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| Product | Description | |
|---|---|---|
| ATP synthase inhibitor 1 | ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F 1 /F O -ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1023043-30-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112715. |  |
| ATP synthase inhibitor 1 | ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels. Synonyms: 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(5-chloro-2-thienyl)sulfonyl]-1-phenyl-. Grade: 99%. CAS No. 1023043-30-2. Molecular formula: C17H18ClN3O3S2. Mole weight: 411.93. |  |
| ATP citrate synthase | The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate-CoA ligase). Group: Enzymes. Synonyms: ATP-citric lyase; ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-?acetyl-CoA] (ATP-dephosphorylating); acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating); adenosine triphosphate citrate lyase; citrate cleavage enzyme; citrate-ATP lyase; citric cleavage enzyme; ATP citrate (pro-S)-lyase. Enzyme Commission Number: EC 2.3.3.8. CAS No. 9027-95-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2324; ATP citrate synthase; EC 2.3.3.8; 9027-95-6; ATP-citric lyase; ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-?acetyl-CoA] (ATP-dephosphorylating); acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating); adenosine triphosphate citrate lyase; citrate cleavage enzyme; citrate-ATP lyase; citric cleavage enzyme; ATP citrate (pro-S)-lyase. Cat No: EXWM-2324. |  |
| 1-Azakenpaullone | 1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β) , with an IC 50 value of 18 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Akp. CAS No. 676596-65-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-59090. | |
| 2,3'-Dichloroacetophenone | 2,3'-Dichloroacetophenone is used as a reagent in the synthesis of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3 β (GSK-3 β). Also used as a reagent in the synthesis of benzimidazolyl pyridinones as insulin-like growth factor I (IGF-1R) kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 21886-56-6. Pack Sizes: 1g, 5g. Molecular Formula: C8H6Cl2O. US Biological Life Sciences. |  Worldwide |
| (2,3-dihydroxybenzoyl)adenylate synthase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:2,3-dihydroxybenzoate adenylyltransferase. This enzyme is also called 2,3-dihydroxybenzoate-AMP ligase. This enzyme participates in biosynthesis of siderophore group nonribosomal. Group: Enzymes. Synonyms: 2,3-dihydroxybenzoate-AMP ligase. Enzyme Commission Number: EC 2.7.7.58. CAS No. 122332-73-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3269; (2,3-dihydroxybenzoyl)adenylate synthase; EC 2.7.7.58; 122332-73-4; 2,3-dihydroxybenzoate-AMP ligase. Cat No: EXWM-3269. | |
| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | Binds 2 Mg2+ ions that are essential for activity. The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the bacterium Streptococcus pneumoniae also harbours the activity of EC 4.1.2.25, dihydroneopterin aldolase, the enzyme from the plant Arabidopsis thaliana harbours the activity of EC 2.5.1.15, dihydropteroate synthase, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities. Group: Enzymes. Synonyms: 2-amino-4-hydroxy-6-hydroxymethyldi. Enzyme Commission Number: EC 2.7.6.3. CAS No. 37278-23-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3222; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; EC 2.7.6.3; 37278-23-2; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; H2-pteridine-CH2OH pyrophosphokinase; 7,8-dihydroxymethylpterin-pyrophosphokinase; HPPK; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; hydroxymethyldihydropteridine pyrophosphokinase; ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase. Cat No: EXWM-3222. | |
| 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (GSK-3ß Inhibitor I, TDZD-8) | Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione, also known as TDZD-8, is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK3b (IC50 =2nM). It binds to the active site of GSK3b. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM). Group: Biochemicals. Alternative Names: GSK-3ß Inhibitor I, TDZD-8. Grades: Highly Purified. CAS No. 327036-89-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 5-(carboxyamino)imidazole ribonucleotide synthase | In Escherichia coli, this enzyme, along with EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase, is required to carry out the single reaction catalysed by EC 4.1.1.21, phosphoribosylaminoimidazole carboxylase, in vertebrates. Belongs to the ATP grasp protein superfamily. Carboxyphosphate is the putative acyl phosphate intermediate. Involved in the late stages of purine biosynthesis. Group: Enzymes. Synonyms: N5-CAIR synthetase; N5-carboxyaminoimidazole ribonucleotide synthetase; PurK. Enzyme Commission Number: EC 6.3.4.18. CAS No. 255379-40-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5787; 5-(carboxyamino)imidazole ribonucleotide synthase; EC 6.3.4.18; 255379-40-9; N5-CAIR synthetase; N5-carboxyaminoimidazole ribonucleotide synthetase; PurK. Cat No: EXWM-5787. | |
| 5-Iodotubercidin | 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC 50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 113939; 5-ITu. CAS No. 24386-93-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 25 mg; 50 mg. Product ID: HY-15424. | |
| 6BIO | Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Apoptosis inducer. Potent antiproliferative agent in malignant lymphoid cell. Group: Biochemicals. Alternative Names: (2'Z,3'E)-6-Bromoindirubin-3'-oxime. Grades: Highly Purified. CAS No. 667463-62-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C16H10BrN3O2. US Biological Life Sciences. | Worldwide |
| 9-ING-41 | 9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC 50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Elraglusib. CAS No. 1034895-42-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113914. | |
| Adenosine 5'-diphosphate monopotassium salt | Adenosine 5'-diphosphate (ADP) is an adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5' position. It is produced by dephosphorylation of adenosine 5'-triphosphate by ATPases and can be converted back to ATP by ATP synthases. Synonyms: Adenosine 5'-(trihydrogen diphosphate), monopotassium salt; Adenosine 5'-Diphosphate Potassium Salt; 5'-ADP monopotassium salt; ADP monopotassium salt. Grade: ≥95%. CAS No. 70285-70-0. Molecular formula: C10H14KN5O10P2. Mole weight: 465.29. | |
| Adenosine 5'-triphosphate (ATP) Disodium Salt | Adenosine-5'-triphosphate is a nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical energy within cells for metabolism. It is one of the end products of photophosphorylation, cellular respiration, and fermentation and used by enzymes and structural proteins in many cellular processes, including biosynthetic reactions, motility, and cell division. One molecule of ATP contains three phosphate groups, and it is produced by a wide variety of enzymes, including ATP synthase, from adenosine diphosphate (ADP) or adenosine monophosphate (AMP) and various phosphate group donors. Substrate level phosphorylation, oxidative phosphorylation in cellular respiration, and photophosphorylation in photosynthesis are three major mechanisms of ATP biosynthesis. Group: Coenzymes. Synonyms: ATP; ATP-Na2; ATP-II; ATP-2. CAS No. 56-65-5. Purity: > 95% (Enzymatic). ATP. Mole weight: 551.2. Storage: Store at -20°C. Form: Crystalline. ATP; ATP-Na2; ATP-II; ATP-2; Adenosine 5'-triphosphate (ATP) Disodium Salt; Adenosine 5'-triphosphate Disodium Salt. Cat No: NATE-0945. | |
| adenylate dimethylallyltransferase (ADP/ATP-dependent) | Involved in the biosynthesis of cytokinins in plants. The IPT4 isoform from the plant Arabidopsis thaliana is specific for ADP and ATP. Other isoforms, such as IPT1 from Arabidopsis thaliana and the enzyme from the common hop, Humulus lupulus, also have a lower activity with AMP (cf. EC 2.5.1.27, adenylate dimethylallyltransferase). Group: Enzymes. Synonyms: cytokinin synthase (ambiguous); isopentenyltransferase (ambiguous); 2-isopentenyl-diphosphate:ADP/ATP Δ2-isopentenyltransferase; adenylate isopentenyltransferase (ambiguous); dimethylallyl diphosphate:ATP/ADP isopentenyltransferase: IPT. Enzyme Commission Number: EC 2.5.1.112. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2728; adenylate dimethylallyltransferase (ADP/ATP-dependent); EC 2.5.1.112; cytokinin synthase (ambiguous); isopentenyltransferase (ambiguous); 2-isopentenyl-diphosphate:ADP/ATP Δ2-isopentenyltransferase; adenylate isopentenyltransferase (ambiguous); dimethylallyl diphosphate:ATP/ADP isopentenyltransferase: IPT. Cat No: EXWM-2728. | |
| adenylyl-sulfate kinase | The human phosphoadenosine-phosphosulfate synthase (PAPSS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC 2.7.7.4) and adenylyl-sulfate kinase (EC 2.7.1.25). Group: Enzymes. Synonyms: adenylylsulfate kinase (phosphorylating); 5'-phosphoadenosine sulfate kinase; adenosine 5'-phosphosulfate kinase; adenosine phosphosulfate kinase; adenosine phosphosulfokinase; . Enzyme Commission Number: EC 2.7.1.25. CAS No. 9012-38-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3055; adenylyl-sulfate kinase; EC 2.7.1.25; 9012-38-8; adenylylsulfate kinase (phosphorylating); 5'-phosphoadenosine sulfate kinase; adenosine 5'-phosphosulfate kinase; adenosine phosphosulfate kinase; adenosine phosphosulfokinase; adenosine-5'-phosphosulfate-3'-phosphokinase; APS kinase. Cat No: EXWM-3055. | |
| (αR, βS)-rel-Bedaquiline | (αR, βS)-rel-Bedaquiline is a promising diarylquinoline candidate in clinical development for the treatment of tuberculosis. (αR, βS)-rel-Bedaquiline inhibits mycobacterial ATP synthase and displays high activity against both drug-susceptible and multidrug-resistant strains of Mycobacterium tuberculosis. Group: Biochemicals. Alternative Names: (αR, βS)-rel-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- β-phenyl-3-quinolineethanol. Grades: Highly Purified. CAS No. 654653-93-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Alsterpaullone | Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Synonyms: 9-Nitropaullone; NSC 705701; 7,12-Dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one. Grade: ≥98%. CAS No. 237430-03-4. Molecular formula: C16H11N3O3. Mole weight: 293.3. | |
| AR-A014418 | AR-A014418 is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β), a serine/threonine protein kinase involved in multiple diseases including Alzheimer's disease and type 2 diabetes. Synonyms: SN 4521; SN4521; SN-4521; AR-A 014418; AR-A014418; AR-A-014418; AR-AO-14418; GSK-3beta Inhibitor VIII; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea. Grade: ≥ 98%. CAS No. 487021-52-3. Molecular formula: C12H12N4O4S. Mole weight: 308.312. | |
| ATP Citrate Lyase Active from Human, Recombinant | ATP Citrate lyase is an enzyme involved in fatty acid synthesis that generates cytosolic acetyl-CoA and oxaloacetate from Citrate and CoA. ATP Citrate lyase is often upregulated in cancer. Applications: Active human atp citrate lyase is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. active human atp citrate lyase has been used in a study to ascertain the nature of the catalytic phosphorylation that initiates the acl reaction, and to identity the active site residues involved. active human atp citrate lyase has also been used in a study to analyze tumor metabolism to reveal mitochondrial glucose oxidation in genetically diverse human glioblastomas. Group: Enzymes. S. Purity: > 90% (SDS-PAGE). ACLY. Mole weight: 147 kDa. Storage: Store at -70°C. Avoid multiple freeze-thaw cycles. Form: Aqueous solution, Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol. Source: Baculovirus. Species: Human. ACLY; ATP-Citrate synthase; ATPCL; CLATP; ATP-citric lyase; ATP:Citrate oxaloacetate-lyase [(pro-S)-CH2COO-->acetyl-CoA] (ATP-dephosphorylating); acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating); adenosine triphosphate Citrate lyase; Citrate cleavage enzyme; Citrate-ATP lyase; citric cleavage enzyme; ATP Citrate (pro-S)-lyase. Cat No: NATE-0944. | |
| Bedaquiline | Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit [1]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMC207; R207910. CAS No. 843663-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14881. | |
| Bedaquiline | TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB. Synonyms: Sirturo; TMC207; TMC-207; TMC 207; R207910; R-207910; R 207910. Grade: 98%. CAS No. 843663-66-1. Molecular formula: C32H31BrN2O2. Mole weight: 555.5. | |
| Bedaquiline fumarate | Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R403323; TMC207 fumarate; R207910 fumarate. CAS No. 845533-86-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14881A. | |
| Bedaquiline fumarate (Standard) | Bedaquiline (fumarate) (Standard) is the analytical standard of Bedaquiline (fumarate). This product is intended for research and analytical applications. Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R403323 (Standard); TMC207 fumarate (Standard); R207910 fumarate (Standard). CAS No. 845533-86-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14881AR. | |
| Bisindolylmaleimide I | Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Group: Biochemicals. Alternative Names: GF-109203X, Gö 6850, BIM I. Grades: Highly Purified. CAS No. 133052-90-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H24N4O2. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide I hydrochloride | Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competitive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Group: Biochemicals. Alternative Names: GF 109203X, Gö 6850, BIM I. Grades: Highly Purified. CAS No. 176504-36-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H24N4O2. HCl. US Biological Life Sciences. | Worldwide |
| BMS-199264 hydrochloride | BMS-199264 hydrochloride is a novel potent inhibitor of the ATP hydrolase activity of mitochondrial F1F0 ATP synthase. Synonyms: BMS-199264 HCl. CAS No. 186180-83-6. Molecular formula: C26H32Cl2N4O4S. Mole weight: 567.53. | |
| Bz 423 | Bz 423 has been found to be an ATP synthase inhibitor and could suppress disease in lupus-prone mice at some extent. Uses: Immunologic factors. Synonyms: Bz-423; Bz 423; Bz423; 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one. Grade: ≥98% by HPLC. CAS No. 216691-95-1. Molecular formula: C27H21ClN2O2. Mole weight: 440.92. | |
| Ca2+/calmodulin-dependent protein kinase | Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase). Group: Enzymes. Synonyms: ATP:caldesmon O-phosphotransferase; caldesmon kinase; caldesmon kinase (phosphorylating); Ca2+/calmodulin-dependent microtubule-associated pro. Enzyme Commission Number: EC 2.7.11.17. CAS No. 141467-21-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3136; Ca2+/calmodulin-dependent protein kinase; EC 2.7.11.17; 141467-21-2; ATP:caldesmon O-phosphotransferase; caldesmon kinase; caldesmon kinase (phosphorylating); Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase; Ca2+/calmodulin-dependent protein kinase 1; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase IV; Ca2+/calmodulin-dependent protein kinase kinase; Ca2+/calmodulin-dependent protein kinase kinase β; calmodulin-dependent kinase II; CaM kinase; CaM kinase II; CAM PKII; CaM-regulated serine/threonine kinase; CaMKI; CaMKII; CaMKIV; CaMKKα; CaMKKβ; microtubule-associated protein 2 kinase; STK20. Cat No: EXWM-3136. | |
| carbamoyl-phosphate synthase (ammonia) | The enzyme catalyses the first committed step in the urea cycle. The reaction proceeds via three separate chemical reactions: phosphorylation of hydrogencarbonate to carboxyphosphate; a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate; and the phosphorylation of carbamate forming carbamoyl phosphate. Two moles of ATP are utilized for the synthesis of one molecule of carbamyl phosphate, making the reaction essentially irreversible. The enzyme requires the allosteric activator N-acetyl-L-glutamate. cf. EC 6.3.5.5, carbamoyl-phosphate synthase (glutamine-hydrolysing). Group: Enzymes. Synonyms: carbon-dioxide-ammonia ligase; carbamoylphosphate synthase; carbamylphosphate synthetase; carbamoylphosphate synthase (ammonia); carbamoylphosphate synthetase; carbamylphosphate s. Enzyme Commission Number: EC 6.3.4.16. CAS No. 9026-23-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5785; carbamoyl-phosphate synthase (ammonia); EC 6.3.4.16; 9026-23-7; carbon-dioxide-ammonia ligase; carbamoylphosphate synthase; carbamylphosphate synthetase; carbamoylphosphate synthase (ammonia); carbamoylphosphate synthetase; carbamylphosphate synthetase I; CPSI (gene name); carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating). Cat No: EXWM-5785. | |
| carbamoyl-phosphate synthase (glutamine-hydrolysing) | The product carbamoyl phosphate is an intermediate in the biosynthesis of arginine and the pyrimidine nucleotides. The enzyme from Escherichia coli has three separate active sites, which are connected by a molecular tunnel that is almost 100 ? in length. The amidotransferase domain within the small subunit of the enzyme hydrolyses glutamine to ammonia via a thioester intermediate. The ammonia migrates through the interior of the protein, where it reacts with carboxyphosphate to produce the carbamate intermediate. The carboxyphosphate intermediate is formed by the phosphorylation of hydrogencarbonate by ATP at a site contained within the N-terminal half of the large ... (gene name); CAD (gene name); hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating). Enzyme Commission Number: EC 6.3.5.5. CAS No. 37233-48-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5808; carbamoyl-phosphate synthase (glutamine-hydrolysing); EC 6.3.5.5; 37233-48-0; carbamoyl-phosphate synthetase (glutamine-hydrolysing); carbamyl phosphate synthetase (glutamine); carbamoylphosphate synthetase II; glutamine-dependent carbamyl phosphate synthetase; carbamoyl phosphate synthetase; CPS; carbon-dioxide:L-glutamine amido-ligase (ADP-forming, carbam | |
| (carboxyethyl)arginine β-lactam-synthase | Forms part of the pathway for the biosythesis of the β-lactamase inhibitor clavulanate in Streptomyces clavuligerus. It has been proposed that L-N2-(2-carboxyethyl)arginine is first converted into an acyl-AMP by reaction with ATP and loss of diphosphate, and that the β-lactam ring is then formed by the intramolecular attack of the β-nitrogen on the activated carboxy group. Group: Enzymes. Synonyms: L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). Enzyme Commission Number: EC 6.3.3.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5776; (carboxyethyl)arginine β-lactam-synthase; EC 6.3.3.4; L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). Cat No: EXWM-5776. | |
| citrate-CoA ligase | The enzyme is a component of EC 2.3.3.8 ATP citrate synthase. Group: Enzymes. Synonyms: citryl-CoA synthetase; citrate:CoA ligase; citrate thiokinase. Enzyme Commission Number: EC 6.2.1.18. CAS No. 856428-87-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5676; citrate-CoA ligase; EC 6.2.1.18; 856428-87-0; citryl-CoA synthetase; citrate:CoA ligase; citrate thiokinase. Cat No: EXWM-5676. | |
| citryl-CoA lyase | The enzyme is a component of EC 4.1.3.6 {[citrate (pro-3S)-lyase]}and EC 2.3.3.8 [ATP citrate synthase]. Also acts on (3S)-citryl thioacyl-carrier protein. Group: Enzymes. Synonyms: (3S)-citryl-CoA oxaloacetate-lyase. Enzyme Commission Number: EC 4.1.3.34. CAS No. 131095-35-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4911; citryl-CoA lyase; EC 4.1.3.34; 131095-35-7; (3S)-citryl-CoA oxaloacetate-lyase. Cat No: EXWM-4911. | |
| cobyrinate a,c-diamide synthase | This enzyme is the first glutamine amidotransferase that participates in the anaerobic (early cobalt insertion) biosynthetic pathway of adenosylcobalamin, and catalyses the ATP-dependent synthesis of cobyrinate a,c-diamide from cobyrinate using either L-glutamine or ammonia as the nitrogen source. It is proposed that the enzyme first catalyses the amidation of the c-carboxylate, and then the intermediate is released into solution and binds to the same catalytic site for the amidation of the a-carboxylate. The Km for ammonia is substantially higher than that for L-glutamine. Group: Enzymes. Synonyms: cobyrinic acid a,c-diamide synthetase; CbiA. Enzyme Commission Number: EC 6.3.5.11. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5804; cobyrinate a,c-diamide synthase; EC 6.3.5.11; cobyrinic acid a,c-diamide synthetase; CbiA. Cat No: EXWM-5804. | |
| C-Peptide 1 (rat) | C-Peptide 1 (rat) specifically binds to G-protein-coupled membrane receptors in the nanomolar concentration range, and subsequently activates Ca2+-dependent intracellular signaling pathways. This leads to a stimulation of the activity of both Na+-K+-ATPase, and endothelial nitric oxide synthase. Administration of C-peptide to streptozotocin induced diabetic rats elicited a substantial increase in whole-body glucose turnover. Synonyms: Insulin 1 Precursor (57-87) (rat); H-Glu-Val-Glu-Asp-Pro-Gln-Val-Pro-Gln-Leu-Glu-Leu-Gly-Gly-Gly-Pro-Glu-Ala-Gly-Asp-Leu-Gln-Thr-Leu-Ala-Leu-Glu-Val-Ala-Arg-Gln-OH; L-alpha-glutamyl-L-valyl-L-alpha-glutamyl-L-alpha-aspartyl-L-prolyl-L-glutaminyl-L-valyl-L-prolyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-leucyl-glycyl-glycyl-glycyl-L-prolyl-L-alpha-glutamyl-L-alanyl-glycyl-L-alpha-aspartyl-L-leucyl-L-glutaminyl-L-threonyl-L-leucyl-L-alanyl-L-leucyl-L-alpha-glutamyl-L-valyl-L-alanyl-L-arginyl-L-glutamine. Grade: ≥95%. CAS No. 41475-27-8. Molecular formula: C140H228N38O51. Mole weight: 3259.53. | |
| CTP synthase (glutamine hydrolysing) | The enzyme contains three functionally distinct sites: an allosteric GTP-binding site, a glutaminase site where glutamine hydrolysis occurs (cf. EC 3.5.1.2, glutaminase), and the active site where CTP synthesis takes place. The reaction proceeds via phosphorylation of UTP by ATP to give an activated intermediate 4-phosphoryl UTP and ADP. Ammonia then reacts with this intermediate generating CTP and a phosphate. The enzyme can also use ammonia from the surrounding solution. Group: Enzymes. Synonyms: UTP-ammonia ligase; cytidine triphosphate synthetase; uridine triphosphate aminase; cytidine 5'-triphosphate synthetase; CTPS (gene name); pyrG (gene name); CTP synthase; UTP:ammonia ligase (ADP-forming). Enzyme Commission Number: EC 6.3.4.2. CAS No. 9023-56-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5789; CTP synthase (glutamine hydrolysing); EC 6.3.4.2; 9023-56-7; UTP-ammonia ligase; cytidine triphosphate synthetase; uridine triphosphate aminase; cytidine 5'-triphosphate synthetase; CTPS (gene name); pyrG (gene name); CTP synthase; UTP:ammonia ligase (ADP-forming). Cat No: EXWM-5789. | |
| D-α-Hydroxyglutaric acid | D-α-Hydroxyglutaric acid is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling. Synonyms: (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid; D-2-Hydroxyglutaric acid. CAS No. 13095-47-1. Molecular formula: C5H8O5. Mole weight: 148.11. | |
| D-α-Hydroxyglutaric acid disodium | D-?-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-?-Hydroxyglutaric acid disodium is a weak competitive antagonist of ?-ketoglutarate (?-KG) and inhibits multiple ?-KG-dependent dioxygenases with a Ki of 10.87 mM. D-?-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-?-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5]. Uses: Scientific research. Group: Natural products. Alternative Names: Disodium (R)-2-hydroxyglutarate. CAS No. 103404-90-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100542. | |
| dethiobiotin synthase | CTP has half the activity of ATP. Group: Enzymes. Synonyms: desthiobiotin synthase. Enzyme Commission Number: EC 6.3.3.3. CAS No. 37259-75-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5775; dethiobiotin synthase; EC 6.3.3.3; 37259-75-9; desthiobiotin synthase. Cat No: EXWM-5775. | |
| diphthine-ammonia ligase | This amidase catalyses the last step in the conversion of an L-histidine residue in the translation elongation factor EF2 to diphthamide. This factor is found in all archaebacteria and eukaryotes, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC 2.4.2.36, NAD+-diphthamide ADP-ribosyltransferase). The substrate of the enzyme, diphthine, is produced by EC 2.1.1.98, diphthine synthase. Group: Enzymes. Synonyms: diphthamide synthase; diphthamide synthetase; DPH6 (gene name); ATPBD4 (gene name); diphthine:ammonia ligase (AMP-forming). Enzyme Commission Number: EC 6.3.1.14. CAS No. 114514-33-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5717; diphthine-ammonia ligase; EC 6.3.1.14; 114514-33-9; diphthamide synthase; diphthamide synthetase; DPH6 (gene name); ATPBD4 (gene name); diphthine:ammonia ligase (AMP-forming). Cat No: EXWM-5717. | |
| DNA ligase (ATP) | The enzyme catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. RNA can also act as substrate, to some extent. cf. EC 6.5.1.2, DNA ligase (NAD+), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP). Group: Enzymes. Synonyms: polydeoxyribonucleotide synthase (ATP);. Enzyme Commission Number: EC 6.5.1.1. CAS No. 9015-85-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5820; DNA ligase (ATP); EC 6.5.1.1; 9015-85-4; polydeoxyribonucleotide synthase (ATP); polynucleotide ligase (ambiguous); sealase; DNA repair enzyme (ambiguous); DNA joinase (ambiguous); DNA ligase (ambiguous); deoxyribonucleic ligase (ambiguous); deoxyribonucleate ligase (ambiguou | |
| DNA ligase (NAD+) | Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA. RNA can also act as substrate, to some extent. cf. EC 6.5.1.1, DNA ligase (ATP), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP). Group: Enzymes. Synonyms: polydeoxyribonucleotide synthase (NAD+); polynucleotide ligase (NAD+); DNA repair enzyme (ambiguous); DNA joinase (ambiguous); polynucleotide synthetase (nicotinamide ad. Enzyme Commission Number: EC 6.5.1.2. CAS No. 37259-52-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5821; DNA ligase (NAD+); EC 6.5.1.2; 37259-52-2; polydeoxyribonucleotide synthase (NAD+); polynucleotide ligase (NAD+); DNA repair enzyme (ambiguous); DNA joinase (ambiguous); polynucleotide synthetase (nicotinamide adenine dinucleotide); deoxyribonucleic-joining enzyme (ambiguous); deoxyribonucleic ligase (ambiguous); deoxyribonucleic repair enzyme (ambiguous); deoxyribonucleic joinase (ambiguous); DNA ligase (ambiguous); deoxyribonucleate ligase (ambiguous); polynucleotide ligase (ambiguous); deoxyribonucleic acid ligase (ambiguous); polynucleotide synthetase (ambiguous); deoxyribonucleic acid joinase (ambiguous); DNA-joining enzyme (ambiguous); polynucleotide ligase (nicotinamide adenine dinucleotide). Cat No: EXWM-5821. | |
| enterobactin synthase | This enzyme complex catalyses the conversion of three molecules each of 2,3-dihydroxybenzoate and L-serine to form the siderophore enterobactin. In Escherichia coli the complex is formed by EntB (an aryl carrier protein that has to be activated by 4'-phosphopantetheine), EntD (a phosphopantetheinyl transferase that activates EntB), EntE (catalyses the ATP-dependent condensation of 2,3-dihydroxybenzoate and holo-EntB to form the covalently arylated form of EntB), and EntF (a four domain protein that catalyses the activation of L-serine by ATP, the condensation of the activated L-serine with the activated 2,3-dihydroxybenzoate, and the trimerization of three such moieties to a single enterobactin molecule). Group: Enzymes. Synonyms: N-(2,3-dihydroxybenzoyl)-serine synthetase; 2,3-dihydroxybenzoylserine synthetase; 2,3-dihydroxybenzoate-serine ligase. Enzyme Commission Number: EC 6.3.2.14. CAS No. 37318-63-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5735; enterobactin synthase; EC 6.3.2.14; 37318-63-1; N-(2,3-dihydroxybenzoyl)-serine synthetase; 2,3-dihydroxybenzoylserine synthetase; 2,3-dihydroxybenzoate-serine ligase. Cat No: EXWM-5735. | |
| fatty-acyl-ethyl-ester synthase | The reaction, forms ethyl esters from fatty acids and ethanol in the absence of coenzyme A or ATP. Best substrates are unsaturated octadecanoic acids; palmitate, stearate and arachidonate also act, but more slowly. Group: Enzymes. Synonyms: FAEES. Enzyme Commission Number: EC 3.1.1.67. CAS No. 90119-16-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3495; fatty-acyl-ethyl-ester synthase; EC 3.1.1.67; 90119-16-7; FAEES. Cat No: EXWM-3495. | |
| Gboxin | Gboxin is an oxidative phosphorylation inhibitor in cancer cells, which inhibits the activity of F0F1 ATP synthase. Synonyms: 2-ethyl-1-methyl-3-[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]-2-oxoethyl]-1H-benzimidazolium, monochloride. Grade: ≥98%. CAS No. 2101315-36-8. Molecular formula: C22H33N2O2·Cl. Mole weight: 392.96. | |
| Gboxin chloride | Gboxin chloride is an oxidative phosphorylation inhibitor that targets glioblastoma but not embryonic fibroblasts or neonatal astrocytes. Gboxin rapidly and irreversibly compromises oxygen consumption in glioblastoma cells. Gboxin relies on its positive charge to associate with mitochondrial oxidative phosphorylation complexes in a manner that is dependent on the proton gradient of the inner mitochondrial membrane, and it inhibits the activity of F0F1 ATP synthase. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2101315-36-8. Molecular formula: C22H33ClN2O2. Mole weight: 392.97. Purity: >98%. IUPACName: 2-Ethyl-1-(2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-3-methyl-1H-benzo[d]imidazol-3-ium chloride. Canonical SMILES: C[N+]1=C(CC)N(CC(O[C@H]2[C@H](C(C)C)CC[C@@H](C)C2)=O)C3=CC=CC=C31.[Cl-]. Product ID: ACM2101315368. Alfa Chemistry ISO 9001:2015 Certified. |  |
| glucose-1-phosphate adenylyltransferase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:alpha-D-glucose-1-phosphate adenylyltransferase. Other names in common use include ADP glucose pyrophosphorylase, glucose 1-phosphate adenylyltransferase, adenosine diphosphate glucose pyrophosphorylase, adenosine diphosphoglucose pyrophosphorylase, ADP-glucose pyrophosphorylase, ADP-glucose synthase, ADP-glucose synthetase, ADPG pyrophosphorylase, ADP:alpha-D-glucose-1-phosphate adenylyltransferase and AGPase. This enzyme participates in starch and sucrose metabolism. Group: Enzymes. Synonyms: ADP glucose pyrophosphorylase; glucose 1-phosphate adenyl. Enzyme Commission Number: EC 2.7.7.27. CAS No. 9027-71-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3238; glucose-1-phosphate adenylyltransferase; EC 2.7.7.27; 9027-71-8; ADP glucose pyrophosphorylase; glucose 1-phosphate adenylyltransferase; adenosine diphosphate glucose pyrophosphorylase; adenosine diphosphoglucose pyrophosphorylase; ADP-glucose pyrophosphorylase; ADP-glucose synthase; ADP-glucose synthetase; ADPG pyrophosphorylase; ADP:α-D-glucose-1-phosphate adenylyltransferase. Cat No: EXWM-3238. | |
| glutathionylspermidine amidase | Spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule. The enzyme from Escherichia coli is bifunctional and also catalyses the glutathionylspermidine synthase (EC 6.3.1.8) reaction, resulting in a net hydrolysis of ATP. Group: Enzymes. Synonyms: glutathionylspermidine amidohydrolase (spermidine-forming). Enzyme Commission Number: EC 3.5.1.78. CAS No. 171040-71-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4469; glutathionylspermidine amidase; EC 3.5.1.78; 171040-71-4; glutathionylspermidine amidohydrolase (spermidine-forming). Cat No: EXWM-4469. | |
| glutathionylspermidine synthase | Requires magnesium ions. Involved in the synthesis of trypanothione in trypanosomatids. The enzyme from Escherichia coli is bifunctional and also catalyses the glutathionylspermidine amidase (EC 3.5.1.78) reaction, resulting in a net hydrolysis of ATP. Group: Enzymes. Synonyms: glutathione:spermidine ligase (ADP-forming). Enzyme Commission Number: EC 6.3.1.8. CAS No. 9077-9-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5728; glutathionylspermidine synthase; EC 6.3.1.8; 9077-09-2; glutathione:spermidine ligase (ADP-forming). Cat No: EXWM-5728. | |
| Glycogen Synthase Kinase 3β, Histidine-tagged, from rabbit, Recombinant | Glycogen synthase kinase-3 is a serine-threonine protein kinase involved in regulation of metabolic enzymes such as glycogen synthase and ATP-Citrate lyase, and of protein phosphatase-1. It also phosphorylates brain tau-proteins, inducing an Alzheimer-like state, and protooncogene transcription factors. GSK-3β is one of two isozymes. > 90% (sds-page), recombinant, expressed in e. coli. Group: Enzymes. Synonyms: Glycogen Synthase Kinase 3β; GSK-3β; GSK3B; 9059-09-0. CAS No. 9059-09-0. Purity: > 90% (SDS-PAGE). GSK-3&beta. Stability: -20°C. Source: E. coli. Species: Rabbit. Glycogen Synthase Kinase 3β; GSK-3β; GSK3B; 9059-09-0. Cat No: NATE-0324. | |
| GMP synthase (glutamine-hydrolysing) | Involved in the de novo biosynthesis of guanosine nucleotides. An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. The enzyme can catalyse the second reaction alone in the presence of ammonia. Group: Enzymes. Synonyms: GMP synthetase (glutamine-hydrolysing); guanylate synthetase (glutamine-hydrolyzing); guanosine monophosphate synthetase (glutamine-hydrolyzing); xanthosine 5'-phosphate amidotransferase; guanosine 5'-monophosphate synthetase. Enzyme Commission Number: EC 6.3.5.2. CAS No. 37318-71-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5805; GMP synthase (glutamine-hydrolysing); EC 6.3.5.2; 37318-71-1; GMP synthetase (glutamine-hydrolysing); guanylate synthetase (glutamine-hydrolyzing); guanosine monophosphate synthetase (glutamine-hydrolyzing); xanthosine 5'-phosphate amidotransferase; guanosine 5'-monophosphate synthetase. Cat No: EXWM-5805. | |
| GSK3β Inhibitor XI | GSK3β inhibitor XI is a cell-permeable, potent and ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK3β; Ki = 25 nM) which is selective for GSK3β over a panel of 79 commonly studied protein kinases. Synonyms: 3-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-(2-pyrazinyl)-1H-pyrrole-2,5-dione. Grade: ≥98%. CAS No. 626604-39-5. Molecular formula: C18H15N5O3. Mole weight: 349.3. | |
| GSK-3 Inhibitor, AR-A014418, (N-[(4-Methoxyphenyl)methyl]-N-(5-nitro-2-thiazolyl)urea) | Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104nm). Inhibition is competitive with respect to ATP (Ki = 38nm). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 =um) and over 26 other kinases. Inhibits b-amyloid-mediated neurodegeneration in hippocampal slices. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| GSK3 Inhibitor XIII | GSK3 Inhibitor XIII is a potent and ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3). Synonyms: Glycogen Synthase Kinase 3 Inhibitor XIII; 5,6,7,8-tetrahydro-N-(5-methyl-1H-pyrazol-3-yl)-2-phenyl-4-quinazolinamine. Grade: ≥98%. CAS No. 404828-08-6. Molecular formula: C18H19N5. Mole weight: 305.4. | |
| GTP diphosphokinase | GDP can also act as acceptor. Group: Enzymes. Synonyms: stringent factor; guanosine 3',5'-polyphosphate synthase; GTP pyrophosphokinase; ATP-GTP 3'-diphosphotransferase; guanosine 5',3'-polyphosphate synthetase; (p)ppGpp synthetase I; (p)ppGpp synthetase II; guanosine pentaphosphate synthetase; GPSI; GPSII. Enzyme Commission Number: EC 2.7.6.5. CAS No. 63690-89-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3224; GTP diphosphokinase; EC 2.7.6.5; 63690-89-1; stringent factor; guanosine 3',5'-polyphosphate synthase; GTP pyrophosphokinase; ATP-GTP 3'-diphosphotransferase; guanosine 5',3'-polyphosphate synthetase; (p)ppGpp synthetase I; (p)ppGpp synthetase II; guanosine pentaphosphate synthetase; GPSI; GPSII. Cat No: EXWM-3224. | |
| H+-transporting two-sector ATPase | A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (Fo, Vo, Ao) and a cytoplasmic-compartment sector (F1, V1, A1). The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 α- and 3 β-subunits) is connected via the Δ-subunit to the membrane sector by several smaller subunits. Within this complex, the γ- and ε-subunits, as well as the 9-12 c subunits rotate by consecutive 120° angles and perform...cal conditions, they pump H+ rather than synthesize ATP. Group: Enzymes. Synonyms: ATP synthase; F1-ATPase; FoF1-ATPase; H+-transporting ATPase; mitochondrial ATPase; coupling factors (F0, F1 and CF1); chloroplast ATPase; bacterial Ca2+/Mg2+ ATPase. Enzyme Commission Number: EC 7.1.2.2 (Formerly EC 3.6.3.14). Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4650; H+-transporting two-sector ATPase; EC 3.6.3.14; ATP synthase; F1-ATPase; FoF1-ATPase; H+-transporting ATPase; mitochondrial ATPase; coupling factors (F0, F1 and CF1); chloroplast ATPase; bacterial Ca2+/Mg2+ ATPase. Cat No: EXWM-4650. | |
| Indirubin-3?-monoxime - CAS 160807-49-8 | A potent, reversible, and ATP-compatible inhibitor of GSK-3? (glycogen synthase kinase 3?), Cdk1 (cyclin-dependent kinase1) and Cdk5 (IC?? = 22 nM, 180 nM, and 100 nM, respectively). Group: Fluorescence/luminescence spectroscopy. |  |
| Isoapoptolidin | It is a ring expanded isomer of apoptolidin originally isolated from Nocardiopsis sp. It demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively). Synonyms: (3E,5E,7E,9R,10R,11E,13E,17S,18S,20S,21R)-10-[(6-Deoxy-4-O-methyl-α-L-glucopyranosyl)oxy]-21-[O-2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-(1→4)-O-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→7)-2,4,6-trideoxy-1-C-hydroxy-2,4-dimethyl-8-O-methyl-L-glycero-β-D-galacto-octopyranosyl]-17,20-dihydroxy-18-methoxy-3,5,7,9,13-pentamethyloxacycloheneicosa-3,5,7,11,13-pentaen-2-one; Isoapoptolidin A. Grade: >90% by HPLC. CAS No. 476647-30-0. Molecular formula: C58H96O21. Mole weight: 1129.38. | |
| L-threonylcarbamoyladenylate synthase | The enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg. Group: Enzymes. Synonyms: yrdC (gene name); Sua5; ywlC (gene name); ATP:L-threonyl,bicarbonate adenylyltransferase. Enzyme Commission Number: EC 2.7.7.87. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3300; L-threonylcarbamoyladenylate synthase; EC 2.7.7.87; yrdC (gene name); Sua5; ywlC (gene name); ATP:L-threonyl,bicarbonate adenylyltransferase. Cat No: EXWM-3300. | |
| methionine adenosyltransferase | S-adenosylmethionine synthetase (EC 2.5.1.6) (also known as methionine adenosyltransferase (MAT)) is an enzyme that creates S-adenosylmethionine (a.k.a. AdoMet, SAM or SAMe) by reacting methionine (a non-polar amino acid) and ATP (the basic currency of energy). Group: Enzymes. Synonyms: adenosylmethionine synthetase; ATP-methionine adenosyltransferase; methionine S-adenosyltransferase; methionine-activating enzyme; S-adenosyl-L-methionine synthetase; S-adenosylmethionine synthase; S-adenosylmethionine synthetase; AdoMet synthetase. Enzyme Commission Number: EC 2.5.1.6. CAS No. 9012-52-6. MAT. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2797; methionine adenosyltransferase; EC 2.5.1.6; 9012-52-6; adenosylmethionine synthetase; ATP-methionine adenosyltransferase; methionine S-adenosyltransferase; methionine-activating enzyme; S-adenosyl-L-methionine synthetase; S-adenosylmethionine synthase; S-adenosylmethionine synthetase; AdoMet synthetase. Cat No: EXWM-2797. | |
| NAD Synthetase from B. subtilis, Recombinant | In enzymology, a NAD+ synthase (EC 6.3.1.5) is an enzyme that catalyzes the chemical reaction:ATP + deamido-NAD+ + NH3<-> AMP + diphosphate + NAD+. The 3 substrates of this enzyme are ATP, deamido-NAD+, and NH3, whereas its 3 products are AMP, diphosphate, and NAD+. This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). This enzyme participates in nicotinate and nicotinamide metabolism and nitrogen metabolism. Group: Enzymes. Synonyms: EC 6.3.1.5; 9032-69-3; NAD+ synthetase; NAD+ synthase; nicotinamide adenine dinucleotide synthetase; diphosphopyridine nucleotide synthetase. Purity: > 98% (SDS-PAGE). NAD Synthetase. Mole weight: ~30.4kDa. Activity: ~0.3 U/mg protein. Stability: Stable for at least 6 months after receipt when stored at -80°C. Storage: Store at -20°C. After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. Form: Liquid. In 50mM TRIS-HCl, pH 8, containing 75mM sodium chloride, 5% glycerol and 5mM DTT. Source: E. coli. Species: B. subtilis. EC 6.3.1.5; 9032-69-3; NAD+ synthetase; NAD+ synthase; nicotinamide adenine dinucleotide synthetase; diphosphopyridine nucleotide synthetase. Cat No: NATE-1244. | |
| Native Bacillus stearothermophilius NAD Synthetase | In enzymology, a NAD+ synthase (EC 6.3.1.5) is an enzyme that catalyzes the chemical reaction:ATP + deamido-NAD+ + NH3<-> AMP + diphosphate + NAD+. The 3 substrates of this enzyme are ATP, deamido-NAD+, and NH3, whereas its 3 products are AMP, diphosphate, and NAD+. This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). This enzyme participates in nicotinate and nicotinamide metabolism and nitrogen metabolism. Is an enzyme produced by microorganisms. this product shall be used for a diagnostics reagent. Applications: Useful for enzymatic determination of atp, ammonia, urea or creatinine. it is also suitable for enzymatic cycling method. Group: Enzymes. Synonyms: EC 6.3.1.5; 9032-69-3; NAD+ synthetase; NAD+ synthase; nicotinamide adenine dinucleotide synthetase; diphosp. Enzyme Commission Number: EC 6.3.1.5. CAS No. 9032-69-3. NAD Synthetase. Mole weight: 50 kDa (gel filtration); 25 kDa (SDS-PAGE). Activity: > 1 U/mg. Appearance: White powder. Storage: Storage at-20°C in the presence of a desiccant is recommended. Form: Freeze dried powder. Source: Bacillus stearothermophilius. EC 6.3.1.5; 9032-69-3; NAD+ synthetase; NAD+ synthase; nicotinamide adenine dinucleotide synthetase; diphosphopyridine nucleotide synthetase. Cat No: NATE-0471. | |
| Native Bacillus stearothermophilus Fructose-6-phosphate Kinase | Fructose-1,6-bisphosphatase (FBP) is an important enzyme in glucose metabolism. It catalyzes the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate. Fructose-6-phosphate kinase converts fructose-6-phosphate into fructose 1,6-bisphophate in the rate limiting step of the glycolysis cycle. Bacillus stearothermophilus phosphofructokinase (bspfk) is a homotetramer that is allosterically inhibited by phosphoenolpyruvate (pep), which binds along one dimer-dimer interface. Applications: Fructose-6-phosphate kinase from bacillus stearothermophilus was shown to interact with neuronal nitric oxide synthase (nnos) causing a defect in glycolytic metabolism and increased fatigability in dystrophic muscle. Group: Enzymes. Sy. Enzyme Commission Number: EC 2.7.1.11. CAS No. 9001-80-3. FBP. Activity: > 50 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing phosphate buffer salt. Source: Bacillus stearothermophilus. EC 2.7.1.11; phosphohexokinase; phosphofructokinase I; phosphofructokinase (phosphorylating); 6-phosphofructose 1-kinase; ATP-dependent phosphofructokinase; D-fructose-6-phosphate 1-phosphotransferase; fructose 6-phosphate kinase; fructose 6-phosphokinase; nucleotide triphosphate-dependent phosphofructokinase; phospho-1,6-fructokinase; PFK; 9001-80-3. Cat No: NATE-0252. | |
| non-specific serine/threonine protein kinase | This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date. Group: Enzymes. Synonyms: A-kinase; AP50 kinase; ATP-protein transphosphorylase; calcium-dependent protein kinase C; calcium/phospholipid-dependent protein kinase; cAMP-dependent protein kinase; cAMP-dependent protein kinase A; casein kinase; casein kinase (phosphorylating); casein kinase 2; casein kinase I; casein kinase II; cGMP-dependent protein kinase; CK-2; CKI; CKII; cyclic AMP-dependent protein kinase; cyclic AMP-dependent protein kinase A; cyclic monophosphate-dependent protein kinase; cyclic nucleotide-dependent protein kinase; cyclin-dependent kinase; cytidine 3',5'-cyclic monophosphate-responsive protein kinase; dsk1; glycogen synthase a kinase; glycogen synthase kinase; HIPK2; Hpr kinase; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase; M phase-specific cdc2 kinase; mitogen-activated S6 kinase; p82 kinase; phosphorylase b kinase kinase; PKA; protein glutamyl kinase; pr. Enzyme Commission Number: EC 2.7.11.1. STK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3128; non-specific serine/threonine protein kinase; EC 2.7.11.1; A-kinase; AP50 kinase; | |
| Oligomycin | Oligomycin, a mixture of A, B, and C Oligomycin isomers, has been found to be a macrolide compound and could exhibit effect in restraining mitochondrial ATP-synthase. It is isolated from Streptomyces diastatochromogenes. Uses: Used as a tool in cytochemistry. Synonyms: RK3325000; Oligomycin A. CAS No. 1404-19-9. Molecular formula: C45H74O11. Mole weight: 791.06. | |
| Oligomycin | Oligomycin, an antifungal antibiotic, is an inhibitor of H + -ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 1404-19-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N6782. | |
| Oligomycin A | Oligomycin A, an ATP synthase inhibitor and a macrolide antibiotic with fungicidal activity isolated from Streptomyces species, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria. Synonyms: Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-; (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-Ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione; MCH 32. Grade: >98%. CAS No. 579-13-5. Molecular formula: C45H74O11. Mole weight: 791.06. | |
| Oligomycin B | A minor component of the oligomycin complex isolated from selected strains of streptomyces; an inhibitor of mitochondrial F1F0-atpas; used as an eukaryotic ATP synthase inhibitor, induces apoptosis. Synonyms: BRN 5705502. Grade: >95% by HPLC. CAS No. 11050-94-5. Molecular formula: C45H72O12. Mole weight: 805.04. | |
| Oligomycin B | Oligomycin B is an antibiotic isolated from marine Streptomyces , used as an eukaryotic ATP synthase inhibitor, induces apoptosis [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 11050-94-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6784. | |
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