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1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C23H21F7N4O3. CAS No. 170729-80-3. Prepack ID 90028467-1g. Molecular Weight 534.43. See USA prepack pricing.
Aprepitant an antiemetic and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3nM; IC50 = 0.09nM for the human receptor).It is selective for NK1 over NK3 receptors (Ki = 454.1nM for human NK3). In vivo, aprepitant (1mg/Kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P. It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting. Group: Biochemicals. Alternative Names: 5-[[ (2R, 3S) -2-[ (1R) -1-[3, 5-Bis (trifluoromethyl) phenyl]ethoxy]-3- (4-fluorophenyl) -4-morpholinyl]methyl]-1, 2-dihydro-3H-1, 2, 4-triazol-3-one; Emend; L 754030; MK-869; ONO-7436. Grades: Highly Purified. CAS No. 170729-80-3. Pack Sizes: 250mg, 500mg, 1g. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.43. US Biological Life Sciences.
Worldwide
Aprepitant
Aprepitant. CAS No. Product ID: 8-04383.
Aprepitant
Aprepitant is a specific NK-1R antagonist, used as an antiemetic agent. Synonyms: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend; L 754030; MK 0869; MK 869; ONO 7436. Grades: 98%. CAS No. 170729-80-3. Molecular formula: C23H21F7N4O3. Mole weight: 534.43.
Aprepitant
Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a K d of 86 pM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-0869; MK-869; L-754030. CAS No. 170729-80-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10052.
Aprepitant EP Impurity B is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: 3-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4'-fluoro-[1,1'-biphenyl]-3-yl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one. CAS No. 2348441-62-1. Molecular formula: C29H25F7N4O3. Mole weight: 610.52.
Aprepitant EP Impurity C
Aprepitant EP Impurity C is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: 3-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4'-fluoro-[1,1'-biphenyl]-4-yl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one; 4-Defluoro-4-(p-fluorophenyl)aprepitant. CAS No. 2348441-63-2. Molecular formula: C29H25F7N4O3. Mole weight: 610.52.
Aprepitant glucuronide
Aprepitant glucuronide is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C29H29F7N4O9. Mole weight: 710.55.
Aprepitant Impurity 1
A metabolite of Aprepitant. Synonyms: (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-morpholine. Grades: > 95%. CAS No. 327623-37-0. Molecular formula: C20H18F7NO2. HCl. Mole weight: 437.36.
Aprepitant Impurity 10
Aprepitant Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride. CAS No. 1333998-21-2. Molecular formula: C20H19ClF7NO2. Mole weight: 473.81. Catalog: APB1333998212.
Aprepitant Impurity 10 HCl
Aprepitant Impurity 10 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: (2R,3R)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride; 1447693-83-5. CAS No. 1447693-83-5. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81.
Aprepitant Impurity 11
Aprepitant Impurity 11. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride. CAS No. 1333995-14-4. Molecular formula: C20H19ClF7NO2. Mole weight: 473.81. Catalog: APB1333995144.
Aprepitant Impurity 11 HCl
Aprepitant Impurity 11 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81.
Aprepitant Impurity 12 HCl
Aprepitant Impurity 12 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81.
Aprepitant Impurity 13
Aprepitant Impurity 13 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C29H25F7N4O3. Mole weight: 610.52.
Aprepitant Impurity 13
Aprepitant Impurity 13. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride. CAS No. 1333998-27-8. Molecular formula: C20H19ClF7NO2. Mole weight: 473.81. Catalog: APB1333998278.
Aprepitant Impurity 14
Aprepitant Impurity 14 is a derivative of Aprepitant, which is a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: 3-Des-(4-fluorophenyl) 3-(R)-(4'-Fluorobiphen-4-yl) Aprepitant. Molecular formula: C29H25F7N4O3. Mole weight: 610.52.
Aprepitant Impurity 15
Aprepitant Impurity 15 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C23H22F6N4O4. Mole weight: 532.43.
Aprepitant Impurity 16
Aprepitant Impurity 16 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. CAS No. 638990-20-2. Molecular formula: C22H24N2O5. Mole weight: 396.44.
Aprepitant Impurity 17
Aprepitant Impurity 17 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C21H19F6NO3. Mole weight: 447.37.
Aprepitant Impurity 18
Aprepitant Impurity 18 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C12H7F9O2. Mole weight: 354.17.
Aprepitant Impurity 19
Aprepitant Impurity 19 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: 3,7-Dimethyl-3-octanol. CAS No. 78-69-3. Molecular formula: C10H22O. Mole weight: 158.28.
Aprepitant Impurity 1 Enantiomer HCl
A metabolite of Aprepitant. Synonyms: (2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl) phenyl]ethoxy]-3-(4-fluorophenyl)-Morpholin. Grades: > 95%. CAS No. 171482-05-6. Molecular formula: C20H18F7NO2. HCl. Mole weight: 437.36 36.46.
Aprepitant Impurity 1 HCl
Aprepitant Impurity 1 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81.
Aprepitant Impurity 2
Aprepitant Impurity 2 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C24H25F7N4O4. Mole weight: 566.47.
Aprepitant Impurity 30
Aprepitant Impurity 30. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (1S,2S,3S)-Aprepitant; 3-(((2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one. CAS No. 1242175-40-1. Molecular formula: C23H21F7N4O3. Mole weight: 534.43. Catalog: APB1242175401.
Aprepitant Impurity 31
Aprepitant Impurity 31. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-(((2R,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one. CAS No. 1242175-34-3. Molecular formula: C23H21F7N4O3. Mole weight: 534.43. Catalog: APB1242175343.
Aprepitant Impurity 40
Aprepitant Impurity 40. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1242175-41-2. Molecular formula: C22H20F7NO6. Mole weight: 527.39. Catalog: APB1242175412.
Aprepitant Impurity 4 HCl
Aprepitant Impurity 4 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. CAS No. 1333998-21-2. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81.
Aprepitant Impurity 5
Aprepitant Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine. CAS No. 1242175-36-5. Molecular formula: C20H18F7NO2. Mole weight: 437.35. Catalog: APB1242175365.
Aprepitant Impurity 55
Aprepitant Impurity 55. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: tribenzyl phosphite. CAS No. 15205-57-9. Molecular formula: C21H21O3P. Mole weight: 352.36. Catalog: APB15205579.
Aprepitant Impurity 5 HCl
Aprepitant Impurity 5 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. CAS No. 1333995-14-4. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81.
Aprepitant Impurity 6
Aprepitant Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine. CAS No. 1242175-38-7. Molecular formula: C20H18F7NO2. Mole weight: 437.35. Catalog: APB1242175387.
Aprepitant Impurity 7 HCl
Aprepitant Impurity 7 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: Des-(4-fluoro-1,2,4-triazol-3-one-5-methyl (2R,3S,1'S)-Aprepitant Hydrochloride. CAS No. 874460-46-5. Molecular formula: C20H19F6NO2.HCl. Mole weight: 455.82.
Aprepitant Impurity 8 HCl
Aprepitant Impurity 8 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: Fosaprepitant Morpholine Hydrochloride; (2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride. CAS No. 1333998-27-8. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81.
Aprepitant impurity A
Aprepitant impurity A is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C27H24F7NO2. Mole weight: 527.47.
Aprepitant Impurity A Enantiomer
Aprepitant Impurity A Enantiomer is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C27H24F7NO2. Mole weight: 527.47.
Aprepitant Impurity B Enantiomer HCl
A metabolite of Aprepitant. Synonyms: (2R,3S)-4-benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine. Grades: > 95%. CAS No. 183901-47-5. Molecular formula: C27H24F7NO2. HCl. Mole weight: 527.49 36.46.
Aprepitant Impurity B HCl
Aprepitant Impurity B HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C27H24F7NO2.HCl. Mole weight: 563.93.
Aprepitant-M3 Metabolite
Aprepitant-M3 Metabolite is a metabolite of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Uses: An active metabolite of aprepitant. Synonyms: (5S,6R)-6-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3-morpholinone; Aprepitant-M3; 3-Morpholinone, 6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-, (5S,6R)-. Grades: ≥95%. CAS No. 419574-04-2. Molecular formula: C20H16F7NO3. Mole weight: 451.33.
Aprepitant N-Oxide
Aprepitant N-Oxide. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS00838. Format: Neat.
Aprepitant Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Aprepitant Related Compound B
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
(1R,2R,3R)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: 5-[[(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one. Grades: > 95%. CAS No. 1148113-53-4. Molecular formula: C23H21F7N4O3. Mole weight: 534.44.
(1R,2S,3R)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: 5-(((2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. Grades: > 95%. CAS No. 1185502-97-9. Molecular formula: C23H21F7N4O3. Mole weight: 534.44.
(1R,2S,3S)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: 5-(((2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. Grades: > 95%. CAS No. 172822-28-5. Molecular formula: C23H21F7N4O3. Mole weight: 534.44.
(1S,2R,3R)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: 5-(((2R,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. Grades: > 95%. CAS No. 1242175-34-3. Molecular formula: C23H21F7N4O3. Mole weight: 534.44.
(1S,2S,3R)-Aprepitant
(1S,2S,3R)-Aprepitant is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C23H21F7N4O3. Mole weight: 516.44.
(1S,2S,3S)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: 5-(((2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. Grades: > 95%. CAS No. 1242175-40-1. Molecular formula: C23H21F7N4O3. Mole weight: 534.44.
[1(S)-Phenylethoxy]-Aprepitant
[1(S)-Phenylethoxy]-Aprepitant is a derivative of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Group: Biochemicals. Grades: Highly Purified. CAS No. 170902-81-5. Pack Sizes: 1mg, 10mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences.
A labeled metabolite of Aprepitant. Group: Biochemicals. Alternative Names: (2R, 3S) -2-[ (1R) -1-[3, 5-Bis (trifluoromethyl) phenyl) ethoxy]-3- (4-fluorophenyl) morpholine-d2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
(2R,3R,1S)-Aprepitant
(2R,3R,1S)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1242175-34-3. Pack Sizes: 1mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences.
Worldwide
(2S,3R,1R)-Aprepitant
(2S,3R,1R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1185502-97-9. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences.
Worldwide
(2S,3S,1R)-Aprepitant
(2S,3S,1R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. (2S,3S,1R)-Aprepitant is also a useful synthetic intermediate in the synthesis of morpholine tachykinin receptor antagonist prodrugs. Group: Biochemicals. Grades: Highly Purified. CAS No. 172822-28-5. Pack Sizes: 1mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences.
3-Des-(4-fluorophenyl) 3-(4-Fluorobiphen-3-yl) is a derivative of Aprepitant, which is a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: 5-{[(2R,3S)-2-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-3-(3-fluoro-4-biphenylyl)-4-morpholinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(3-fluoro[1,1'-biphenyl]-4-yl)-4-morpholinyl]methyl]-2,4-dihydro-. Molecular formula: C29H25F7N4O3. Mole weight: 610.52.
An active metabolite of Aprepitant. Group: Biochemicals. Alternative Names: Aprepitant-M3 Metabolite. Grades: Highly Purified. CAS No. 419574-04-2. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Defluoro aprepitant
Defluoro aprepitant. Group: Biochemicals. Alternative Names: 5-[[ (2R, 3S) -2-[ (1R) -1-[3, 5-Bis (trifluoromethyl) phenyl]ethoxy]-3-phenyl-4-morpholinyl]methyl]-1, 2-dihydro-3H-1, 2, 4-triazol-3-one. Grades: Highly Purified. CAS No. 170729-76-7. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C23H22F6N4O3. US Biological Life Sciences.
Worldwide
Defluoro Aprepitant
A metabolite of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: Aprepitant EP Impurity A; 5-([(2R,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-phenyl morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one. Grades: > 95%. CAS No. 170729-76-7. Molecular formula: C23H22F6N4O3. Mole weight: 516.45.
Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: (2S,3R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine. CAS No. 1185503-48-3. Molecular formula: C20H18F7NO7. Mole weight: 517.35.
Desfluoro Aprepitant
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.