Adhesion Kinase Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 Quick inquiry Where to buy Suppliers range | The Focal Adhesion Kinase Inhibitor I, also referenced under CAS 4506-66-5, controls the biological activity of Foca Adhesion Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 4506-66-5. Pack Sizes: 5MG. Mole weight: 138.17. Catalog: AP4506665-B. Assay: ≥95% (elemental analysis). | |
Focal Adhesion Kinase Inhibitor III (FAK Inhibitor III, N-(4-tert-Butylbenzyl)-1,5-dimethyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-amine-4,4-dioxide) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrazolobenzothiazined ioxide compound that targets and locks FAK in its inactive conformation, resulting in preincubation time-dependent inhibition in kinase assays and FAK autophosphorylation in human prostate cancer PC3M-luc cells (IC50 = 7.1uM with 30 min inhibitor preincubation), while exhibiting little activity toward Akt1, Aurora B, HER2, MEK1, p38alpha, Pyk2, or Src even at concentrations as high as 10uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
FAK, Negative Control (non-phospho) Peptide (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) Quick inquiry Where to buy Suppliers range | Synthetic non-phosphopeptide (~10aa) derived from the region of FAK that contains serine 910. See corresponding antibody F0019-58N1. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
FAK [pS910], Positive Control Peptide (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) Quick inquiry Where to buy Suppliers range | Synthetic phosphopeptide (~10aa) derived from the region of FAK that contains serine 910. See corresponding antibody F0019-58N1. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
FAK [pY397], Negative Control Peptide, non-phospho, for F0019-58A (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) Quick inquiry Where to buy Suppliers range | Peptide (linear) Content: 80 ± 4%. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
FAK [pY397], Positive Control Peptide, phospho, for F0019-58A (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) Quick inquiry Where to buy Suppliers range | Peptide (linear) Content: 80 ± 4%. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
2-Methyl-4-isothiazolin-3-one Hydrochloride (MIT) Quick inquiry Where to buy Suppliers range | MIT is used to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites. 2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-containing solution. Group: Biochemicals. Alternative Names: 2-Methyl-2H-isothiazol-3-one; 2-Methyl-3(2H)-isothiazolone Hydrochloride; 2-Methyl-3-isothiazolone Hydrochloride; 2-Methyl-4-isothiazolin-3-one Hydrochloride; 2-Methyl-4-isothiazoline-3-ketone Hydrochloride; 2-Methyl-4-isothiazoline-3-one Hydrochloride; KB 838 Hydrochloride; Kathon CG 243 Hydrochloride; Kordek 50 Hydrochloride; Kordek 50C Hydrochloride; Kordek 573F Hydrochloride; Kordek MLX Hydrochloride; MIT Hydrochloride; MIT (biocide) Hydrochloride; Methylisothiazolinone Hydrochloride; Microcare MT; N-Methylisothiazolin-3-one Hydrochloride; N-Methylisothiazolone Hydrochloride; Neolone Hydrochloride; Neolone 950 Hydrochloride; Neolone CapG Hydrochloride; Neolone M 10 Hydrochloride; Neolone M 50 Hydrochloride; Neolone PE Hydrochloride; Optiphen MIT Hydrochloride; ProClin 950 Hydrochloride. Grades: Highly Purified. CAS No. 26172-54-3. Pack Sizes: 5g, 10g, 25g. Molecular Formula: C?H?ClNOS, Molecular Weight: 151.61. US Biological Life Sciences. | Worldwide |
4-Amino-1,5-dimethylpyrazole Quick inquiry Where to buy Suppliers range | 4-Amino-1,5-dimethylpyrazole is used in the preparation of pyridine compounds as focal adhesion kinase inhibitors. Group: Biochemicals. Alternative Names: 1,5-Dimethyl-1H-pyrazol-4-amine; 4-Amino-1,5-dimethyl-1H-pyrazole. Grades: Highly Purified. CAS No. 121983-36-6. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
Bisindolylmaleimide X hydrochloride Quick inquiry Where to buy Suppliers range | Bisindolylmaleimide X hydrochloride is a potent and selective cell-permeable protein kinase C (PKC) inhibitor with IC50 of 15 nM for rat brain PKC. It has also been identified as an inhibitor of Cdk2 with IC50 of 200. It has been used to activate mesenchymal stem cells, which increases the surface expression of homing ligands that bind to intercellular adhesion molecule and target delivery of these cells to sites of inflammation. Uses: Enzyme inhibitors. Synonyms: BIM X; Ro 31-8425. Grades: ≥98%. CAS No. 145317-11-9. Molecular formula: C26H24N4O2·HCl. Mole weight: 461. | |
CEP-37440 Quick inquiry Where to buy Suppliers range | CEP-37440 is an orally available dual kinase inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and focal adhesion kinase (FAK), with potential antineoplastic activity. Upon administration, ALK-FAK inhibitor CEP-37440 selectively binds to and inhibits ALK kinase and FAK kinase. The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; its dysregulation and gene rearrangements are associated with a variety of tumors. The cytoplasmic tyrosine kinase FAK, a signal transducer for integrins, is upregulated and constitutively activated in various tumor types; it plays a key role in tumor cell migration, proliferation, survival, and tumor angiogenesis. Synonyms: CEP-37440; CEP 37440; CEP37440. CAS No. 1391712-60-9. Molecular formula: C30H38ClN7O3. Mole weight: 580.12. | |
Danshensu Quick inquiry Where to buy Suppliers range | Danshensu is an active component of Salvia miltiorrhiza that shows wide cardiovascular benefit. It suppresses the formation of reactive oxygen species and inhibits platelet adhesion and aggregation. It also protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. It increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. It may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation. It significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size in vitro. It also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis. It significantly lowered tHcy in rats with elevated tHcy. Danshensu is a natural compound, which can also be used in cosmetics material. Synonyms: Benzenepropanoic acid, α,3,4-trihydroxy-, (αR)-; (αR)-α,3,4-Trihydroxybenzenepropanoic acid; Benzenepropanoic acid, α,3,4-trihydroxy-, (R)-; (R)-(+)-3-(3,4-Dihydroxyphenyl)lactic acid; (R)-3-(3,4-Dihydroxyphenyl)-2-hydroxypropionic acid; 3-(3',4'-Dihydroxyphenyl)-(2R)-lactic acid; D-(+)-β-(3,4-Dihydroxyphenyl)lactic acid; Dan Shen Su; Dan shen suan A; DS 182; Salianic acid A; Salvianic acid A; Tanshinol. Grades: >98%. CAS No. 76822-21-4. Molecular formula: C9H10O5. Mole weight: 198.17. | |
Defactinib Quick inquiry Where to buy Suppliers range | Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is , a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation. Synonyms: N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide; VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878. Grades: >98%. CAS No. 1073154-85-4. Molecular formula: C20H21F3N8O3S. Mole weight: 510.496. | |
GSK-2256098 Quick inquiry Where to buy Suppliers range | GSK2256098, also known as GTPL7939, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. Synonyms: GSK2256098; GSK 2256098; GSK-2256098; GTPL7939; GTPL-7939; GTP L7939. Grades: 98%. CAS No. 1224887-10-8. Molecular formula: C20H23ClN6O2. Mole weight: 414.89. | |
JANEX-1 Quick inquiry Where to buy Suppliers range | A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 μM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation. Synonyms: WHI-P131, WHI P-131, WHI P131, Janex 1. Grades: >98%. CAS No. 202475-60-3. Molecular formula: C16H15N3O3. Mole weight: 297.31. | |
LY-333,531 hydrochloride Quick inquiry Where to buy Suppliers range | Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta). PKCbetaI and PKCbetaII isozyme inhibitor. Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy. Anti-cancer and anti-angiogenic compound. Suppresses glucose-induced adhesion of human monocytes to endothelial cells. Suppresses ERK1/2 and Akt phosphorylation. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H28N4O3 HCl. US Biological Life Sciences. | Worldwide |
Okadaic acid ammonium salt (High Purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155716-06-6. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H67O13. NH4, Molecular Weight: 822. US Biological Life Sciences. | Worldwide |
Okadaic acid (High Purity) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H68O13, Molecular Weight: 805. US Biological Life Sciences. | Worldwide |
Okadaic acid potassium salt (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) (High Purity) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1uM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Okadaic acid sodium salt (high purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
PF 431396 Quick inquiry Where to buy Suppliers range | PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 717906-29-1. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?S. US Biological Life Sciences. | Worldwide |
PF-431396 Quick inquiry Where to buy Suppliers range | PF-431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Synonyms: PF-431396; PF 431396; PF431396. Grades: >98%. CAS No. 717906-29-1. Molecular formula: C22H21F3N6O3S. Mole weight: 506.5. | |
PF-573228 Quick inquiry Where to buy Suppliers range | A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells. Group: Biochemicals. Alternative Names: 3, 4-Dihydro-6-[[4-[[[3- (methylsulfonyl) phenyl]methyl]amino]-5- (trifluoromethyl) -2-pyrimidinyl]amino]-2 (1H) -quinolinone; 6- [ (4- ( (3- (Methanesulfonyl) benzyl) amino) -5-trifluoro methyl pyrimidin-2-yl) amino] -3, 4-dihydro-1H-quinolin-2-one; PF 573228. Grades: Highly Purified. CAS No. 869288-64-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF-573228 Quick inquiry Where to buy Suppliers range | PF-573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50= 4 nM). Displays 50 - 250-fold selectivity for FAK over other protein kinases. PF573228 was recognized to affect cell adhesion and migration in many types of cells. Synonyms: PF-573228; PF 573228; PF573228; PF573,228; PF-573; 228; PF 573; 228. Grades: 0.98. CAS No. 869288-64-2. Molecular formula: C22H20F3N5O3S. Mole weight: 491.489. | |
Phenylmethylene hydantoin Quick inquiry Where to buy Suppliers range | Anticancer compound. Chemopreventive. Shows anti-metastatic activity in prostate cancer cells through enhancement of cell-cell adhesion. Anti-invasive compound. Glycogen synthase kinase-3beta (GSK-3 beta) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 80171-33-1. Pack Sizes: 1mg. Molecular Formula: C10H8N2O3, Method for Determining. US Biological Life Sciences. | Worldwide |
Saracatinib Quick inquiry Where to buy Suppliers range | Saracatinib, also known as AZD0530, is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities. Src and Abl are protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. Saracatinib binds to and inhibits these tyrosine kinases and their effects on cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival. Specifically, Saracatinib inhibits Src kinase-mediated osteoclast bone resorption. Uses: Antineoplastic agents. Synonyms: AZD 0530; AZD-0530; AZD0530. Grades: >98%. CAS No. 379231-04-6. Molecular formula: C27H32ClN5O5. Mole weight: 542.03. | |
SF1126 Quick inquiry Where to buy Suppliers range | SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival. Integrins are transmembrane cell adhesion proteins expressed on the surfaces of endothelial and tumor cells. Synonyms: SF 1126, SF-1126. CAS No. 936487-67-1. Molecular formula: C39H48N8O14. Mole weight: 852.84. | |
SKF-86002 Quick inquiry Where to buy Suppliers range | SKF-86002 is a p38 MAP kinase inhibitor, the IC50 is 0.1 - 1 μM. It potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes, the IC50 is1 μM. It also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO). In vitro: SKF-86002 inhibited prostaglandin H2 synthase activity, the IC50 is 120 mM as well as prostanoid production by rat basophilic leukemia cells, the IC50 is mM and its sonicate ( the IC50 is 100 mM and human monocytes (the IC50 is 1 mM. It inhibited the generation of dihydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid by a high speed supernatant fraction of RBL-1 cells (the IC50 is 10 mM). It blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP. Uses: Skf-86002 could potently inhibit lps-induced il-1 and tnf-α production in human monocytes. it acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. Synonyms: SKF-86002; SKF 86002; SKF86002. 6-(4-fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole; 4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene. Grades: >98%. CAS No. 72873-74-6. Molecular formula: C16H12FN3S. Mole weight: 297.36. | |
TAE226 Quick inquiry Where to buy Suppliers range | TAE226 is a novel and potent ATP competitive inhibitor of FAK and IGF-IR with potential anticancer activity. TAE226 can block FAK and IGF-IR signaling pathways. TAE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal-related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 also decreased glioma cell adhesion, migration, and invasion through an artificial extracellular matrix. Synonyms: NVPTAE226, NVP TAE226, NVP-TAE226, TAE226, TAE226, TAE 226. Grades: 0.98. CAS No. 761437-28-9. Molecular formula: C23H25ClN6O3. Mole weight: 468.942. | |
TAK-659 dihydrochloride Quick inquiry Where to buy Suppliers range | TAK-659 is a potent spleen tyrosine kinase (syk) inhibitor under the development of Takeda Oncology, with potential anti-inflammatory, immunomodulating, and antineoplastic activities. TAK-659 may inhibit the activity of syk, which abrogates downstream BCR (B-cell receptor) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Phase I/II for the treatment Acute myeloid leukaemia, phase I for the treatment of Breast cancer, Gastrointestinal cancer, Head and neck cancer, Lymphoma, Non-small cell lung cancer and Solid tumours was on-going. Uses: Acute myeloid leukaemia;breast cancer; gastrointestinal cancer; head and neck cancer; lymphoma; non-small cell lung cancer; solid tumours most recent events. Synonyms: 6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one dihydrochloride; TAK659; TAK-659; TAK 659; TAK-659 HCl; TAK659 dihydrochloride. Grades: 98%. CAS No. 1312691-41-0. Molecular formula: C17H23Cl2FN6O. Mole weight: 417.31. | |
Tyroserleutide Quick inquiry Where to buy Suppliers range | Tyroserleutide is a tripeptide consisting of tyrosine, serine, and leucine with potential antineoplastic activity. Although the mechanism of its antitumor activity has yet to be fully elucidated, tyroserleutide appears to inhibit the expression of ICAM-1 (CD54), a cell adhesion factor of the immunoglobulin (Ig) superfamily that plays an important role in the invasion, adhesion, and metastasis of tumor cells. In addition, this agent may influence the Ca2+/calmodulin pathway, inhibiting phosphatidylinositol 3 kinase (PI3K); PI3K is upregulated in tumor cells and is involved in cellular proliferation. Synonyms: Tyroserleutide; YSL; CMS 024. H-Tyr-Ser-Leu-OH; CMS024; CMS-024. CAS No. 138168-48-6. Molecular formula: C18H27N3O6. Mole weight: 381.43. | |
Y 11 Quick inquiry Where to buy Suppliers range | Y 11 is a potent inhibitor of focal adhesion kinase (FAK); Y 11 prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1uM). Y 11 decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines. Group: Biochemicals. Alternative Names: 1-(2-Hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo[3. 3. 1. 13, 7]decane Bromide. Grades: Highly Purified. CAS No. 1086639-59-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |