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| Product | Description | |
|---|---|---|
| Apoptosis Activator 2 | Apoptosis Activator 2. Group: Biochemicals. Grades: Purified. CAS No. 79183-19-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Apoptosis Activator 2 | Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. It increases procaspase-9 processing and subsequent caspase-3 activation. It induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM). Synonyms: Apoptosis Activator 2; AAII; N-(3,4-dichlorobenzyl) Isatin. MDK83190; MDK-83190; MDK 83190. CAS No. 79183-19-0. Molecular formula: C15H9Cl2NO2. Mole weight: 306.142. |  |
| 2,4-Di-tert-butylphenol | 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXR&alpha. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of medicines and fragrances [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 2,4-DTBP. CAS No. 96-76-4. Pack Sizes: 10 mM * 1 mL; 100 g; 500 g. Product ID: HY-W014589. |  |
| Actinomycin D (Dactinomycin) | Suitable for use in nucleic acid inhibition. Actinomycin D inhibits the proliferation of cells in a cell-cycle nonspecific way by forming a stable complex with DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It is used in cell culture as a selection agent. Antibiotic. Antitumor compound. Cytotoxic. Apoptosis inducer. RNA synthesis inhibitor. DNA intercalating agent. Mcl-1 expression inhibitor. p53 pathway activator. Source:Streptomyces sp. Group: Biochemicals. Alternative Names: Streptomyces antibioticus; 2-Amino- (N, N) -1-bis (hexadeca hydro-6, 13-diisopropyl -2, 5, 9-tri methyl -1, 4, 7, 11, 14-pentaoxo-1H-pyrrolo [2, 1] - [1, 4, 7, 10, 13] oxatetra azacyclohexadecin-10-yl ) -4, 6-di methyl -3-oxo-3H-phenoxazine-1, 9-dicarboxamide ; Dactinomycin, Actinomycin IV, Actinomycin C1; Actactinomycin A IV; Actinomycin 7; Dilactone Actinomycindioic D Acid; Lyovac Cosmegen; Cosmogen; Meractinomycin. Grades: Cell Culture Grade. CAS No. 50-76-0. Pack Sizes: 5mg, 10mg, 25mg, 100mg, 500mg. Molecular Formula: C62H86N12O16, Molecular Weight: 1255.43. US Biological Life Sciences. | Worldwide |
| AICAR | Cell permeable AMP-activated protein kinase (AMPK) activator. Insulin mimetic. Adipocyte differentiation inhibitor. Apoptosis inducer. PPARalpha inhibitor. mTOR inhibitor. P70S6K inhibitor. LPS-induced TNFalpha production inhibitor. TORC2 phosphorylation inducer. Anti-inflammatory. Anti-tumor compound. Autophagy inhibitor. HSP90 inhibitor. Group: Biochemicals. Alternative Names: 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside. Grades: Highly Purified. CAS No. 2627-69-2. Pack Sizes: 10mg, 50mg, 100mg. Molecular Formula: C9H14N4O5. US Biological Life Sciences. | Worldwide |
| AICAR phosphate | AICAR phosphate, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle tissue, as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell. Synonyms: Acadesine phosphate; AICA Riboside phosphate. Grades: >98%. CAS No. 681006-28-0. Molecular formula: C9H17N4O9P. Mole weight: 356.23. | |
| Apoptozole | Apoptozole, also known as Apoptosis Activator VII, is an apoptosis-inducing small molecule that inhibits the ATPase activity of heat shock cognate 70 (Hsc70) and Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 μM). Synonyms: 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl)methyl)benzamide; Apoptozole; Apoptosis Activator VII. CAS No. 1054543-47-3. Molecular formula: C33H25F6N3O3. Mole weight: 625.57. | |
| Atiprimod | atiprimod is orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis. Synonyms: azaspirane; SKF 106615; SKF106615; SKF-106615; SK&F 106615; SK&F-106615. CAS No. 123018-47-3. Molecular formula: C22H44N2. Mole weight: 336.60. | |
| Bardoxolone | Bardoxolone (RTA 401; CDDO) is a novel nuclear regulatory factor ( NRf-2 ) activator. Bardoxolone is a potent necroptosis inhibitor that inhibits Z-VAD-FMK-induced necroptosis. Bardoxolone methyl enhances the antioxidant system, modulates inflammatory cytokines and inhibits apoptosis in rat kidney, demonstrating inhibition on APAP-induced acute kidney injury (AKI) and analgesic effect. Additionally, Bardoxolone methyl decreases Paclitaxel (PAC) (HY-B0015)-induced mitochondrial damage in neuronal cells. Bardoxolone methyl is promising for the research of chemotherapy-induced neuropathic pain and chronic kidney disease [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CDDO; RTA 401. CAS No. 218600-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14909. | |
| Bardoxolone methyl | Bardoxolone methyl (also known as "RTA 402" and "CDDO-methyl ester") is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class. It is the most potent known inducer of the Nrf2 pathway to enter clinical development and works to suppress both oxidative stress and inflammation. Uses: A nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells; antioxidant inflammation modulator (aim); for the treatment of advanced chronic kidney disease (ckd) in type 2 diabetes mellitus patients. Synonyms: CDDO Methyl ester; CDDOMe; RTA 402; RTA-402; RTA402; TP-155; TP155; TP 155; 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid methyl ester; bardoxolone methyl; CDDO-Me; methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate; (4aS,6aR,6bS,8aR,12aS,14bS)-Methyl 11-cyano-2, 2, 6a, 6b, 9, 9, 12a-heptamethyl-10, 14-dioxo-1, 2, 3, 4, 4a, 5, 6, 6a, 6b, 7, 8, 8a, 9, 10, 12a, 14, 14a, 14b-octadecahydropicene-4a-carboxylate. Grades: ≥ 98.0%. CAS No. 218600-53-4. Molecular formula: C32H43NO4. Mole weight: 505.70. | |
| Birinapant | Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Check for active clinical trials or closed clinical trials using this agent. Synonyms: TL-32711; TL32711; TL 32711. Birinapant. Grades: >99.50%. CAS No. 1260251-31-7. Molecular formula: C42H56F2N8O6. Mole weight: 806.957. | |
| Brivudine | Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU treatment result in the decrease or prevention of chemoresistance. In addition, this agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells towards a pancreatic cancer cell line in vitro. Synonyms: (E)-5-(2-Bromovinyl)-2'-deoxyuridine; (E)-5-(2-Bromovinyl)deoxyuridine; (E)-5-O-(2-bromoethenyl)-2'-deoxyuridine; 5-[(1E)-2-Bromoethenyl]-2'-deoxyuridine; 5-[(E)-2-Bromoethenyl]-2'-deoxyuridine; BVDU; Brivudin; Bromovinyldeoxyuridine; Helpin. Grades: ≥98% by HPLC. CAS No. 69304-47-8. Molecular formula: C11H13BrN2O5. Mole weight: 333.14. | |
| C2 Ceramide | C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis , inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ceramide 2. CAS No. 3102-57-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101180. | |
| C6 Ceramide | C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. C6 Ceramide exhibits multiple anti-cancer properties including cell cycle arrest, Apoptosis , inhibition of tumor growth and enhances the effects of chemotherapy in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: C6-Cer; N-Hexanoylsphingosine. CAS No. 124753-97-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19542. | |
| Chromium picolinate | Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Chromium (III) picolinate; Cr(Pic)3. CAS No. 14639-25-9. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-125588. | |
| Colivelin | Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3 , suppresses neuronal death by activating STAT3 in vitro [1]. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease [2]. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury [1]. Uses: Scientific research. Group: Peptides. CAS No. 867021-83-8. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P1061. | |
| Colivelin TFA | Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3 , suppresses neuronal death by activating STAT3 in vitro [1]. Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease [2]. Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury [1]. Uses: Scientific research. Group: Peptides. CAS No. 2803948-60-7. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1061A. | |
| COTI-2 | COTI-2 is an p53 gene activator and the PI3K/AKT/mTOR pathway inhibitor. COTI-2 induces apoptosis and suppresses proliferation of a wide variety of human cancer cell lines in vitro. Synonyms: COTI-2; COTI2; COTI 2. 2BTA1O65BR; ZINC114475331; CS-8156; CS 8156; CS8156; N-[(E)-6,7-dihydro-5H-quinolin-8-ylideneamino]-4-pyridin-2-ylpiperazine-1-carbothioamide. Grades: 99%. CAS No. 1039455-84-9. Molecular formula: C19H22N6S. Mole weight: 366.48. | |
| CTB | CTB is a potent p300 histone acetyltransferase activator [1]. CTB can effectively induce apoptosis in MCF-7 cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 451491-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134964. | |
| Cucurbitacin B | Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids; could repress cancer cell progression.IC50 value:Target: anticancer natural compoundin vitro: Cucurbitacin-B inhibited growth and modulated expression of cell-cycle regulators in SHSY5Y cells. At the molecular level, we found that Cucurbitacin-B inhibited AKT signaling activation through up-regulation of PTEN. CuB induced apoptosis of A549 cells in a -concentration-dependent manner, as determined by fluorescence microscopy, flow cytometry and transmission electron microscopy. CuB dose-dependently inhibited lung cancer cell proliferation, with cell cycle inhibition and cyclin B1 downregulation. Apoptosis induced by CuB was shown to be associated with cytochrome c release, B-cell lymphoma 2 downregulation and signal transducer and activator of transcription 3 pathway inhibition. CuB inhibited ITGA6 and ITGB4 (integrin α6 and integrin β4), which are overexpressed in breast cancer. Furthermore, CuB also induced the expression of major ITGB1and ITGB3, which are known to cause integrin-mediated cell death. Cuc B treatment caused DNA double-strand breaks (DSBs) without affecting the signal transducer and activator of transcription 3 (STAT3), the potential molecular target for Cuc B. Cuc B triggers ATM-activated Chk1-Cdc25C-Cdk1, which could be reversed by both ATM siRNA and Chk1 siRNA. Cuc B also triggers ATM-activated p53-14-3-3-σ pa |  |
| Cucurbitacin D | Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis , exhibiting anti-tumor and anti-inflammatory effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 3877-86-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1986. | |
| Decursin | Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Decursin. CAS No. 5928-25-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18981. | |
| Etoposide, 95.0-105.0% (HPLC) USP | Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a progressive inhibition of DNA replication. p53 activator. Blocks the cell cycle between the end of the S phase and the early G2 phase. Oncoprotein Mdm2 synthesis inhibitor. Apoptosis inducer through the cytochrome c/Apaf-1/caspase-9 pathway and the Fas-mediated death signaling pathway. Cell cycle checkpoint activator. Affects gene expression at different levels (chromatin remodeling, transcrip- tion and alternative splicing). Chemotherapeutic compound used in cancers. Used in conditioning regimen prior to a bone marrow or blood stem cell transplantation. Highly effective in mobilizing stem cells. Group: Biochemicals. Alternative Names: 4-Des methyl epipodophyllotoxin; VP-16-213, NSC 141540. Grades: USP. CAS No. 33419-42-0. Pack Sizes: 250mg, 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Fenbendazole (Standard) | Fenbendazole (Standard) is the analytical standard of Fenbendazole. This product is intended for research and analytical applications. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1&alpha. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 43210-67-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0413R. | |
| Flunisolide | Flunisolide is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide can induce eosinophil apoptosis , and is used for the research of asthma or rhinitis, and inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3385-3-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B1121. | |
| GDC-0152 | GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Smac, the endogenous IAP antagonist, relies on its N-terminal four amino-acid motif for binding to IAPs. Synonyms: GDC-0152; GDC0152; GDC 0152. CAS No. 873652-48-3. Molecular formula: C25H34N6O3S. Mole weight: 498.646. | |
| GDC-0917 | CUDC-427, also known as, GDC-0917, is an orally available, monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic CUDC-427 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Synonyms: GDC-0917; GDC0917; GDC 0917; CUDC-427; CUDC427; CUDC-427. Grades: 0.98. CAS No. 1446182-94-0. Molecular formula: C29H36N6O4S. Mole weight: 564.705. | |
| GL0388 | GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC 50 s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis. GL0388 suppresses breast cancer xenograft tumor growth in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2886772-68-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132173. | |
| Harmol | Harmol is a TFEB activator, an orally active monoamine oxidase inhibitor that has anti-tumor, anti-depressant, and anti-aging effects. Harmol can induce cell mitosis, autophagy and apoptosis. Harmol promotes the degradation of α-synuclein through the regulation of the autophagy-lysosomal pathway, improving motor deficits in mouse models of Parkinson's disease [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 487-03-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107811. | |
| Imiquimod | Cell-permeable. Topical immune response modifier that displays anti-angiogenic, anti-viral and anti-inflammatory properties. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway. Stimulates proinflammatory cytokine production interferon-alpha (IFN-alpha), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and activates NF-kappaB. Caspase-3 activator that directly induces procaspase-3 cleavage. Anti-cancer compound. Apoptosis inducer. Antiproliferative, independent of immune system activation or function. Approved treatment for external genital warts caused by human papillomavirus infection. Group: Biochemicals. Alternative Names: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; R-837; S-26308. Grades: Highly Purified. CAS No. 99011-02-6. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C14H16N4. US Biological Life Sciences. | Worldwide |
| Isovalerylcarnitine | Isovalerylcarnitine is a product of the catabolism of L-leucine. Isovalerylcarnitine is also a selective and reversible calpain activator that induces apoptosis [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 31023-24-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-113221. | |
| LCL-161 | LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation. Synonyms: LCL161; LCL 161; LCL-161. CAS No. 1005342-46-0. Molecular formula: C26H33FN4O3S. Mole weight: 500.633. | |
| Luteolin (3',4',5,7-Tetrahydroxyflavone, Luteolol, BRN 0292084, C.I. Natural Yellow 2, Digitoflavone, Flacitran, Flavopurpol, Daphneflavonol, Argemexitin) | Anticancer and antimetastatic. alpha-Glucosidase inhibitor. Topoisomerase I Inhibitor. Apoptosis inducer. Anti-inflammatory. 15-Lipoxygenase (15-LOX) inhibitor. IL-6 production inhibitor. Fatty acid synthase (FAS) inhibitor. Antioxidant. Free radical scavenger. Antiadipogenic. PPAR-y. inhibitor. Neuroprotective. Monoamine transporter activator. Inhibitor of phosphodiesterases 1-5 (PDE1-5). PKC(e) and Src kinase inhibitor. HDAC inhibitor. Autophagy modulator. Phosphatidylinositol 3-kinase (PI3K) / Akt signaling inhibitor. p90 ribosomal S6 kinase (RSK1/RSK2) kinase activity inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 491-70-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C15H10O6. US Biological Life Sciences. | Worldwide |
| LY294002 | LY294002 is a broad-spectrum inhibitor of PI3K with IC 50 s of 0.5, 0.57, and 0.97 μM for PI3Kα , PI3Kδ and PI3Kβ , respectively [1]. LY294002 also inhibits CK2 with an IC 50 of 98 nM [2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC 50 of 1.4 μM. LY294002 is an apoptosis activator [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 154447-36-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10108. | |
| LYN-1604 HCl | LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 could induce cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells. To further explore LYN-1604-induced autophagic mechanisms, we found some potential ULK1 interactors, such as ATF3, RAD21, and caspase3, by performing comparative microarray analysis. LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: LYN-1604 HCl; LYN-1604 hydrochloride; LYN-1604; LYN 1604; LYN1604. Product Category: Activators. Appearance: Solid powder. CAS No. 2216753-86-3. Molecular formula: C33H44Cl3N3O2. Mole weight: 621.08. Purity: >98%. IUPACName: 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-ethanone hydrochloride. Canonical SMILES: ClC1=CC=C(C(OCC2=CC=C3C=CC=CC3=C2)CN4CCN(C(CN(CC(C)C)CC(C)C)=O)CC4)C(Cl)=C1.Cl. Product ID: ACM2216753863. Alfa Chemistry ISO 9001:2015 Certified. | |
| MDV 3100 | MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer. Group: Biochemicals. Alternative Names: 4-[3-[4-Cyano-3- (trifluoromethyl) phenyl]-5, 5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide; MDV3100; MDV-3100; Enzalutamide. Grades: Highly Purified. CAS No. 915087-33-1. Pack Sizes: 50mg, 100mg, 250mg, 500mg. Molecular Formula: C21H16F4N4O2S, Molecular Weight: 464.44. US Biological Life Sciences. | Worldwide |
| MG-132 | MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC 50 s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Z-Leu-Leu-Leu-al; MG132. CAS No. 133407-82-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13259. | |
| ML-291 | ML-291 is a novel activator of the apoptotic arm of the unfolded protein response (UPR), but not the adaptive arm. It induces apoptosis in mouse embryonic fibroblasts overexpressing CHOP, but not in wild-type or CHOP knockout cells. Synonyms: ML 291; ML291; N-(4-((4-chloropiperidin-1-yl)sulfonyl)phenyl)-5-nitrofuran-2-carboxamide. Grades: ≥98%. CAS No. 1523437-16-2. Molecular formula: C16H16ClN3O6S. Mole weight: 413.8. | |
| N- (Ethoxycarbonylmethyl) piperazine | N- (Ethoxycarbonylmethyl) piperazine is used in the preparation of aralkylpiperazine- and aryl-substituted hydrazines, particularly benzylpiperazineacetyl hydrazones of hydroxyaryl aldehydes, as selective inducers of apoptosis and activators of procaspases for use as anticancer agents. Group: Biochemicals. Alternative Names: 1-Piperazineacetic Acid Ethyl Ester; 2-(Piperazin-1-yl)acetic Acid Ethyl Ester; 4- (Carboethoxymethyl) piperazine; Ethyl 1-piperazineacetate; Ethyl 1-Piperazinylacetate; Ethyl 2-(piperazin-1-yl)acetate; Ethyl 2-Piperazinoacetate; Ethyl Piperazinoacetate; N- (Carboethoxymethyl) piperazine; N- (Ethoxycarbonylmethyl) piperazine; Piperazin-1-ylacetic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 40004-08-8. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Nigericin | Nigericin, derived from S. hygroscopicus, is an antibiotic potassium ionophore. It exchanges K+ for H+ across biological membranes. Nigericin can be a NLRP3 activator that induces the release of IL-1β as a NALP3-dependent manner. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to induction of oxidative stress. Nigericin triggers apoptosis. Synonyms: 2-[6-[[2-[5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid; Antibiotic K178; Antibiotic X464; Azalomycin M; Helexin C, Polyetherin A. Grades: >98%. CAS No. 28380-24-7. Molecular formula: C40H68O11. Mole weight: 724.96. | |
| Nutlin-3 ((±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one) | Cell-permeable. Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist (IC50=90nM for Nutlin-3a and 13.6uM for Nutlin-3b), p53 pathway activator, and apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 548472-68-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Ochratoxin A | Ochratoxin A is a chlorinated benzopyran coupled to the amino acid phenylalanine, produced by several Aspergillus and Penicillium sp. associated with food spoilage. Ochratoxins are widely distributed in the environment and are known to be nephrotoxic, teratogenic and possibly carcinogenic. Ochratoxin A may act by induction of DNA strand breaks, sister chromatid exchanges, DNA adduct formation, or reactive oxygen but the mechanism of action as a toxin is not yet resolved. At the molecular level, ochratoxin A has been shown to specifically inhibit NK cell activity, increase growth of transplantable tumor cells in mice, increase apoptosis, activate c-Jun N terminal kinase in human kidney epithelial cells, and block metaphase/anaphase transition. It also inhibits plasminogen activator inhibitor-2 production by human blood mononuclear cells. Source:Aspergillus ochraceus MST-FP2005. Group: Biochemicals. Alternative Names: OTA; Ochratoxin A; Aspergillus ochraceus; N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine; (-)-N-[(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenylalanine; (R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbon. Grades: Highly Purified. CAS No. 303-47-9. Pack Sizes: 1mg. Molecular Formula: C??H??ClNO?, Molecular Weight: 403.8. US Biological Life Sciences. | Worldwide |
| PAC-1 | PAC-1 is a procaspase-3 activator that induces apoptosis in cancer cells with an EC 50 of 2.08 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Procaspase activating compound 1. CAS No. 315183-21-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13523. | |
| PAWI-2 | PAWI-2 is a p53 -Activator and Wnt Inhibitor. PAWI-2 inhibits β3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin β3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1448427-02-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-123929. | |
| Phytosphingosine | Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC 50 value of 33.4 μM and can be used in the study of type II diabetes [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 4-Hydroxysphinganine. CAS No. 554-62-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W011303. | |
| Piceatannol | Wide range of tyrosine and serine/threonine protein kinase inhibitor, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K. Inhibits the tyrosine phosphorylation of STAT3 and STAT5. Potent apoptosis inducer. Potent anticancer compound. Suppresses NF-kB activation through IkBalpha kinase inhibition. Activator of human deacetylase SIRT1 (sirtuin 1). Potent antioxidant with anti-proliferative, anti-inflammatory and cardioprotective properties. Neuoprotective. Adipogenesis inhibitor. Promotes glucose uptake, AMPK phosphorylation and GLUT4 translocation. Group: Biochemicals. Grades: Highly Purified. CAS No. 10083-24-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| PKM2 Activator III (N- (4- (4- (2-Methoxyphenyl) piperazine-1-carbonyl) phenyl) quinoline-8-sulfonamide, Pyruvate Kinase M2 Activator III) | A cell-permeable quinoline-sulfonamide that acts as a potent allosteric PKM2 activator both in cell-free enzymatic assays (AC50 = 17nM with 40ng PKM2/200ul) and in cultures (AC50 = 45nM in A549 cells) via a high affinity, 2:1 stoichiometric binding, effectively locking PKM2 in an active tetrameric state resistant to known intracellular negative regulators of FBP-activated PKM2 tetramer. PKM2 stimulation by compound treatment is shown to result in decreased serine biosynthesis (by 56%; 500nM for 24h) with concomitant increase in serine influx as a compensating mechanism for maintaining cellular serine level necessary for supporting A549 proliferation. Simultaneous PKM2 activation and culture serine withdrawal results in cytostatic A549 growth arrest, but not apoptosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PRIMA-1 | PRIMA-1, named for p53 reactivation and induction of massive apoptosis, is an inhibitor of the growth of cell lines derived from various human tumor types in a mutant p53-dependent manner. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high μM to mM concentrations. It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. Synonyms: 2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one. Grades: ≥99% by HPLC. CAS No. 5608-24-2. Molecular formula: C9H15NO3. Mole weight: 185.22. | |
| Resveratrol | Potent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 (COX-1). Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2 phase. Anticancer and antiproliferative compound. Apoptosis inducer. Protein kinase D inhibitor. Does not inhibit PKC. Autophagy inducer. Potent SIRT1 (sirtuin 1) activator. Neuroprotective. Adipogenesis inhibitor. PGC-1alpha activator. Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity. Cardioprotective. Anti-diabetic. Senescence modulator. Extends lifespan. Group: Biochemicals. Alternative Names: 3,4,5-Trihydroxy-trans-stilbene; 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol. Grades: Highly Purified. CAS No. 501-36-0. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C14H12O3, Molecular Weight: 228.24. US Biological Life Sciences. | Worldwide |
| SB 202190 | Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Group: Biochemicals. Alternative Names: 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol. Grades: Highly Purified. CAS No. 152121-30-7. Pack Sizes: 5mg. Molecular Formula: C20H14FN3O. US Biological Life Sciences. | Worldwide |
| SB202190 (FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole) | Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Group: Biochemicals. Alternative Names: FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole. Grades: Highly Purified. CAS No. 152121-30-7. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C20H14FN3O. US Biological Life Sciences. | Worldwide |
| SCH 529074 | SCH 529074 is a small molecule activator of mutant p53 that binds p53 DNA binding domain (Kd = 1-2 μM) and restores wild-type function to many oncogenic mutants by acting as a chaperone. SCH 529074 blocks ubiquitination of p53 by HDM2, and induces apoptosis in tumor cell lines. Synonyms: SCH 529074; SCH529074; SCH-529074; N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine. Grades: ≥98% by HPLC. CAS No. 922150-11-6. Molecular formula: C31H36Cl2N6. Mole weight: 563.56. | |
| SMBA 1 | SMBA 1 is a selelctive and high affinity Bax activator (Ki = 43.3 nM) that binds to the S184 binding pocket and inhibits Bax phosphorylation. SMBA 1 exhibits no affinity for other Bcl-2 family members, including Bcl-2, Bak and Bid. SMBA 1 induces apoptosis in lung cancer cell lines which expresses high levels of Bax. Synonyms: SMBA1; SMBA-1; SMBA 1; NSC-408730; NSC408730; NSC 408730; CYD-1-94; CYD 1 94; CYD194; 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol. Grades: ≥98% by HPLC. CAS No. 906440-37-7. Molecular formula: C20H13NO3. Mole weight: 315.32. | |
| Sorafenib | Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC 50 s of 6 nM and 20 nM for Raf-1 and B-Raf , respectively. Sorafenib is a multikinase inhibitor with IC 50 s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2 , VEGFR3 , PDGFRβ , FLT3 and c-Kit , respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bay 43-9006. CAS No. 284461-73-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g. Product ID: HY-10201. | |
| Sorafenib tosylate | Sorafenib tosylate (Bay 43-9006 tosylate) is a potent and orally active Raf inhibitor with IC 50 s of 6 nM and 20 nM for Raf-1 and B-Raf , respectively. Sorafenib tosylate is a multikinase inhibitor with IC 50 s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2 , VEGFR3 , PDGFRβ , FLT3 and c-Kit , respectively. Sorafenib tosylate induces autophagy and apoptosis. Sorafenib tosylate has anti-tumor activity. Sorafenib tosylate is a ferroptosis activator [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bay 43-9006 tosylate. CAS No. 475207-59-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-10201A. | |
| Tamoxifen | Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator ( SERM ) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [1] [2] [3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC 50 of 0.1 μM and 1.8 μM, respectively [5]. Tamoxifen activates autophagy and induces apoptosis [4]. Tamoxifen also can induce gene knockout of CreER transgenic mouse [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen. CAS No. 10540-29-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-13757A. | |
| Tamoxifen Citrate | Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator ( SERM ) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [1] [2] [3].Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC 50 of 0.1 μM and 1.8 μM, respectively [5]. Tamoxifen Citrate activates autophagy and induces apoptosis [4]. Tamoxifen Citrate also can induce gene knockout of CreER transgenic mouse [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate. CAS No. 54965-24-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-13757. | |
| Tamoxifen (Standard) | Tamoxifen (Standard) is the analytical standard of Tamoxifen (HY-13757A). This product is intended for research and analytical applications. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator ( SERM ) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [1] [2] [3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC 50 of 0.1 μM and 1.8 μM, respectively [5]. Tamoxifen activates autophagy and induces apoptosis [4]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 47699(Standard); (Z)-Tamoxifen(Standard); trans-Tamoxifen (Standard). CAS No. 10540-29-1. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-13757AR. | |
| Theophylline | Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 1,3-Dimethylxanthine; Theo-24. CAS No. 58-55-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-B0809. | |
| Theophylline | Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Acet-theocin. Product Category: Inhibitors. Appearance: White powder. CAS No. 58-55-9. Molecular formula: C7H8N4O2. Mole weight: 180.16. Purity: 0.98. IUPACName: 1,3-Dimethyl-7H-purine-2,6-dione. Canonical SMILES: CN1C2=C(C(=O)N(C1=O)C)NC=N2. Density: 1.3640 g/cm³. Product ID: ACM58559. Alfa Chemistry ISO 9001:2015 Certified. | |
| Theophylline monohydrate | Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 5967-84-0. Molecular formula: C7H8N4O2?H2O. Mole weight: 198.18. Product ID: ACM5967840. Alfa Chemistry ISO 9001:2015 Certified. | |
| Theophylline (Standard) | Theophylline (Standard) is the analytical standard of Theophylline. This product is intended for research and analytical applications. Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 1,3-Dimethylxanthine(Standard); Theo-24 (Standard). CAS No. 58-55-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0809R. | |
| Uridine 5'-monophosphate | Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 5'-Uridylic acid. CAS No. 58-97-9. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-101981. | |
| Uridine 5'-monophosphate (Standard) | Uridine 5'-monophosphate (Standard) is the analytical standard of Uridine 5'-monophosphate. This product is intended for research and analytical applications. Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea. Uses: Scientific research. Group: Natural products. Alternative Names: 5'-Uridylic acid (Standard). CAS No. 58-97-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101981R. | |
| WEHI-539 | WEHI-539, a selective BCL-XL inhibitor that can be function as a single-agent inducer of apoptosis while sparing normal cells, it leads to MOMP and apoptosis due to displacing bound activator BH3s or monomeric BAX and BAK from BCL-XL to induce the homo-ol. Synonyms: 4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-; 5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid; WEHI 539; WEHI539; 5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazineylidene)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid. Grades: ≥95%. CAS No. 1431866-33-9. Molecular formula: C31H29N5O3S2. Mole weight: 583.73. | |
| WY-14643 | Potent peroxisome proliferator-activated receptor (PPARalpha) activator. Activates also PPARgamma but not PPARdelta. Potent anti-hypercholesterolemic agent. Hypolipidemic compound. Lipogenesis inducer. Tumor promoter. Causes increased cell proliferation and decreased apoptosis. Anti-inflammatory. Inhibits NF-kappaB transcriptional activity and decreases the inflammatory response by reducing the production of inflammatory cytokines (TNF-alpha, IL1beta). Reduces oxidative stress. Increases fatty acid oxidation. Directly affects insulin signaling. Increases glucose uptake. Group: Biochemicals. Grades: Highly Purified. CAS No. 50892-23-4. Pack Sizes: 10mg, 50mg, 250mg. Molecular Formula: C14H14ClN3O2S. US Biological Life Sciences. | Worldwide |
| YC-1 | Nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator. Induces concentration-dependent increase in cGMP levels. Inhibits platelet adhesion to collagen. Thombosis inhibitor. Non-specific phosphodiesterase inhibitor. Na+ channel blocker. Anticancer compound. HIF-alpha inhibitor. Blocks angiogenesis. Tumor growth inhibitor. Apoptosis inducer. NK cell differentiation enhancer. Group: Biochemicals. Alternative Names: 1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole; Lificiguat, 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole. Grades: Highly Purified. CAS No. 170632-47-0. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C??H??N?O?, Method for Determining. US Biological Life Sciences. | Worldwide |
| 10-DEBC hydrochloride | 10-DEBC hydrochloride is a selective and reversible Akt/PKB inhibitor suppressing the IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), and inhibiting downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. 10-DEBC hydrochloride inhibits cell growth (IC50 ~ 2-6 μM) and leads to apoptosis in rhabdomyosarcoma cells. Synonyms: 10H-Phenoxazine-10-butanamine, 2-chloro-N,N-diethyl-, hydrochloride (1:1); Akt Inhibitor X; 2-Chloro-N,N-diethyl-10H-phenoxazine-10-butanamine hydrochloride; 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride; 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 925681-41-0. Molecular formula: C20H25N2OCl.HCl. Mole weight: 381.34. | |
| 10-DEBC hydrochloride | Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5uM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6uM) and induces apoptosis in rhabdomyosarcoma cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 925681-41-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C20H25N2OCl.HCl, Method for Determining. US Biological Life Sciences. | Worldwide |
| 10-Gingerol | 10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC 50 value of 10.47 μM against DPPH radical, an IC 50 value of 1.68 μM against superoxide radical and an IC 50 value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC 50 of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol is promising for research of ulcerative colitis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 23513-15-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N0448. | |
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