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| Product | Description | |
|---|---|---|
| 1-deoxypentalenic acid 11β-hydroxylase | The enzyme requires Fe(II) and ascorbate. Isolated from the bacterium Streptomyces avermitilis. Part of the pathway for pentalenolactone biosynthesis. Group: Enzymes. Synonyms: ptlH (gene name); sav2991 (gene name); pntH (gene name). Enzyme Commission Number: EC 1.14.11.35. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0653; 1-deoxypentalenic acid 11β-hydroxylase; EC 1.14.11.35; ptlH (gene name); sav2991 (gene name); pntH (gene name). Cat No: EXWM-0653. |  |
| (+)-abscisic acid 8'-hydroxylase | A heme-thiolate protein (P-450). Catalyses the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone. CO inhibits the reaction, but its effects can be reversed by the presence of blue light. The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously. Other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase). Group: Enzymes. Synonyms: (+)-ABA 8'-hydroxylase; ABA 8'-hydroxylase. Enzyme Commission Number: EC 1.14.13.93. CAS No. 153190-37-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0902; (+)-abscisic acid 8'-hydroxylase; EC 1.14.13.93; 153190-37-5; (+)-ABA 8'-hydroxylase; ABA 8'-hydroxylase. Cat No: EXWM-0902. | |
| docosahexaenoic acid ω-hydroxylase | Isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid. Group: Enzymes. Synonyms: CYP4F3B; CYP4V2; docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming). Enzyme Commission Number: EC 1.14.13.199. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0799; docosahexaenoic acid ω-hydroxylase; EC 1.14.13.199; CYP4F3B; CYP4V2; docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming). Cat No: EXWM-0799. | |
| enduracididine β-hydroxylase | Fe2+-dependent enzyme. The enzyme is involved in biosynthesis of the nonproteinogenic amino acid β-hydroxyenduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotic), produced by Streptomyces hygroscopicus NRRL 30439. Group: Enzymes. Synonyms: MppO; L-enduracididine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating). Enzyme Commission Number: EC 1.14.11.40. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0659; enduracididine β-hydroxylase; EC 1.14.11.40; MppO; L-enduracididine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating). Cat No: EXWM-0659. | |
| HIF-PHD Inhibitor II, JNJ-42041935 (HIF Prolyl Hydroxylase Inhibitor II, 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid) | A cell-permeable benzimidazolopyrazole compound that acts as an active-site binding, iron insensitive, 2-oxoglutarate competitive, reversible and potent inhibitor of PHD1, 2 and 3 isozymes (pKi=7.91, 7.29 and 7.65, respectively). Displays >100-fold selectivity over FIH (factor inhibiting hydroxylase; pIC50 ~4) and minimal affinity towards a panel of receptors, enzymes and kinases. Shown to elevate HIF-1a levels in Hep3B cells and stimulate erythropoietin secretion in mice, and reverse inflammation-induced anemia in rats (100uM/kg). Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?ClF?N?O?, Molecular Weight: 346.7. US Biological Life Sciences. |  Worldwide |
| 12(S)-hydroxy-16-heptadecynoic acid | 12(S)-hydroxy-16-heptadecynoic acid is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase. It inhibits prostaglandin ω-hydroxylase with a Ki value of 1.8 μM. Synonyms: 16-Heptadecynoic acid,12-hydroxy-, (S)- (9CI); 12-Hydroxy-heptadec-16-ynoic acid. Grades: ≥98%. CAS No. 148019-74-3. Molecular formula: C17H30O3. Mole weight: 282.4. |  |
| 1,3,7-trimethyluric acid 5-monooxygenase | The enzyme, characterized from the bacterium Pseudomonas sp. CBB1, is part of the bacterial C-8 oxidation-based caffeine degradation pathway. The product decomposes spontaneously to a racemic mixture of 3,6,8-trimethylallantoin. The enzyme shows no acitivity with urate. cf. EC 1.14.13.113, FAD-dependent urate hydroxylase. Group: Enzymes. Synonyms: tmuM (gene name). Enzyme Commission Number: EC 1.14.13.212. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0814; 1,3,7-trimethyluric acid 5-monooxygenase; EC 1.14.13.212; tmuM (gene name). Cat No: EXWM-0814. | |
| 1,4-DPCA | The pro-angiogenic factor HIF-1α is targeted for destruction in non-hypoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH). It is a promotor of wound healing and tissue regeneration in mice. Synonyms: 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid. Grades: ≥98%. CAS No. 331830-20-7. Molecular formula: C13H8N2O3. Mole weight: 240.2. | |
| 17-ODYA | 17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC 50 <100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes [1] [2] [3]. 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 34450-18-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-101016. |  |
| 1,8-cineole 2-exo-monooxygenase | A heme-thiolate protein (P-450). The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 1.14.13.97 (taurochenodeoxycholate 6-hydroxylase), EC 1.14.13.67 (quinine 3-monooxygenase) and EC 1.14.13.32 (albendazole monooxygenase). Group: Enzymes. Synonyms: CYP3A4. Enzyme Commission Number: EC 1.14.13.157. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0757; 1,8-cineole 2-exo-monooxygenase; EC 1.14.13.157; CYP3A4. Cat No: EXWM-0757. | |
| 1-hydroxy-2-naphthoate hydroxylase | The enzyme is involved in the catabolic pathway for the degradation of chrysene in some bacteria. Group: Enzymes. Synonyms: 1-hydroxy-2-naphthoic acid hydroxylase. Enzyme Commission Number: EC 1.14.13.135. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0734; 1-hydroxy-2-naphthoate hydroxylase; EC 1.14.13.135; 1-hydroxy-2-naphthoic acid hydroxylase. Cat No: EXWM-0734. | |
| 1-Pyrrolidinebutyric Acid Hydrochloride | 1-Pyrrolidinebutyric Acid Hydrochloride is used in biological studies in the preparation of betaine analogs of mildronate as inhibitors of γ-butyrobetaine hydroxylase, and crystal structures of BBOX-inhibitor complexes. Group: Biochemicals. Grades: Highly Purified. CAS No. 49637-21-0. Pack Sizes: 1g, 10g. Molecular Formula: C8H16ClNO2, Molecular Weight: 193.67. US Biological Life Sciences. | Worldwide |
| 2-(1a-methyl-6-oxo-3-phenoxy-1,1a,6,6a-tetrahydroindeno[1,2-b]azirine-6a-carboxamido)acetic acid | 2-(1a-methyl-6-oxo-3-phenoxy-1,1a,6,6a-tetrahydroindeno[1,2-b]azirine-6a-carboxamido)acetic acid is an impurity of Roxadustat. Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI). It promotes coordinated erythropoiesis through increasing endogenous erythropoietin, improving iron availability, and reducing hepcidin. Synonyms: (1a-methyl-6-oxo-3-phenoxy-1,1a,6,6a-tetrahydroindeno[1,2-b]azirine-6a-carbonyl)glycine; Rosastat impurity 02. CAS No. 2301113-15-3. Molecular formula: C19H16N2O5. Mole weight: 352.35. | |
| 2-Amino-5,6,7,8-tetrahydro-6-methyl-4(1H)-pteridinone Dihydrochloride | 2-Amino-5,6,7,8-tetrahydro-6-methyl-4(1H)-pteridinone is an analog of tetrahydrobiopterin with cofactor activity for aromatic amino acid hydroxylases. It is also used to study mechanisms of nitric oxide (NO) synthase and free radical induced L-DOPA release from striatal tissue. Group: Biochemicals. Grades: Highly Purified. CAS No. 69113-63-9. Pack Sizes: 100mg, 1g. Molecular Formula: C7H13Cl2N5O, Molecular Weight: 254.12. US Biological Life Sciences. | Worldwide |
| 2-?Aminoindan-?2-?carboxylic Acid | 2-?Aminoindan-?2-?carboxylic Acid can be used as a potential tyrosine hydroxylase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 27473-62-7. Pack Sizes: 250mg, 1g. Molecular Formula: C10H11NO2. US Biological Life Sciences. | Worldwide |
| 2-Aminoindane-2-carboxylic acid | 2-Aminoindane-2-carboxylic acid can be used as a potential tyrosine hydroxylase inhibitor. Synonyms: Aic-OH; 2-Amino-2-indancarboxylic acid; 2-amino-2,3-dihydro-1H-indene-2-carboxylic acid; 2-Aminoindan-2-carboxylic acid; 2-Amino-indan-2-carboxylic acid; 1H-Indene-2-carboxylic acid, 2-amino-2,3-dihydro-; (+/-)-2-Aminoindane-2-carboxylic acid; 2-azanyl-1,3-dihydroindene-2-carboxylic acid; Aic OH. Grades: ≥ 99 % (HPLC). CAS No. 27473-62-7. Molecular formula: C10H11NO2. Mole weight: 177.20. | |
| 3,5-Pyridinedicarboxylic Acid | Competitive inhibitor of butyrobetaine hydroxylase. Group: Biochemicals. Alternative Names: Dinicotinic Acid; 3,5-Pyridinedicarboxylate; 5-Carboxynicotinic Acid; NSC 6497. Grades: Highly Purified. CAS No. 499-81-0. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase | Requires ATP. The reaction in mammals possibly involves dehydrogenation to give a 24(25)-double bond followed by hydration. However, in amphibians such as the Oriental fire-bellied toad (Bombina orientalis), it is probable that the product is formed via direct hydroxylation of the saturated side chain of (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate and not via hydration of a 24(25) double bond. In microsomes, the free acid is preferred to the coenzyme A ester, whereas in mitochondria, the coenzyme A ester is preferred to the free-acid form of the substrate. Group: Enzymes. Synonyms: trihydroxycoprostanoyl-CoA oxidase; THC-CoA oxidase; THCA-CoA oxidase; 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA oxidase; 3α,. Enzyme Commission Number: EC 1.17.99.3. CAS No. 119799-47-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1103; 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase; EC 1.17.99.3; 119799-47-2; trihydroxycoprostanoyl-CoA oxidase; THC-CoA oxidase; THCA-CoA oxidase; 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA oxidase; 3α,7α,12α-trihydroxy-5β-cholestan-26-oate 24-hydroxylase. Cat No: EXWM-1103. | |
| 3-Benzotriazol-1-yl-propionic Acid | 3-Benzotriazol-1-yl-propionic Acid is used in biological studies of azole derivatives as a novel non-iron-chelating inhibitors of prolyl hydroxylase 3 for HIF-1 activation. Group: Biochemicals. Grades: Highly Purified. CAS No. 654-15-9. Pack Sizes: 250mg, 1g. Molecular Formula: C9H9N3O2, Molecular Weight: 191.19. US Biological Life Sciences. | Worldwide |
| 3-hydroxybenzoate 6-monooxygenase | A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions; NADPH can act instead of NADH, but more slowly. Group: Enzymes. Synonyms: 3-hydroxybenzoate 6-hydroxylase; m-hydroxybenzoate 6-hydroxylase; 3-hydroxybenzoic acid-6-hydroxylase. Enzyme Commission Number: EC 1.14.13.24. CAS No. 51570-26-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0832; 3-hydroxybenzoate 6-monooxygenase; EC 1.14.13.24; 51570-26-4; 3-hydroxybenzoate 6-hydroxylase; m-hydroxybenzoate 6-hydroxylase; 3-hydroxybenzoic acid-6-hydroxylase. Cat No: EXWM-0832. | |
| 4-Chloro-DL-phenylalanine | 4-Chloro-DL-phenylalanine is a pharmaceutical intermediate. It acts as a selective and irreversible inhibitor of tryptophan hydroxylase. It is a rate-limiting enzyme in the biosynthesis of serotonin. It has been used experimentally to treat carcinoid syndrome. It is used in scientific research in humans and animals to investigate the effects of serotonin depletion. It binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain. Uses: 4-chloro-dl-phenylalanine has been used experimentally to treat carcinoid syndrome. it is used in scientific research in humans and animals to investigate the effects of serotonin depletion. it binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain. Synonyms: CP-10,188; CP10,188; CP 10,188; CP-10188; CP10188; CP 10188; Fenclonine; DL-3-(4-Chlorophenyl)alanine; Fenclonin; NSC 77370; p-Clorophenylalanine.; DL-4-Chlorophenylalanine;p-Chlorophenylalanine;(S)-2-amino-3-(4-chlorophenyl)propanoic acid;2-Amino-3-(4-chlorophenyl)propanoic acid; DL-3-(4-Chlorophenyl)alanine; Fenclonin; Fenclonine; PCP; PCPA; CP-10188. Grades: ≥ 99% (HPLC). CAS No. 7424-00-2. Molecular formula: C9H10ClNO2. Mole weight: 199.63. | |
| 4-Chloro-DL-phenylalanine methyl ester hydrochloride | 4-Chloro-DL-phenylalanine methyl ester hydrochloride is a tryptophan hydroxylase (TPH) inhibitor and a serotonin synthesis inhibitor. 4-Chloro-DL-phenylalanine methyl ester hydrochloride is also known to induce memory deficits in rats. Synonyms: DL-Phe(4-Cl)-OMe HCl; p-Chloro-DL-Phe-OMe HCl; (RS)-2-Amino-3-(4-chlorophenyl)propionic acid methyl ester hydrochloride; methyl 2-amino-3-(4-chlorophenyl)propanoate hydrochloride; H-DL-Phe(4-Cl)-OMe HCl; DL-p-Chlorophenylalanine methyl ester hydrochloride; DL-4-Chlorophenylalanine methyl ester hydrochloride; H-p-Chloro-D-Phe-OMe HCl. Grades: ≥ 99% (HPLC). CAS No. 14173-40-1. Molecular formula: C10H12ClNO2·HCl. Mole weight: 250.12. | |
| 4-Chloro-D-phenylalanine | 4-Chloro-D-phenylalanine is an inhibitor of liver tryptophan-5-hydroxylase. A specific depletor of brain serotonin. Synonyms: D-Phe(4-Cl)-OH; p-Chloro-D-phenylalanine; (R)-2-Amino-3-(4-chlorophenyl)propionic acid; D-4-Chlorophenylalanine; D-Phenylalanine, 4-chloro-; H-D-PHE(4-CL)-OH; (R)-2-AMINO-3-(4-CHLOROPHENYL)PROPANOIC ACID; (2R)-2-amino-3-(4-chlorophenyl)propanoic acid; d-p-chlorophenylalanine; (R)-fenclonine. Grades: ≥ 99% (HPLC). CAS No. 14091-08-8. Molecular formula: C9H10ClNO2. Mole weight: 199.63. | |
| 4-Chloro-D-phenylalanine methyl ester hydrochloride | 4-Chloro-D-phenylalanine Methyl Ester Hydrochloride is one of the enatiomer in 4-Chloro-DL-phenylalanine Methyl Ester Hydrochloride which is a tryptophan hydroxylase (TPH) inhibitor and a serotonin synthesis inhibitor. 4-Chloro-D-phenylalanine methyl ester hydrochloride is also known to induce memory deficits in rats. Synonyms: D-Phe(4-Cl)-OMe HCl; p-Chloro-D-Phe-OMe HCl; (R)-2-amino-3-(4-chlorophenyl)propionic acid methyl ester hydrochloride; H-D-Phe(4-Cl)OMe HCl; D-Phenylalanine, 4-chloro-, methyl ester, hydrochloride; D-Methyl 4-chlorophenylalaninate hydrochloride; 4-Chloro-D-phenylalanine methyl ester hydrochloride; 4-Chloro-D-Phe-OMe HCl. Grades: ≥ 98% (HPLC). CAS No. 33965-47-8. Molecular formula: C10H12ClNO2·HCl. Mole weight: 250.12. | |
| 4-hydroxybenzoate 3-monooxygenase | A flavoprotein (FAD). Most enzymes from Pseudomonas are highly specific for NADPH (cf. EC 1.14.13.33 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]). Group: Enzymes. Synonyms: p-hydroxybenzoate hydrolyase; p-hydroxybenzoate hydroxylase; 4-hydroxybenzoate 3-hydroxylase; 4-hydroxybenzoate monooxygenase; 4-hydroxybenzoic hydroxylase; p-hydroxybenzoate-3-hydroxylase; p-hydroxybenzoic acid hydrolase; p-hydroxybenzoic acid hydroxylase; p-hydroxybenzoic hydroxylase. Enzyme Commission Number: EC 1.14.13.2. CAS No. 9059-23-8. p-Hydroxybenzoate Hydroxylase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0800; 4-hydroxybenzoate 3-monooxygenase; EC 1.14.13.2; 9059-23-8; p-hydroxybenzoate hydrolyase; p-hydroxybenzoate hydroxylase; 4-hydroxybenzoate 3-hydroxylase; 4-hydroxybenzoate monooxygenase; 4-hydroxybenzoic hydroxylase; p-hydroxybenzoate-3-hydroxylase; p-hydroxybenzoic acid hydrolase; p-hydroxybenzoic acid hydroxylase; p-hydroxybenzoic hydroxylase. Cat No: EXWM-0800. | |
| 4-hydroxyphenylacetate 3-monooxygenase | The enzyme from Escherichia coli attacks a broad spectrum of phenolic compounds. The enzyme uses FADH2 as a substrate rather than a cofactor. FADH2 is provided by EC 1.5.1.36, flavin reductase (NADH). Group: Enzymes. Synonyms: p-hydroxyphenylacetate 3-hydroxylase; 4-hydroxyphenylacetic acid-3-hydroxylase; p-hydroxyphenylacetate hydroxylase (FAD); 4 HPA 3-hydroxylase; p-hydroxyphenylacetate 3-hydroxylase (FAD); HpaB. Enzyme Commission Number: EC 1.14.14.9. CAS No. 37256-71-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0933; 4-hydroxyphenylacetate 3-monooxygenase; EC 1.14.14.9; 37256-71-6; p-hydroxyphenylacetate 3-hydroxylase; 4-hydroxyphenylacetic acid-3-hydroxylase; p-hydroxyphenylacetate hydroxylase (FAD); 4 HPA 3-hydroxylase; p-hydroxyphenylacetate 3-hydroxylase (FAD); HpaB. Cat No: EXWM-0933. | |
| 4-hydroxyphenylpyruvate dioxygenase | The Pseudomonas enzyme contains one Fe3+ per mole of enzyme; the enzymes from other sources may contain essential iron or copper. Group: Enzymes. Synonyms: p-hydroxyphenylpyruvic hydroxylase; p-hydroxyphenylpyruvate hydroxylase; p-hydroxyphenylpyruvate oxidase; p-hydroxyphenylpyruvic oxidase; p-hydroxyphenylpyruvate dioxygenase; p-hydroxyphenylpyruvic acid hydroxylase; 4-hydroxyphenylpyruvic acid dioxygenase. Enzyme Commission Number: EC 1.13.11.27. CAS No. 9029-72-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0546; 4-hydroxyphenylpyruvate dioxygenase; EC 1.13.11.27; 9029-72-5; p-hydroxyphenylpyruvic hydroxylase; p-hydroxyphenylpyruvate hydroxylase; p-hydroxyphenylpyruvate oxidase; p-hydroxyphenylpyruvic oxidase; p-hydroxyphenylpyruvate dioxygenase; p-hydroxyphenylpyruvic acid hydroxylase; 4-hydroxyphenylpyruvic acid dioxygenase. Cat No: EXWM-0546. | |
| 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase | The enzyme, characterized from yeast and mammals, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to (4R)-4-hydroxysphinganine during de novo ceramide synthesis. The enzymes from yeast and from mammals contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.7, dihydroceramide fatty acyl 2-hydroxylase. Group: Enzymes. Synonyms: FA2H (gene name); SCS7 (gene name). Enzyme Commission Number: EC 1.14.18.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0968; 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase; EC 1.14.18.6; FA2H (gene name); SCS7 (gene name). Cat No: EXWM-0968. | |
| 5β-cholestane-3α,7α-diol 12α-hydroxylase | A heme-thiolate protein (P-450). This is the key enzyme in the biosynthesis of the bile acid cholic acid (3α,7α,12α-trihydroxy-5β-cholanoic acid). The activity of this enzyme determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid. The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent. Group: Enzymes. Synonyms: 5β-cholestane-3α,7α-diol 12α-monooxygenase; sterol 12α-hydroxylase (ambiguous); CYP8B1; cytochrome P450 8B1. Enzyme Commission Number: EC 1.14.13.96. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0904; 5β-cholestane-3α,7α-diol 12α-hydroxylase; EC 1.14.13.96; 5β-cholestane-3α,7α-diol 12α-monooxygenase; sterol 12α-hydroxylase (ambiguous); CYP8B1; cytochrome P450 8B1. Cat No: EXWM-0904. | |
| 6-hydroxynicotinate dehydrogenase | Contains [2Fe-2S] iron-sulfur centres, FAD and molybdenum. It also has a catalytically essential, labile selenium that can be removed by reaction with cyanide. In Bacillus niacini, this enzyme is required for growth on nicotinic acid. Group: Enzymes. Synonyms: 6-hydroxynicotinic acid hydroxylase; 6-hydroxynicotinic acid dehydrogenase; 6-hydroxynicotinate hydroxylase; 6-hydroxynicotinate:O2 oxidoreductase. Enzyme Commission Number: EC 1.17.3.3. CAS No. 122191-32-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1089; 6-hydroxynicotinate dehydrogenase; EC 1.17.3.3; 122191-32-6; 6-hydroxynicotinic acid hydroxylase; 6-hydroxynicotinic acid dehydrogenase; 6-hydroxynicotinate hydroxylase; 6-hydroxynicotinate:O2 oxidoreductase. Cat No: EXWM-1089. | |
| (6R)-5,6,7,8-Tetrahydro-L-biopterin 2HCl | Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative. Group: Biochemicals. Alternative Names: (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride; 6R-BH4; Sapropterin; Sapropterin dihydrochloride; BioMarin T 1401, Biopten, Kuvan, SUN 0588; Shiratori SN 0588. Grades: Highly Purified. CAS No. 69056-38-8,17528-72-2. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C?H??N?O?; 2(HCl), Molecular Weight: 314.17. US Biological Life Sciences. | Worldwide |
| 7,8-Dihydro-L-biopterin-d3 | 7,8-Dihydro-L-biopterin-d3 is a labeled reduced form of Biopterin. An oxidation product of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase, is involved in the synthesis of tyrosine and neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM. Applications: Noncompetitive inhibitor of gtp cyclohydrolase i. Group: Coenzymes. Synonyms: 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydro-4(3H)-pteridinone; 7,8-Dihydrobiopterin. CAS No. 6779-87-9 (unlabeled). Mole weight: 242.25. Form: Solid. 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydro-4(3H)-pteridinone; 7,8-Dihydrobiopterin; 7,8-Dihydro-L-biopterin-d3; 6779-87-9 (unlabeled). Cat No: COEC-091. | |
| 7α-hydroxycholest-4-en-3-one 12α-hydroxylase | A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH-hemoprotein reductase and cytochrome b5 for maximal activity. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid. Group: Enzymes. Synonyms: 7α-hydroxy-4-cholesten-3-one 12α-monooxygenase; CYP12; sterol 12α-hydroxylase (ambiguous); HCO 12α-hydroxylase. Enzyme Commission Number: EC 1.14.18.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0970; 7α-hydroxycholest-4-en-3-one 12α-hydroxylase; EC 1.14.18.8; 7α-hydroxy-4-cholesten-3-one 12α-monooxygenase; CYP12; sterol 12α-hydroxylase (ambiguous); HCO 12α-hydroxylase. Cat No: EXWM-0970. | |
| 7-Ketocholesterol | 7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis ( apoptosis ) [1]. Uses: Scientific research. Group: Natural products. CAS No. 566-28-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113342. | |
| 9-cis-epoxycarotenoid dioxygenase | Requires iron(II). Acts on 9-cis-violaxanthin and 9'-cis-neoxanthin but not on the all-trans isomers. In vitro, it will cleave 9-cis-zeaxanthin. Catalyses the first step of abscisic-acid biosynthesis from carotenoids in chloroplasts, in response to water stress. The other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.14.13.93 [(+)-abscisic acid 8'-hydroxylase]. Group: Enzymes. Synonyms: nine-cis-epoxycarotenoid dioxygenase; NCED; AtNCED3; PvNCED1; VP14. Enzyme Commission Number: EC 1.13.11.51. CAS No. 199877-10-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0570; 9-cis-epoxycarotenoid dioxygenase; EC 1.13.11.51; 199877-10-6; nine-cis-epoxycarotenoid dioxygenase; NCED; AtNCED3; PvNCED1; VP14. Cat No: EXWM-0570. | |
| abieta-7,13-dien-18-ol hydroxylase | A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine), and the gene encoding the enzyme has been identified in Pinus taeda (loblolly pine). The recombinant enzyme catalyses the oxidation of multiple diterpene alcohol and aldehydes, including levopimaradienol, isopimara-7,15-dienol, isopimara-7,15-dienal, dehydroabietadienol and dehydroabietadienal. It is not able to oxidize abietadiene. Group: Enzymes. Synonyms: CYP720B1; PtAO; abietadienol hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.109. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0708; abieta-7,13-dien-18-ol hydroxylase; EC 1.14.13.109; CYP720B1; PtAO; abietadienol hydroxylase (ambiguous). Cat No: EXWM-0708. | |
| abieta-7,13-diene hydroxylase | A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). The enzyme is localized in the microsomal fraction and requires both oxygen and NADPH. Inhibition by carbon monoxide and several substituted N-heterocyclic inhibitors suggests that the enzyme is a cytochrome P-450-dependent monooxygenase. Activity is induced by wounding of the plant tissue. Group: Enzymes. Synonyms: abietadiene hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.108. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0707; abieta-7,13-diene hydroxylase; EC 1.14.13.108; abietadiene hydroxylase (ambiguous). Cat No: EXWM-0707. | |
| abscisic-aldehyde oxidase | Acts on both (+)- and (-)-abscisic aldehyde. Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.1.1.288, (xanthoxin dehydrogenase), EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase) and EC 1.14.13.93 [(+)-abscisic acid 8'-hydroxylase]. While abscisic aldehyde is the best substrate, the enzyme also acts with indole-3-aldehyde, 1-naphthaldehyde and benzaldehyde as substrates, but more slowly. Group: Enzymes. Synonyms: abscisic aldehyde oxidase; AAO3; AOd; AO&Delta. Enzyme Commission Number: EC 1.2.3.14. CAS No. 129204-36-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1208; abscisic-aldehyde oxidase; EC 1.2.3.14; 129204-36-0; abscisic aldehyde oxidase; AAO3; AOd; AO&Delta. Cat No: EXWM-1208. | |
| Alahopcin | It is produced by the strain of Streptamyces albulus subsp. ochra-gerus B-52653. It can resist gram-positive bacteria, negative bacteria and plant pathogenic fungi, and inhibit Collagen-Proline hydroxylase. Synonyms: (2S)-2-((S)-2-aminopropanamido)-2-(1,5-dihydroxy-2-oxopyrrolidin-3-yl)acetic acid; B-52653. Grades: 95%. CAS No. 82576-50-9. Molecular formula: C9H15N3O6. Mole weight: 261.23. | |
| alkane 1-monooxygenase | Some enzymes in this group are heme-thiolate proteins (P-450). Also hydroxylates fatty acids in the ω-position. Group: Enzymes. Synonyms: alkane 1-hydroxylase; ω-hydroxylase; fatty acid ω-hydroxylase; alkane monooxygenase; 1-hydroxylase; alkane hydroxylase. Enzyme Commission Number: EC 1.14.15.3. CAS No. 9059-16-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0946; alkane 1-monooxygenase; EC 1.14.15.3; 9059-16-9; alkane 1-hydroxylase; ω-hydroxylase; fatty acid ω-hydroxylase; alkane monooxygenase; 1-hydroxylase; alkane hydroxylase. Cat No: EXWM-0946. | |
| α-Hydroxyglutaric acid | α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid. CAS No. 2889-31-8. Pack Sizes: 5 mg (67.52 mM * 0.5mL in Ethanol); 10 mg (67.52 mM * 1mL in Ethanol); 25 mg (67.52 mM * 2.5mL in Ethanol). Product ID: HY-113038B. | |
| α-Hydroxyglutaric acid-13C5 disodium | α-Hydroxyglutaric acid- 13 C 5 (sodium) is the 13 C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: 2-Hydroxyglutarate- 13 C5 disodium; 2-Hydroxyglutaric acid- 13 C5 sodium; 2-Hydroxypentanedioic acid- 13 C5 disodium. CAS No. 2482467-23-0. Pack Sizes: 1 mg. Product ID: HY-113038AS. | |
| α-Hydroxyglutaric acid disodium | α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium. CAS No. 40951-21-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113038A. | |
| anthranilate 1,2-dioxygenase (deaminating, decarboxylating) | Requires Fe2+. Group: Enzymes. Synonyms: anthranilate hydroxylase; anthranilic hydroxylase; anthranilic acid hydroxylase. Enzyme Commission Number: EC 1.14.12.1. CAS No. 9059-17-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0678; anthranilate 1,2-dioxygenase (deaminating, decarboxylating); EC 1.14.12.1; 9059-17-0; anthranilate hydroxylase; anthranilic hydroxylase; anthranilic acid hydroxylase. Cat No: EXWM-0678. | |
| anthranilate 3-monooxygenase | Requires Fe2+. Group: Enzymes. Synonyms: anthranilate 3-hydroxylase; anthranilate hydroxylase; anthranilic hydroxylase; anthranilic acid hydroxylase. Enzyme Commission Number: EC 1.14.16.3. CAS No. 37256-79-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0955; anthranilate 3-monooxygenase; EC 1.14.16.3; 37256-79-4; anthranilate 3-hydroxylase; anthranilate hydroxylase; anthranilic hydroxylase; anthranilic acid hydroxylase. Cat No: EXWM-0955. | |
| benzoate 4-monooxygenase | Requires Fe2+ and tetrahydropteridine. Group: Enzymes. Synonyms: benzoic acid 4-hydroxylase; benzoate 4-hydroxylase; benzoic 4-hydroxylase; benzoate-p-hydroxylase; p-hydroxybenzoate hydroxylase. Enzyme Commission Number: EC 1.14.13.12. CAS No. 39391-25-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0720; benzoate 4-monooxygenase; EC 1.14.13.12; 39391-25-8; benzoic acid 4-hydroxylase; benzoate 4-hydroxylase; benzoic 4-hydroxylase; benzoate-p-hydroxylase; p-hydroxybenzoate hydroxylase. Cat No: EXWM-0720. | |
| Carboetomidate | Carboetomidate is the pyrolle analog of the hypnotic Etomidate. Carboetomidate was specifically designed not to bind with high affinity to 11 β-hydroxylase. Carboetomidate is a promising new sedative hypnotic for use in critically ill patients as it does not suppress the synthesis of steroids by the adrenal gland that are necessary for survival. Group: Biochemicals. Alternative Names: 1-[(1R)-1-Phenylethyl]-1H-pyrrole-2-carboxylic Acid Ethyl Ester; (R)-Ethyl 1-(1-phenylethyl)-1H-pyrrole-2-carboxylate. Grades: Highly Purified. CAS No. 1257067-10-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| cholestanetriol 26-monooxygenase | This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. It catalyses the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway. Can also act on cholesterol, cholest-5-ene-3β,7α-diol, 7α-hydroxycholest-4-en-3-one, and 5β-cholestane-3α,7α-diol. The enzyme can also hydroxylate cholesterol at positions 24 and 25. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase. Group: Enzymes. Synonyms: 5β-cholestane-3α,7α,12α-triol 26-hydroxylase; 5β-cholestane-3α,7α,12α-triol hydroxylase; cholestanetriol 26-hydroxylase; sterol 27-hydroxylase; sterol 26-hydroxylase; cholesterol 27-hydroxyla. Enzyme Commission Number: EC 1.14.15.15. CAS No. 52227-77-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0940; cholestanetriol 26-monooxygenase; EC 1.14.15.15; 52227-77-7; 5β-cholestane-3α,7α,12α-triol 26-hydroxylase; 5β-cholestane-3α,7α,12α-triol hydroxylase; cholestanetriol 26-hydroxylase; sterol 27-hydroxylase; sterol 26-hydroxylase; cholesterol 27-hydroxylase; CYP27A; CYP27A1; cytochrome P450 27A1'. Cat No: EXWM-0940. | |
| cholesterol 7α-monooxygenase | A P-450 heme-thiolate liver protein that catalyses the first step in the biosynthesis of bile acids. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: cholesterol 7α-hydroxylase; CYP7A1 (gene name). Enzyme Commission Number: EC 1.14.14.23. CAS No. 9037-53-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0920; cholesterol 7α-monooxygenase; EC 1.14.14.23; 9037-53-0; cholesterol 7α-hydroxylase; CYP7A1 (gene name). Cat No: EXWM-0920. | |
| cis-4-Hydroxy-L-proline | Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline. Group: Biochemicals. Alternative Names: (4S)-4-Hydroxy-L-proline; (2S,4S)-4-Hydroxyproline; (S)-Allo-hydroxyproline; (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic Acid; L-Allohydroxyproline; cis-4-Hydroxyproline; cis-Hydroxyproline. Grades: Highly Purified. CAS No. 618-27-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| CMP-N-acetylneuraminate monooxygenase | This enzyme contains both a Rieske-type [2Fe-2S] cluster and a second iron site. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2). The enzyme can be activated by Fe2+ or Fe3+. Group: Enzymes. Synonyms: CMP-N-acetylneuraminic acid hydroxylase; CMP-Neu5Ac hydroxylase; cytidine monophosphoacetylneuraminate monooxygenase; N-acetylneuraminic monooxygenase; cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase. Enzyme Commission Number: EC 1.14.18.2. CAS No. 116036-67-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0964; CMP-N-acetylneuraminate monooxygenase; EC 1.14.18.2; 116036-67-0; CMP-N-acetylneuraminic acid hydroxylase; CMP-Neu5Ac hydroxylase; cytidine monophosphoacetylneuraminate monooxygenase; N-acetylneuraminic monooxygenase; cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase. Cat No: EXWM-0964. | |
| deoxyhypusine monooxygenase | The enzyme catalyses the final step in the formation of the amino acid hypusine in the eukaryotic initiation factor 5A. Group: Enzymes. Synonyms: deoxyhypusine hydroxylase; deoxyhypusine dioxygenase. Enzyme Commission Number: EC 1.14.99.29. CAS No. 101920-83-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1045; deoxyhypusine monooxygenase; EC 1.14.99.29; 101920-83-6; deoxyhypusine hydroxylase; deoxyhypusine dioxygenase. Cat No: EXWM-1045. | |
| dihydroceramide fatty acyl 2-hydroxylase | The enzyme, characterized from plants, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis. The enzyme requires an external cytochrome b5 as the electron donor. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase. Group: Enzymes. Synonyms: FAH1 (gene name); FAH2 (gene name); plant sphingolipid fatty acid 2-hydroxylase. Enzyme Commission Number: EC 1.14.18.7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0969; dihydroceramide fatty acyl 2-hydroxylase; EC 1.14.18.7; FAH1 (gene name); FAH2 (gene name); plant sphingolipid fatty acid 2-hydroxylase. Cat No: EXWM-0969. | |
| dihydromonacolin L hydroxylase | A heme-thiolate protein (cytochrome P-450). The dehydration of 3α-hydroxy-3,5-dihydromonacolin L acid is believed to be spontaneous. The enzyme from fungi also catalyses the reaction of EC 1.14.13.198, monacolin L hydroxylase. Group: Enzymes. Synonyms: LovA (ambiguous). Enzyme Commission Number: EC 1.14.13.197. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0797; dihydromonacolin L hydroxylase; EC 1.14.13.197; LovA (ambiguous). Cat No: EXWM-0797. | |
| Dimethyloxaloylglycine (DMOG) | Prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions. Group: Biochemicals. Alternative Names: N-[ (Methoxycarbonyl) methyl]oxamic Acid Methyl Ester; N- (methoxyoxoacetyl) glycine Methyl Ester; N-(2-Methoxy-2-oxoacetyl)glycine methyl ester. Grades: Highly Purified. CAS No. 89464-63-1. Pack Sizes: 50mg, 100mg, 250mg, 500mg. Molecular Formula: C?H?NO?, Molecular Weight: 175.14. US Biological Life Sciences. | Worldwide |
| Ethyl 3,4-dihydroxybenzoate | Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate protects myocardium by activating NO synthase and generating mitochondrial ROS. Ethyl 3,4-dihydroxybenzoate induces cell autophagy and apoptosis in ESCC cells. Ethyl 3,4-dihydroxybenzoate is a collagen synthesis inhibitor and has a bone protecting-effect [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Protocatechuic acid ethyl ester. CAS No. 3943-89-3. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-W016409. | |
| factor-independent urate hydroxylase | This enzyme was previously thought to be a copper protein, but it is now known that the enzymes from soy bean (Glycine max), the mould Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalysed pathway in which EC 3.5.2.17, hydroxyisourate hydrolase, catalyses the first step. The enzyme is different from EC 1.14.13.113 (FAD-dependent urate hydroxylase). Group: Enzymes. Synonyms: uric acid oxidase; uricase; uricase II; urate oxidase. Enzyme Commission Number: EC 1.7.3.3. CAS No. 9002-12-4. UO. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1626; factor-independent urate hydroxylase; EC 1.7.3.3; 9002-12-4; uric acid oxidase; uricase; uricase II; urate oxidase. Cat No: EXWM-1626. | |
| fatty-acid peroxygenase | A cytosolic heme-thiolate protein with sequence homology to P-450 monooxygenases. Unlike the latter, it needs neither NAD(P)H, dioxygen nor specific reductases for function. Enzymes of this type are produced by bacteria (e.g. Sphingomonas paucimobilis, Bacillus subtilis). Catalytic turnover rates are high compared with those of monooxygenation reactions as well as peroxide shunt reactions catalysed by the common P-450s. A model substrate is myristate, but other saturated and unsaturated fatty acids are also hydroxylated. Oxidizes the peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) and peroxygenates aromatic substrates in a fatty-acid-dependent reaction. Group: Enzymes. Synonyms: fatty acid hydroxylase (ambiguous); P450 peroxygenase; CYP152A1; P450BS; P450SP&alpha. Enzyme Commission Number: EC 1.11.2.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0515; fatty-acid peroxygenase; EC 1.11.2.4; fatty acid hydroxylase (ambiguous); P450 peroxygenase; CYP152A1; P450BS; P450SP&alpha. Cat No: EXWM-0515. | |
| Fusaric acid | Fusaric acid is a potent dopamine β-hydroxylase inhibitor. Uses: Scientific research. Group: Natural products. CAS No. 536-69-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-128483. | |
| γ-(6-Aminohexyl)-ATP - ATTO-488 | γ-(6-Aminohexyl)-ATP - ATTO-488 is an indispensable analytical asset, extensively employed to probe unimaginable intricacies of prolyl 4-hydroxylases (PHDs) present in human lungs. As a pivotal fluorescent derivative of ATP, it poses as a potent tool against complex alpha, beta, and gamma PHDs. Not just that, it never fails to impress with its dynamicity during live-cell imaging, capturing the fascinating nuances of calcium signaling events and gene expression. Synonyms: γ-(6-Aminohexyl)-adenosine-5'-triphosphate, labeled with ATTO 488, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C41H50N9O22P3S2(free acid). Mole weight: 1177.17 (free acid). | |
| JMJD Histone Demethylase Inhibitor III ( (E) -4- (Hydroxy (4- (4- ( (naphthalen-1-ylcarbamoyloxy) methyl) benzylamino) butyl) amino) -4-oxobut-2-enoic Acid) | A substrate (methyl lysine) and cofactor (a-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50=4.3, 3.4, 5.9, 10 and 43uM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50=54, 83, 31, 22, 620, 680 and >800uM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| JMJD Histone Demethylase Inhibitor IV, Methylstat ( (E) -Methyl-4- (hydroxy (4- ( (4- ( ( (naphthalen-1-ylcarbamoyl) oxy) methyl) benzyl) amino) butyl) amino) -4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, Methylstat) | A methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3=10.3 and 8.6uM in KYSE150 cells, and 6.7 and 6.3uM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| kynurenine 7,8-hydroxylase | This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating). Other names in common use include kynurenic acid hydroxylase, kynurenic hydroxylase, and kynurenate 7,8-hydroxylase. This enzyme participates in tryptophan metabolism. Group: Enzymes. Synonyms: kynurenic acid hydroxylase; kynurenic hydroxylase; kynurenate 7,8-hydroxylase. Enzyme Commission Number: EC 1.14.99.2. CAS No. 9029-63-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1037; kynurenine 7,8-hydroxylase; EC 1.14.99.2; 9029-63-4; kynurenic acid hydroxylase; kynurenic hydroxylase; kynurenate 7,8-hydroxylase. Cat No: EXWM-1037. | |
| L-α-Methyltyrosine | L-α-Methyltyrosine is a tyrosine hydroxylase inhibitor. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. It reduces the elevated levels of catecholamines associated with pheochromocytoma, thus preventing hypertension. It significantly inhibits COX-2 activity and has anti-inflammatory and anti-ulcer effects. Uses: L-α-methyltyrosine is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. Synonyms: α-Methyl-L-tyrosine; (S)-2-(4-Hydroxybenzyl)-2-aminopropanoic Acid; (S)-α-Methyltyrosine; Demser; L(-)-Metyrosine; L-α-MT; Metirosine; Racemetirosine; L-α-Methyl-p-tyrosine; Metyrosine. Grades: 98%. CAS No. 672-87-7. Molecular formula: C10H13NO3. Mole weight: 195.21. | |
| L-asparagine hydroxylase | Requires Fe2+. The enzyme is only able to hydroxylate free L-asparagine. It is not active toward D-asparagine. The β-hydroxylated asparagine produced is incorporated at position 9 of the calcium-dependent antibiotic (CDA), an 11-residue non-ribosomally synthesized acidic lipopeptide lactone. Group: Enzymes. Synonyms: L-asparagine 3-hydroxylase; AsnO. Enzyme Commission Number: EC 1.14.11.39. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0657; L-asparagine hydroxylase; EC 1.14.11.39; L-asparagine 3-hydroxylase; AsnO. Cat No: EXWM-0657. | |
| Liarozole | This active molecular has a potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits P450-dependent ATRA-4-hydroxylase to an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. Meanwhile, liarozole also inhibits aromatase that catalyzes estrogen biosynthesis in rating-limited step. In Aug 2005, clinical development was ongoing for Ichthyosis in Europe.In Jan 2006, Phase-II/III clinical trials in Ichthyosis was ongoing in Europe and in Canada. Uses: Treatment for ichthyosis. Synonyms: 6-[(3-chlorophenyl)-imidazol-1-ylmethyl]-1H-benzimidazole, R 75251; R-75251; R75251. Grades: 98%. CAS No. 115575-11-6. Molecular formula: C17H13ClN4. Mole weight: 308.771. | |
| Liarozole hydrochloride | Liarozole is a benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis. Synonyms: Liarozole HCl; R75251 (hydrochloride); 5-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole hydrochloride. CAS No. 145858-50-0. Molecular formula: C17H14Cl2N4. Mole weight: 345.23. | |
| lithocholate 6β-hydroxylase | A heme-thiolate protein (P-450). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters. Group: Enzymes. Synonyms: lithocholate 6β-monooxygenase; CYP3A10; 6β-hydroxylase; cytochrome P450 3A10/lithocholic acid 6β-hydroxylase. Enzyme Commission Number: EC 1.14.13.94. CAS No. 9075-83-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0903; lithocholate 6β-hydroxylase; EC 1.14.13.94; 9075-83-6; lithocholate 6β-monooxygenase; CYP3A10; 6β-hydroxylase; cytochrome P450 3A10/lithocholic acid 6β-hydroxylase. Cat No: EXWM-0903. | |
| L-ornithine N5-monooxygenase (NADPH) | A flavoprotein (FAD). The enzyme is involved in biosynthesis of N5-hydroxy-L-ornithine, N5-formyl-N5-hydroxy-L-ornithine or N5-acetyl-N5-hydroxy-L-ornithine. These nonproteinogenic amino acids are building blocks of siderophores produced by some bacteria (e.g. Streptomyces coelicolor, Saccharopolyspora erythraea and Pseudomonas aeruginosa). The enzyme is specific for NADPH. cf. EC 1.14.13.196, L-ornithine N5-monooxygenase [NAD(P)H]. Group: Enzymes. Synonyms: CchB; ornithine hydroxylase; EtcB; PvdA; Af-OMO; dffA (gene name). Enzyme Commission Number: EC 1.14.13.195. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0795; L-ornithine N5-monooxygenase (NADPH); EC 1.14.13.195; CchB; ornithine hydroxylase; EtcB; PvdA; Af-OMO; dffA (gene name). Cat No: EXWM-0795. | |
| LP-533401 | LP-533401 is an inhibitor of tryptophan 5-hydroxylase 1 (Tph1) that suppresses serotonin production in the gut. It prevents the development of osteoporosis in ovariectomized and aged mice. Synonyms: (2S)-2-Amino-3-[4-[2-amino-6-[2,2,2-trifluoro-1-[4-(3-fluorophenyl)phenyl]ethoxy]pyrimidin-4-yl]phenyl]propanoic acid. Grades: ≥98%. CAS No. 945976-43-2. Molecular formula: C27H22F4N4O3. Mole weight: 526.5. | |
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