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| Product | Description | |
|---|---|---|
| ANTITHROMBIN III | ANTITHROMBIN III. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TENSTOP(TM);THROMSTOP(R);ATIII;ANTITHROMBIN 3;ANTITHROMBIN III PLASMA;ANTITHROMBIN III, HUMAN PLASMA;ANTITHROMBIN III, HUMAN;ANTITHROMBIN III. Product Category: Heterocyclic Organic Compound. CAS No. 52014-67-2. Product ID: ACM52014672. Alfa Chemistry ISO 9001:2015 Certified. Categories: Antithrombin III deficiency. |  |
| Immobilized human antithrombin | May be used repeatedly. Protocol for purifying high affinity heparin with immobilized antithrombin:1. Equilibrate immobilized antithrombin in TBS (0.1M Tris-HCl, 0.15M NaCl, pH 7. 4) or PBS (0.05M Sodium Phosphate, 0.15M NaCl, pH 7. 4). 2. Apply heparin in TBS or PBS. Binding capacity is ~0.1 mg high affinity heparin / ml resin and must be determined by the end user. 3. Wash and elute heparin with 3M NaCl in TBS or PBS. 4. Re-equilabrate resin in TBS or PBS. 5. Add 0.02percent Sodium Azide for storage. Group: Enzymes. Synonyms: Antithrombin; AT; ATIII; AT3, AT3D, THPH7, serpin family C member 1. Purity: >95% by SDS-PAGE analysis. Mole weight: 58200. Stability: 12 months from delivery. Storage: 4°C. Form: Frozen liquid. Source: Human plasma. Species: Human. Antithrombin; AT; ATIII; AT3, AT3D, THPH7, serpin family C member 1; Immobilized Antithrombin. Cat No: NATE-1756. |  |
| Argatroban | Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. Uses: Antithrombins; platelet aggregation inhibitors. Synonyms: (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic Acid. Grades: >98%. CAS No. 74863-84-6. Molecular formula: C23H36N6O5S. Mole weight: 508.63. |  |
| Bivalirudin | Bivalirudin is a specific and reversible direct thrombin inhibitor (DTI). It is a synthetic congener of the naturally occurring drug hirudin. It is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. It is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, while also inhibiting thrombin-mediated platelet activation and aggregation. It has a quick onset of action and a short half-life. It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore, it has a predictable antithrombotic response. It does not require a binding cofactor such as antithrombin and does not activate platelets. Synonyms: Hirulog; Hirulog I; Angiomax; Hirulog-1; Hirulog1; Hirulog 1; BG8967; BG 8967; BG-8967; LS-172701; LS172701; LS 172701. Grades: > 95%. CAS No. 128270-60-0. Molecular formula: C98H138N24O33. Mole weight: 2180.32. | |
| Coagulation Factor Calibrator Plasma | The Coagulation Factor Calibrator Plasma is a lyophilized reference plasma intended for use in the calibration of Antigen assays for factor II, factor VII, factor X, factor XI, factor XIII, Protein C, Protein S, Antithrombin III, von Willebrand Factor and fibrinogen by ELISA. It is prepared from a pool of normal citrated human plasma collected from a minimum of 20 donors, buffered with HEPES and stabilizers and lyophilized. Group: Biologicals. Pack Sizes: 1ml. US Biological Life Sciences. |  Worldwide |
| Dermatan sulphate sodium | Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 54328-33-5. Pack Sizes: 5 mg. Product ID: HY-N8278. |  |
| D-Glucosamine-2-N,3-O,6-O-trisulfate sodium salt | It is the predominant 3-O-sulfated unit found in the antithrombin binding site in porcine mucosal heparin. Synonyms: 2-Deoxy-2-(sulfoamino)-D-glucose 3,6-bis(hydrogen sulfate) trisodium salt; D-Glucosamine N2,3,6-trisulfate sodium salt. CAS No. 157297-02-4. Molecular formula: C6H10NNa3O14S3. Mole weight: 485.31. | |
| D-Glucosamine-2-N,3-O-disulphate disodium salt | It is the residue found in the antithrombin binding site in heparin. Synonyms: D-Glucosamine N2,3-disulfate disodium salt; 2-Deoxy-2-sulfamino-D-glucopyranose-3-sulfate disodium salt; [(3R,4R,5R,6R)-2,5-dihydroxy-6-(hydroxymethyl)-3-(sulfonatoamino)oxan-4-yl] sulfate disodium. Grades: ≥95%. CAS No. 112898-34-7. Molecular formula: C6H11NO11S2Na2. Mole weight: 383.25. | |
| D-Glucosamine-3,6-di-O-sulphate sodium salt | It's part of the heparin antithrombin binding site. Synonyms: Sodium (2R,3R,4R,5R)-5-amino-2,3-dihydroxy-6-oxohexane-1,4-diyl bis(sulfate); 2-Amino-2-deoxy-D-glucose 3,6-bis(hydrogen sulfate) disodium salt. CAS No. 536741-53-4. Molecular formula: C6H11NNa2O11S2. Mole weight: 383.25. | |
| D-Glucosamine-3-O-sulphate | It's part of the heparin antithrombin binding site. Synonyms: 3-O-Sulfate glucosamine; glucosamine 3-O-sulfate; D-Glucose, 2-amino-2-deoxy-, 3-(hydrogen sulfate); D-Glucosamine 3-sulfate; 2-Amino-2-deoxy-D-glucose 3-sulfate. Grades: ≥95%. CAS No. 76330-20-6. Molecular formula: C6H13NO8S. Mole weight: 259.23. | |
| Enoxaparin | Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19 [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PK 10169; Enoxaparin sodium. CAS No. 679809-58-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109509. | |
| Fondaparinux sodium | Fondaparinux sodium is an antithrombin-dependent factor Xa inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Fondaparin sodium; SR-90107A. CAS No. 114870-03-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0597. | |
| Fondaparinux Sodium | Fondaparinux sodium is a factor Xa inhibitor that mediates the interaction of herparin with antithrombins. It is used for the prevention of venous thromboembolism after surgery. Synonyms: Arixtra; Quixidar; Fondaparinux sodium; Fondaparinux sodium salt; PENTA; Arixtra; Xantidar; SR 90107A; IC-85158; SR-90107A; SR90107A; IC 85158; IC85158. Grades: > 95%. CAS No. 114870-03-0. Molecular formula: C31H43N3Na10O49S8. Mole weight: 1728.035. | |
| [heparan sulfate]-glucosamine 3-sulfotransferase 1 | This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases [EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2) and EC 2.8.2.30 ([heparan sulfate]-glucosamine 3-sulfotransferase 3)] by being the most selective for a precursor of the antithrombin-binding site. It has a minimal acceptor sequence of: ? GlcNAc6S? GlcA? GlcN2S*+/-6S? IdoA2S? GlcN2S?, the asterisk marking the target (symbols as in 2-Carb-38) using +/- to mean the presence or absence of a substituent, and > to separate a predominant structure from a minor one. Thus Glc(N2S > NAc) means a residue of glucosamine where the N carries a sulfo group mainly but occasionally a...sulfotransferase; glucosaminyl 3-O-sulfotransferase; heparan sulfate D-glucosaminyl 3-O-sulfotransferase; isoform/isozyme 1 (3-OST-1, HS3ST1). Enzyme Commission Number: EC 2.8.2.23. CAS No. 183257-54-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3382; [heparan sulfate]-glucosamine 3-sulfotransferase 1; EC 2.8.2.23; 183257-54-7; heparin-glucosamine 3-O-sulfotransferase; 3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase; glucosaminyl 3-O-sulfotransferase; heparan sulfate D-glucosaminyl 3-O-sulfotransferase; isoform/isozyme 1 (3-OST-1, HS3ST1). Cat No: EXWM-3382. | |
| [heparan sulfate]-glucosamine 3-sulfotransferase 3 | Two major substrates contain the tetrasaccharides: ? undetermined 2-sulfo-uronic acid? GlcN2S? IdoA2S? GlcN*? and ? undetermined 2-sulfo-uronic acid? GlcN2S? IdoA2S? GlcN6S*? (symbols as in 2-Carb-38) with modification of the N-unsubstituted glucosamine residue (shown with an asterisk). Modification of selected sequences containing N-sulfo-glucosamine residues cannot yet be excluded. The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex virus type 1 as an entry receptor to infect the target cells. There are two isozymes, known as 3-OST-3A and 3-OST-3B, which have identical catalytic domains but are encoded by different mammalian genes. The specificity of this enzyme differs from that of the other [heparan sulfate]-glucosamine 3-sulfotransferases. It is inefficient at modifying precursors of the antithrombin binding site [in contrast to EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1)] and it does not modify glucosamine preceded by GlcA2S [unlike EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2)]. Group: Enzymes. Enzyme Commission Number: EC 2.8.2.30. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3390; [heparan sulfate]-glucosamine 3-sulfotransferase 3; EC 2.8.2.30. Cat No: EXWM-3390. | |
| Heparinase I | This enzyme selectively cleaves highly sulfated polysaccharide chains containing 1-4 linkages between N-sulfated glucaoamine and 2-O-sulfated iduronic acid. It cleaves heparin sulfate but only to a limited extent in the sulfated zone. It also cleaves the antithrombin III pentasaccharide unit in the heparin molecule. Optimum pH 7.0-7.6. Stabilised with 0.2-0.4% BSA, 0.22 μm sterile filtered and dispensed into sterile tubes/vials. Synonyms: Native Flavobacterium Heparinum Heparinase I; EC 4.2.2.7; Heparinase I; Heparin Eliminase; Heparinase; Heparin Lyase; Heparinase I From Bacteroides Eggerthii, Recombinant. Grades: 95%. CAS No. 9025-39-2. Mole weight: 42.8 kDa. | |
| Heparin Sodium | Heparin sodium is an anticoagulant, is a kind of mucosaccharide, is extracted from the intestinal mucosa of pigs, cattle, sheep sodium salt glucosamine sulfate, in the human body is secreted by mast cells and naturally exists in the blood. Heparin sodium Chemicalbook can prevent platelet aggregation and destruction, inhibit the transformation of fibrinogen into fibrin monomer, inhibit the formation of thrombin and counter the already formed thrombin, prevent the transformation of prothrombin into thrombin and antithrombin. Synonyms: SODIUM HEPARIN;SODIUM HEPARINATE;REVIPARIN SODIUM;PORCINE HEPARIN SODIUM;BOVINE HEPARIN SODIUM;HEP, NA, BOVINE;HEP, NA, PORCINE;HEPARIN PORCINE SODIUM SALT. CAS No. 9041-8-1. Product ID: PAP-0071. Molecular formula: (C12H16NS2Na3)20. Category: Cardiovascular. Product Keywords: Cardiovascular Series; Heparin Sodium; PAP-0071; Cardiovascular; (C12H16NS2Na3)20; 9041-08-1. Standard: CP. Chemical Name: SODIUM HEPARIN;SODIUM HEPARINATE;REVIPARIN SODIUM;PORCINE HEPARIN SODIUM;BOVINE HEPARIN SODIUM;HEP, NA, BOVINE;HEP, NA, PORCINE;HEPARIN PORCINE SODIUM SALT. Grade: Pharmaceutical Grade. Solubility: H2O: 50 mg/mL, clear, faintly yellow. Storage: 2-8°C. Melting Point: >181°C (dec.). Product Description: Heparin sodium is an anticoagulant, is a kind of mucosaccharide, is extracted from the intestinal mucosa of pigs, cattle, sheep sodium salt glucosamine sulfate, in the human body is secreted by ma |  |
| Heparin sodium salt | Heparin sodium salt (Sodium heparin) is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. Heparin sodium salt significantly inhibits exosome-cell interactions. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sodium heparin; Sodium heparinate. CAS No. 9041-8-1. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-17567A. | |
| Hirudin | Extractives and their physically modified derivatives such as proteins, carbohydrates, lipids, nucleic acids, inorganic ions, etc. obtained from Hirudo medicinalis. Uses: Antithrombins. Synonyms: Exhirud; Exhirudine; Hirudex. Grades: 98%. CAS No. 8001-27-2. Molecular formula: C287H440N80O113S7. Mole weight: 7044. | |
| Human Factor XII | Factor XII (XII) (Hageman Factor) is a single chain (Mr=78,000) glycoprotein zymogen that circulates in plasma at a concentration of 40 ug/ml. Reciprical activation of XII to the active serine protease factor XIIa (XIIa) by kallikrein is central to initiation of the intrinsic coagulation pathway. Surface bound α-XIIa in turn activates factor XI to XIa. Secondary cleavage of α-XIIa by kallikrein yields β-XIIa, which catalyzes solution phase activation of kallikrein, factor VII and the classical complement cascade.The ability of a variety of negatively charged substances, both physiological and nonphysiological to promote XII activation and, thus, initiation of the int...ain (Mr=28,000) contains the catalytic triad (His-40, Asp-89, Ser-191), while the NH2-terminal heavy chain (Mr=52,000) conatins the anionic surface binding portion of the molecule. A secondary cleavage of α-XIIa by kallikrein outside the disulfide bond yields β-XIIa (XIIf, BHFa, HFf, hageman factor fragments) (Mr=28,000), which no longer binds anionic surfaces. β-XIIa can activate prekallikrein, but has little procoagulant activity. Several other minor intermediate forms of XIIa are indicated in the figure above.Inhibitors of XIIa include C1-INH, α2-antiplasmin, α2-macroglobulin and antithrombin III. At physiological concentrations, the relative effectiven | |
| limulus clotting factor C | From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. Factor C is activated by Gram-negative bacterial lipopolysaccharides and chymotrypsin. Inhibited by antithrombin III. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: factor C; limulus factor C. Enzyme Commission Number: EC 3.4.21.84. CAS No. 115743-27-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4176; limulus clotting factor C; EC 3.4.21.84; 115743-27-6; factor C; limulus factor C. Cat No: EXWM-4176. | |
| Melagatran | Melagatran is a direct and orally active inhibitor of thrombin , without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia [1]. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 159776-70-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129056. | |
| N-Acetyl-de-O-sulfated heparin sodium salt | N-Acetyl-de-O-sulfated heparin sodium salt is an enzyme substrate that inactivates thrombin through an antithrombin (AT) dependent mechanism, thereby preventing fibronectin formation. Synonyms: N-Acetyl-de-O-sulfated heparin (Heparin IV-A) sodium salt. CAS No. 133686-69-8. | |
| Native Streptomyces griseus Protease | Protease from Streptomyces griseus is a mixture of at least three proteolytic activities including an extracellular serine protease. In general, serine proteases display a wide range of substrate specificities, which are believed to be mediated by an active site composed of one Asp, one His, and a Ser residue in the molecule. This enzyme prefers to hydrolyze peptide bonds on the carboxyl side of glutamic or aspartic acid. Collected from culture broth of s. griseus and purified by successive column procedures. a mixture of at least three proteolytic activities including an extracellular serine protease. in general, serine proteases display a wide range of substrate specifici...de aldehydes and serine proteases. protease is typically used in nucleic acid isolation procedures in incubations of 0.5-3.0 hours supplemented with 0.2% sodium dodecyl sulfate and 10 mm edta. the enzyme from creative enzymes has been used for the digestion and analysis of antithrombin-heparin complexes. it has also been used for the isolation of enzyme-resistant starch. this enzyme is more active at a higher ph range than the known alkaline protease, showing the proteolytic activity even in 0.2n naoh solution. this enzyme is useful for proteolysis of insoluble protein and for structure investigation of protein. Group: Enzymes. Synonyms: Protease; 9036-06-0; Actinase E, Pro | |
| Odiparcil | Odiparcil (SB-424323) is an orally active beta-d-thioxyloside analog with antithrombotic activity associated with a reduced risk of adverse bleeding events. Odiparcil (SB-424323) is indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-424323. CAS No. 137215-12-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10277. | |
| Sulodexide | Sulodexide is an orally active mixture of glycosaminoglycans composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III ( AT III ) and heparin cofactor II ( HC II ), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 57821-29-1. Pack Sizes: 250 LSU. Product ID: HY-100897. | |
| venombin AB | From the venom of the Gaboon viper Bitis gabonica. Activates Factor XIII. Not inhibited by antithrombin III/heparin or hirudin, unlike EC 3.4.21.5, thrombin. Group: Enzymes. Synonyms: gabonase; okinaxobin II; Bitis gabonica venom serine proteinase; afa?cytin. Enzyme Commission Number: EC 3.4.21.55. CAS No. 104003-74-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4147; venombin AB; EC 3.4.21.55; 104003-74-9; gabonase; okinaxobin II; Bitis gabonica venom serine proteinase; afa?cytin. Cat No: EXWM-4147. | |
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