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β-(2-Thienyl)-D-alanine is an alanine derivative that is D-alanine in which one of the methyl hydrogens is replaced by a 2-thienyl group. It is a D-alpha-amino acid and a member of thiophenes. It derives from a D-alanine. Synonyms: 3-D-Ala(2-thienyl)-OH; (R)-α-Amino-2-thiophenepropionic acid; 3-(2-Thienyl)-D-alanine; D-2-THIENYLALANINE; (R)-2-amino-3-(thiophen-2-yl)propanoic acid; beta-(2-Thienyl)-D-alanine; (2R)-2-amino-3-thiophen-2-ylpropanoic acid; H-D-Thi-OH; UNII-PJ4EM0CL5E; beta-2-thienyl-D-alanine. Grades: ≥ 99% (HPLC). CAS No. 62561-76-6. Molecular formula: C7H9NO2S. Mole weight: 171.22.
epi-Canagliflozin is an epimeric impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: (1R)-1,5-Anhydro-1-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-D-glucitol; epi-Canagliflozin; D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1R)-; (1R)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol; (2R,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; Canagliflozin alpha-Isomer; Canagliflozin α-isomer. Grades: ≥95%. CAS No. 1589590-87-3. Molecular formula: C24H25FO5S. Mole weight: 444.53.
Lorediplon
Lorediplon is a hypnotic drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit. It is a novel nonbenzodiazepine of the pyrazolopyrimidine family. It is a drug for the treatment of insomnia. It demonstrated a dose-dependent improvement in sleep. It has been successfully completed with a best-in-class efficacy profile in terms of maintaining sleep and sleep quality. It demonstrates a minimum of 10-fold and 6-fold increase in potency in the spontaneous motor activation studies. It was developed by Ferrer and has been in Cilinic Phase 2. Uses: Lorediplon is a drug for the treatment of insomnia. Synonyms: Acetamide, N-(2-fluoro-5-(3-(2-thienylcarbonyl)pyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-methyl-;N-(2-Fluoro-5-(3-(thiophene-2-carbonyl)pyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-methylacetamide. Grades: >98%. CAS No. 917393-39-6. Molecular formula: C20H15FN4O2S. Mole weight: 394.42.
Tak-044 has been found to be an endothelin receptor antagonist that was once studied against some sort of liver disorders and subarachnoid haemorrhage. Synonyms: TAK-044, TAK 044, TAK044; CHEMBL61425; AC1L3XH4; Cyclo(D-alpha-aspartyl-3-((4-phenylpiperazin-1-yl)carbonyl)-L-alanyl-L-alpha-aspartyl-D-2-(2-thienyl)glycyl-L-leucyl-D-tryptophyl) disodium salt; AM017317. Grades: 98%. CAS No. 157380-72-8. Molecular formula: C45H51N9Na2O11S. Mole weight: 971.99.
THI0019
THI0019 is an agonist of very late antigen-4 (VLA-4) integrin that induces progenitor cell adhesion. THI0019 greatly enhanced the adhesion of cultured cell lines and primary progenitor cells to α4β1 ligands VCAM-1 and CS1 under both static and flow conditions. Furthermore, THI0019 facilitated the rolling and spreading of cells on VCAM-1 and the migration of cells toward SDF-1&alpha. Molecular modeling predicted that the compound binds at the α/β subunit interface overlapping the ligand-binding site thus indicating that the compound must be displaced upon ligand binding. Co-administering progenitor cells with a compound such as THI0019 may provide a mechanism for enhancing stem cell therapy. Group: Agonists. Alternative Names: THI0019; THI-0019; THI 0019. CAS No. 1378532-99-0. Molecular formula: C29H35N3O7S2. Mole weight: 601.73. Appearance: Solid powder. Purity: >98%. IUPACName: (3S,7S)-3-(1,3-Benzodioxol-5-yl)-7-butyl-5,10-dioxo-12-(2-thienyl)-11-(2-thienylmethyl)-9-oxa-4,6,11-triazadodecanoic acid methyl ester. Canonical SMILES: O=C (OC)C[C@@H] (C1=CC=C (OCO2)C2=C1)NC (N[C@@H] (CCCC)COC (N (CC3=CC=CS3)CC4=CC=CS4)=O)=O. Catalog: ACM1378532990.
It is produced by the strain of Semisynthetic penicillin. The activity against pseudomonas aeruginosa was stronger than carboxylpenicillin, and it was also effective against enterobacteriaceae, Neisseria and Proteus singularis. Klebsiella is often resistant to this antibiotic. Synonyms: alpha-carboxy-3-thienylmethylpenicillin; α-Carboxy-3-thienylmethylpenicillin; Ticarcilina; Ticarcilline; Ticarcillinum. Grades: ≥95%. CAS No. 34787-01-4. Molecular formula: C15H16N2O6S2. Mole weight: 384.43.
A highly potent non-ergoline dopamine D2 and D3 receptor agonist (Ki = 13 and 0.71nM for D2 and D3 respectively). Also displays significant affinity for 5-HT1A and adrenergic alpha2B receptors. Transdermally used in treatment of Parkinson's disease and restless legs syndrome. Group: Biochemicals. Grades: Highly Purified. CAS No. 125572-93-2. Pack Sizes: 10mg. Molecular Formula: C??H??NOS HCl. US Biological Life Sciences.
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