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| Product | Description | |
|---|---|---|
| Active Focal Adhesion Kinase from Human, Recombinant | FAK is a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-le...Protein-tyrosine kinase 2; FAK; FADK; FAK1; PTK2; FRNK; PPP1R71; p125FAK. Enzyme Commission Number: EC 2.7.10.2. Purity: Greater than 70% as determined by SDS-PAGE. FAK. Mole weight: 146.7 kDa. Activity: 72 nmole of phosphate transferred to poly [Glu,Tyr] 4:1 substrate/minute/mg of total protein at 30°C. Stability: Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C to -80°C for longer periods of time. Avoid multiple freeze-thaw cycles. Source: Baculovirus, SF9 insect cells. Species: Human. Focal adhesion kinase 1; EC 2.7.10.2; FADK 1; pp125FAK; Protein-tyrosine kinase 2; FAK; FADK; FAK1; PTK2; FRNK; PPP1R71; p125FAK. Cat No: NATE-0800. |  |
| FAK, Negative Control (non-phospho) Peptide (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) | Synthetic non-phosphopeptide (~10aa) derived from the region of FAK that contains serine 910. See corresponding antibody F0019-58N1. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| FAK [pS910], Positive Control Peptide (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) | Synthetic phosphopeptide (~10aa) derived from the region of FAK that contains serine 910. See corresponding antibody F0019-58N1. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| FAK [pY397], Negative Control Peptide, non-phospho, for F0019-58A (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) | Peptide (linear) Content: 80 ± 4%. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| FAK [pY397], Positive Control Peptide, phospho, for F0019-58A (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) | Peptide (linear) Content: 80 ± 4%. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 | The Focal Adhesion Kinase Inhibitor I, also referenced under CAS 4506-66-5, controls the biological activity of Foca Adhesion Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. |  |
| Focal Adhesion Kinase Inhibitor III (FAK Inhibitor III, N-(4-tert-Butylbenzyl)-1,5-dimethyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-amine-4,4-dioxide) | A cell-permeable pyrazolobenzothiazined ioxide compound that targets and locks FAK in its inactive conformation, resulting in preincubation time-dependent inhibition in kinase assays and FAK autophosphorylation in human prostate cancer PC3M-luc cells (IC50 = 7.1uM with 30 min inhibitor preincubation), while exhibiting little activity toward Akt1, Aurora B, HER2, MEK1, p38alpha, Pyk2, or Src even at concentrations as high as 10uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| 2-Methyl-4-isothiazolin-3-one Hydrochloride (MIT) | MIT is used to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites. 2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-containing solution. Group: Biochemicals. Alternative Names: 2-Methyl-2H-isothiazol-3-one; 2-Methyl-3(2H)-isothiazolone Hydrochloride; 2-Methyl-3-isothiazolone Hydrochloride; 2-Methyl-4-isothiazolin-3-one Hydrochloride; 2-Methyl-4-isothiazoline-3-ketone Hydrochloride; 2-Methyl-4-isothiazoline-3-one Hydrochloride; KB 838 Hydrochloride; Kathon CG 243 Hydrochloride; Kordek 50 Hydrochloride; Kordek 50C Hydrochloride; Kordek 573F Hydrochloride; Kordek MLX Hydrochloride; MIT Hydrochloride; MIT (biocide) Hydrochloride; Methylisothiazolinone Hydrochloride; Microcare MT; N-Methylisothiazolin-3-one Hydrochloride; N-Methylisothiazolone Hydrochloride; Neolone Hydrochloride; Neolone 950 Hydrochloride; Neolone CapG Hydrochloride; Neolone M 10 Hydrochloride; Neolone M 50 Hydrochloride; Neolone PE Hydrochloride; Optiphen MIT Hydrochloride; ProClin 950 Hydrochloride. Grades: Highly Purified. CAS No. 26172-54-3. Pack Sizes: 5g, 10g, 25g. Molecular Formula: C?H?ClNOS, Molecular Weight: 151.61. US Biological Life Sciences. | Worldwide |
| 4-Amino-1,5-dimethylpyrazole | 4-Amino-1,5-dimethylpyrazole is used in the preparation of pyridine compounds as focal adhesion kinase inhibitors. Group: Biochemicals. Alternative Names: 1,5-Dimethyl-1H-pyrazol-4-amine; 4-Amino-1,5-dimethyl-1H-pyrazole. Grades: Highly Purified. CAS No. 121983-36-6. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| AMP-945 | AMP-945 is an inhibitor of the enzyme focal adhesion kinase (FAK). Synonyms: Benzeneacetamide, 2-[2-[2-[[2-methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]ethyl]-; 2-(2-{2-[2-{[2-Methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino}-5-(trifluoromethyl)-4-pyrimidinyl]ethyl}phenyl)acetamide. Grade: ≥98%. CAS No. 1393653-34-3. Molecular formula: C28H32F3N5O2. Mole weight: 527.58. |  |
| Biotin Phosphatidylinositol 3,4-bisphosphate | Biotin Phosphatidylinositol 3,4-bisphosphate is a water-soluble analog of PI(3,4)P2 labelled with biotin at the sn-1 position. PI(3,4)P2 is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions. Synonyms: Biotin PI(3,4)P2. Grade: >95%. Molecular formula: C37H62N4Na5O22P3S. Mole weight: 1153.84. | |
| Bisindolylmaleimide X hydrochloride | Bisindolylmaleimide X hydrochloride is a potent and selective cell-permeable protein kinase C (PKC) inhibitor with IC50 of 15 nM for rat brain PKC. It has also been identified as an inhibitor of Cdk2 with IC50 of 200. It has been used to activate mesenchymal stem cells, which increases the surface expression of homing ligands that bind to intercellular adhesion molecule and target delivery of these cells to sites of inflammation. Uses: Enzyme inhibitors. Synonyms: BIM X; Ro 31-8425. Grade: ≥98%. CAS No. 145317-11-9. Molecular formula: C26H24N4O2·HCl. Mole weight: 461. | |
| CEP-37440 | CEP-37440 is an orally available dual kinase inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and focal adhesion kinase (FAK), with potential antineoplastic activity. Upon administration, ALK-FAK inhibitor CEP-37440 selectively binds to and inhibits ALK kinase and FAK kinase. The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; its dysregulation and gene rearrangements are associated with a variety of tumors. The cytoplasmic tyrosine kinase FAK, a signal transducer for integrins, is upregulated and constitutively activated in various tumor types; it plays a key role in tumor cell migration, proliferation, survival, and tumor angiogenesis. Synonyms: CEP-37440; CEP 37440; CEP37440. CAS No. 1391712-60-9. Molecular formula: C30H38ClN7O3. Mole weight: 580.12. | |
| Cholesteryl sulfate sodium | Cholesteryl sulfate sodium is an orally available, NPC2 -targeted cholesterol biosynthesis agonist. Cholesteryl sulfate sodium activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis ( EC 50 =50 μM). Cholesteryl sulfate sodium enhances the self-assembly ability of Mitoxantrone hydrochloride (HY-13502A), while repairing the intestinal mucosal barrier and inhibiting inflammation by regulating serine protease activity and PKCη signaling pathway. Cholesteryl sulfate sodium is a component of the platelet cell membrane and supports platelet adhesion. Cholesteryl sulfate sodium also regulates the activity of selective protein kinase C isoforms and modulates the specificity of PI3K, playing a role in keratinocyte differentiation [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 2864-50-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111355B. |  |
| Defactinib | Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is , a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation. Synonyms: N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide; VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878. Grade: >98%. CAS No. 1073154-85-4. Molecular formula: C20H21F3N8O3S. Mole weight: 510.496. | |
| δ-Tocotrienol | δ-Tocotrienol is from palm oil. Delta-tocotrienol is a potential angiogenic inhibitor that significantly suppresses human colorectal adenocarcinoma cells (DLD-1-CM)-induced tube formation, migration, and adhesion on human umbilical vein endothelial cells. Delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offer a potential starting point for the design of novel anticancer agents. Delta-tocotrienol displays significant radioprotective effects that protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Synonyms: [R-(E,E)]-3,4-Dihydro-2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol; (2R)-3,4-Dihydro-2,8-dimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol; 2,8-Dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-6-chromanol; (R)-δ-Tocotrienol; 8-Methyltocotrienol; d-δ-Tocotrienol. Grade: 95%. CAS No. 25612-59-3. Molecular formula: C27H40O2. Mole weight: 396.60. | |
| FAK inhibitor 2 | FAK inhibitor 2 is a potent inhibitor of focal adhesion kinase (FAK) with an IC50 ?of 0.07? nM. It has antitumor and anti-angiogenesis activity. Synonyms: 2-(Dimethylamino)ethyl 4-(4-{[4-{[2-(methylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)-2-pyrimidinyl]amino}benzoyl)-1-piperazinecarbodithioate; 1-Piperazinecarbodithioic acid, 4-[4-[[4-[[2-[(methylamino)carbonyl]phenyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzoyl]-, 2-(dimethylamino)ethyl ester. Grade: ≥95%. CAS No. 2354405-14-2. Molecular formula: C29H33F3N8O2S2. Mole weight: 646.75. | |
| Fangchinoline | Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing[1]. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK[2]. Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer[3]. Uses: Scientific research. Group: Natural products. CAS No. 436-77-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N1372A. | |
| Fangchinoline | Fangchinoline is isolated fromStephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK. Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 12-O-Methylatherospermoline. Product Category: Inhibitors. CAS No. 436-77-1. Mole weight: 608.7. Purity: 98%+. Product ID: ACM436771. Alfa Chemistry ISO 9001:2015 Certified. |  |
| GloPIPs Biotin-PI(3,4)P2 | GloPIPs Biotin-PI(3,4)P2 is labelled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labelled PIPs has been changed to a more stable amide from an ester. PI(3,4)P2 is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions. Grade: >95%. Molecular formula: C31H52N4Na5O20P3S. Mole weight: 1040.69. | |
| GSK215 | GSK215, a potent and selective PROTAC focal adhesion kinase (FAK) degrader, is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. It induces rapid and prolonged degradation of FAK, with a long-lasting effect on FAK levels and a significant disconnect in pharmacokinetic/pharmacodynamics (PK/PD). Synonyms: (2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide. Grade: ≥95%. CAS No. 2743427-26-9. Molecular formula: C50H59F3N10O6S. Mole weight: 985.13. | |
| GSK215 | GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader with a pDC50 of 8.4. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2743427-26-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132296. | |
| GSK-2256098 | GSK2256098, also known as GTPL7939, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. Synonyms: GSK2256098; GSK 2256098; GSK-2256098; GTPL7939; GTPL-7939; GTP L7939. Grade: 98%. CAS No. 1224887-10-8. Molecular formula: C20H23ClN6O2. Mole weight: 414.89. | |
| GSK-2256098 hydrochloride | GSK-2256098 hydrochloride is a focal adhesion kinase (FAK) inhibitor that exhibits potential antiangiogenic and antineoplastic activities. GSK-2256098 hydrochloride targets FAK to inhibit tumor cell growth by regulating cell adhesion, migration, proliferation, and survival. Uses: Scientific research. Group: Signaling pathways. CAS No. 1416771-10-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100498A. | |
| Ifebemtinib | Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase ( FAK ) inhibitor (recombinant FAK IC 50 =1 nM). Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase and FES Kinase with IC 50 s of 900 nM and 1040 nM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BI-853520; IN-10018. CAS No. 1227948-82-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122844. | |
| IKK 16 hydrochloride | IKK 16 hydrochloride is a potent and selective IκB kinase (IKK) inhibitor with IC50s of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα, respectively. It inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Synonyms: N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride; [4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone hydrochloride; Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-, hydrochloride (1:1). Grade: 98%. CAS No. 1186195-62-9. Molecular formula: C28H30ClN5OS. Mole weight: 520.09. | |
| LY-333,531 hydrochloride | Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta). PKCbetaI and PKCbetaII isozyme inhibitor. Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy. Anti-cancer and anti-angiogenic compound. Suppresses glucose-induced adhesion of human monocytes to endothelial cells. Suppresses ERK1/2 and Akt phosphorylation. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H28N4O3 HCl. US Biological Life Sciences. | Worldwide |
| Narmafotinib | Narmafotinib (AMP-945) is an orally active inhibitor of the enzyme focal adhesion kinase (FAK, KD=0.21 nM). Narmafotinib inhibits autophosphorylation of 397Y-FAK in MDA-MB-231 cells with an IC50=7 nM and exhibits low general cellular toxicity (IC50=2.7 ?M, MDA-MB-231 cells). Narmafotinib can be used for anti-cancer study[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMP-945. CAS No. 1393653-34-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145652. | |
| non-specific protein-tyrosine kinase | Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families. Group: Enzymes. Synonyms: ABL; ABL1; ABL2; ABLL; ACK1; ACK2; AGMX1; ARG; ATK; ATP:protein-tyrosine O-phosphotransferase (ambi. Enzyme Commission Number: EC 2.7.10.2. FAK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3127; non-specific protein-tyrosine kinase; EC 2.7.10.2; ABL; ABL1; ABL2; ABLL; ACK1; ACK2; AGMX1; ARG; ATK; ATP:protein-tyrosine O-phosphotransferase (ambiguous); BLK; Bmk; BMX; BRK; Bruton's tyrosine kinase; Bsk; BTK; BTKL; CAKb; Cdgip; CHK; CSK; CTK; CYL; cytoplasmic protein tyrosine kinase; EMT; ETK; Fadk; FAK; FAK2; FER; Fert1/2; FES; FGR; focal adhesion kinase; FPS; FRK; FYN; HCK; HCTK; HYL; IMD1; ITK; IYK; JAK1; JAK2; JAK3; Janus kinase 1; Janus kinase 2; Janus kinase 3; JTK1; JTK9; L-JAK; LCK; LSK; LYN; MATK; Ntk; p60c-src protein tyrosine kinase; PKB; protein-tyrosine kinase (ambiguous); PSCTK; PSCTK1; PSCTK2; PSCTK4; PSCTK5; PTK2; PTK2B; PTK6; PYK2; RAFTK; RAK; Rlk; Sik; SLK; SRC; SRC2; SRK; SRM; SRMS; STD; SYK; SYN; Tck; TEC; TNK1; Tsk; TXK; TYK2; TYK3; YES1; YK2; ZAP70. Cat No: EXWM-3127. | |
| Okadaic acid ammonium salt (High Purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155716-06-6. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H67O13. NH4, Molecular Weight: 822. US Biological Life Sciences. | Worldwide |
| Okadaic acid (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H68O13, Molecular Weight: 805. US Biological Life Sciences. | Worldwide |
| Okadaic acid potassium salt (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1uM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic acid sodium salt (high purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
| Petunidin chloride | Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis. Uses: Scientific research. Group: Natural products. CAS No. 1429-30-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-126410. | |
| PF 431396 | PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 717906-29-1. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?S. US Biological Life Sciences. | Worldwide |
| PF-431396 | PF-431396 is an orally active dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with IC50 values of 2 nM and 11 nM, respectively[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 717906-29-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10460. | |
| PF-573228 | A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells. Group: Biochemicals. Alternative Names: 3, 4-Dihydro-6-[[4-[[[3- (methylsulfonyl) phenyl]methyl]amino]-5- (trifluoromethyl) -2-pyrimidinyl]amino]-2 (1H) -quinolinone; 6- [ (4- ( (3- (Methanesulfonyl) benzyl) amino) -5-trifluoro methyl pyrimidin-2-yl) amino] -3, 4-dihydro-1H-quinolin-2-one; PF 573228. Grades: Highly Purified. CAS No. 869288-64-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Phenylmethylene hydantoin | Anticancer compound. Chemopreventive. Shows anti-metastatic activity in prostate cancer cells through enhancement of cell-cell adhesion. Anti-invasive compound. Glycogen synthase kinase-3beta (GSK-3 beta) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 80171-33-1. Pack Sizes: 1mg. Molecular Formula: C10H8N2O3, Method for Determining. US Biological Life Sciences. | Worldwide |
| Y 11 | Y 11 is a potent inhibitor of focal adhesion kinase (FAK); Y 11 prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1uM). Y 11 decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines. Group: Biochemicals. Alternative Names: 1-(2-Hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo[3. 3. 1. 13, 7]decane Bromide. Grades: Highly Purified. CAS No. 1086639-59-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Y15 | Y15 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FAK Inhibitor 14. CAS No. 4506-66-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12444. | |
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