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| Product | Description | |
|---|---|---|
| Apamin | Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity[1]. Uses: Scientific research. Group: Peptides. Alternative Names: Apamine. CAS No. 24345-16-2. Pack Sizes: 500 ?g; 1 mg. Product ID: HY-P0256. |  |
| Apamin | Apamin. Group: Biochemicals. Grades: Purified. CAS No. 24345-16-2. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Apamin | from bee venom, ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Apamin | synthetic, ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Apamin, Bee Venom - CAS 24345-16-2 | Polypeptide neurotoxin known to pass through the blood-brain barrier. Group: Fluorescence/luminescence spectroscopy. | |
| Bicuculline methiodide | Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca 2+ -activated K + channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca 2+ -activated K + current [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (-)-Bicuculline methiodide; l-Bicuculline methiodide. CAS No. 40709-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103474. | |
| Dequalinium Chloride | Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR , and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 522-51-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0567. | |
| Dequalinium Chloride | Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM. Synonyms: Dequalinium chloride; Dequavagyn; NSC 166454; NSC-166454; NSC166454. Grade: >98%. CAS No. 522-51-0. Molecular formula: C30H40N4.2Cl. Mole weight: 527.57. |  |
| Dequalinium chloride hydrate | Dequalinium chloride is a selective blocker of apamin-sensitive K+ channels and inhibitor of XIAP (X-linked inhibitor of apoptosis protein). Synonyms: 1,1'-(Decane-1,10-diyl)bis(4-amino-2-methylquinolin-1-ium) chloride hydrate. CAS No. 1255077-34-9. Molecular formula: C30H42Cl2N4O. Mole weight: 545.59. | |
| NS8593 ((R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine) | An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels (SK1-3; =420nM, 600nM, and 730nM for SK1, SK2, SK3, respectively) in a Ca2+-dependent manner. It mediates channel gating by interacting with gating structures deep within the inner pore vestibule where Ser507 and Ala532 are deemed to be important for inhibition. Interacts at a site that is distinct from the apamin binding site in SK channels. Can access high-affinity binding sites from both the inside and outside of the cell membrane. Does not affect QT intervals, but prolongs the atrial effective refractive period and prevents acetylcholine-induced atrial fibrillations in ex vivo and in vivo models. Also shown to reversibly block TRPM7 channel (IC50=1.6mM) in smooth muscle cells, primary podocytes, HEK293 cells expressing TRPM7, and ventricular myocytes in a Mg2+-dependent manner and blocks the motility of cells in culture. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| [Tyr2] Scyllatoxin | [Tyr2]-Scyllatoxin allows labelling by iodination. 31-amino acid polypeptide with 3 disulfide bridges. Synthetic, originally from Leiurus quinquestriatus hebraeus scorpion venom. A blocker of Apamin-sensitive Ca2+-activated K+ channels. Grade: 95 %. Mole weight: 3447. | |
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