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| Product | Description | |
|---|---|---|
| barrierpepsin | A secreted endopeptidase known from bakers yeast (Saccharomyces cerevisiae). In peptidase family A1 (pepsin A family). Group: Enzymes. Synonyms: barrier proteinase; Bar proteinase. Enzyme Commission Number: EC 3.4.23.35. CAS No. 152060-38-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4272; barrierpepsin; EC 3.4.23.35; 152060-38-3; barrier proteinase; Bar proteinase. Cat No: EXWM-4272. |  |
| 1, 1, 2, 2-Tetra hydroperfluorodecanol | 1, 1, 2, 2-Tetra hydroperfluorodecanol is applied to the formation of a barrier and self-healing coating on zinc metal materials. This compound has also been seen to induce cell death and formation of oxidative or reactive oxygen species in cerebellar granule cells. Group: Biochemicals. Alternative Names: 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 9, 9, 10, 10, 10-Heptadecafluoro-1-decanol; (Perfluorooctyl) ethanol; 1, 1, 2, 2-Tetra hydroheptadecafluoro decanol; 1, 1, 2, 2-Tetra hydroperfluorodecan-1-ol; 1, 1, 2, 2-Tetra hydroperfluorodecanol; 1, 1, 2, 2-Tetra hydroperfluorodecyl Alcohol; 1H,1H,2H,2H-Perfluorodecan-1-ol; 1H,1H,2H,2H-Perfluorodecanol; 2- (Heptadecafluorooctyl) ethanol; 2- (Perfluorooctyl) ethanol; 2-(Perfluorooctyl)ethyl Alcohol; 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 9, 9, 10, 10, 10-Heptadecafluoro-1-decanol; 8-2 Fluorotelomer alc.; 8-2 Fluorotelomer alcohol; 8-2 Telomer B alcohol; 8:2 FTOH; A 1820; C 1820; Daikin A 1820; Fluowet EA 800; PFA 8; β - (Heptadecafluorooctyl) ethanol. Grades: Highly Purified. CAS No. 678-39-7. Pack Sizes: 10g. US Biological Life Sciences. |  Worldwide |
| 1,2-Distearoyl-3-oleoyl-rac-glycerol | 1,2-Distearoyl-3-oleoyl-rac-glycerol is used in the study of leptin resistance at the blood-brain barrier. Group: Biochemicals. Grades: Highly Purified. CAS No. 2190-29-6. Pack Sizes: 50mg, 500mg. Molecular Formula: C57H108O6, Molecular Weight: 889.46. US Biological Life Sciences. | Worldwide |
| 1,2-Distearoyl-3-oleoyl-rac-glycerol-d5 | 1,2-Distearoyl-3-oleoyl-rac-glycerol-d5 is labelled 1,2-Distearoyl-3-oleoyl-rac-glycerol (D493520) which is used in the study of leptin resistance at the blood-brain barrier. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C57H103D5O6, Molecular Weight: 894.49. US Biological Life Sciences. | Worldwide |
| 1- [ [ (2-Methyl-1-oxopropyl) amino] methyl] cyclohexaneacetic Acid | 1- [ [ (2-Methyl-1-oxopropyl) amino] methyl] cyclohexaneacetic Acid is derived from Gabapentin (G117250), which is an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant. Also, it is an impurity formed in the synthesis of [1-[[ (α -isobutanoyloxyethoxy) carbonyl]aminomethyl]-1-cyclohexane Acetic Acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 1281568-83-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C13H23NO3, Molecular Weight: 241.33. US Biological Life Sciences. | Worldwide |
| 1-(3-Bromopropyl)-1,3-dihydro-3-(1-methylethenyl)-2H-benzimidazol-2-one | 1-(3-Bromopropyl)-1,3-dihydro-3-(1-methylethenyl)-2H-benzimidazol-2-one is an intermediate in the synthesis of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier. Group: Biochemicals. Grades: Highly Purified. CAS No. 864267-63-0. Pack Sizes: 100mg, 1g. Molecular Formula: C13H15BrN2O. US Biological Life Sciences. | Worldwide |
| 1-(Isobutyryloxy) Ethyl 3-Oxo-2-azaspiro[4,5]decane-2-carboxylate | 1-(Isobutyryloxy) Ethyl 3-Oxo-2-azaspiro[4,5]decane-2-carboxylate is derived from Gabapentin (G117250), which is an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 50mg. Molecular Formula: C16H25NO5, Molecular Weight: 311.37. US Biological Life Sciences. | Worldwide |
| 1-Methyl-1,8-diazaspiro[4.5]decane Dihydrochloride | 1-Methyl-1,8-diazaspiro[4.5]decane Dihydrochloride is used in the image-guided synthesis of potent blood-brain barrier permeable histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1432679-85-0. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H18N2; HCi, Molecular Weight: 154.252364599999. US Biological Life Sciences. | Worldwide |
| 1-O-Hexylglycerol | 1-O-Hexylglycerol is used as a green solvo-surfactant. It can also enhance the blood-brain barrier permedability for cytostatic and antibiotic agents in rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 10305-38-1. Pack Sizes: 100mg, 500mg. Molecular Formula: C9H20O3, Molecular Weight: 176.25. US Biological Life Sciences. | Worldwide |
| 1-O-Hexylglycerol-d5 | 1-O-Hexylglycerol-d5 is labelled 1-O-Hexylglycerol (H297700) which is used as a green solvo-surfactant. It can also enhance the blood-brain barrier permedability for cytostatic and antibiotic agents in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C9H15D5O3, Molecular Weight: 181.28. US Biological Life Sciences. | Worldwide |
| 1-O-Propylglycerol | 1-O-Propylglycerol enhances the penetration of anticancer agents through the blood-brain barrier (BBB). It is also a constituent of hexadecyl phosphocholine (miltefosine) as an anticancer agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 61940-71-4. Pack Sizes: 500mg, 1g. Molecular Formula: C6H14O3. US Biological Life Sciences. | Worldwide |
| 1-O-Propylglycerol-d5 | 1-O-Propylglycerol-d5 is labelled 1-O-Propylglycerol (P837050) which enhances the penetration of anticancer agents through the blood-brain barrier (BBB). It is also a constituent of hexadecyl phosphocholine (miltefosine) as an anticancer agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6H9D5O3, Molecular Weight: 139.199999999999. US Biological Life Sciences. | Worldwide |
| 2- (2-Dimethylaminoethyl) pyridine | 2- (2-Dimethylaminoethyl) pyridine was used in the study of determining rapid calculation of polar molecular surface area in prediction of blood-brain barrier penetration. Group: Biochemicals. Grades: Highly Purified. CAS No. 6304-27-4. Pack Sizes: 250mg, 1g. Molecular Formula: C9H14N2, Molecular Weight: 150.22. US Biological Life Sciences. | Worldwide |
| 2,3,4,6-Tetra-O-methyl-D-glucose | 2,3,4,6-Tetra-O-methyl-D-glucose- a crucial and intricate biological substance. Its biomedical research applications are of utmost significance, often employed as a non-metabolizable analog of glucose and as a catalyst in the study of glucose transport across the blood-brain barrier. The substance is also adept in devising kinetic properties of transporters and their regulation, enabling us to explore new dimensions in our comprehension of glucose uptake in cells. Its profuse potential in delimiting the transport mechanism of the glucose transporters is unparalleled, making it a must-have in any biomedical laboratory. CAS No. 7506-68-5. Molecular formula: C10H20O6. Mole weight: 236.26. |  |
| 2-Amino-5-chloro Benzene sulfonamide | 2-Amino-5-chloro Benzene sulfonamide is a metabolite of IDRA-21 (I232500), which inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960). Group: Biochemicals. Grades: Highly Purified. CAS No. 5790-69-2. Pack Sizes: 500mg, 2.5g. Molecular Formula: C6H7ClN2O2S, Molecular Weight: 206.65. US Biological Life Sciences. | Worldwide |
| 2-Chlorohexadecanoic acid | 2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 19117-92-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-131688. |  |
| 2-? ( (Cyclohexanecarbony?l) ?oxy) ?acetic Acid | 2-? ( (Cyclohexanecarbony?l) ?oxy) ?acetic Acid (Gabapentin EP Impurity E; Gabapentin USP Related Compound E) is a metabolite of Gabapentin (G117250), amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant. Group: Biochemicals. Grades: Highly Purified. CAS No. 667465-00-1. Pack Sizes: 50mg, 500mg. Molecular Formula: C9H14O4, Molecular Weight: 186.21. US Biological Life Sciences. | Worldwide |
| 2-Oxo-2,3-dihydrobenzimidazole-1-carboxylic Acid tert-Butyl Ester | 2-Oxo-2,3-dihydrobenzimidazole-1-carboxylic Acid tert-Butyl Ester is an substituent in the synthesis of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier and is used as an anti-emetic agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 161468-45-7. Pack Sizes: 250mg, 500 mg. Molecular Formula: C12H14N2O3. US Biological Life Sciences. | Worldwide |
| 3-(3-Bromopropyl)-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic Acid 1,1-Dimethylethyl Ester | 3-(3-Bromopropyl)-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic Acid 1,1-Dimethylethyl Ester is an impurity of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier and is used as an anti-emetic agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 1148017-48-4. Pack Sizes: 5mg, 25mg. Molecular Formula: C15H19BrN2O3. US Biological Life Sciences. | Worldwide |
| 3-Aminobenzoic acid | 3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent targeting the tight junction (TJ) regulatory pathways in intestinal epithelial cells. 3-Aminobenzoic acid improves intestinal inflammation by enhancing intestinal barrier integrity and reducing epithelial permeability. It can be used in studies related to improving gut health. Additionally, 3-Aminobenzoic acid analogs can act as γ-aminobutyric acid transaminase ( GABA-AT ) inhibitors, exhibiting anticonvulsant effects [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: m-Aminobenzoic acid; 3ABA. CAS No. 99-05-8. Pack Sizes: 10 mM * 1 mL; 100 g. Product ID: HY-I0746. | |
| 3'-Azido-N6-benzoyl-5'-O-DMT-2',3'-dideoxyadenosine | 3'-Azido-N6-benzoyl-5'-O-DMT-2',3'-dideoxyadenosine, an esteemed biomedical marvel, boasts exceptional potency as an antiviral agent. With its unrivaled efficacy, this remarkable compound serves as a formidable weapon against the pernicious HIV, impeding its replication. Functioning as a nucleotide reverse transcriptase inhibitor, it disrupts the conversion of viral RNA to DNA, manifesting as a barrier to the proliferation of HIV. Grades: 95%. Molecular formula: C38H34N8O5. Mole weight: 682.73. | |
| 3-Methyl-2-buten-1-ol | 3-Methyl-2-buten-1-ol (MBO321) is an orally active endogenous metabolite found in pine trees and is used as a fragrance ingredient in cosmetics and detergents. 3-Methyl-2-buten-1-ol passes cell barrier. 3-Methyl-2-buten-1-ol reduces body weight in rats [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: MBO321. CAS No. 556-82-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W013035. | |
| 3-Nitropropionic Acid | A cell-permeable, irreversible inactivator (~3mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38mg/kg/day) is shown to cause activation of c-Jun kinase in striatum. Group: Biochemicals. Alternative Names: 3-NP, 3-NPA, 3NPA. Grades: Highly Purified. CAS No. 504-88-1. Pack Sizes: 50mg. Molecular Formula: C?H?NO?. US Biological Life Sciences. | Worldwide |
| 4-Amino-7-(2-deoxy-b-D-ribofuranosyl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one | 4-Amino-7-(2-deoxy-b-D-ribofuranosyl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one is a profound antiviral compound, predominantly used to study herpes simplex virus (HSV) and varicella-zoster virus (VZV). Acting as a barrier against viral DNA research and development, it meticulously obstructs the viruses' replication process. Synonyms: 4-Amino-7-(2-deoxy-b-D-erythro-pentofuranosyl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one. CAS No. 103173-80-4. Molecular formula: C11H14N4O4. Mole weight: 266.25. | |
| 4-Chloro Kynurenine-13C2,15N | 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application. Group: Biochemicals. Alternative Names: α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; (+/-)-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 4-Hydroperoxyifosfamide | 4-Hydroperoxyifosfamide is an anticancer agent that can penetrate the blood-brain barrier (BBB) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 39800-28-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-134228. | |
| 4-Phenylpiperidine-4-carboxylic acid | 4-Phenylpiperidine-4-carboxylic acid is used to prepare CB1 antagonists with lowered propensity to pass the blood-brain-barrier. It is also used to synthesize 4,4-disubstituted piperidines as NK1 antagonists. Synonyms: 4-Phenyl-4-piperidine carboxylic acid; Norpethidinic acid; 4-Phenyl-4-piperidinecarboxylic acid; 4-Piperidinecarboxylic acid, 4-phenyl-; Normeperidinic acid; N-Demthylmeperidinic acid. Grades: ≥ 98%. CAS No. 3627-45-0. Molecular formula: C12H15NO2. Mole weight: 205.25. | |
| 5-Methylresorcinol monohydrate | 5-Methylresorcinol monohydrate (Orcinol monohydrate) is a tyrosinase inhibitor. 5-Methylresorcinol monohydrate shows cytotoxicity. 5-Methylresorcinol monohydrate also is an oral active and cross the blood-brain barrier anxiolytic agent [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Orcinol monohydrate. CAS No. 6153-39-5. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-W015715. | |
| 5'-O-DMT-3'-TBDMS-N4-Acetyl-cytidine 2'-CE phosphoramidite | 5'-O-DMT-3'-TBDMS-N4-Acetyl-cytidine 2'-CE phosphoramidite, a revolutionary advancement in biomedicine, defies conventional limitations. Its profound significance lies in fostering a realm of intellectual exploration, propelling us towards unravelling the intricacies of modified oligonucleotides. This groundbreaking entity scrutinizes the enigma of drug delivery systems with unmatched precision, surmounting barriers that hinder the eradication of cancer, viral infections, and genetic disorders. Synonyms: 3'-TBDMS-Ac-rC Phosphoramidite. Grades: ≥97% by HPLC. Molecular formula: C47H64N5O9PSi. Mole weight: 902.11. | |
| 6-Deoxy-D-glucose | 6-Deoxy-D-glucose is a synthetic glucose molecule that cannot be metabolized by cells, making it useful in scientific research for studying glucose uptake and metabolism. It has also been investigated as a potential cancer treatment by inhibiting glycolysis and inducing cell death in cancer cells. Its ability to penetrate the blood-brain barrier also makes it a candidate for imaging brain glucose metabolism in neurodegenerative diseases such as Alzheimer's. Synonyms: Quinovose D-Isorhamnose Epifucose. CAS No. 7658-8-4. Molecular formula: C6H12O5. Mole weight: 164.16. | |
| 6'''-Feruloylspinosin | 6'''-Feruloylspinosin is a flavonoid isolated from seeds of Ziziphus jujuba. 6'''-Feruloylspinosin can across the blood-brain barrier and enhance the expression of GABAAα1, GABAAα5, and GABABR1 mRNA in rat hippocampal neurons [1]. Uses: Scientific research. Group: Natural products. CAS No. 77690-92-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2160. | |
| 6-Methoxyflavanone | 6-Methoxyflavanone (6-MeOF) is an orally active flavonoid compound. 6-Methoxyflavanone has anxiolytic properties. 6-Methoxyflavanone targets unique sites on GABA-A receptors, different from traditional benzodiazepines. 6-Methoxyflavanone can be used to study anxiety disorders. 6-Methoxyflavanone readily crosses the blood brain barrier (BBB) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 6-MeOF. CAS No. 3034-4-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-N8852. | |
| 6PPD-Q | 6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2 , CNR1 , AA2AR , LCAT , and TRPA1 , with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 6PPD-Quinone. CAS No. 2754428-18-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153169. | |
| A - 971432 | This active molecular is a selective S1P5 (Sphingosine-1-Phosphate Receptor 5) agonist originated by AbbVie for the treatment of neurodegenerative disorders. A 971432 is highly selective for S1P5 with IC50 value of 6 nM for S1P5, 362 nM for S1P1 and >10 μM for S1P3. A 971432 improves blood-brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice. S1P5 agonists have been reported as an innovative mechanism for the treatment of neurodegenerative disorders including Alzheimer's disease and lysosomal storage disorders such as Niemann-Pick disease. Uses: Neurodegenerative disorder;lysosomal storage disorders. Synonyms: A971432; A 971432; 1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic Acid. Grades: 95%. CAS No. 1240308-45-5. Molecular formula: C18H17Cl2NO3. Mole weight: 366.24. | |
| A-971432 | A-971432 is a potent, selective and orally active sphingosine-1-phosphate (S1P) receptor 5 agonist with IC 50 s of.362, >10, 0.006 μM for S1P1, S1P3, S1P5 respectively. A-971432 protects blood - brain barrier (BBB) homeostasis. A-971432 reverses age-related cognitive decline. A-971432 has the potential for the research of alzheimers disease or multiple sclerosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1240308-45-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-110291. | |
| AA147 | AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 393121-74-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124293. | |
| Abacavir | Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 136470-78-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-17423. | |
| Abacavir sulfate | Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abacavir Hemisulfate; ABC sulfate. CAS No. 188062-50-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17423A. | |
| Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide | Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide is an analog of product H-4876 with small chemical modifications which enhance its stability against proteolytic degradation. It is a β-sheet breaker peptide that crosses the blood-brain barrier faster than most known proteins and peptides selectively absorbed by the brain, so it is assumed that the peptide is specifically transported to the brain. Synonyms: iAβ5p; Ac-LPFFD-NH2; N-acetyl-L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-isoasparagine; L-α-Asparagine, N-acetyl-L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-. Grades: ≥95%. CAS No. 339990-02-2. Molecular formula: C35H46N6O8. Mole weight: 678.78. | |
| a-Chaconine | a-Chaconine is a genotoxic agent that inhibits the production of energy through mitochondrial electron transport and ATP synthesis. It binds to the matrix effect, which is a protective barrier against the passage of toxic substances from blood to other organs. This compound also has anti-inflammatory effects and is used in vitro assays for assessing the effects of chemical compounds on cell growth. a-Chaconine has been shown to inhibit acetylcholinesterase activity in rats, leading to acute toxicities such as respiratory depression. This compound also causes DNA strand breaks in vitro, and can be detected using polymerase chain reaction (PCR) analysis. Group: Other alkaloids. Alternative Names: (3b)-Solanid-5-en-3-yl O-6-deoxy-a-L-mannopyranosyl-(1-2)-O-(6-deoxy-a-L-mannopyranosyl-(1-4))-b-D-glucopyranoside. CAS No. 20562-03-2. Molecular formula: C45H73NO14. Mole weight: 852.06 g/mol. Canonical SMILES: C[C@H]1CC[C@@H]2[C@H] ([C@H]3[C@@H] (N2C1)C[C@@H]4[C@@]3 (CC[C@H]5[C@H]4CC=C6[C@@]5 (CC[C@@H] (C6)O[C@H]7[C@@H] ([C@H] ([C@@H] ([C@H] (O7)CO)O[C@H]8[C@@H] ([C@@H] ([C@H] ([C@@H] (O8)C)O)O)O)O)O[C@H]9[C@@H] ([C@@H] ([C@H] ([C@@H] (O9)C)O)O)O)C)C)C. Catalog: ACM20562032. |  |
| Acivicin | Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: AT-125; U-42126. CAS No. 42228-92-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W016586. | |
| Acivicin | Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties. Group: Inhibitors. Alternative Names: (alpha-s, 5s)-alpha-amino-3-chloro-4, 5-dihydro-5-isoxazoleaceticacid; (s-(r*, r*))-4, 5-dihydro-alpha-amino-3-chloro-5-isoxazoleaceticacid; 4, 5-dihydro-alpha-amino-3-chloro-, (s-(r*, r*))-5-isoxazoleaceticaci; acivicine; antibioticat125; nsc-163501; AT-125; ALPHA-AMINO-3-CHLORO-4, 5-DIHYDRO-5-ISOXAZOLEACETIC ACID. CAS No. 42228-92-2. Molecular formula: C5H7ClN2O3. Mole weight: 178.57. Appearance: Solid. Canonical SMILES: ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1. Catalog: ACM42228922. | |
| Acivicin hydrochloride | Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus , is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: AT-125 hydrochloride; U-42126 hydrochloride. CAS No. 161922-40-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W016586A. | |
| Adenosine A1 Receptor Antagonist I, DPCPX (8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948) | A blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9nM, 130nM, 1.0uM, 4.0uM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 102146-07-6. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?, Primary Target: A1. US Biological Life Sciences. | Worldwide |
| Adenosine A2A/A1 Receptor Antagonist (2-Amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]-pyrimidin-5-one, diHCl) | A blood-brain barrier-permeant indenopyrimidinone that acts as a dual A1/A2A antagonist (Ki = 48.2 and 6.5nM, respectively, against agonist-induced cAMP response in A1- or A2A-expressing CHO-K1 cells) and effectively reverses D2 antagonist haloperidol- (1mg/kg; s.c.) induced catalepsy in both rats and mice (ED50 = 0.3 and <0.1mg/kg, respectively) in vivo by simultaneously reversing A1-mediated inhibition of DA (Dopamine) release and A2A-dependent inhibition of D2 receptor response to DA. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Akt Activator II, SC79 (Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate) | A cell-permeable and blood-brain barrier permeant HA14-1 analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4ug/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4ug/ml) in vitro and in a murine MCAO model (40mg/kg, i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 305834-79-1. Pack Sizes: 25mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
| Allura Red AC | Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine ( 5-HT ) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: FD&C RED NO. 40; CI 16035. CAS No. 25956-17-6. Pack Sizes: 50 mg; 100 mg. Product ID: HY-123630. | |
| Allylamine dihydrogen phosphate | Polyallylamine hydrochloride is a cationic polyelectrolyte prepared by the polymerization of allylamine. Uses: Poly(allylamine hydrochloride) has many biomedical applications. the most prominent use of this polyelectrolyte is in the field of cell encapsulation. a layer by layer method is used by alternating positively and negatively charged polyelectrolytes to build a barrier between the cell and the harsher outside environment. upon cell lysis, the capsule of layered polyelectrolytes maintains its structural integrity and can be used for purposes such as drug delivery. Group: Heterocyclic organic compoundallyl monomers. Alternative Names: phosphoricacid; prop-2-en-1-amine. CAS No. 121092-93-1. Molecular formula: C3H10NO4P. Mole weight: 155.09 g/mol. Purity: 0.95. IUPACName: phosphoric acid;prop-2-en-1-amine. Canonical SMILES: NCC=C.OP(O)(O)=O. Catalog: ACM-MO-121092931. | |
| Aloin-A | Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Barbaloin-A. CAS No. 1415-73-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N0123. | |
| α-Thujone | α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC 50 for α-Thujone is 21 μM in suppressing the GABA -induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and easily penetrates the blood-brain barrier [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 546-80-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121618. | |
| Anatibant hydrochloride | Anatibant (LF 16-0687; XY-2405) hydrochloride is a selective non-peptide bradykinin B2 receptor antagonist. Anatibant hydrochloride binds to the human, rat and guinea-pig recombinant B2 receptor with K i values of 0.67 nM, 1.74 nM and 1.37 nM, respectively. Anatibant hydrochloride crosses the blood-brain barrier (BBB). Anatibant hydrochloride can be used in research on brain damage diseases [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LF 16-0687 hydrochloride; XY-2405 hydrochloride. CAS No. 209788-45-4. Pack Sizes: 1 mg. Product ID: HY-121156A. | |
| ANG1005 | ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: GRN1005; Paclitaxel trevatide. CAS No. 1075214-55-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4073. | |
| Antalarmin | Antalarmin is a selective nonpeptide corticotropin-releasing factor receptor 1 ( CRHR1 ) antagonist with a K i of 2.7 nM. Antalarmin can pass through the blood - brain barrier [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 157284-96-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-124475. | |
| Antihistamine-1 | Antihistamine-1 is a H1-antihistamine ( K i =6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC 50 s of 5.4 and 0.8 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186430-60-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100238. | |
| APE1 Inhibitor III (Apurinic Endonuclease 1 Inhibitor III) (Apurinic/Apyrimidinic Endonuclease 1 Inhibitor III)(N-(3-(1,3-Benzo[d]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide) | A cell-permeable benzothiazolyltetra hydrothienopyridine compound that acts as a potent, competitive, and active site targeting inhibitor of APE1 (IC50=2.0uM in a fluorescence based HTS assay; and 12uM in a radiotracer incision assay). Shown to block APE1 activity in HEK293T and HeLa cells extract (IC50=600nM) and increase genomic AP site accumulation. Potentiates the cytotoxicity of DNA-damaging alkylating agents in HeLa cells by ~3-fold. Exhibits favorable pharmacokinetic properties and desirable ADME attributes. Due to its lipophilic nature, it crosses the blood-brain barrier rather easily and shows desirable stability (t1/2=80min). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Arecoline-d5, Hydrobromide Salt (1,2,5,6-Tetrahydro-1-(methyl-d3)-3-pyridine-2,6-d2-carboxylic Acid, Methyl Ester Hydrobromide) | Labelled Arecoline, which is reported to be a cholinergic agonist that readily crosses the blood-brain barrier. Group: Biochemicals. Alternative Names: 1,2,5,6-Tetrahydro-1-(methyl-d3)-3-pyridine-2,6-d2-carboxylic Acid, Methyl Ester Hydrobromide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| ARN2966 | ARN2966, also called 2-PMAP, as a Amyloid-β inhibitor, is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: 2-(pyridin-2-ylmethylamino)phenol; 2-PMAP; ARN2966; ARN-2966; Phenol, 2-[(2-pyridinylmethyl)amino]-; 102212-26-0; AGN-PC-0031SD; GTPL7530; 2-(2-Pyridylmethylamino)phenol; SCHEMBL10886688; AOB1080; SYN5152; 2-(pyridin-2-ylmethylamino)phenol; 3970AH; ZINC34411048; AKOS022987680; CS-3335; HY-18292; ARN-2966; CS 3335; HY 18292; ARN 2966; CS3335; HY18292; ARN2966. Grades: > 98%. CAS No. 102212-26-0. Molecular formula: C12H12N2O. Mole weight: 200.24. | |
| Artemether | Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.Target: AntiparasiticArtemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. Artemether exhibits the highest activity against juvenile stages of the parasites, while adult worms are significantly less susceptible. There was no indication of neurotoxicity following repeated high doses of artemether given fortnightly for up to 5 months. Artemether-integrated with other control strategies-has considerable potential for reducing the current burden of schistosomiasis in different epidemiological settings. There were remarkably inhibitory effects of artmeter on brain glioma growth and angiogenesis in SD rats and the mechanism that artemether inhibited brain glioma growth might be penetrating the blood-brain barrier and inhibiting angiogenesis. Group: Inhibitors. CAS No. 71963-77-4. Molecular formula: C16H26O5. Mole weight: 298.37. Appearance: Solid. Purity: 0.98. Canonical SMILES: C[C@H]1[C@@H] (OC)O[C@@]2 ([H])[C@]34[C@@] ([C@H] (C)CC[C@]41[H]) ([H])CC[C@@] (O2) (C)OO3. Catalog: ACM71963774. | |
| Asiatic acid | Asiatic acid, a pentacyclic triterpene found in Centella asiatica ( Centella asiatica ), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 464-92-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0194. | |
| Asimadoline hydrochloride | Asimadoline (EMD-61753) hydrochloride is an orally active, selective and peripherally active κ-opioid agonist with IC 50 s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline hydrochloride has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline hydrochloride ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EMD-61753 hydrochloride. CAS No. 185951-07-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-107384A. | |
| AZ32 | AZ32 is an orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) that radiosensitizes intracranial gliomas in mice. AZ32 was highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. Group: Inhibitors. Alternative Names: AZ32; AZ-32; AZ 32. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.38. Appearance: Solid powder. Purity: >98%. IUPACName: N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Canonical SMILES: O=C (NC)C (C=C1)=CC=C1C2=CN=C3C=NC (C4=CC=CC=C4)=CN32. Catalog: ACM2288709964. | |
| AZ32 | AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with IC50 of <6.2 nM for ATM enzyme and IC50 of 0.31 μM for ATM in cell. AZ32 is tolerated in C57Bl6 and Nude mice dosed orally at 200mg/kg which was efficacious in orthotopic mouse models. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. It also shows adequate selectivity over ATR and also has high cell permeability. Synonyms: AZ-32; AZ 32; N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Grades: ≥98%. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.37. | |
| AZD1390 | AZD1390 is a first-in-class, orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. It can be used to cross the blood-brain barrier suitable for the treatment of intracranial malignancies. Synonyms: AZD-1390; AZD 1390. Grades: ≥98%. CAS No. 2089288-03-7. Molecular formula: C27H32FN5O2. Mole weight: 477.57. | |
| AZD 2066 | AZD-2066 is a selective, orally active and blood-brain barrier-permeating mGluR5 antagonist. AZD 2066 activates the BDNF/trkB signaling pathway. AZD 2066 can be used in the research of neuropathic pain, major depressive disorder and gastroesophageal reflux disease [1] [2] [3] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 934282-55-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-110255. | |
| AZD3293 | AZD3293, a spiro compound, has been found to be a β-secretase inhibitor that has good blood-brain barrier penetration and could probably be significant in studies of Alzheimer's disease. It was just planed a Phase III trial in several areas. IC50: 0.2 nM. Synonyms: AZD-3293; AZD 3293; AZD3293; LY3314814; GTPL7789; LY 3314814; GTPL 7789; LY-3314814; GTPL-7789; SCHEMBL9948271; (1r,4r)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine. Grades: 98%. CAS No. 1628076-74-3. Molecular formula: C26H28N4O. Mole weight: 412.53. | |
| Baclofen | Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA B receptor (GABA B R) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABA B receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1134-47-0. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-B0007. | |
| Baclofen-d4 | Baclofen-d 4 is the deuterium labeled Baclofen. Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research[1][2][3]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1189938-30-4. Pack Sizes: 1 mg. Product ID: HY-B0007S. | |
| Bexarotene (4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic Acid) | A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce AB40 and AB42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6h and 50% reduction in 72h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of AB proteases, insulin degrading enzyme, and neprilysin. Group: Biochemicals. Grades: Highly Purified. CAS No. 153559-49-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Bezisterim | Bezisterim (HE 3286; NE-3107) is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. Bezisterim is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim freely penetrates the blood brain barrier in mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis [1] [2] [3]. Bezisterim is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HE 3286; NE-3107. CAS No. 1001100-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108039. | |
| Bilirubin Conjugate, Sodium Salt | Bilirubin conjugate is a stable, water-soluble ditaurate derivative of bilirubin meant to mimic endogenous bilirubin glucuronide derivatives. In vivo, bilirubin circulates in the plasma and is taken up by hepatocytes and conjugated to one or two glucuronic acids in a reaction catalyzed by UDP glucuronidase to form bilirubin mono or diglucuronide. This water-soluble form is then excreted from the liver in bile in the feces or is converted to urobilinogen and excreted in the urine. In addition to aiding in the disposal of heme, bilirubin and its conjugated derivatives have been shown to exhibit anti-oxidant and antimutagenic effects and to play a role in gut barrier function.1,2. Group: Molecular Biology. Alternative Names: 2,2'-[(2,17-diethenyl-1,10,11,19,22,23-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-diyl)bis[(1-oxo-3,1-propanediyl)imino]]bis-ethanesulfonic acid, disodium salt; Bilirubin Ditaurate. Grades: Molecular Biology Grade. CAS No. 68683-34-1. Molecular Formula: C37H44N6O10S2Na2, Molecular Weight: 842.91. US Biological Life Sciences. | Worldwide |
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