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| Product | Description | |
|---|---|---|
| 2-[(2,4-Dichlorophenyl)amino]-4-(trifluoromethyl)-5-pyrimidinecarboxylic Acid Methyl Ester | 2-[(2,4-Dichlorophenyl)amino]-4-(trifluoromethyl)-5-pyrimidinecarboxylic Acid Methyl Ester is used to prepare a selective CB2 receptor agonist for the treatment of inflammatory pain. Group: Biochemicals. Grades: Highly Purified. CAS No. 666260-76-0. Pack Sizes: 25mg, 250mg. Molecular Formula: C13H8Cl2F3N3O2, Molecular Weight: 366.12. US Biological Life Sciences. |  Worldwide |
| 2-Amino-4,6-dichloropyrimidine-13C2 | 2-Amino-4,6-dichloropyrimidine-13C2. Group: Biochemicals. Alternative Names: 4,6-Dichloro-2-pyrimidinamine-13C2; 2-Amino-4,6-dichloro-pyrimidine-13C2; (4,6-Dichloropyrimidin-2-yl)amine-13C2; 2-Amino-4,6-dichloropyrimidine-13C2; 4,6-Dichloro-2-aminopyrimidine-13C2; 4,6-Dichloro-2-pyrimidinamine-13C2; NSC 18698-13C2; Py 11-13C2. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde | 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde. Group: Biochemicals. Grades: Highly Purified. CAS No. 5604-46-6. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences. | Worldwide |
| 4-Amino-2,6-dichloropyrimidine | Pyrimidines. CAS No. 10132-07-7. Molecular formula: C4H3Cl2N3. Mole weight: 163.99. Appearance: Powder or Crystals. Purity: 0.95. Catalog: ACM10132077. |  |
| 5-Amino-2,4-dichloropyrimidine | A pyrimidinamine derivative as Plk1 inhibitors. Group: Biochemicals. Alternative Names: 2,4-Dichloro-5-pyrimidinamine. Grades: Highly Purified. CAS No. 5177-27-5. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 5-Amino-4,6-dichloropyrimidine (4,6-Dichloro-pyrimidin-5-ylamine) | 5-Amino-4,6-dichloropyrimidine (4,6-Dichloro-pyrimidin-5-ylamine). Group: Biochemicals. Alternative Names: 4,6-Dichloro-pyrimidin-5-ylamine. Grades: Highly Purified. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Hydrochloride | 2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Hydrochloride acts as a reagent in the preparation of fused aminopyrimidines as glucose uptake inhibitors for treating parasitic and viral infections. Group: Biochemicals. Grades: Highly Purified. CAS No. 1208901-69-2. Pack Sizes: 10mg, 25mg. Molecular Formula: C7H7Cl2N3; HCl, Molecular Weight: 204.063646. US Biological Life Sciences. | Worldwide |
| 2,4-Dichloro-6-methyl-pyrimidin-5-ylamine | 2,4-Dichloro-6-methyl-pyrimidin-5-ylamine. Group: Biochemicals. Alternative Names: 2,4-Dichloro-5-amino-6-methylpyrimidine. Grades: Highly Purified. CAS No. 13162-27-1. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| Avanafil Impurity 18 | Avanafil Impurity 18. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid compound with methane (1:1). Molecular Formula: C15H17Cl2N3O3S. Mole Weight: 390.28. Catalog: APB02786. |  |
| Avanafil Impurity 22 | Avanafil Impurity 22. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(methylsulfinyl)pyrimidine-5-carboxylate. Molecular Formula: C16H17Cl2N3O4S. Mole Weight: 418.29. Catalog: APB02781. | |
| Avanafil Impurity 29 | Avanafil Impurity 29. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-ethyl 4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate. Molecular Formula: C20H24Cl2N4O4. Mole Weight: 455.33. Catalog: APB02776. | |
| Avanafil Impurity 33 | Avanafil Impurity 33. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylic acid. Molecular Formula: C18H20Cl2N4O4. Mole Weight: 427.28. Catalog: APB02770. | |
| Avanafil Impurity 35 | Avanafil Impurity 35. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. Molecular Formula: C23H25Cl2N7O3. Mole Weight: 518.4. Catalog: APB02768. | |
| Avanafil Impurity 5 | Avanafil Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate. Molecular Formula: C16H17Cl2N3O3S. Mole Weight: 402.3. Catalog: APB02654. | |
| Carboxyamidotriazole orotate | Carboxyamidotriazole orotate (CTO) is the orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores, resulting in the disruption of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Synonyms: L-651582 Orotate; CAI Orotate; CTO; 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, compd. with 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide (1:1); 2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid 5-amino-1-[3,5-dichloro-4-(4-chlorobenzoyl)benzyl]-1H-1,2,3-triazole-4-carboxamide (1:1). Grades: ≥90%. CAS No. 187739-60-2. Molecular formula: C22H16Cl3N7O6. Mole weight: 580.76. |  |
| PD166326 | PD166326 is one of the most potent members of the pyridopyrimidine class of protein tyrosine kinase inhibitors. In mice with the CML-like disease, PD166326 rapidly inhibited Bcr/Abl kinase activity after a single oral dose and demonstrated marked antileukemic activity in vivo. In vivo, PD166326 was also superior to imatinib mesylate in inhibiting the constitutive tyrosine phosphorylation of numerous leukemia-cell proteins, including the src family member Lyn. PD166326 also prolonged the survival of mice with imatinib mesylate-resistant CML induced by the Bcr/Abl mutants P210/H396P and P210/M351T. Synonyms: PD-166326; PD 166326; 6-(2,6-Dichlorophenyl)-2-[[3-(hydroxymethyl)phenyl]amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one. CAS No. 185039-91-2. Molecular formula: C21H16Cl2N4O2. Mole weight: 427.28. | |
| 2,4-Dichloro-3-aminophenol Hydrochloride | 2,4-Dichloro-3-aminophenol Hydrochloride is a useful reagent in the study fo aryl-pyrimidinyl ureas preparation as potential FGFR tyrosine kinase inhibitors and antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 61693-43-4. Pack Sizes: 100mg, 250mg. Molecular Formula: C6H5Cl2NO; HCl, Molecular Weight: 178.023646. US Biological Life Sciences. | Worldwide |
| 3- (2, 6-Dichloro-3, 5-dimethoxyphenyl) -1-[6-[[4- (4-ethylpiperazin-1-yl) phenyl]amino]pyrimidin-4-yl]-1-methylurea | 3- (2, 6-Dichloro-3, 5-dimethoxyphenyl) -1-[6-[[4- (4-ethylpiperazin-1-yl) phenyl]amino]pyrimidin-4-yl]-1-methylurea. Group: Biochemicals. Grades: Highly Purified. CAS No. 872511-34-7. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| 4-[ (4, 6-Dichloro-2-pyrimidinyl) amino]benzonitrile | 4-[ (4, 6-Dichloro-2-pyrimidinyl) amino]benzonitrile. Group: Biochemicals. Grades: Highly Purified. CAS No. 329187-59-9. Pack Sizes: 250mg, 500mg, 1g, 5g, 10g. Molecular Formula: C11H6Cl2N4. US Biological Life Sciences. | Worldwide |
| 4-[ (4, 6-Dichloro-2-pyrimidinyl) amino]benzonitrile-13C3 | Intermediate in the preparation of HIV replication inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-[ (5-Bromo-4, 6-dichloro-2-pyrimidinyl) amino]benzonitrile | 4-[ (5-Bromo-4, 6-dichloro-2-pyrimidinyl) amino]benzonitrile. Group: Biochemicals. Grades: Highly Purified. CAS No. 269055-75-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C11H5BrCl2N4. US Biological Life Sciences. | Worldwide |
| 4-[ (5-Bromo-4, 6-dichloro-2-pyrimidinyl) amino]benzonitrile-13C3 | Intermediate in the preparation of HIV replication inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| BGJ-398 | BGJ398, also known as NVP-BGJ398, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Synonyms: 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea; NVPBGJ398; NVPBGJ 398; NVPBGJ-398; BGJ398; BGJ-398; BG J398; Infigratinib. Grades: 0.98. CAS No. 872511-34-7. Molecular formula: C26H31Cl2N7O3. Mole weight: 560.48. | |
| CHIR 98014 | CHIR 98014. Group: Biochemicals. Alternative Names: N6- [2- [ [4- (2, 4-Dichlorophenyl) -5- (1H-imidazol-2-yl) -2-pyrimidinyl] amino] ethyl] -3-nitro-2, 6-pyridinediamine. Grades: Highly Purified. CAS No. 556813-39-9. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C20H17Cl2N9O2. US Biological Life Sciences. | Worldwide |
| CHIR-98014 | A glycogen synthase kinase-3 (GSK-3). Group: Biochemicals. Alternative Names: N6- [2- [ [4- (2, 4-Dichlorophenyl) -5- (1H-imidazol-2-yl) -2-pyrimidinyl] amino] ethyl] -3-nitro-2, 6-pyridinediamine. Grades: Highly Purified. CAS No. 556813-39-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CHIR-99021 | A potent and highly selective inhibitor of glycogen synthase kinase-3beta (GSK-3b) (IC50 = 6.7nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402. Group: Biochemicals. Alternative Names: 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2- yl) pyrimidin-2-yl) amino) ethyl) amino) nicotinonitrile; CT99021; CHIR 911. Grades: Highly Purified. CAS No. 252917-06-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CHIR-99021 | CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. It enhances reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs in combination with tranylcypromine. It also induces cardiomyocyte differentiation from human embryonic stem (ES). Uses: Potential antineoplastic agent. Synonyms: CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile. Grades: >98%. CAS No. 252917-06-9. Molecular formula: C22H18Cl2N8. Mole weight: 465.342. | |
| CHIR 99021 dihydrochloride | CHIR 99021 is a potent glycogen synthase kinase GSK-3 inhibitor. Synonyms: CHIR-99021 dihydrochloride; CHIR99021 dihydrochloride; CT-99021 dihydrochloride; CT 99021 dihydrochloride; CT99021 dihydrochloride; GSK-3 Inhibitor XVI dihydrochloride; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile dihydrochloride. Grades: 99%. CAS No. 2109414-84-6. Molecular formula: C22H18Cl2N8.2HCl. Mole weight: 538.26. | |
| CHIR99021 HCl | CHIR99021, also known as CT99021, is a GSK-3α/β inhibitor (IC50= 10 nM/6.7 nM) with antiproliferative activity in vitro and in vivo. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. Synonyms: 6-((2-((4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile hydrochloride; CHIR99021 HCl; CHIR99021 hydrochloride; CHIR99021; CHIR-99021; CHIR 99021; CT99021; CT-99021; CT 99021. CAS No. 1797989-42-4. Molecular formula: C22H19Cl3N8. Mole weight: 501.8. | |
| CHIR-99021 Hydrochloride | CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. Group: Biochemicals. Alternative Names: 6- [ [2- [ [4- (2, 4-Dichlorophenyl) -5- (5-methyl-1H-imidazol-2-yl) -2-pyrimidinyl] amino] ethyl] amino] -3-pyridinecarbonitrile Hydrochloride; CHIR 911 Hydrochloride; CT 99021 Hydrochloride. Grades: Highly Purified. CAS No. 1797989-42-4. Pack Sizes: 10mg. Molecular Formula: C22H19Cl3N8, Molecular Weight: 501.8. US Biological Life Sciences. | Worldwide |
| CHIR 99021 trihydrochloride | CHIR 99021 is a highly selective GSK-3 inhibitor. CHIR 99021 is used in the treatment of parkinsonism. Uses: The treatment of parkinsonism. Synonyms: CHIR-99021 trihydrochloride; CHIR 99021 trihydrochloride; CHIR99021 trihydrochloride; 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride. Grades: ≥98% by HPLC. CAS No. 1782235-14-6. Molecular formula: C22H18Cl2N8.3HCl. Mole weight: 574.72. | |
| FIIN-1 | FIIN-1 is a potent, irreversible and selective FGFR inhibitor with IC50s of 9.2, 6.2, 11.9 and 189 nM against FGFR1/2/3/4, respectively. FIIN-1 binds to FGFR1/2/3/4 and Flt1/4 with Kds of 2.8, 6.9, 5.4, 120 nM and 32, 120 nM, respectively. Synonyms: FGFR irreversible inhibitor-1; N-[3-[[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-7-[[4-(diethylamino)butyl]amino]-3,4-dihydro-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-2-propenamide; Fibroblast Growth Factor Receptor Irreversible Inhibitor 1; N-[3-[[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-7-[[4-(diethylamino)butyl]amino]-3,4-dihydro-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]acrylamide. Grades: ≥95%. CAS No. 1256152-35-8. Molecular formula: C32H39Cl2N7O4. Mole weight: 656.60. | |
| H3B-6527 | H3B-6527 is a potent, highly selective and orally active FGFR4 inhibitor with potential antineoplastic activity. Synonyms: N-{2-[ (6-{[ (2, 6-Dichloro-3, 5-dimethoxyphenyl)carbamoyl] (methyl)amino}-4-pyrimidinyl)amino]-5- (4-ethyl-1-piperazinyl)phenyl}acrylamide; H3B-6527; H3B 6527; H3B6527. CAS No. 1702259-66-2. Molecular formula: C29H34Cl2N8O4. Mole weight: 629.543. | |
| LDN 193188 | LDN 193188 is a phosphatidylcholine transfer protein inhibitor. It regulates hepatic glucose metabolism and can be used in the management of hepatic insulin resistance. Synonyms: LDN-193188; LDN 193188; LDN193188; 2, 4-Dichloro-N- [ [ [4- [ [ (4, 6-dimethyl-2-pyrimidinyl) amino] sulfonyl] phenyl] amino] carbonyl] benzamide. Grades: ≥99% by HPLC. CAS No. 1267610-30-9. Molecular formula: C20H17Cl2N5O4S. Mole weight: 494.35. | |
| N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide | Abacavir intermediate. A purine derivative. Group: Biochemicals. Alternative Names: N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide. Grades: Highly Purified. CAS No. 171887-03-9. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| N-[2-Amino-6- (3, 5-dichlorophenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea | N-[2-Amino-6- (3, 5-dichlorophenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea is a broad tyrosine kinase inhibitor. N-[2-Amino-6- (3, 5-dichlorophenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea inhibits PDGFr, FGFr, EGFr, and c-src tyrosine kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1135256-66-4. Pack Sizes: 5mg, 50mg. Molecular Formula: C18H18Cl2N6O, Molecular Weight: 405.28. US Biological Life Sciences. | Worldwide |
| N-[2-Amino-6-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea | 2H Labeled Compounds. Alternative Names: 1-(2-Amino-6-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea. CAS No. 1135256-66-4. Molecular formula: C18H18Cl2N6O. Mole weight: 405.28. Catalog: ACM1135256664. | |
| PD0166285 | PD0166285 is a potent Wee1 inhibitor and Chk1 inhibitor with activity at nanomolar concentrations. This G2 checkpoint abrogation by PD0166285 was demonstrated to kill cancer cells, there at a toxic highest dose of 0.5 muM in some cell lines for exposure periods of no longer than 6 hours. The deregulated cell cycle progression may have ultimately damaged the cancer cells. We herein report one of the mechanism by which PD0166285 leads to cell death in the B16 mouse melanoma cell line. Synonyms: PD166285; 6-(2,6-dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one; 6-(2,6-Dichlorophenyl)-2-[4-(2-diethylaminoethoxy)phenylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one; Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-. Grades: ≥98%. CAS No. 185039-89-8. Molecular formula: C26H27Cl2N5O2. Mole weight: 512.44. | |
| PD089828 | PD089828 is a potent FGFR inhibitor, which inhibits human full-length fibroblast growth factor (FGF) receptor-1 (FGFR-1), platelet-derived growth factor (PDGF) receptor beta subunit (PDGFR-beta), Src nonreceptor tyrosine kinase (c-Src) and epidermal growth factor (EGF) receptor (EGFR) tyrosine kinases with half-maximal inhibitory potencies (IC50 values) of 0.15 +/- 0.02 (n = 4), 0.18 +/- 0.04 (n = 3), 1.76 +/- 0.28 (n = 4) and 5.47 +/- 0.78 (n = 6) microM, respectively. The results highlight the biological characteristics of PD 089828 as a novel, broadly active protein tyrosine kinase inhibitor with long-lasting but reversible cellular effects. The potential therapeutic use of these broadly acting, nonselective inhibitors as antiproliferative and antimigratory agents could extend to such diseases as cancer, atherosclerosis and restenosis in which redundancies in growth-signaling pathways are known to exist. Synonyms: PD-089828; PD 089828; N-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea; 1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-(2-methyl-2-propanyl)urea; EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor. Grades: ≥98%. CAS No. 179343-17-0. Molecular formula: C18H18Cl2N6O. Mole weight: 405.28. | |
| PD 161570 | PD 161570. Group: Biochemicals. Alternative Names: N-[6- (2, 6-Dichlorophenyl) -2-[[4- (diethylamino) butyl]amino]pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea; 1-tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylamino-butylamino)pyrido[2,3-d]pyrimidin-7-yl]urea. Grades: Highly Purified. CAS No. 192705-80-9. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H35Cl2N7O. US Biological Life Sciences. | Worldwide |
| PD-161570 | A novel FGF-1 receptor tyrosine kinase inhibitor which has been shown to effectively suppress constitutive phosphorylation of the FGF-1 receptor in human ovarian carcinoma cells. Group: Biochemicals. Alternative Names: N-[6- (2, 6-Dichlorophenyl) -2-[[4- (diethylamino) butyl]amino]pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea; 1-Tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylamino-butylamino)pyrido[2,3-d]pyrimidin-7-yl]urea. Grades: Highly Purified. CAS No. 192705-80-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD-161570 | PD-161570 is a selective inhibitor of human FGF-1 receptor tyrosine kinase, with IC50 values to be 40, 262 and 3700 nM for FGFR1, PDGFR and EGFR tyrosine kinases, respectively. In addintion, PD-161570 inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro. Synonyms: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea; PD-161570; PD 161570; PD161570. CAS No. 192705-80-9. Molecular formula: C26H35Cl2N7O. Mole weight: 532.51. | |
| PD 166285 | PD 166285. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -2-[[4-[2- (diethylamino) ethoxy]phenyl]amino]-8-methylpyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 212391-63-4. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H29Cl4N5O2. US Biological Life Sciences. | Worldwide |
| PD-166285 | A broad-spectrum receptor tyrosine kinase (RTK) inhibitor. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -2-[[4-[2- (diethylamino) ethoxy]phenyl]amino]-8-methylpyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 212391-63-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD-166285-d4 | A labeled broad-spectrum receptor tyrosine kinase (RTK) inhibitor. Group: Biochemicals. Alternative Names: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy-d4]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PD 166285 dihydrochloride | PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. Synonyms: PD 166285 dihydrochloride; PD166285 dihydrochloride; PD-166285 dihydrochloride6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride. Grades: ≥99% by HPLC. CAS No. 212391-63-4. Molecular formula: C26H27Cl2N5O2.2HCl. Mole weight: 585.35. | |
| PD 173952 | PD 173952. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -8-methyl-2-[[4- (4-morpholinyl) phenyl]amino]pyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 305820-75-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C24H21Cl2N5O2. US Biological Life Sciences. | Worldwide |
| PD-173952 | A Bcr-Abl tyrosine kinase inhibitor used in treatment research for chronic myelegenous leukemia (CML). Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -8-methyl-2-[[4- (4-morpholinyl) phenyl]amino]pyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 305820-75-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PD-173955 | PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth. Group: Inhibitors. Alternative Names: PD173955; PD 173955; PD173955. CAS No. 260415-63-2. Molecular formula: C21H16Cl2N4OS. Mole weight: 443.35. Appearance: White solid powder. Purity: >98%. IUPACName: 6- (2, 6-dichlorophenyl)-8-methyl-2- ( (3- (methylthio)phenyl)amino)pyrido[2, 3-d]pyrimidin-7 (8H)-one. Canonical SMILES: O=C1C (C2=C (Cl)C=CC=C2Cl)=CC3=CN=C (NC4=CC=CC (SC)=C4)N=C3N1C. Catalog: ACM260415632. | |
| PD180970 | PD180970 is a novel Bcr-Abl inhbiitor. PD180970 inhibited in vivo tyrosine phosphorylation of p210Bcr-Abl (IC50 = 170 nM) and the p210BcrAbl substrates Gab2 and CrkL (IC50 = 80 nM) in human K562 chronic myelogenous leukemic cells. In vitro, PD180970 potently inhibited autophosphorylation of p210Bcr-Abl (IC50 = 5 nM) and the kinase activity of purified recombinant Abl tyrosine kinase (IC50 = 2.2 nM). Incubation of K562 cells with PD180970 resulted in cell death. PD180970 is among the most potent inhibitors of the p210Bcr-Abl tyrosine kinase, which is present in almost all cases of human chronic myelogenous leukemia. PD180970 is a promising candidate as a novel therapeutic agent for Bcr-Abl-positive leukemia. Synonyms: PD 180970; PD-180970; PF-1515965; PF 1515965; PF1515965; 6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one; Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-. Grades: ≥95%. CAS No. 287204-45-9. Molecular formula: C21H15Cl2FN4O. Mole weight: 429.27. | |
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