Barrier Suppliers USA
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Product | Description | |
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GRAPHENE NANOPLATELETS ENHANCED FOR BARRIER PROPERTIES Quick inquiry Where to buy Suppliers range | Higher electronic conductivity compared to conventional carbon inksReduced cost compared to other conductive inksHigh printing capacity and moderate drying condition. Uses: Packaging; Sports Equipment and Toys; Rubber and Plastic; Automobile; Aerospace and Defense. Product ID: ACMA00020913. Appearance: Black /Grey Powder. | |
1, 1, 2, 2-Tetra hydroperfluorodecanol Quick inquiry Where to buy Suppliers range | 1, 1, 2, 2-Tetra hydroperfluorodecanol is applied to the formation of a barrier and self-healing coating on zinc metal materials. This compound has also been seen to induce cell death and formation of oxidative or reactive oxygen species in cerebellar granule cells. Group: Biochemicals. Alternative Names: 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 9, 9, 10, 10, 10-Heptadecafluoro-1-decanol; (Perfluorooctyl) ethanol; 1, 1, 2, 2-Tetra hydroheptadecafluoro decanol; 1, 1, 2, 2-Tetra hydroperfluorodecan-1-ol; 1, 1, 2, 2-Tetra hydroperfluorodecanol; 1, 1, 2, 2-Tetra hydroperfluorodecyl Alcohol; 1H,1H,2H,2H-Perfluorodecan-1-ol; 1H,1H,2H,2H-Perfluorodecanol; 2- (Heptadecafluorooctyl) ethanol; 2- (Perfluorooctyl) ethanol; 2-(Perfluorooctyl)ethyl Alcohol; 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 9, 9, 10, 10, 10-Heptadecafluoro-1-decanol; 8-2 Fluorotelomer alc.; 8-2 Fluorotelomer alcohol; 8-2 Telomer B alcohol; 8:2 FTOH; A 1820; C 1820; Daikin A 1820; Fluowet EA 800; PFA 8; β - (Heptadecafluorooctyl) ethanol. Grades: Highly Purified. CAS No. 678-39-7. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
1,2-Distearoyl-3-oleoyl-rac-glycerol Quick inquiry Where to buy Suppliers range | 1,2-Distearoyl-3-oleoyl-rac-glycerol is used in the study of leptin resistance at the blood-brain barrier. Group: Biochemicals. Grades: Highly Purified. CAS No. 2190-29-6. Pack Sizes: 50mg, 500mg. Molecular Formula: C57H108O6, Molecular Weight: 889.46. US Biological Life Sciences. | Worldwide |
1,2-Distearoyl-3-oleoyl-rac-glycerol-d5 Quick inquiry Where to buy Suppliers range | 1,2-Distearoyl-3-oleoyl-rac-glycerol-d5 is labelled 1,2-Distearoyl-3-oleoyl-rac-glycerol (D493520) which is used in the study of leptin resistance at the blood-brain barrier. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C57H103D5O6, Molecular Weight: 894.49. US Biological Life Sciences. | Worldwide |
1- [ [ (2-Methyl-1-oxopropyl) amino] methyl] cyclohexaneacetic Acid Quick inquiry Where to buy Suppliers range | 1- [ [ (2-Methyl-1-oxopropyl) amino] methyl] cyclohexaneacetic Acid is derived from Gabapentin (G117250), which is an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant. Also, it is an impurity formed in the synthesis of [1-[[ (α -isobutanoyloxyethoxy) carbonyl]aminomethyl]-1-cyclohexane Acetic Acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 1281568-83-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C13H23NO3, Molecular Weight: 241.33. US Biological Life Sciences. | Worldwide |
1-(3-Bromopropyl)-1,3-dihydro-3-(1-methylethenyl)-2H-benzimidazol-2-one Quick inquiry Where to buy Suppliers range | 1-(3-Bromopropyl)-1,3-dihydro-3-(1-methylethenyl)-2H-benzimidazol-2-one is an intermediate in the synthesis of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier. Group: Biochemicals. Grades: Highly Purified. CAS No. 864267-63-0. Pack Sizes: 100mg, 1g. Molecular Formula: C13H15BrN2O. US Biological Life Sciences. | Worldwide |
1% Hyaluronic acid in water with Phenoxyethanol Quick inquiry Where to buy Suppliers range | 1% hyaluronic acid in water with Phenoxyethanol is a commonly used skincare product ingredient. Hyaluronic acid is a natural compound found in the body that acts as a humectant, which means it draws and retains moisture to the skin. This makes it a great ingredient for hydration and strengthening the skin's barrier function. Phenoxyethanol is a preservative that helps to prevent bacterial and fungal growth in the product. It also helps to extend the shelf life of the product. Together, these ingredients create a moisturizing and protective product that can help to reduce the appearance of fine lines and wrinkles, and improve overall skin texture and tone. Group: Skin Actives. Product ID: ACMA00029467. Appearance: clear, colorless liquid that has a slightly thick consistency. | |
1-(Isobutyryloxy) Ethyl 3-Oxo-2-azaspiro[4,5]decane-2-carboxylate Quick inquiry Where to buy Suppliers range | 1-(Isobutyryloxy) Ethyl 3-Oxo-2-azaspiro[4,5]decane-2-carboxylate is derived from Gabapentin (G117250), which is an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 50mg. Molecular Formula: C16H25NO5, Molecular Weight: 311.37. US Biological Life Sciences. | Worldwide |
1-Methyl-1,8-diazaspiro[4.5]decane Dihydrochloride Quick inquiry Where to buy Suppliers range | 1-Methyl-1,8-diazaspiro[4.5]decane Dihydrochloride is used in the image-guided synthesis of potent blood-brain barrier permeable histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1432679-85-0. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H18N2; HCi, Molecular Weight: 154.252364599999. US Biological Life Sciences. | Worldwide |
1-O-Hexylglycerol Quick inquiry Where to buy Suppliers range | 1-O-Hexylglycerol is used as a green solvo-surfactant. It can also enhance the blood-brain barrier permedability for cytostatic and antibiotic agents in rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 10305-38-1. Pack Sizes: 100mg, 500mg. Molecular Formula: C9H20O3, Molecular Weight: 176.25. US Biological Life Sciences. | Worldwide |
1-O-Hexylglycerol-d5 Quick inquiry Where to buy Suppliers range | 1-O-Hexylglycerol-d5 is labelled 1-O-Hexylglycerol (H297700) which is used as a green solvo-surfactant. It can also enhance the blood-brain barrier permedability for cytostatic and antibiotic agents in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C9H15D5O3, Molecular Weight: 181.28. US Biological Life Sciences. | Worldwide |
1-O-Propylglycerol Quick inquiry Where to buy Suppliers range | 1-O-Propylglycerol enhances the penetration of anticancer agents through the blood-brain barrier (BBB). It is also a constituent of hexadecyl phosphocholine (miltefosine) as an anticancer agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 61940-71-4. Pack Sizes: 500mg, 1g. Molecular Formula: C6H14O3. US Biological Life Sciences. | Worldwide |
1-O-Propylglycerol-d5 Quick inquiry Where to buy Suppliers range | 1-O-Propylglycerol-d5 is labelled 1-O-Propylglycerol (P837050) which enhances the penetration of anticancer agents through the blood-brain barrier (BBB). It is also a constituent of hexadecyl phosphocholine (miltefosine) as an anticancer agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6H9D5O3, Molecular Weight: 139.199999999999. US Biological Life Sciences. | Worldwide |
2- (2-Dimethylaminoethyl) pyridine Quick inquiry Where to buy Suppliers range | 2- (2-Dimethylaminoethyl) pyridine was used in the study of determining rapid calculation of polar molecular surface area in prediction of blood-brain barrier penetration. Group: Biochemicals. Grades: Highly Purified. CAS No. 6304-27-4. Pack Sizes: 250mg, 1g. Molecular Formula: C9H14N2, Molecular Weight: 150.22. US Biological Life Sciences. | Worldwide |
2,3,4,6-Tetra-O-methyl-D-glucose Quick inquiry Where to buy Suppliers range | 2,3,4,6-Tetra-O-methyl-D-glucose- a crucial and intricate biological substance. Its biomedical research applications are of utmost significance, often employed as a non-metabolizable analog of glucose and as a catalyst in the study of glucose transport across the blood-brain barrier. The substance is also adept in devising kinetic properties of transporters and their regulation, enabling us to explore new dimensions in our comprehension of glucose uptake in cells. Its profuse potential in delimiting the transport mechanism of the glucose transporters is unparalleled, making it a must-have in any biomedical laboratory. CAS No. 7506-68-5. Molecular formula: C10H20O6. Mole weight: 236.26. | |
2,6-Dichlorobenzonitrile Quick inquiry Where to buy Suppliers range | 2,6-Dichlorobenzonitrile. Group: Heterocyclic Organic Compound. Alternative Names: SILBENIL;NIAGARA 5006;2,6-DICHLOROBENZONITRILE;AKOS BBS-00004654;BARRIER;LGC (1113);H-133;CASORON. CAS No. 1194-65-6. Molecular formula: C7H3Cl2N. Mole weight: 172.01. Symbol: GHS07,GHS09. Boiling Point: 270-275°C. Melting Point: 143-146°C(lit.). Flash Point: 270°C. Safty Description: 36/37-61. Hazard statements: Xn, N, T, Xi. Supplemental Hazard Statements: H312-H411. | |
2-Amino-5-chloro Benzene sulfonamide Quick inquiry Where to buy Suppliers range | 2-Amino-5-chloro Benzene sulfonamide is a metabolite of IDRA-21 (I232500), which inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960). Group: Biochemicals. Grades: Highly Purified. CAS No. 5790-69-2. Pack Sizes: 500mg, 2.5g. Molecular Formula: C6H7ClN2O2S, Molecular Weight: 206.65. US Biological Life Sciences. | Worldwide |
2-? ( (Cyclohexanecarbony?l) ?oxy) ?acetic Acid Quick inquiry Where to buy Suppliers range | 2-? ( (Cyclohexanecarbony?l) ?oxy) ?acetic Acid (Gabapentin EP Impurity E; Gabapentin USP Related Compound E) is a metabolite of Gabapentin (G117250), amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant. Group: Biochemicals. Grades: Highly Purified. CAS No. 667465-00-1. Pack Sizes: 50mg, 500mg. Molecular Formula: C9H14O4, Molecular Weight: 186.21. US Biological Life Sciences. | Worldwide |
2-Oxo-2,3-dihydrobenzimidazole-1-carboxylic Acid tert-Butyl Ester Quick inquiry Where to buy Suppliers range | 2-Oxo-2,3-dihydrobenzimidazole-1-carboxylic Acid tert-Butyl Ester is an substituent in the synthesis of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier and is used as an anti-emetic agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 161468-45-7. Pack Sizes: 250mg, 500 mg. Molecular Formula: C12H14N2O3. US Biological Life Sciences. | Worldwide |
3-(3-Bromopropyl)-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic Acid 1,1-Dimethylethyl Ester Quick inquiry Where to buy Suppliers range | 3-(3-Bromopropyl)-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic Acid 1,1-Dimethylethyl Ester is an impurity of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier and is used as an anti-emetic agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 1148017-48-4. Pack Sizes: 5mg, 25mg. Molecular Formula: C15H19BrN2O3. US Biological Life Sciences. | Worldwide |
3'-Azido-N6-benzoyl-5'-O-DMT-2',3'-dideoxyadenosine Quick inquiry Where to buy Suppliers range | 3'-Azido-N6-benzoyl-5'-O-DMT-2',3'-dideoxyadenosine, an esteemed biomedical marvel, boasts exceptional potency as an antiviral agent. With its unrivaled efficacy, this remarkable compound serves as a formidable weapon against the pernicious HIV, impeding its replication. Functioning as a nucleotide reverse transcriptase inhibitor, it disrupts the conversion of viral RNA to DNA, manifesting as a barrier to the proliferation of HIV. Grades: 95%. Molecular formula: C38H34N8O5. Mole weight: 682.73. | |
3-Nitropropionic Acid Quick inquiry Where to buy Suppliers range | A cell-permeable, irreversible inactivator (~3mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38mg/kg/day) is shown to cause activation of c-Jun kinase in striatum. Group: Biochemicals. Alternative Names: 3-NP, 3-NPA, 3NPA. Grades: Highly Purified. CAS No. 504-88-1. Pack Sizes: 50mg. Molecular Formula: C?H?NO?. US Biological Life Sciences. | Worldwide |
4-Amino-7-(2-deoxy-b-D-ribofuranosyl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one Quick inquiry Where to buy Suppliers range | 4-Amino-7-(2-deoxy-b-D-ribofuranosyl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one is a profound antiviral compound, predominantly used to study herpes simplex virus (HSV) and varicella-zoster virus (VZV). Acting as a barrier against viral DNA research and development, it meticulously obstructs the viruses' replication process. Synonyms: 4-Amino-7-(2-deoxy-b-D-erythro-pentofuranosyl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one. CAS No. 103173-80-4. Molecular formula: C11H14N4O4. Mole weight: 266.25. | |
4-Chloro Kynurenine-13C2,15N Quick inquiry Where to buy Suppliers range | 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application. Group: Biochemicals. Alternative Names: α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; (+/-)-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
4-Phenylpiperidine-4-carboxylic acid Quick inquiry Where to buy Suppliers range | 4-Phenylpiperidine-4-carboxylic acid is used to prepare CB1 antagonists with lowered propensity to pass the blood-brain-barrier. It is also used to synthesize 4,4-disubstituted piperidines as NK1 antagonists. Synonyms: 4-Phenyl-4-piperidine carboxylic acid; Norpethidinic acid; 4-Phenyl-4-piperidinecarboxylic acid; 4-Piperidinecarboxylic acid, 4-phenyl-; Normeperidinic acid; N-Demthylmeperidinic acid. Grades: ≥ 98%. CAS No. 3627-45-0. Molecular formula: C12H15NO2. Mole weight: 205.25. | |
5'-O-DMT-3'-TBDMS-N4-Acetyl-cytidine 2'-CE phosphoramidite Quick inquiry Where to buy Suppliers range | 5'-O-DMT-3'-TBDMS-N4-Acetyl-cytidine 2'-CE phosphoramidite, a revolutionary advancement in biomedicine, defies conventional limitations. Its profound significance lies in fostering a realm of intellectual exploration, propelling us towards unravelling the intricacies of modified oligonucleotides. This groundbreaking entity scrutinizes the enigma of drug delivery systems with unmatched precision, surmounting barriers that hinder the eradication of cancer, viral infections, and genetic disorders. Synonyms: 3'-TBDMS-Ac-rC Phosphoramidite. Grades: ≥97% by HPLC. Molecular formula: C47H64N5O9PSi. Mole weight: 902.11. | |
6-Deoxy-D-glucose Quick inquiry Where to buy Suppliers range | 6-Deoxy-D-glucose is a synthetic glucose molecule that cannot be metabolized by cells, making it useful in scientific research for studying glucose uptake and metabolism. It has also been investigated as a potential cancer treatment by inhibiting glycolysis and inducing cell death in cancer cells. Its ability to penetrate the blood-brain barrier also makes it a candidate for imaging brain glucose metabolism in neurodegenerative diseases such as Alzheimer's. Synonyms: Quinovose D-Isorhamnose Epifucose. CAS No. 7658-8-4. Molecular formula: C6H12O5. Mole weight: 164.16. | |
A - 971432 Quick inquiry Where to buy Suppliers range | This active molecular is a selective S1P5 (Sphingosine-1-Phosphate Receptor 5) agonist originated by AbbVie for the treatment of neurodegenerative disorders. A 971432 is highly selective for S1P5 with IC50 value of 6 nM for S1P5, 362 nM for S1P1 and >10 μM for S1P3. A 971432 improves blood-brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice. S1P5 agonists have been reported as an innovative mechanism for the treatment of neurodegenerative disorders including Alzheimer's disease and lysosomal storage disorders such as Niemann-Pick disease. Uses: Neurodegenerative disorder;lysosomal storage disorders. Synonyms: A971432; A 971432; 1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic Acid. Grades: 95%. CAS No. 1240308-45-5. Molecular formula: C18H17Cl2NO3. Mole weight: 366.24. | |
Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide Quick inquiry Where to buy Suppliers range | Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide is an analog of product H-4876 with small chemical modifications which enhance its stability against proteolytic degradation. It is a β-sheet breaker peptide that crosses the blood-brain barrier faster than most known proteins and peptides selectively absorbed by the brain, so it is assumed that the peptide is specifically transported to the brain. Synonyms: iAβ5p; Ac-LPFFD-NH2; N-acetyl-L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-isoasparagine; L-α-Asparagine, N-acetyl-L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-. Grades: ≥95%. CAS No. 339990-02-2. Molecular formula: C35H46N6O8. Mole weight: 678.78. | |
Acrylates Copolymer Quick inquiry Where to buy Suppliers range | Acrylates Copolymer is a type of polymer that is commonly used in many cosmetic products. It is a water-soluble polymer made up of several different monomers, including methyl methacrylate and butyl acrylate. Acrylates copolymer is added to cosmetic products to help them thicken, stabilize, and provide a smooth texture. Some of the cosmetic products that may contain acrylates copolymer include hairsprays, nail polishes, and lotions. In hairsprays, acrylates copolymer is used to help hold hair in place and provide a firm yet flexible hold. In nail polishes, acrylates copolymer is used to thicken the polish and help it adhere to the nail better. In lotions, acrylates copolymer is used to stabilize the emulsion, which allows the ingredients in the lotion to remain blended together. Uses: 1. Acrylates copolymer is commonly used as a thickening agent in personal care products such as lotions, creams, and gels. 2. It is also used in hair care products such as hair sprays, mousses, and styling gels to provide hold and volume to the hair. 3. Acrylates copolymer is used in sunscreen formulations to enhance the product's water resistance. 4. It is used in adhesives and sealants as a binding agent and to improve the adhesive properties of the product. 5. Acrylates copolymer is also used in paints and coatings as a film-forming agent, providing a protective barrier and enhancing the durability of the product. Group: Rheology Modifiers. Alternative Names: Polymer of one or more monomers of acrylic acid, methacrylic acid or one of their simple esters. CAS No. 25133-97-5. Product ID: ACM25133975. Molecular formula: C14H22O6. Mole weight: 286.32g/mol. IUPAC Name: ethyl prop-2-enoate;methyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid. Appearance: white or colorless powder. SMILES: CCOC(=O)C=C. CC(=C)C(=O)O. CC(=C)C(=O)OC. | |
Adenosine A1 Receptor Antagonist I, DPCPX (8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948) Quick inquiry Where to buy Suppliers range | A blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9nM, 130nM, 1.0uM, 4.0uM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 102146-07-6. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?, Primary Target: A1. US Biological Life Sciences. | Worldwide |
Adenosine A2A/A1 Receptor Antagonist (2-Amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]-pyrimidin-5-one, diHCl) Quick inquiry Where to buy Suppliers range | A blood-brain barrier-permeant indenopyrimidinone that acts as a dual A1/A2A antagonist (Ki = 48.2 and 6.5nM, respectively, against agonist-induced cAMP response in A1- or A2A-expressing CHO-K1 cells) and effectively reverses D2 antagonist haloperidol- (1mg/kg; s.c.) induced catalepsy in both rats and mice (ED50 = 0.3 and <0.1mg/kg, respectively) in vivo by simultaneously reversing A1-mediated inhibition of DA (Dopamine) release and A2A-dependent inhibition of D2 receptor response to DA. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Akt Activator II, SC79 (Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate) Quick inquiry Where to buy Suppliers range | A cell-permeable and blood-brain barrier permeant HA14-1 analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4ug/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4ug/ml) in vitro and in a murine MCAO model (40mg/kg, i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 305834-79-1. Pack Sizes: 25mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
Allylamine dihydrogen phosphate Quick inquiry Where to buy Suppliers range | Polyallylamine hydrochloride is a cationic polyelectrolyte prepared by the polymerization of allylamine. Uses: Poly(allylamine hydrochloride) has many biomedical applications. The most prominent use of this polyelectrolyte is in the field of cell encapsulation. A layer by layer method is used by alternating positively and negatively charged polyelectrolytes to build a barrier between the cell and the harsher outside environment. Upon cell lysis, the capsule of layered polyelectrolytes maintains its structural integrity and can be used for purposes such as drug delivery. Group: Allylamine Hydrophilic Polymers. Alternative Names: Allylamine dihydrogen phosphate, 121092-93-1. CAS No. 121092-93-1. IUPAC Name: phosphoric acid;prop-2-en-1-amine. Molecular Weight: 155.09. Molecular Formula: C3H7N · H3PO4. SMILES: NCC=C.OP(O)(O)=O. Flash Point: 95%. | |
APE1 Inhibitor III (Apurinic Endonuclease 1 Inhibitor III) (Apurinic/Apyrimidinic Endonuclease 1 Inhibitor III)(N-(3-(1,3-Benzo[d]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide) Quick inquiry Where to buy Suppliers range | A cell-permeable benzothiazolyltetra hydrothienopyridine compound that acts as a potent, competitive, and active site targeting inhibitor of APE1 (IC50=2.0uM in a fluorescence based HTS assay; and 12uM in a radiotracer incision assay). Shown to block APE1 activity in HEK293T and HeLa cells extract (IC50=600nM) and increase genomic AP site accumulation. Potentiates the cytotoxicity of DNA-damaging alkylating agents in HeLa cells by ~3-fold. Exhibits favorable pharmacokinetic properties and desirable ADME attributes. Due to its lipophilic nature, it crosses the blood-brain barrier rather easily and shows desirable stability (t1/2=80min). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Arecoline-d5, Hydrobromide Salt (1,2,5,6-Tetrahydro-1-(methyl-d3)-3-pyridine-2,6-d2-carboxylic Acid, Methyl Ester Hydrobromide) Quick inquiry Where to buy Suppliers range | Labelled Arecoline, which is reported to be a cholinergic agonist that readily crosses the blood-brain barrier. Group: Biochemicals. Alternative Names: 1,2,5,6-Tetrahydro-1-(methyl-d3)-3-pyridine-2,6-d2-carboxylic Acid, Methyl Ester Hydrobromide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
ARN2966 Quick inquiry Where to buy Suppliers range | ARN2966, also called 2-PMAP, as a Amyloid-β inhibitor, is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: 2-(pyridin-2-ylmethylamino)phenol; 2-PMAP; ARN2966; ARN-2966; Phenol, 2-[(2-pyridinylmethyl)amino]-; 102212-26-0; AGN-PC-0031SD; GTPL7530; 2-(2-Pyridylmethylamino)phenol; SCHEMBL10886688; AOB1080; SYN5152; 2-(pyridin-2-ylmethylamino)phenol; 3970AH; ZINC34411048; AKOS022987680; CS-3335; HY-18292; ARN-2966; CS 3335; HY 18292; ARN 2966; CS3335; HY18292; ARN2966. Grades: > 98%. CAS No. 102212-26-0. Molecular formula: C12H12N2O. Mole weight: 200.24. | |
AZ32 Quick inquiry Where to buy Suppliers range | AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with IC50 of <6.2 nM for ATM enzyme and IC50 of 0.31 μM for ATM in cell. AZ32 is tolerated in C57Bl6 and Nude mice dosed orally at 200mg/kg which was efficacious in orthotopic mouse models. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. It also shows adequate selectivity over ATR and also has high cell permeability. Synonyms: AZ-32; AZ 32; N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Grades: ≥98%. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.37. | |
AZD1390 Quick inquiry Where to buy Suppliers range | AZD1390 is a first-in-class, orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. It can be used to cross the blood-brain barrier suitable for the treatment of intracranial malignancies. Synonyms: AZD-1390; AZD 1390. Grades: ≥98%. CAS No. 2089288-03-7. Molecular formula: C27H32FN5O2. Mole weight: 477.57. | |
AZD3293 Quick inquiry Where to buy Suppliers range | AZD3293, a spiro compound, has been found to be a β-secretase inhibitor that has good blood-brain barrier penetration and could probably be significant in studies of Alzheimer's disease. It was just planed a Phase III trial in several areas. IC50: 0.2 nM. Synonyms: AZD-3293; AZD 3293; AZD3293; LY3314814; GTPL7789; LY 3314814; GTPL 7789; LY-3314814; GTPL-7789; SCHEMBL9948271; (1r,4r)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine. Grades: 98%. CAS No. 1628076-74-3. Molecular formula: C26H28N4O. Mole weight: 412.53. | |
Bathocuproine Quick inquiry Where to buy Suppliers range | Bathocuproine. Uses: 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline, also known as Bathocuproine (BCP), is a wide-band-gap material and has a high electron affinity. When it is embedded into organic electronic devices, bathocuproine acts as an exciton-blocking barrier which prohibits exciton diffusion process towards the Al electrode otherwise being quenched. One of the most commonly used buffer layer between acceptor and cathode layers is bathocuproine. The introduction of the buffer layer can greatly improve the PCE of polymer organic solar cells. BCP is one of the most popular hole-blocking layer materials that is used in organic electronics, including perovskite solar cells. It was demonstrated that a BCP buffer layer reduces nonradiative recombination of excitons at the C60 -Al interface. Its most important function is to establish an Ohmic contact between the C60 film and the Al electrode in photovoltaic devices. Group: Solution-Processed OLED. Alternative Names: SBB008863; 2, 9-Dimethyl-4, 7-diphenyl-1, 10-phenanthroline; KS-00000IQG; 92127-EP2272828A1; VZ23039; 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline/Bathocuproine; EINECS 225-240-5; BCP11188; AM62655; NSC 89195. CAS No. 4733-39-5. Molecular formula: C26H20N2. Mole weight: 360.46g/mol. IUPAC Name: 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline. Exact Mass: 360.163g/mol. EC Number: 225-240-5. SMILES: CC1=NC2=C (C=CC3=C2N=C (C=C3C4=CC=CC=C4)C)C (=C1)C5=CC=CC=C5. InChI: InChI=1S/C26H20N2/c1-17-15-23(19-9-5-3-6-10-19)21-13-14-22-24(20-11-7-4-8-12-20)16-18(2)28-26(22)25(21)27-17/h3-16H,1-2H3. InChIKey: STTGYIUESPWXOW-UHFFFAOYSA-N. | |
Behenyl Beeswax Quick inquiry Where to buy Suppliers range | Behenyl Beeswax is a natural wax derived from the honeycomb of bees. It is made up of a mixture of esters, hydrocarbons and free fatty acids. This wax is derived from the hydrolysis of beeswax and is then further processed to remove any impurities. Behenyl Beeswax is commonly used in skincare and cosmetic products as a thickener, emulsifier and stabilizer. It can help to improve the texture of products, providing them with a smooth and creamy consistency. This wax has moisturizing properties, which can help to keep the skin hydrated and nourished. Behenyl Beeswax is also used in hair care products, where it can help to provide hold, shine and protection to the hair. It is commonly found in hair waxes, pomades and gels. Uses: 1. Emulsifier: Behenyl beeswax is commonly used as an emulsifier to combine oil and water in products such as creams and lotions. 2. Thickener: It can also act as a thickening agent, giving products a thicker, more luxurious texture. 3. Binding agent: It is used as a binding agent in products such as lipsticks and balms, helping to hold the ingredients together. 4. Moisturizer: The wax has moisturizing properties that can help to soothe and hydrate the skin. 5. Protective barrier: It can create a protective barrier on the skin, helping to prevent moisture loss and providing a barrier against environmental stressors. Group: Surfactants/Emulsifiers. CAS No. 144514-52-3. Product ID: ACM144514523. Appearance: yellowish solid wax that has a slightly shiny and waxy appearance. | |
Bexarotene (4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic Acid) Quick inquiry Where to buy Suppliers range | A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce AB40 and AB42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6h and 50% reduction in 72h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of AB proteases, insulin degrading enzyme, and neprilysin. Group: Biochemicals. Grades: Highly Purified. CAS No. 153559-49-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
Bilirubin Conjugate, Sodium Salt Quick inquiry Where to buy Suppliers range | Bilirubin conjugate is a stable, water-soluble ditaurate derivative of bilirubin meant to mimic endogenous bilirubin glucuronide derivatives. In vivo, bilirubin circulates in the plasma and is taken up by hepatocytes and conjugated to one or two glucuronic acids in a reaction catalyzed by UDP glucuronidase to form bilirubin mono or diglucuronide. This water-soluble form is then excreted from the liver in bile in the feces or is converted to urobilinogen and excreted in the urine. In addition to aiding in the disposal of heme, bilirubin and its conjugated derivatives have been shown to exhibit anti-oxidant and antimutagenic effects and to play a role in gut barrier function.1,2. Group: Molecular Biology. Alternative Names: 2,2'-[(2,17-diethenyl-1,10,11,19,22,23-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-diyl)bis[(1-oxo-3,1-propanediyl)imino]]bis-ethanesulfonic acid, disodium salt; Bilirubin Ditaurate. Grades: Molecular Biology Grade. CAS No. 68683-34-1. Molecular Formula: C37H44N6O10S2Na2, Molecular Weight: 842.91. US Biological Life Sciences. | Worldwide |
BRD4884 Quick inquiry Where to buy Suppliers range | BRD4884 is a selective HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 μM for HDAC1, 2, and 3. It possesses preferential binding kinetics with seven-fold longer half-life. BRD4884 crosses the blood brain barrier and has been evaluated in CK-p25 mice, a mouse model of neurodegeneration. It acts by enhancing the learning and memory processes. Synonyms: BRD-4884; BRD 4884. Grades: ≥98%. CAS No. 1404559-91-6. Molecular formula: C18H19FN2O2. Mole weight: 314.4. | |
BRD6688 Quick inquiry Where to buy Suppliers range | BRD6688 is an HDAC inhibitor with IC50 values of 21 nM, 100 nM, and 11.48 μM for HDAC1, 2, and 3, respectively. It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1. It crosses the blood brain barrier and has been shown to rescue the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration. Synonyms: BRD-6688; BRD 6688. Grades: ≥98%. CAS No. 1404562-17-9. Molecular formula: C16H18N4O. Mole weight: 282.3. | |
Byakangelicol Quick inquiry Where to buy Suppliers range | Byakangelicol is a furanocoumarin derivative which shows inhibitory effects against P-glycoprotein at the blood-brain barrier. It acts as an anti-proliferative agent causing G2/M arrest in melanoma cells. Synonyms: (R)-(+)-9-(2,3-Epoxy-3-methylbutoxy)-4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one. Grades: >98%. CAS No. 26091-79-2. Molecular formula: C17H16O6. Mole weight: 316.3. | |
C14-22 Alkane Quick inquiry Where to buy Suppliers range | C14-22 Alkane is a mixture of hydrocarbons with carbon chain lengths ranging from 14 to 22 carbons. It is also known as a fatty alkane or fatty acid alkane. It is commonly used in the cosmetic industry as an emollient and viscosity-enhancing agent in various skin and hair care products, such as creams, lotions, and shampoos. It helps to moisturize and soften the skin and hair by forming a protective barrier on the surface. C14-22 Alkane is also used in other industries, such as the pharmaceutical and personal care industries, as an ingredient in various formulations. Additionally, it can be used as a fuel source and can also be found in some natural sources, such as beeswax and lanolin. Uses: 1. Cosmetics and Personal Care Products: C14-22 Alkane is used as an emollient, texture enhancer, and skin conditioning agent in various cosmetics and personal care products such as lotions, creams, and make-up products. 2. Pharmaceutical Products: C14-22 Alkane is used as an excipient, i.e. as an inert substance used as a carrier for the active ingredient in pharmaceuticals. It is used in the manufacturing of drugs in various dosage forms such as tablets, capsules, and injections. 3. Industrial Lubricants: C14-22 Alkane is used as a base oil in the manufacturing of industrial lubricants such as greases, hydraulic fluids, and gear oils. It provides excellent lubricity and thermal stability. 4. Polymer Additives: C14-22 Alkane is used as a processing aid and lubricant in the manufacturing of various polymers such as polyethylene, polypropylene, and PVC. It improves the processability and enhances the mechanical properties of the polymer. 5. Coatings and Paints: C14-22 Alkane is used as a solvent in the manufacturing of coatings and paints. It improves the solubility of the pigments and resins, and also reduces the viscosity of the paint. Group: Silicone Replacements. Product ID: ACMA00029418. Appearance: colorless, odorless, and have a waxy or oily texture. | |
C15-19 Alkane Quick inquiry Where to buy Suppliers range | C15-19 Alkane is a mixture of saturated hydrocarbons that contains different chain lengths of 15 to 19 carbon atoms. Alkanes are a type of hydrocarbon that consists of only carbon and hydrogen atoms, with single covalent bonds between the atoms. C15-19 Alkanes may be derived from petroleum, and they are commonly used as ingredients in various personal care and cosmetic products, such as shampoos, conditioners, lotions, and soaps, as well as in industrial applications such as lubricants and solvents. C15-19 Alkanes are known to have excellent moisturizing properties, and they are typically used as emollients, which help to soften and soothe the skin. They can also assist in the spreadability and absorption of other ingredients in a product, and they may help to create a protective barrier on the skin to prevent moisture loss. Uses: 1. Personal care products: C15-19 Alkanes are widely used in personal care products such as skin creams, lotions, and deodorants as an emollient to provide a smooth texture to the skin. 2. Industrial lubricants: These compounds are used in synthetic industrial lubricants to provide excellent heat resistance and stability at high temperatures. 3. Paints and coatings: C15-19 Alkanes are used as solvents in the formulation of paints and coatings due to their low toxicity and low VOC levels. 4. Medical applications: These compounds are used in the formulation of certain medical devices and implants due to their biocompatibility. 5. Pesticides: C15-19 Alkanes are used as solvents in the formulation of certain types of insecticides and herbicides. 6. Textile applications: These compounds are used as softeners and lubricants in the textile industry to improve the feel and wearability of fabrics. 7. Plasticizers: Some C15-19 Alkanes are used as plasticizers in the production of plastics to improve their flexibility and durability. 8. Fuel additives: Certain types of C15-19 Alkanes are used as fuel additives to improve the performance and efficiency of engines. Group: Rheology Modifiers. CAS No. 64741-76-0 / 64742-46-7. Product ID: ACM64741760. Appearance: colorless, odorless, and oily liquid. | |
C20-C24 Alkyl Dimethicone Quick inquiry Where to buy Suppliers range | C20-C24 Alkyl Dimethicone is a type of silicone-based emollient that is often used in cosmetic and personal care formulations, such as lotions, creams, hair conditioners, and sunscreen products. This ingredient is derived from silicon, a naturally occurring mineral element that is widely used in the cosmetic industry due to its emollient, smoothing, and protective properties. C20-C24 Alkyl Dimethicone is a mixture of alkylated silicones, which means it contains molecules of different sizes and structures with carbon chains ranging from 20 to 24 carbons. This blend of silicones can provide various skin and hair benefits such as a smooth and silky texture, improved spreadability, enhanced moisture retention, and reduced dryness and flakiness. Uses: 1. C20-C24 Alkyl Dimethicone is commonly used as an emollient in various cosmetic formulations such as moisturizers, lotions, and hair care products. 2. It forms a protective barrier on the skin and hair, preventing moisture loss and providing a silky, smooth feel. 3. Due to its low viscosity, it can easily penetrate the skin and hair shaft, delivering hydration and nourishment. 4. C20-C24 Alkyl Dimethicone also helps to improve the texture and spreadability of cosmetic formulations, making it easier to apply and absorb. 5. It is non-comedogenic and non-irritating, making it suitable for use in sensitive skin formulations. 6. C20-C24 Alkyl Dimethicone is also often used as a silicone oil substitute in natural and organic cosmetic products, providing similar benefits without the use of synthetic ingredients. Group: Emollients/Oils/Wax. CAS No. 200074-76-6. Product ID: ACM200074766-2. Appearance: clear, colorless liquid with a silky-smooth texture. | |
Cancer Hydrolase KIAA1363 Inhibitor, JW480 (2-Isopropylphenyl-2- (2-naphthyl) ethylcarbamate, AADACL1 Inhibitor, Arylacetamide Deacetylase-Like 1 Inhibitor, NCEH1 Inhibitor, Neutral Cholesterol Ester Hydrolase 1 Inhibitor) Quick inquiry Where to buy Suppliers range | A membrane-permeable, highly potent and selective inhibitor against the 2-acetyl MAGE (monoakylglycerol ether) hydrolase KIAA1363/AADACL1 of both human (IC50=12nM; PC3 lysate) and murine (IC50=20nM; brain membrane samples) origin, with no significant effect toward other PC3 or murine brain serine hydrolase activities, including HSL, FAAH, and AChE. Readily crosses blood-brain barrier in mice and effectively suppresses PC3-derived tumor growth in mice in vivo (by 56% on day 33; 80mg/kg/day; o.g.). Also inhibits blood carboxylesterase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Caprylyl Methicone Quick inquiry Where to buy Suppliers range | Caprylyl methicone is a type of silicone-based emollient that is commonly used in skin care and personal care products. It functions as a moisturizer, skin conditioning agent, and lubricant, helping to improve the texture and appearance of the skin. Caprylyl methicone has a lightweight and non-greasy texture, making it ideal for use in products such as lotions, creams, and serums. It has a quick-drying and silky smooth finish that leaves the skin feeling soft and velvety. In addition to its cosmetic benefits, caprylyl methicone has been found to have antistatic and water-resistant properties, which can help to improve the performance of hair care and sunscreen products. It also has a low viscosity and high spreadability, which means it can be easily incorporated into a range of formulations and is highly effective at delivering active ingredients to the skin. Overall, caprylyl methicone is a versatile and effective ingredient that is commonly used in a wide range of personal care products due to its excellent moisturizing and skin conditioning properties. Uses: 1. Skin care: Caprylyl Methicone is widely used in skin care products due to its light and silky texture. It acts as an emollient, helping to soften and smooth the skin, while also providing a barrier to lock in moisture. 2. Sunscreens: Caprylyl Methicone is a common ingredient in sunscreens due to its ability to enhance the spreadability of the product, making it easier to apply and ensuring even coverage. It also provides a lightweight feel on the skin, which is important for sunscreens as they can sometimes feel heavy. 3. Hair care: Caprylyl Methicone is used in hair care products as a conditioning agent. It helps to improve the texture and manageability of hair, while also providing a silky-smooth finish. 4. Makeup: Caprylyl Methicone is used in makeup formulations as a texturizing agent, helping to create a smooth and even application. It also improves the staying power of makeup products, ensuring they stay in place for longer periods of time. 5. Topical pharmaceuticals: Caprylyl Methicone is sometimes used in topical pharmaceuticals due to its ability to improve the skin penetration of active ingredients. This can help to enhance the effectiveness of these products. Group: Silicones & Emulsions. | |
Caprylyl Methicone 17955-88-3 Quick inquiry Where to buy Suppliers range | Caprylyl Methicone is a type of silicone-based emollient and skin-conditioning agent that is commonly used in cosmetic and personal care products. It is derived from Caprylic acid, a fatty acid found in coconut oil. Caprylyl Methicone has a light and silky texture that helps to spread easily on the skin and gives a smooth and soft finish. It has a low viscosity, which makes it ideal for use in lotions, creams, serums, and other cosmetic formulations. Caprylyl Methicone offers several benefits to the skin, including moisturization, hydration, and improved skin texture. It also helps to reduce the greasiness and tackiness of cosmetics, making them feel more comfortable on the skin. Additionally, it enhances the spreadability and durability of sunscreen products, increasing their efficacy against UV radiation. Caprylyl Methicone is considered safe for use in cosmetics and personal care products, as it is non-toxic, non-irritating, and non-sensitizing to the skin. Uses: 1. Caprylyl Methicone is used in personal care products as a silicone-based emollient and skin conditioner. 2. It is used in skin lotions, creams, hand creams, sun care products, hair care products, and makeup products. 3. It offers a silky, non-greasy, and luxurious feel to the skin and hair. 4. It is a light-weight ingredient that does not clog pores or cause acne. 5. Caprylyl Methicone has excellent spreading properties, which allows for even application and absorption into the skin. 6. It provides a protective barrier on the skin, preventing moisture loss and promoting hydration. 7. It can improve the texture and appearance of the skin by filling in fine lines and wrinkles. 8. It is resistant to sweat and water, making it an ideal ingredient for long-wear makeup products and sunscreen. Group: Emollients/Oils/Wax. CAS No. 17955-88-3. Product ID: ACM17955883-6. Appearance: clear, colorless liquid. | |
Carbidopa Quick inquiry Where to buy Suppliers range | Carbidopa (Lodosyn) is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism oflevodopa. This property is significant in that it allows a greater proportion of peripheral levodopa to cross the blood - brain barrier for central nervous system effect. Uses: API. CAS No. 28860-95-9. Product ID: 10-101-135. | |
Carmustine Quick inquiry Where to buy Suppliers range | Carmustine is antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. It is used in the treatment of brain tumors, multiple myeloma and some lymphomas. Synonyms: 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin. Grades: ≥98%. CAS No. 154-93-8. Molecular formula: C5H9Cl2N3O2. Mole weight: 214.05. | |
Cetearyl Alcohol (CAS 67762-27-0) Quick inquiry Where to buy Suppliers range | Cetearyl alcohol is a fatty alcohol that is commonly used in cosmetic and skincare products as an emollient, texture enhancer, and viscosity controlling agent. Despite the name, it is not a drying or irritating alcohol like ethanol, isopropyl alcohol, or methanol. It is derived from natural sources such as coconut oil and is a mixture of cetyl and stearyl alcohols. Cetearyl alcohol works by forming a protective barrier on the skin and preventing moisture loss, making it popular in moisturizers, lotions, and creams. It is also used as an emulsifier to bind water and oil-based ingredients together, giving consistency to products such as hair conditioners and body washes. Additionally, cetearyl alcohol is a mild ingredient that is well-tolerated by most skin types and does not typically cause irritation or allergic reactions. Uses: 1. Cetearyl Alcohol is used as an emulsifier in cosmetic formulations. 2. It helps to improve the texture and stability of lotions, creams, and other personal care products. 3. It has moisturizing properties that can help to hydrate and condition the skin. 4. Cetearyl Alcohol acts as a thickener, providing viscosity to formulations and enhancing their feel. 5. It can also be used to solubilize other ingredients and increase the efficacy of active compounds. 6. Cetearyl Alcohol is considered safe for use in personal care products, as it is non-toxic, non-irritating, and generally well-tolerated by all skin types. Group: Hair Actives. CAS No. 67762-27-0 / 8005-44-5. Product ID: ACM67762270-2. Appearance: wax-like, white solid or flakes. | |
Cetirizine Quick inquiry Where to buy Suppliers range | Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine. It is a racemic selective H1 receptor inverse agonist. It is used in cutaneous mastocytosis. It is used in the treatment of allergies, hay fever, angioedema, and urticaria. It crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. Uses: Cetirizine used in the treatment of allergies, hay fever, angioedema, and urticaria. it crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. it has also been shown to inhibit eosinophil chemotaxis and ltb4 release. Synonyms: Virlix;Cetirizina;Cetryn;2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid. Grades: 95%. CAS No. 83881-51-0. Molecular formula: C21H25ClN2O3. Mole weight: 388.89. | |
CGP 35348 (GABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348) Quick inquiry Where to buy Suppliers range | A selective antagonist of post-synaptic GABAB receptors (IC50 = 34uM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices. Group: Biochemicals. Grades: Highly Purified. CAS No. 123690-79-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
CGP 7930 (GABA B Receptor Antagonist, CGP7930, CGP 7930, CGP-7930) Quick inquiry Where to buy Suppliers range | A blood brain barrier permeable, positive allosteric modulator of the metabotropic GABAB receptor. Shown to modulate GABAB receptor in the high affinity state and thereby increases agonist affinity for the receptor. Also enhances agonist potency and efficacy even on recombinant GABAB receptors. Exhibits anxiolytic effects in rodents. Group: Biochemicals. Grades: Highly Purified. CAS No. 57717-80-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) Quick inquiry Where to buy Suppliers range | It is a peptide extracted from the rabies virus glycoprotein (RVG). Since neurotropic viruses infect brain cells across the blood-brain barrier, the same strategy could be used to enter the central nervous system and deliver siRNA to the brain. To enable siRNA to bind, this chimeric peptide is synthesized by adding a non-Amer arginine residue to the carboxyl terminus of RVG. The RVG-9R peptide binds and transduces siRNA to neuronal cells in vitro, resulting in efficient gene silencing. After intravenous injection into mice, RVG-9R delivered siRNA to the neuronal cells, resulting in specific gene silencing within the brain. Rvg-9r provides a safe, non-invasive method for delivering siRNA and other therapeutic molecules across the blood-brain barrier. Synonyms: H-Tyr-Thr-Ile-Trp-Met-Pro-Glu-Asn-Pro-Arg-Pro-Gly-Thr-Pro-Cys-Asp-Ile-Phe-Thr-Asn-Ser-Arg-Gly-Lys-Arg-Ala-Ser-Asn-Gly-Gly-Gly-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH. Grades: >95%. Molecular formula: C201H334N82O55S2. Mole weight: 4843.51. | |
Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) Quick inquiry Where to buy Suppliers range | This is a peptide derived from rabies virus glycoprotein (RVG). Because neurotropic viruses cross the blood-brain barrier to infect brain cells, the same strategy may be used to enter the central nervous system and deliver siRNA to the brain. To enable siRNA binding, this chimeric peptide was synthesized by adding nonamer arginine residues at the carboxy terminus of RVG. This RVG-9R peptide was able to bind and transduce siRNA to neuronal cells in vitro, resulting in efficient gene silencing. After intravenous injection into mice,RVG-9R delivered siRNA to the neuronal cells, resulting in specific gene silencing within the brain. RVG-9R provides a safe and noninvasive approach for the delivery of siRNA and potentially other therapeutic molecules across the blood - brain barrier. Uses: Chimeric Peptides. Product ID: GR1902. | |
Chloropyramine Impurity 1 HCl Quick inquiry Where to buy Suppliers range | Tripelennamine hydrochloride, the hydrochloride salt form of tripelennamine, is a blood-brain barrier penetrant and orally active H1 receptor antagonist. Tripelennamine, also known as Pyribenzamine, exhibits antipruritic and first-generation antihistamine properties. Uses: Anti-allergic agents. Synonyms: Tripelennamine HCl; Ahistamin; Piristin; N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine hydrochloride. Grades: > 95%. CAS No. 154-69-8. Molecular formula: C16H22ClN3. Mole weight: 291.82. | |
Cholesterol Quick inquiry Where to buy Suppliers range | Cholesterol is a natural waxy substance that is found in human skin and is also commonly used in cosmetics and skincare products. In cosmetics, cholesterol is used as a moisturizer and emollient to help soften and smooth the skin, as well as to improve the appearance of fine lines and wrinkles. It is also believed to help strengthen the skin's barrier function and protect against environmental damage. The chemical formula of cholesterol is C27H46O, and it typically appears as a white or off-white powder or solid. It is also available in liquid form, often in combination with other ingredients. Group: Cholesteryl Esters. Alternative Names: 3β-Hydroxycholest-5-ene. Grades: 98%. CAS No. 57-88-5. Product ID: ACM57885. Molecular formula: C27H46O. Mole weight: 386.66. IUPAC Name: (3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol. Appearance: White powder. Boiling Point: 360 °C. Melting Point: 148-150 °C. Flash Point: 250 °C. Density: 1.06 g/cm³. | |
Clobenpropit dihydrobromide Quick inquiry Where to buy Suppliers range | Clobenpropit dihydrobromide is a highly potent histamine H3 antagonist/inverse agonist (pA2=9.93) that can cross blood-brain barrier. It also displays partial agonist activity at H4 receptors. Synonyms: Carbamimidothioic acid, N-[(4-chlorophenyl)methyl]-, 3-(1H-imidazol-5-yl)propyl ester, hydrobromide (1:2); Carbamimidothioic acid, [(4-chlorophenyl)methyl]-, 3-(1H-imidazol-4-yl)propyl ester, dihydrobromide; Clobenpropit hydrobromide; 3-(1H-imidazol-5-yl)propyl (4-chlorobenzyl)carbamimidothioate dihydrobromide. Grades: ≥99% by HPLC. CAS No. 145231-35-2. Molecular formula: C14H17ClN4S.2HBr. Mole weight: 470.65. | |
Copernicia Cerifera Wax Quick inquiry Where to buy Suppliers range | Copernicia Cerifera Wax, also known as Carnauba Wax, is a natural plant-based wax extracted from the leaves of the Copernicia prunifera palm tree that is native to Brazil. It is a hard, yellowish-brown wax that commonly used in various industries, including cosmetics, pharmaceuticals, food, and automotive. In cosmetics, Copernicia Cerifera Wax is used as a thickening agent, emulsifier, and binder in a variety of products such as lipsticks, mascaras, and creams. It is preferred as a natural alternative to synthetic waxes because it provides a glossy finish and high melting point, making it suitable for hot climates. Uses: 1. Skincare Products: It is used in skincare products such as moisturizers, lotions, and lip balms, as it helps to prevent moisture loss and provides a protective barrier on the skin. 2. Hair Care Products: Copernicia Cerifera Wax is commonly used in hair care products such as hair gels and pomades, as it helps to hold hair in place and add shine. 3. Candles: It is used in the production of candles as it has a high melting point and creates a hard, durable wax. 4. Food Industry: In the food industry, Copernicia Cerifera Wax is used as a coating for fruits, vegetables, and candies to enhance their appearance, as well as to prevent moisture loss and spoilage. 5. Pharmaceutical Industry: As it has a low toxicity and is insoluble in water, it is used in some medications and supplements as a coating material. 6. Industrial Applications: Copernicia Cerifera Wax is used in various industrial applications such as in the production of polishes, varnishes, and coatings for cars, floors, and furniture. Group: Emollients/Oils/Wax. CAS No. 8015-86-9. Product ID: ACM8015869-6. Appearance: hard, yellowish-brown, translucent wax. | |
CRANAD 2 Quick inquiry Where to buy Suppliers range | Near-infrared probe that binds to A β40 aggregates (Kd = 38nM) and elicits an emission blue shift. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo. Penetrates the blood-brain barrier. Group: Biochemicals. Alternative Names: (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron. Grades: Purified. CAS No. 1193447-34-5. Pack Sizes: 10mg. Molecular Formula: C23H25BF2N2O2, Molecular Weight: 410.26. US Biological Life Sciences. | Worldwide |
Cyclopentasiloxane Quick inquiry Where to buy Suppliers range | Cyclopentasiloxane is a silicone-based cyclic compound that is used primarily in personal care and cosmetic products as a conditioning agent, solvent, and lubricant due to its unique properties. It is a clear, colorless liquid with a low viscosity, high volatility, and low surface tension, which makes it easy to spread and evaporate quickly on the skin without leaving an oily residue. Cyclopentasiloxane is also known for its ability to improve the texture, feel, and appearance of skin and hair by forming a protective barrier that helps to lock in moisture and reduce the loss of natural oils. In addition to personal care products, Cyclopentasiloxane is also used in various industrial applications, such as in the formulation of adhesives, sealants, and coatings. Uses: 1. Cyclopentasiloxane is used as a solvent and carrier for cosmetics and personal care products. 2. It is used as a conditioning agent for skin and hair products. 3. Cyclopentasiloxane is used as a lubricant in medical devices and personal care products. 4. It is used as a viscosity controlling agent in lotions and creams. 5. Cyclopentasiloxane is used as a dispersant for pigments and other insoluble materials in cosmetic formulations. Group: Silicones & Emulsions. CAS No. 541-02-6. Product ID: ACM541026-2. Appearance: clear, odorless, and colorless liquid with a low viscosity. | |
D-Amino Acid Oxidase Inhibitor III, AS057278 (5-methyl-1H-pyrazole-3-carboxylic Acid, DAAO Inhibitor III) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC50 = 910nM against human DAO; [D-ser] = 10mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50mM) exposure (ED50 ≤3.95uM), while exhibiting little affinity toward nMDAR glycine binding site or inhibitory activity against D-aspartate oxidase (DDO/DSOX). Reported to be orally available and blood-brain barrier-permeant in rats and effectively prevent PCP (phencyclidine) from suppressing PPI (prepulse inhibition) response in mice (single 80mg/kg or 56X 20mg/kg/12h b.i.d. oral dosages) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 402-61-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
Debio 0932 Quick inquiry Where to buy Suppliers range | Debio 0932, also known as CUDC-305, is a novel Hsp90 inhibitor with strong affinity for Hsp90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance. Furthermore, Debio 0932 is able to extend animal survival in models of brain metastasis due to its ability to cross the blood-brain barrier, and it enhances the activity of several standard-of-care agents in animal models of cancer. Synonyms: Debio0932; Debio 0932; CUDC-305; CUDC305; CUDC 305. Grades: >98%. CAS No. 1061318-81-7. Molecular formula: C22H30N6O2S. Mole weight: 442.58. | |
Diazepinomicin Quick inquiry Where to buy Suppliers range | Diazepinomicin, also known as TLN-4601, is a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity. Diazepinomicin binds to and inhibits Ras kinase, thereby preventing the phosphorylation and activation of proteins downstream of the Ras signal transduction pathway, including serine/threonine kinase RAF (BRAF) and extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK-2). This agent also selectively binds to the peripheral benzodiazepine receptor (PBR), a receptor highly expressed in certain tumor cell types cells, inducing cell cycle arrest and apoptosis in PBR-expressing cells. Diazepinomicin can cross the blood-brain barrier (BBB). Synonyms: TLN-4601; TLN 4601; TLN4601; ECO 4601; ECO4601; BU 4664L; ECO 04601; BU4664L; BU-4664L; 4,6,8-trihydroxy-10-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one. CAS No. 733035-26-2. Molecular formula: C28H34N2O4. Mole weight: 462.59. |