenzazocine as inhibitors of 17 β-hydroxysteroid dehydrogenase type 3. Group: Biochemicals. Grades: Highly Purified. CAS No. 1643575-37-4. Pack Sizes: 100mg, 500mg. Molecular Formula: , Molecular Weight: US Biological Life Sciences. | Worldwide |
3-(Difluoromethyl)-1H-pyrazole-4-carboxylic Acid Quick inquiry Where to buy Suppliers range | 3-(Difluoromethyl)-1H-pyrazole-4-carboxylic Acid is an intermediate in synthesizing Sedaxane (S242000), a broad-spectrum seed treatment fungicide used for control of seed- and soil-borne diseases in a broad range of crops. It inhibits fungal respiration by binding to the succinate dehydrogenase complex in the fungal mitochondrium. Group: Biochemicals. Grades: Highly Purified. CAS No. 151734-02-0. Pack Sizes: 2.5g, 5g. Molecular Formula: C6H6F2N2O2. US Biological Life Sciences. | Worldwide |
3-Nitropropionic Acid Quick inquiry Where to buy Suppliers range | A cell-permeable, irreversible inactivator (~3mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38mg/kg/day) is shown to cause activation of c-Jun kinase in striatum. Group: Biochemicals. Alternative Names: 3-NP, 3-NPA, 3NPA. Grades: Highly Purified. CAS No. 504-88-1. Pack Sizes: 50mg. Molecular Formula: C?H?NO?. US Biological Life Sciences. | Worldwide |
3-Nitropropionic acid (3-NP) Quick inquiry Where to buy Suppliers range | A plant and fungal toxin, 3-nitropropionic acid acts as an irreversible inactivator of succinate dehydrogenase. Selectively inhibits succinic dehydrogenase complex (Complex II) in the mitochondrial electron transport chain. Also shown to cause brain lesions similar to those of Huntington?s disease. Group: Biochemicals. Alternative Names: 3-NP, 3-NPA, 3NPA. Grades: Highly Purified. CAS No. 504-88-1. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
5-OxoETE Quick inquiry Where to buy Suppliers range | 5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase. Synonyms: 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; 5-KETE; 5-ketoeicosatetraenoic acid. Grades: >98%. CAS No. 106154-18-1. Molecular formula: C20H30O3. Mole weight: 318.46. | |
6-Phosphogluconic acid,trisodium salt dihydrate Quick inquiry Where to buy Suppliers range | 6-Phosphogluconic acid, trisodium salt dihydrate is a vital compound used in the biomedical industry. It plays a crucial role in studying metabolic disorders and certain diseases related to abnormal glucose metabolism. This compound acting as a modulator of glucose-6-phosphate dehydrogenase. Synonyms: Trisodium 6-phospho-D-gluconate dihydrate; D-Gluconate 6-phosphate trisodium salt dihydrate. CAS No. 57775-17-4. Molecular formula: C6H14Na3O12P. Mole weight: 378.11. | |
7α,12α-Dihydroxy-5 β-cholestan-3-one Quick inquiry Where to buy Suppliers range | Substrate for 3α-Hydroxysteroid Dehydrogenase in primary bile acid biosynthesis. Group: Biochemicals. Alternative Names: (5 β, 7α, 12α)-7, 12-Dihydroxy-cholestan-3-one. Grades: Highly Purified. CAS No. 547-97-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Abacavir 5'-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | Abacavir 5'-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester is an intermediate used in the synthesis of various Abacavir metabolites. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Molecular formula: C33H46N6O10. Mole weight: 686.75. | |
AKR1C1 Inhibitor, 5-PBSA Quick inquiry Where to buy Suppliers range | A cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki=4nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki=0.087, 4.2 and 18.2uM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50=460nM in AKR1C1 overexpressing BAECs).CAS No.4906-68-7. Group: Biochemicals. Alternative Names: Aldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA. Grades: Highly Purified. CAS No. 4906-68-7. Pack Sizes: 25mg. Molecular Formula: C??H?BrO?. US Biological Life Sciences. | Worldwide |
AKR1C3 Inhibitor (3- (4- (Trifluoromethyl) phenylamino) benzoic Acid) Quick inquiry Where to buy Suppliers range | A cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17b-hydroxysteroid dehydrogenase) (IC50 = 60nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50uM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100uM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
all trans-Retinal Quick inquiry Where to buy Suppliers range | All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Synonyms: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal. Grades: > 95 %. CAS No. 116-31-4. Molecular formula: C20H28O. Mole weight: 284.44. | |
all-trans Retinal (Vitamin A Aldehyde, Retinene, Retinylaldehyde) Quick inquiry Where to buy Suppliers range | Corotenoid component of the visual pigments. All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Group: Biochemicals. Alternative Names: (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenal; all -trans-Vitamin A Aldehyde; Retinene; Retinylaldehyde. Grades: Highly Purified. CAS No. 116-31-4. Pack Sizes: 500mg, 1g. US Biological Life Sciences. | Worldwide |
Az-33 Quick inquiry Where to buy Suppliers range | Az-33 is a lactate dehydrogenase A (LDHA) inhibitor, which is a key enzyme in anaerobic glycolysis process and is deregulated in human malignancies. Uses: Az-33 is a lactate dehydrogenase a (ldha) inhibitor. Synonyms: Az 33; Az33; 2-(4-(4-((3-((2-Methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonic acid. Grades: ≥98%. CAS No. 1370290-34-8. Molecular formula: C25H27N3O6S. Mole weight: 497.56. | |
AZD4017 Quick inquiry Where to buy Suppliers range | AZD4017 is a potent, selective, and orally bioavailable 11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor). Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome. Synonyms: AZD-4017; AZD 4017; (S)-2-(1-(5-(Cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid. Grades: 96%. CAS No. 1024033-43-9. Molecular formula: C22H33N3O3S. Mole weight: 419.58. | |
AZD8329 Quick inquiry Where to buy Suppliers range | AZD8329 is a potent, selective 11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor) with reduced acyl glucuronide liability. AZD8329 demonstrates to have improved technical profile in terms of both solubility and pharmacokinetics. The extent of acyl glucuronidation was reduced through structural optimization of both the carboxylic acid and amide substituents, coupled with a reduction in lipophilicity leading to an overall increase in metabolic stability. Synonyms: AZD-8329; AZD 8329; 4-(4-((1r,3r,5r,7r)-adamantan-2-ylcarbamoyl)-5-(tert-butyl)-1H-pyrazol-1-yl)benzoic acid. Grades: 98%. CAS No. 1048668-70-7. Molecular formula: C25H31N3O3. Mole weight: 421.54. | |
BAY 1436032 Quick inquiry Where to buy Suppliers range | BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations. BAY 1436032 showed a favourable selectivity profile against wtIDH1/2 and a large panel of off-targets in vitro. Synonyms: 3-(2-[[4-(Trifluoromethoxy)phenyl]amino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic Acid; BAY-1436032. Grades: ≥98%. CAS No. 1803274-65-8. Molecular formula: C26H30F3N3O3. Mole weight: 489.53. | |
b-D-Glucose 6-phosphate Sodium Salt 99+% (HPLC) Quick inquiry Where to buy Suppliers range | Substrate for Glucose-6-Phosphate dehydrogenase. Group: Biochemicals. Alternative Names: G-6-P Na; β-D-Glucose-6-phosphoric acid sodium salt. Grades: Reagent Grade. CAS No. 54010-71-8. Pack Sizes: 1g, 5g, 25g. Molecular Formula: C6H12O9PNa, Molecular Weight: 282.1. US Biological Life Sciences. | Worldwide |
Benzenebutanoic Acid Ethyl Ester Quick inquiry Where to buy Suppliers range | Benzenebutanoic Acid Ethyl Ester is used in the synthesis of thiazolium salts with potent antimalarial activity. Also used in the preparation of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Alternative Names: Ethyl 4-phenylbutanoate; Ethyl 4-phenylbutyrate; NSC 163318. Grades: Highly Purified. CAS No. 10031-93-3. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
β-NADH, Reduced Disodium Salt (Nicotinamide Adenine Dinucleotide) Quick inquiry Where to buy Suppliers range | Beta-nicotinamide adenine dinucleotide hydrate. Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.NAD is a coenzyme formed from the nucleotide, nicotinamide, adenosine monophosphateand a phosphate group joining the first two components. NADP has the same structure with the addition of an extra phosphate group to AMP. NAD can be reduced to NADH during coupling with reactions which oxidize various organic substrates. For example, the reaction catalyzed by glyceraldehyde phosphate dehydrogenase during glycolysis. NADH then passes to the inside of mitochondria where it donates the electrons it is carrying to the electron transport chain. In this manner, NAD acts as an intermediate energy storage compound that indirectly generates ATP. Generally, NADP accepts electrons from catabolic reactions to form NADPH. An example is its coupling with the conversion of glucose-6-phosphate to ribose-5-phosphate in the pentose phosphate pathway. NADPH has a slightly different role to NADH in that it does not donate electrons to the electron transport chain. Instead, it tends to reduce intermediates in anabolic pathways e.g. fatty acid synthesis. NAD participates in many redox reactions in cells, including those in glycolysis and most of those in the citric acid cycle of cellular respiration. Nicotinamide adenine dinucleotide (NAD) and its relative nicotinamide adenine dinucleotide phosphate (NADP) are two of the most important coenzymes in the cell. In cells, most oxidations are accomplished by the removal of hydrogen atoms. Both of these coenzymes play crucial roles in this. Each molecule of NAD+ (or NADP+) can acquire two electrons; that is, be reduced by two electrons. However, only one proton accompanies the reduction. The other proton produced as two hydrogen atoms are removed from the molecule being oxidized is liberated into the surrounding medium. Group: Biochemicals. Alternative Names: β-DPNH; β-NADH; DPNH; Diphosphopyridine nucleotide, reduced form; NADH. Grades: Highly Purified. CAS No. 606-68-8. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C21H27N7O14P2Na2, Molecular Weight: 709.41. US Biological Life Sciences. | Worldwide |
β-NADPH Tetrasodium Salt Hydrate Quick inquiry Where to buy Suppliers range | One of the biologically active forms of nicotinic acid. Differs from NAD by an additional phosphate group at the 2'-position of the adenosine moiety. Serves as a coenzyme of hydrogenases and dehydrogenases. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions. Synonyms: 2'-(Dihydrogen Phosphate) 5'-(Trihydrogen Pyrophosphate)adenosine 5'5'-Ester 1,4-Dihydro-1-β-D-ribofuranosylnicotinamide Tetrasodium Salt Hydrate;β-NADPH; 2'-NADPH Hydrate; Coenzyme II Reduced Tetrasodium Salt Hydrate; Triphosphopyridine Nucleotide Reduced Tetrasodium Salt Hydrate; Dihydronicotinamide Adenine Dinucleotide Phosphate Tetrasodium Salt Hydrate. Grades: 95%. Molecular formula: C21H26N7Na4O17P3 XH2O. Mole weight: 833.35. | |
β-Nicotinamide Adenine Dinucleotide Phosphate, Sodium Salt Hydrate ( β-NADP-Na, TPN-Na) Quick inquiry Where to buy Suppliers range | NAD is a coenzyme formed from the nucleotide, nicotinamide, adenosine monophosphateand a phosphate group joining the first two components. NADP has the same structure with the addition of an extra phosphate group to AMP. NAD can be reduced to NADH during coupling with reactions which oxidize various organic substrates. For example, the reaction catalyzed by glyceraldehyde phosphate dehydrogenase during glycolysis. NADH then passes to the inside of mitochondria where it donates the electrons it is carrying to the electron transport chain. In this manner, NAD acts as an intermediate energy storage compound that indirectly generates ATP. Generally, NADP accepts electrons from catabolic reactions to form NADPH. An example is its coupling with the conversion of glucose-6-phosphate to ribose-5-phosphate in the pentose phosphate pathway. NADPH has a slightly different role to NADH in that it does not donate electrons to the electron transport chain. Instead, it tends to reduce intermediates in anabolic pathways e.g. fatty acid synthesis. NAD participates in many redox reactions in cells, including those in glycolysis and most of those in the citric acid cycle of cellular respiration. Nicotinamide adenine dinucleotide (NAD) and its relative nicotinamide adenine dinucleotide phosphate (NADP) are two of the most important coenzymes in the cell. In cells, most oxidations are accomplished by the removal of hydrogen atoms. Both of these coenzymes play crucial roles in this. Each molecule of NAD+ (or NADP+) can acquire two electrons; that is, be reduced by two electrons. However, only one proton accompanies the reduction. The other proton produced as two hydrogen atoms are removed from the molecule being oxidized is liberated into the surrounding medium. Group: Biochemicals. Alternative Names: b-NADP sodium salt hydrate; β-NADP-Na, β-NADP-sodium salt, Coenzyme II sodium salt, NADP, TPN-Na, TPN, Triphosphopyridine nucleotide sodium salt; 2'-(Dihydrogen Phosphate) Adenosine 5'-(Trihydrogen Diphosphate) P'?5'-Ester with 3-(Aminocarbonyl)-1- β -D-ribofuranosyl pyridinium , Inner Salt Sodium Salt; 2'-(Dihydrogen phosphate) Adenosine 5'-(Trihydrogen Diphosphate) P'?5'-Ester with 3-(Aminocarbonyl)-1- β -D-ribofuranosyl pyridinium Inner Salt Sodium Salt; Adenosine 5'-(Trihydrogen Diphosphate), P'?5'-Ester with 3-(Aminocarbonyl)-1- β -D-ribofuranosyl pyridinium Inner Salt, 2'-(Dihydrogen Phosphate) Monosodium Salt; NSC 20273; Sodium NADP. Grades: Highly Purified. CAS No. 698999-85-8,1184-16-3. Pack Sizes: 100mg, 500mg, 1g, 5g. Molecular Formula: C21H27N7O17P3 Na xH2O, Molecular Weight: 765.42 (anhydrous). US Biological Life Sciences. | Worldwide |
b-Nicotinamide Adenine Dinucleotide Phosphate, reduced form, tetrasodium salt ( β-NADPH) Quick inquiry Where to buy Suppliers range | One of the biologically active forms of nicotinic acid. Differs from NAD by an additional phosphate group at the 2-position of the adenosine moiety. Serves as a coenzyme of hydrogenases and dehydrogenases. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions. Group: Biochemicals. Alternative Names: 2'-(Dihydrogen Phosphate) 5'-(Trihydrogen Pyrophosphate) adenosine 5'5'-Ester 1,4-Dihydro-1- β -D-ribofuranosyl nicotinamide Tetrasodium Salt Hydrate; β-NADPH; 2?-NADPH Hydrate; Coenzyme II Reduced Tetrasodium Salt Hydrate; Triphosphopyridine Nucleotide Reduced Tetrasodium Salt Hydrate; Dihydronicotinamide Adenine Dinucleotide Phosphate Tetrasodium Salt Hydrate. Grades: Highly Purified. CAS No. 2646-71-1. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C??H??N?Na?O??P?; xH?O, Molecular Weight: 833.35. US Biological Life Sciences. | Worldwide |
Brequinar Quick inquiry Where to buy Suppliers range | Brequinar is a synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. Check for active clinical trials or closed clinical trials using this agent. Synonyms: DUP785; NSC 368390; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-; Biphenquinate. Grades: ≥98%. CAS No. 96187-53-0. Molecular formula: C23H15F2NO2. Mole weight: 375.37. | |
Brequinar sodium Quick inquiry Where to buy Suppliers range | Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM), which causes the blockade of de novo pyrimidine nucleotide biosynthesis. Uses: Antineoplastic agents. Synonyms: Dup785; Dup 785; Dup-785; Brequinar Sodium. 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium; Dup 785. Grades: ≥99% by HPLC. CAS No. 96201-88-6. Molecular formula: C23H14F2NO2Na. Mole weight: 397.35. | |
BT2 Quick inquiry Where to buy Suppliers range | BT2 is an allosteric inhibitor of branched-chain α-ketoacid dehydrogenase (BCKDC) kinase (BDK; IC50 = 3.19 μM). BT2 can dissociate BDK from BCKDC via binding to BDK. Synonyms: BT2; BT-2; BT 2; 3,6-Dichloro-1-benzothiophene-2-carboxylic acid. Grades: 99%. CAS No. 34576-94-8. Molecular formula: C9H4Cl2O2S. Mole weight: 247.1. | |
Carbenoxolone disodium Quick inquiry Where to buy Suppliers range | The sodium salt form of Carbenoxolone, which has been found to be an anti-inflammatory glucocorticoid and could inhibit 11β-hydroxysteroid dehydrogenase. Uses: Anti-ulcer agents. Synonyms: (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid disodium. Grades: ≥98% by HPLC. CAS No. 7421-40-1. Molecular formula: C34H48Na2O7. Mole weight: 614.72. | |
CGP 3466B maleate Quick inquiry Where to buy Suppliers range | CGP 3466B maleate, a potent anti-apoptotic drug, is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. CGP 3466B maleate was tested in clinical trials for its ability to help treat Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) but the clinical trials have been terminated due to lack of benefit. Synonyms: N-(benzo[b][1]benzoxepin-5-ylmethyl)-N-methylprop-2-yn-1-amine;but-2-enedioic acid; Omigapil maleate; CGP 3466B; CGP-3466B; CGP3466B; TCH-346; TCH 346; TCH346; Omigapil maleate. Grades: >99 %. CAS No. 200189-97-5. Molecular formula: C23H21NO5. Mole weight: 391.42. | |
CVT 10216 Quick inquiry Where to buy Suppliers range | Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models. Group: Biochemicals. Alternative Names: 3-[[[3-[4-[ (Methylsulfonyl) amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid. Grades: Highly Purified. CAS No. 1005334-57-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
CVT10216 Quick inquiry Where to buy Suppliers range | CVT10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) with IC50 value of 29nM, thereby inhibiting dopamine synthesis. It is active in suppressing alcohol and cocaine use, and anxiety. It has been shown to produce anxiolytic effects in four different rodent models, including a model of repeated alcohol withdrawal-induced anxiety. It increases acetaldehyde after alcohol gavage and inhibits 2-bottle choice alcohol intake in heavy drinking rodents. It prevents operant self-administration and eliminates cue-induced reinstatement of alcohol seeking. It also prevents alcohol-induced increases in NAc DA without changing basal levels. Uses: Cvt10216 is active in suppressing alcohol and cocaine use, and anxiety. Synonyms: CVT-10216; CVT 10216; CVT10216. 3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-chromen-7-yl]oxy]methyl]benzoic acid;GS 455534. Grades: >98 %. CAS No. 1005334-57-5. Molecular formula: C24H19NO7S. Mole weight: 465.48. | |
Danshensu Quick inquiry Where to buy Suppliers range | Danshensu is an active component of Salvia miltiorrhiza that shows wide cardiovascular benefit. It suppresses the formation of reactive oxygen species and inhibits platelet adhesion and aggregation. It also protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. It increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. It may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation. It significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size in vitro. It also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis. It significantly lowered tHcy in rats with elevated tHcy. Danshensu is a natural compound, which can also be used in cosmetics material. Synonyms: Benzenepropanoic acid, α,3,4-trihydroxy-, (αR)-; (αR)-α,3,4-Trihydroxybenzenepropanoic acid; Benzenepropanoic acid, α,3,4-trihydroxy-, (R)-; (R)-(+)-3-(3,4-Dihydroxyphenyl)lactic acid; (R)-3-(3,4-Dihydroxyphenyl)-2-hydroxypropionic acid; 3-(3',4'-Dihydroxyphenyl)-(2R)-lactic acid; D-(+)-β-(3,4-Dihydroxyphenyl)lactic acid; Dan Shen Su; Dan shen suan A; DS 182; Salianic acid A; Salvianic acid A; Tanshinol. Grades: >98%. CAS No. 76822-21-4. Molecular formula: C9H10O5. Mole weight: 198.17. | |
DCA Quick inquiry Where to buy Suppliers range | DCA is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. DCA also induces apoptosis and reverses the KV1.5 channels downregulation in cancer. Synonyms: Sodium dichloroacetate; Sodium 2,2-dichloroacetate; Dichloroacetic acid sodium salt. CAS No. 2156-56-1. Molecular formula: C2HCl2NaO2. Mole weight: 150.92. | |
Dihydroxy Analogue of Mycophenolic Acid Quick inquiry Where to buy Suppliers range | An impurity of Mycophenolic Acid which is a selective inhibitor of inosine monphosphate dehydrogenase. Synonyms: O-Desmethyl Mycophenolic Acid; (4E)-6-(1,3-Dihydro-4,6-dihydroxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid; Demethylmycophenolic Acid; Nor-O-methyl Mycophenolic Acid. Grades: > 95%. CAS No. 31858-65-8. Molecular formula: C16H18O6. Mole weight: 306.32. | |
Ds(+)-threo-Isocitric acid trisodium salt Quick inquiry Where to buy Suppliers range | Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation. Group: Biochemicals. Alternative Names: (1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid; (2R,3S)-Isocitric acid trisodium salt. Grades: Highly Purified. CAS No. 903507-52-8. Pack Sizes: 25mg, 100mg. Molecular Formula: C6H5O7 3Na, Molecular Weight: 258.1. US Biological Life Sciences. | Worldwide |
EC 1.1.1.47 Quick inquiry Where to buy Suppliers range | EC 1.1.1.47. Uses: Used for research and manufacturing. Group: Food Ingredients. Alternative Names: glucose dehydrogenase F. bacillus mega-terium;Dehydrogenase, glucose;GLUCOSE DEHYDROGENASE THERMOPLASMA,*ACID OPHILUM REC;BETA-D-GLUCOSE: NADP+ 1-OXIDOREDUCTASE;GLUCOSE DEHYDROGENASE;GLUCOSE DEHYDROGENASE, NADP DEPENDENT;GDH;EC 1.1.1.47. CAS No. 9028-53-9. Product ID: CDF4-0056. | |
Enasidenib mesylate Quick inquiry Where to buy Suppliers range | Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes indicated for the treatment of adult patients with replased or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation. Synonyms: methanesulfonic acid;2-methyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]-6-[[2-(trifluoromethyl)pyridin-4-yl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol; Enasidenib (mesylate); AG-221 mesylate; Enasidenib mesilate; Enasidenib methanesulfonate; Enasidenib mesylate [USAN]. CAS No. 1650550-25-6. Molecular formula: C20H21F6N7O4S. Mole weight: 569.48. | |
Etiroxate Carboxylic Acid Quick inquiry Where to buy Suppliers range | Thyroxin derivative inhibiting glutamate dehydrogenase, isocitrate dehydrogenase, alcohol dehydrogenase, rat liver mitochondrial phosphorylation and electron transfer. Administration also induces hypothyroid state. Group: Biochemicals. Alternative Names: O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-α-methyl-tyrosine; α-Methyl-DL-thyroxine. Grades: Highly Purified. CAS No. 3414-34-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |