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| Product | Description | |
|---|---|---|
| AMPK activator | AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. D942 is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels. AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, which shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 μM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therapeutic target for controlling human diseases including metabolic syndrome and cancer. Synonyms: D942; AMPK activator; 5-[3-[4-[2-(4-Fluorophenyl)ethoxy]phenyl]propyl]furan-2-carboxylic Acid. Grade: ≥95%. CAS No. 849727-81-7. Molecular formula: C22H21FO4. Mole weight: 368.4. |  |
| AMPK activator 1 | AMPK activator 1 is an AMPK activator extracted from patent WO2013116491A1 (compound No.1-75, EC50 < 0.1μM). Synonyms: 2-Benzofurancarboxamid?e, N-[1-(4-pyridinylmethyl)?-4-piperidinyl]?-5-[[1-[4-(trifluoromethyl)?phenyl]?-4-piperidinyl]?oxy]?-. CAS No. 1152423-98-7. Molecular formula: C32H33F3N4O3. Mole weight: 578.62. | |
| AMPK activator 4 | AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. Anti-hyperglycemic effect. Synonyms: AMPK activator 4; 2493239-46-4; CHEMBL4798218; MS-27389; HY-131334; CS-0133422; 2-(4-chlorophenoxy)-N-[4-[(4-cyanophenyl)methoxy]phenyl]-2-methylpropanamide. Grade: 99%. CAS No. 2493239-46-4. Molecular formula: C24H21ClN2O3. Mole weight: 420.89. | |
| AMPK Activator - CAS 849727-81-7 | The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications. Group: Fluorescence/luminescence spectroscopy. |  |
| AMPK Activator III, DHPO | The AMPK Activator III, DHPO modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications. Group: Fluorescence/luminescence spectroscopy. | |
| AMPK Activator V, Ampkinone | The AMPK Activator V, Ampkinone modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
| AMPK Activator V, Ampkinone (AKN, AMPK Signaling Activator V) | A cell-permeable benzopyran compound that stimulates both LKB1 and CaMKK-mediated AMPK activity indirectly with no noticeable effect on purified AMPK, cellular AMP/ATP ratio, PI 3-K/Akt signaling and respiratory chain, and displays antidiabetic and antiobesity properties. Shown to induce phosphorylation of AMPK-Thr172 and ACC-Ser79 in L6 cells (EC50 = 4.3uM), C2C12 myocytes, 3T3-L1 preadipocytes and HepG2 hepatic cells, and enhance glucose uptake and insulin sensitivity in high fat-diet-induced obesity mouse model (10mg/kg, s.c.) with the lowering of cholesterol and nonesterified fatty acids. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| AMPK Activator VI, RSVA314 - CAS 316130-82-2 | The AMPK Activator VI, RSVA314 modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
| AMPK Signaling Activator IX, F17 - CAS 280112-24-5 | The AMPK Signaling Agonist, F17, also referenced under CAS 280112-24-5, controls the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
| AMPK Signaling Activator XIII, ZLN005 (2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV) | A cell-permeable benzimidazole that, in addition to its inhibitory potency against luciferase activity (IC50 <10nM), also activates AMPK signaling by increasing cellular ADP/ATP ratio via mitochondria respiration upcoupling, effectively activating AMPK & PGC-1alpha in muscle, but not liver, cell types both in cultures (5-20uM in rat L6 myotubes) in vitro and in db/db mice (15mg/kg/day via p.o.) in vivo. Reported to improve glucose and insulin tolerance of db/db mice without any apparent effects on body weight or food intake. Group: Biochemicals. Grades: Highly Purified. CAS No. 4529-96-8. Pack Sizes: 25mg. Molecular Formula: C??H??N?. US Biological Life Sciences. | Worldwide |
| ATIC Dimerization Inhibitor (Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR Transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI) | A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691nM, Kd = 240nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~24h), compared to AICA-riboside. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Nur77 LBD Antagonist, TMPA (AMPK Signaling Activator XII, Liver Kinase B Activator, LKB1 Activator, MARK Signaling Activator, STK11 Activator, TR3 LBD Antagonist, Ethyl-2- (2, 3, 4-trimethoxy-6- (1-octanoyl) phenyl) acetate) | A cell-permeable phenylacetate compound that blocks Nur77 (TR3) LKB1 nuclear-sequestering function by antagonizing against Nur77-LKB1 interaction via direct binding at the LKB1 LBD/ligand binding domain (Kd = 0.14 against 5uM LKB1 binding to 5uM full-length Nur77). Shown to induce LKB1 Ser428 phosphorylation (10 & 20uM for 6h) and LKB1 nuclear-to-cytosol translocation in hepatic LO2 cells, resulting in enhanced phosphorylations of LKB1 cytosolic effectors AMPKalpha and MARK1/2/3 without affecting Nur77 transactivation activity. Daily i.p. dosing (50mg/kg) is shown to increase liver LKB1 Ser428/AMPKalpha Thr172 phosphorylations in diabetic db/db mice in vivo, effectively improving animal glucose tolerance. Also reported to lower fasting blood glucose level in STZ-treated, high fat diet-fed type II diabetic mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-[[ (3E) -3-[ (4-Chlorophenyl) phenylmethylene]-2, 3-dihydro-2-oxo-1H-indol-1-yl]methyl]benzoic Acid | 3-[[ (3E) -3-[ (4-Chlorophenyl) phenylmethylene]-2, 3-dihydro-2-oxo-1H-indol-1-yl]methyl]benzoic Acid is an activator of AMP-activated protein kinase (AMPK), which is a enzyme involved in the regulation of cellular energy homeostasis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1273323-67-3. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C29H20ClNO3, Molecular Weight: 465.93. US Biological Life Sciences. | Worldwide |
| 3-Guanidinopropionic acid | 3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coactivator 1α (PGC-1α). 3-Guanidinopropionic acid is an acidic guanidine derivative that has been shown to ameliorate hyperglycemia in animal models of noninsulin-dependent diabetes. Synonyms: β-GPA; PNU 10483; 3-Guanidinopropanoic acid. Grade: ≥98%. CAS No. 353-09-3. Molecular formula: C4H9N3O2. Mole weight: 131.1. | |
| 5-[3-[4-[2- (4-Fluorophenyl) ethoxy]phenyl]propyl]-2-furancarboxylic Acid | 5-[3-[4-[2- (4-Fluorophenyl) ethoxy]phenyl]propyl]-2-furancarboxylic Acid. Group: Biochemicals. Alternative Names: 5- [3- [4- [2- (4-Fluorophenyl) ethoxy] phenyl] propyl] furan-2-carboxylic Acid; D942; AMPK Activator. Grades: Highly Purified. CAS No. 849727-81-7. Pack Sizes: 2.5mg. Molecular Formula: C22H21FO4, Molecular Weight: 368.4. US Biological Life Sciences. | Worldwide |
| 7-Methoxyisoflavone | 7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK). Synonyms: MIF; 7-methoxy-3-phenyl-4H-chromen-4-one. CAS No. 1621-56-3. Molecular formula: C16H12O3. Mole weight: 252.26. | |
| 7-Methoxyisoflavone | 7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase ( AMPK ). Uses: Scientific research. Group: Signaling pathways. CAS No. 1621-56-3. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N6631. |  |
| A-769662 | A-769662 is a AMP-activated protein kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC50 = 0.8 ?M) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50 = 3.2 ?M). A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 844499-71-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50662. | |
| A-769662 | A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity. Synonyms: 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile. Grade: ≥95%. CAS No. 844499-71-4. Molecular formula: C20H12N2O3S. Mole weight: 360.4. | |
| A-769662 (4-Hydroxy-3-(2-hydroxy-[1,1-biphenyl]-4-yl-)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile) | Cell-permeable. A potent AMPK activator. Directly stimulates partially purified rat liver AMPK (EC50 = 0.8uM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50 = 3.2uM). Group: Biochemicals. Alternative Names: 4-Hydroxy-3-(2-hydroxy-[1,1-biphenyl]-4-yl-)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile. Grades: Highly Purified. CAS No. 844499-71-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| A-769662 (6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile) | A-769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). AMPK is an alpha beta gamma heterotrimer and plays an important role in regulating cellular and whole-body metabolism. A-769662 only activates AMPK heterotrimers containing the B1 subunit. A-769662 activates AMPK through the beta subunit carbohydrate-binding module and the gamma subunit but not the AMP-binding sites. Group: Biochemicals. Grades: Highly Purified. CAS No. 844499-71-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Adenosine-2-carboxamide | Adenosine-2-carboxamide is a chemical compound that has potential use in treating a variety of diseases such as acute lymphoblastic leukemia, neuroblastoma and colorectal cancer by acting as an AMPK activator. It has also been studied for its neuroprotective effects, making it a promising candidate for Alzheimer's and Parkinson's disease research. Synonyms: 2-Aminocarbonyl adenosine; 6-amino-9-β-D-ribofuranosyl-9H-purine-2-carboxylic acid amide; 6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purine-2-carboxylic acid amide; 2-Carbamoyladenosine. Grade: ≥95%. CAS No. 70255-72-0. Molecular formula: C11H14N6O5. Mole weight: 310.27. | |
| Adenosine 5'-monophosphate monohydrate | Adenosine 5'-monophosphate monohydrate (5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). Synonyms: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate; hydrate. Grade: ≥95%. CAS No. 18422-05-4. Molecular formula: C10H14N5O7P·H2O. Mole weight: 365.24. | |
| AdipoR agonist 1 | AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor ( AdipoR ), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). AdipoR agonist 1 is utilized in preventive doping research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 949745-75-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-130479. | |
| AdipoRon (2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide) | Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low um concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 924416-43-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AICAR | AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy , YAP and mitophagy inhibitor [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Acadesine; AICA Riboside. CAS No. 2627-69-2. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13417. | |
| AICAR | Cell permeable AMP-activated protein kinase (AMPK) activator. Insulin mimetic. Adipocyte differentiation inhibitor. Apoptosis inducer. PPARalpha inhibitor. mTOR inhibitor. P70S6K inhibitor. LPS-induced TNFalpha production inhibitor. TORC2 phosphorylation inducer. Anti-inflammatory. Anti-tumor compound. Autophagy inhibitor. HSP90 inhibitor. Group: Biochemicals. Alternative Names: 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside. Grades: Highly Purified. CAS No. 2627-69-2. Pack Sizes: 10mg, 50mg, 100mg. Molecular Formula: C9H14N4O5. US Biological Life Sciences. | Worldwide |
| AICA-Riboside, 5?-Phosphate - CAS 3031-94-5 | A 5'-phosphorylated analog of membrane permeable AICA-Riboside that mimics AMP and acts as an activator of AMPK (AMP-activated protein kinase). Group: Fluorescence/luminescence spectroscopy. | |
| AICAR phosphate | AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy , YAP and mitophagy inhibitor [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Acadesine phosphate; AICA Riboside phosphate. CAS No. 681006-28-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13417A. | |
| AMPK-IN-1 | AMPK-IN-1 is an activator of AMPK ( EC 50 : 551 nM for isoform α2β2γ1 ). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1219739-95-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120904. | |
| AMPK Inhibitor, Compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, BMP Inhibitor I) | A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50=25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbR-I, ZAPK, Syk, PKCth, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100=2.5uM) and VEGF signaling-dependent intersomitic vessel formation (EC50=5uM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR and/or Metformin for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. CAS Number:866405-64-3. Group: Biochemicals. Grades: Highly Purified. CAS No. 866405-64-3. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??N?O. US Biological Life Sciences. | Worldwide |
| ASP4132 | ASP4132 is an orally active activator of adenosine monophosphate-activated protein kinase (AMPK) with EC50 of 0.018 μM. CAS No. 1640294-30-9. Molecular formula: C46H51F3N6O8S2. Mole weight: 937.06. | |
| BMP Inhibitor II, DMH1 (ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4- (6- (4-Isopropoxyphenyl) pyrazolo[1, 5-a]pyrimidin-3-yl) quinoline) | A cell-permeable pyrrazolopyrimidine compound that inhibits against R/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50=25.1, 148, and 234.6nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbR-I, ZAPK, Syk, PKCth, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100=2.5uM) and VEGF signaling-dependent intersomitic vessel formation (EC50=5uM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR and/or Metformin for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1206711-16-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Buformin | Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase. Buformin is a potent AMPK activator and acts as an orally active biguanide antidiabetic agent. Synonyms: Imidodicarbonimidic diamide, N-butyl-; Biguanide, 1-butyl-; N-Butylimidodicarbonimidic diamide; 1-Butylbiguanide; Buformine; Butformin; Butylbiguanide; Butyldiguanide; DBV; Dibetos B; Glybigid; H 224; N1-Butylbiguanide; W 37. Grade: ≥95%. CAS No. 692-13-7. Molecular formula: C6H15N5. Mole weight: 157.22. | |
| Buformin hydrochloride | Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Butylbiguanide hydrochloride. CAS No. 1190-53-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg. Product ID: HY-B2099A. | |
| Buformin hydrochloride | Buformin is a potent AMPK activator and acts as an orally active biguanide antidiabetic agent. Synonyms: Imidodicarbonimidic diamide, N-butyl-, hydrochloride (1:x); Biguanide, 1-butyl-, hydrochloride; Imidodicarbonimidic diamide, N-butyl-, hydrochloride; Adebit; Butylbiguanide hydrochloride; Silubin; Silubin-retard; 1-Butylbiguanide hydrochloride (1:x); Buformine hydrochloride (1:x); Butylbiguanide hydrochloride (1:x). Grade: ≥95%. CAS No. 15537-73-2. Molecular formula: C6H15N5.xHCl. Mole weight: 157.22 (free base). | |
| Cordycepin (3'-Deoxyadenosine) | Cordycepin is a known polyadenylation inhibitor with a large spectrum of biological activities, including anti-proliferative, pro-apoptotic and anti-inflammatory effects. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Also acts as an AMPK activator and Akt inhibitor. Group: Biochemicals. Alternative Names: 3'-Deoxyadenosine; 9-(3-Deoxy- β-D-ribofuranosyl)adenine; 9-(3-Deoxy- β-D-erythro-pentofuranosyl)-9H-purin-6-amine; 9-Cordyceposidoadenine; Cordycepine; NSC 401022; NSC 63984. Grades: Highly Purified. CAS No. 73-03-0. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??N?O?, Molecular Weight: 251.24. US Biological Life Sciences. | Worldwide |
| Demethyleneberberine | Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD) [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 25459-91-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N0592. | |
| Demethyleneberberine chloride | Demethyleneberberine chloride is a natural mitochondria-targeted antioxidant. Demethyleneberberine chloride alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine chloride could serve as a AMPK activator for researching non-alcoholic fatty liver disease (NAFLD) [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 16705-03-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N0592A. | |
| ETC-1002 | ETC-1002 is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule and is activator of hepatic AMP-activated protein kinase (AMPK). It also has potent inhibitory activity against hepatic ATP-citrate lyase. Synonyms: ESP-55016; ESP55016; ESP 55016; ETC-1002; ETC 1002; ETC1002; Bempedoate; Bempedoic acid. Grade: >98%. CAS No. 738606-46-7. Molecular formula: C19H36O5. Mole weight: 344.49. | |
| Etilefrine | Etilefrine (3-[2-(ethylamino)-1-hydroxyethyl]phenol) is an α adrenergic agonist [2]. Etilefrine also is an AMPK activator [1]. Etilefrine can be used for the research of postural hypotension [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 709-55-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-A0144. | |
| Etilefrine hydrochloride | Etilefrine hydrochloride is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an AMPK activator. Etilefrine hydrochloride can be used for the research of postural hypotension [1] [2] [3] [4]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 943-17-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-A0144A. | |
| EX229 | EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase (AMPK), with Kds of 0.06 ?M, 0.06 ?M and 0.51 ?M for ?1?1?1, ?2?1?1 and ?1?2?1 in biolayer interferometry, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1219739-36-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112769. | |
| EX229 | EX229 (compound 991), also known as AMPK Activator 991, is a potent AMPK activator that displays 5-10-fold more potent than A769662 in activating AMPK. Synonyms: Compound 991; AMPK Activator 991; 5-[[6-chloro-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy]-2-methylbenzoic acid. Grade: ≥98%. CAS No. 1219739-36-2. Molecular formula: C24H18ClN3O3. Mole weight: 431.87. | |
| GSK621 | GSK621 is an activator of AMP-activated protein kinase (AMPK). GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation. Synonyms: GSK-621; GSK 621. Grade: 98%. CAS No. 1346607-05-3. Molecular formula: C26H20ClN3O5. Mole weight: 489.91. | |
| GSK621 | GSK621 is a specific AMPK activator, with IC50 values of 13-30 ?M for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2? phosphorylation-a hallmark of UPR activation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346607-05-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100548. | |
| Lixumistat acetate | Lixumistat (IM156; HL156A; HL271) acetate, a chemical derivative of Metformin (HY-B0627), is a potent and orally active AMPK activator that increases AMPK phosphorylation. Lixumistat (acetate) attenuates aging-associated cognitive impairment in animal model [1] [2]. Lixumistat (acetate) is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IM156; HL156A; HL271 acetate. CAS No. 1422365-94-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136093A. | |
| MK8722 | MK8722 is a potent and systemic pan-AMPK activator. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394371-71-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111363. | |
| MK-8722 | MK-8722 is a potent pan-AMPK activator. MK-8722 improves glucose homeostasis but induces cardiac hypertrophy. In rodents and rhesus monkeys, MK-8722-mediated AMPK activation in skeletal muscle induced robust, durable, insulin-independent glucose uptake and glycogen synthesis, with resultant improvements in glycemia and no evidence of hypoglycemia. These effects translated across species, including diabetic rhesus monkeys, but manifested with concomitant cardiac hypertrophy and increased cardiac glycogen without apparent functional sequelae. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MK-8722; MK 8722; MK8722. Product Category: Activators. Appearance: Solid powder. CAS No. 1394371-71-1. Molecular formula: C24H20ClN3O4. Mole weight: 449.89. Purity: >98%. IUPACName: (3R,3aR,6R,6aR)-6-((6-([1,1'-biphenyl]-4-yl)-7-chloro-3H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol. Canonical SMILES: ClC1=C2C(NC(O[C@@H]3CO[C@@]4([H])[C@]3([H])OC[C@H]4O)=N2)=NC=C1C5=CC=C(C6=CC=CC=C6)C=C5. Product ID: ACM1394371711. Alfa Chemistry ISO 9001:2015 Certified. |  |
| O-304 | O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1261289-04-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112233. | |
| PF-06409577 | PF-06409577 is a potent and selective allosteric activator of AMPK ?1?1?1 isoform with an EC50 of 7 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1467057-23-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103683. | |
| PF-739 | PF-739 is an orally active and non-selective activator of AMPK. PF-739 activates 12 heterotrimeric AMPK complexes and significantly reduces the level of glucose in plasma complexes[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1852452-14-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117755. | |
| Piceatannol | Wide range of tyrosine and serine/threonine protein kinase inhibitor, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K. Inhibits the tyrosine phosphorylation of STAT3 and STAT5. Potent apoptosis inducer. Potent anticancer compound. Suppresses NF-kB activation through IkBalpha kinase inhibition. Activator of human deacetylase SIRT1 (sirtuin 1). Potent antioxidant with anti-proliferative, anti-inflammatory and cardioprotective properties. Neuoprotective. Adipogenesis inhibitor. Promotes glucose uptake, AMPK phosphorylation and GLUT4 translocation. Group: Biochemicals. Grades: Highly Purified. CAS No. 10083-24-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Platycodin D | Platycodin D is a saponin isolated from Platycodon grandiflorus , acts as an activator of AMPKα , with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 58479-68-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N1411. | |
| PT1 | PT1 is an AMPKα1 activator that directly activates the inactive truncated forms of AMPKα1 monomers [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 331002-70-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103239. | |
| Sauchinone (1?-Epimer dihydrocarpanone) | Hepatoprotective antioxidant. Anti-inflammatory. Suppresses NF-kB p65 activity. Neuroprotective. Apoptosis inhibitor. Bone resorption / osteoclastogenesis inhibitor. Reduces ROS formation. Antiseptic. AMP-activated kinase (AMPK) activator. Akt phosphorylation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 177931-17-8. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| ZLN024 hydrochloride | ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC 50 s of 0.42 μM, 0.95 μM, 1.1 μM and 0.13 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1883548-91-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16708A. | |
| 10-Gingerol | 10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC 50 value of 10.47 μM against DPPH radical, an IC 50 value of 1.68 μM against superoxide radical and an IC 50 value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC 50 of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol is promising for research of ulcerative colitis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 23513-15-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N0448. | |
| (1E,6E)-Demethoxycurcumin | Natural demethoxy curcuminoid. Anticancer, antiproliferative and antioxidant activity. Inhibits various signaling pathways including Wnt/β-catenin, AMPK and MAPK. Uses: Antitumor, fight free radicals and lipid. Synonyms: (1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (E,E)-; 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(p-hydroxyphenyl)-; (1E,6E)-1-(4-Hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; Curcumin II; Demethoxycurcumin; Desmethoxycurcumin; Monodemethoxycurcumin; 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (1E,6E)-. Grade: >98%. CAS No. 22608-11-3. Molecular formula: C20H18O5. Mole weight: 338.35. | |
| (20S)-Protopanaxadiol | (20S)-Protopanaxadiol is used in the treatment of cerebral ischemic injury and the reversal of oxidative stress. A novel class of AMP-activated protein kinase (AMPK) inhibitors affecting glucose and lipid metabolism. Group: Biochemicals. Grades: Highly Purified. CAS No. 30636-90-9. Pack Sizes: 5mg, 50 mg. Molecular Formula: C30H52O3. US Biological Life Sciences. | Worldwide |
| 2-APQC | 2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (Kd=2.756 ?M), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-?/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 500271-63-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-158426. | |
| 2-Deoxy-D-glucose | 2-deoxy-D-glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis. This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response. 2-deoxy-D-glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models. Synonyms: 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose; 2-DG; 2 DG; 2DG. Grade: >98%. CAS No. 154-17-6. Molecular formula: C6H12O5. Mole weight: 164.16. | |
| 6-Azuridine | 6-Azuridine (6-Azauridine) is an orally active purine nucleoside analogue. 6-Azuridine activates autophagic flux , induces Apoptosis that depends on AMPK and p53. 6-Azuridine exhibit both antitumor and antiviral activities [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 6-Azauridine. CAS No. 54-25-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-131611. | |
| 8-Chloroadenosine | 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 8-Cl-Ado. CAS No. 34408-14-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-103400. | |
| [acetyl-CoA carboxylase] kinase | Phosphorylates and inactivates EC 6.4.1.2, acetyl-CoA carboxylase, which can be dephosphorylated and reactivated by EC 3.1.3.17, [phosphorylase] phosphatase. The enzyme is more active towards the dimeric form of acetyl-CoA carboxylase than the polymeric form. Phosphorylates serine residues. Group: Enzymes. Synonyms: acetyl coenzyme A carboxylase kinase (phosphorylating); acetyl-CoA carboxylase bound kinase; acetyl-CoA carboxylase kinase; acetyl-CoA carboxylase kinase (cAMP-independent); acetyl-CoA carboxylase kinase 2; acetyl-CoA carboxylase kinase-2; acetyl-CoA carboxylase kinase-3 (AMP-activated); acetyl-coenzyme A carboxylase kinase; ACK2; ACK3; AMPK; I-peptide kinase; STK5. Enzyme Commission Number: EC 2.7.11.27. CAS No. 77000-06-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3147; [acetyl-CoA carboxylase] kinase; EC 2.7.11.27; 77000-06-7; acetyl coenzyme A carboxylase kinase (phosphorylating); acetyl-CoA carboxylase bound kinase; acetyl-CoA carboxylase kinase; acetyl-CoA carboxylase kinase (cAMP-independent); acetyl-CoA carboxylase kinase 2; acetyl-CoA carboxylase kinase-2; acetyl-CoA carboxylase kinase-3 (AMP-activated); acetyl-coenzyme A carboxylase kinase; ACK2; ACK3; AMPK; I-peptide kinase; STK5. Cat No: EXWM-3147. |  |
| Adenosine 5'-monophosphate disodium | Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 4578-31-8. Pack Sizes: 100 mg; 500 mg. Product ID: HY-W011012. | |
| AdipoRon hydrochloride | AdipoRon hydrochloride is the hydrochloride salt and water-soluble derivative of AdipoRon, which is a potent and selective agonist of adiponectin receptors AdipoR1 and AdipoR2 with Kd values of 1.8 and 3.1 μM respectively. It activates PPAR-α and AMPK pathways in the liver and muscle. It ameliorates dyslipidemia, insulin resistance and glucose intolerance in db/db mice. It is a promising treatment for obesity-related diseases such as type 2 diabetes. It is orally active antidiabetic agent. Synonyms: 2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride. Grade: ≥98% by HPLC. CAS No. 1781835-20-8. Molecular formula: C27H29N2O3Cl. Mole weight: 464.98. | |
| Aldometanib | Aldometanib is an active aldolase inhibitor. It prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AMPK. Aldometanib can be used for the research of metabolic homeostasis. Grade: >98.0%. CAS No. 2904601-67-6. Molecular formula: C27H43Cl2IN2. Mole weight: 593.46. | |
| Aldometanib | Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LXY-05-029. CAS No. 2904601-67-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148189. | |
| Alizarin | Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. CAS No. 72-48-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-N0563. | |
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