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Also acts on CoA derivatives of other bileacids. Taurine and 2-fluoro-β-alanine can act as substrates, but more slowly. The enzyme can also conjugate fatty acids to glycine and can act as a very-long-chain acyl-CoA thioesterase. Bile-acid-amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol. This is the second enzyme in a two-step process leading to the conjugation of bileacids with amino acids; the first step is the conversion of bileacids into their acyl-CoA thioesters, which is catalysed by EC 6.2.1.7, cholate-CoA ligase. Group: Enzymes. Synonyms: glycine-taurine N-acyltransferase; amino acid N-choloyltransferase; BAT; glycine N-choloyltransferase; BACAT; cholyl-CoA glycine-taurine N-acyltransferase; cholyl-CoA:taurine N-acyltransferase. Enzyme Commission Number: EC 2.3.1.65. CAS No. 65979-40-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2245; bileacid-CoA:amino acid N-acyltransferase; EC 2.3.1.65; 65979-40-0; glycine-taurine N-acyltransferase; amino acid N-choloyltransferase; BAT; glycine N-choloyltransferase; BACAT; cholyl-CoA glycine-taurine N-acyltransferase; cholyl-CoA:taurine N-acyltransferase. Cat No: EXWM-2245.
bileacid CoA-transferase
The enzyme, characterized from the gut bacterium Clostridium scindens, catalyses the last step in bileacid 7α-dehydroxylation, the removal of the CoA moiety from the products. By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules. Clostridium scindens possesses two forms of the enzyme, encoded by the baiF and baiK genes. While the enzymes have a broad acceptor specificity and can use allocholate, ursodeoxycholate, and β-muricholate, the donor specificity is more strict. BaiF acts on lithocholoyl-CoA and deoxycholoyl-CoA, and BaiK acts only on the latter. Group: Enzymes. Synonyms: baiF (gene name); baiK (gene name); bileacid coenzyme A transferase. Enzyme Commission Number: EC 2.8.3.25. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3421; bileacid CoA-transferase; EC 2.8.3.25; baiF (gene name); baiK (gene name); bileacid coenzyme A transferase. Cat No: EXWM-3421.
3α-hydroxy bileacid-CoA-ester 3-dehydrogenase
This bacterial enzyme is involved in the 7-dehydroxylation process associated with bileacid degradation. The enzyme has very little activity with unconjugated bileacid substrates. It has similar activity with choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA. Group: Enzymes. Synonyms: baiA1 (gene name); baiA2 (gene name); baiA3 (gene name). Enzyme Commission Number: EC 1.1.1.395. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0315; 3α-hydroxy bileacid-CoA-ester 3-dehydrogenase; EC 1.1.1.395; baiA1 (gene name); baiA2 (gene name); baiA3 (gene name). Cat No: EXWM-0315.
bile-acid 7α-dehydratase
This enzyme, characterized from the gut bacterium Clostridium scindens (previously known as Eubacterium sp. strain VPI 12708), participates in the 7-dehydroxylation process associated with bileacid degradation. Group: Enzymes. Synonyms: baiE (gene name); 7α,12α-dihydroxy-3-oxochol-4-enoate hydro-lyase; 7α,12α-dihydroxy-3-oxochol-4-enoate hydro-lyase (12α-hydroxy-3-oxochola-4,6-dienoate-forming); BA7 α dehydratase. Enzyme Commission Number: EC 4.2.1.106. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4945; bile-acid 7α-dehydratase; EC 4.2.1.106; baiE (gene name); 7α,12α-dihydroxy-3-oxochol-4-enoate hydro-lyase; 7α,12α-dihydroxy-3-oxochol-4-enoate hydro-lyase (12α-hydroxy-3-oxochola-4,6-dienoate-forming); BA7 α dehydratase. Cat No: EXWM-4945.
A cell-permeable, orally available, phenoxypyrimidine carboxamide derivative that acts as a highly potent and selective agonist of Protein coupled receptor TGR5 (EC50 = 720 pM and 6.2nM for human and mouse TGR5, respectively). Does not exhibit any significant affinity towards other related targets such as GPR40, GPR119, and GPR120. Shown to increase glucagon-like peptide-1 (GLP-1) secretion in a dose-dependent manner and significantly reduce blood glucose levels in db/db mice following a single oral dose (50mg/kg). Exhibits desirable pharmacokinetic properties in rodent models (t½ = 1.5h, Cmax = 56ng/ml; and AUC = 147ng.h/ml following an oral dose of 5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
1,2,3,4-Tetra-O-acetyl-D-[6-13C]glucuronide methyl ester, a labeled chemical analogue, is widely applied in investigations of bileacids and steroids metabolism, specifically in hepatic disorders and ailments. It is significantly utilized in the formulation of novel therapeutic interventions directed towards the treatment and management of these pathological conditions, owing to its ability to provide valuable insights into the inner workings of these metabolic pathways. Mole weight: 376.31.
12α-hydroxysteroid dehydrogenase
Catalyses the oxidation of the 12α-hydroxy group of bileacids, both in their free and conjugated form. Also acts on bile alcohols. Group: Enzymes. Synonyms: 12α-hydroxy steroid dehydrogenase; NAD+-dependent 12α-hydroxysteroid dehydrogenase; NADP+-12α-hydroxysteroid dehydrogenase. Enzyme Commission Number: EC 1.1.1.176. CAS No. 61642-40-8. 12α-Hydroxysteroid Dehydrogenase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0079; 12α-hydroxysteroid dehydrogenase; EC 1.1.1.176; 61642-40-8; 12α-hydroxy steroid dehydrogenase; NAD+-dependent 12α-hydroxysteroid dehydrogenase; NADP+-12α-hydroxysteroid dehydrogenase. Cat No: EXWM-0079.
12 β-Deoxycholic Acid Methyl Ester 3α-Benzoate
12 β-Deoxycholic Acid Methyl Ester 3α-Benzoate is an intermediate in the synthesis of 3α,12 β-Dihydroxycholanoic Acid is a bileacid that may decrease of the toxic effects of deoxycholic acid on lipid peroxidn. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 50mg. Molecular Formula: C32H46O5. US Biological Life Sciences.
Worldwide
12 β-Hydroxy-5 β-cholan-24-oic Acid
12 β-Hydroxy-5 β-cholan-24-oic Acid is a bileacid. Group: Biochemicals. Grades: Highly Purified. CAS No. 15173-23-6. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C24H40O3, Molecular Weight: 376.57. US Biological Life Sciences.
Worldwide
12 β-Hydroxyisocholic Acid
12 β-Hydroxyisocholic Acid is a bileacid. Group: Biochemicals. Grades: Highly Purified. CAS No. 71883-64-2. Pack Sizes: 5mg, 50mg. Molecular Formula: C24H40O5. US Biological Life Sciences.
Worldwide
12 β-Hydroxyisocholic Acid Methyl Ester
12 β-Hydroxyisocholic Acid Methyl Ester is an intermediate in the synthesis of 12 β-Hydroxyisocholic Acid (H943480), a bileacid. Group: Biochemicals. Grades: Highly Purified. CAS No. 71883-63-1. Pack Sizes: 10mg, 25mg. Molecular Formula: C25H42O5, Molecular Weight: 422.6. US Biological Life Sciences.
Worldwide
12β-hydroxysteroid dehydrogenase
Acts on a number of bileacids, both in their free and conjugated forms. Group: Enzymes. Synonyms: 12β-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase. Enzyme Commission Number: EC 1.1.1.238. CAS No. 118390-62-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0145; 12β-hydroxysteroid dehydrogenase; EC 1.1.1.238; 118390-62-8; 12β-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase. Cat No: EXWM-0145.
1 β-Hydroxydeoxycholic Acid-d5
1 β-Hydroxydeoxycholic Acid-d5 is the isotope labelled analog of 1 β-Hydroxydeoxycholic Acid (H934880); a metabolite of Taurodeoxycholic Acid (T009000) which is a steroidal amphipathic hepatic bile salt formed in the liver through the conjugation of Deoxycholate (S624090) with Taurine (T007850). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H35D5O5, Molecular Weight: 413.6. US Biological Life Sciences.
Worldwide
[(25R)-3α,7α-Dihydroxy-5 β-cholestan-26-oyl]taurine-d4 Sodium Salt
[(25R)-3α,7α-Dihydroxy-5 β-cholestan-26-oyl]taurine-d4 Sodium Salt is the labeled deuterium form of [(25R)-3α,7α-Dihydroxy-5 β-cholestan-26-oyl]taurine Sodium Salt (D452630) that is derived from Chenodeoxycholic Acid (C291900), which is a major bileacid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bileacids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Facilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C29H46D4NNaO6S, Molecular Weight: 567.79. US Biological Life Sciences.
Worldwide
[(25R)-3α,7α-Dihydroxy-5 β-cholestan-26-oyl]taurine Sodium Salt
[(25R)-3α,7α-Dihydroxy-5 β-cholestan-26-oyl]taurine Sodium Salt is derived from Chenodeoxycholic Acid (C291900), which is a major bileacid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bileacids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Facilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C29H50NNaO6S, Molecular Weight: 563.77. US Biological Life Sciences.
Worldwide
(25S)-5 β-Cholestane-3α, 7α, 12α, 26-tetrol
(25S)-5 β-Cholestane-3α, 7α, 12α, 26-tetrol, can be used in the study of High-performance liquid chromatographic separation of bileacids and bile alcohols diastereoisomeric at C-25. Group: Biochemicals. Grades: Highly Purified. CAS No. 134002-65-6. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C27H48O4, Molecular Weight: 436.67. US Biological Life Sciences.
Worldwide
2-Chloro-5-nitrobenzophenone
2-Chloro-5-nitrobenzophenone is used as a reagent in the synthesis of bileacid transporter inhibitors in the treatment of atherosclerosis. Also used in the synthesis of antiinflammatory agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 34052-37-4. Pack Sizes: 1g, 5g. Molecular Formula: C13H8ClNO3, Molecular Weight: 261.66. US Biological Life Sciences.
Worldwide
2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline
2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline is used in the synthesis of Glycochenodeoxycholic Acid 3-Sulfate Disodium Salt which is a bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. Synonyms: 1-(Ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline; 2-Ethoxy-1(2H)-quinolinecarboxylic acid ethyl ester; 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline; 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline; EEDQ; Ethyl 2-ethoxy-1(2H)-quinolinecarboxylate; N-(Ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline; N-Carbethoxy-2-ethoxy-1,2-dihydroquinoline; NSC 147831; Ethyl N-(2-ethoxy-1,2-dihydroquinoline)carboxylate. Grades: 99 % (HPLC). CAS No. 16357-59-8. Molecular formula: C14H17NO3. Mole weight: 247.29.
2'-Isopropylacetanilide
2'-Isopropylacetanilide is an intermediate used to prepare SR 142948 (S684350) which is an antagonist of NT1/NT2 receptors inhibiting bileacid secretion. Group: Biochemicals. Grades: Highly Purified. CAS No. 19246-04-9. Pack Sizes: 500mg, 1g. Molecular Formula: C11H15NO, Molecular Weight: 177.24. US Biological Life Sciences.
Worldwide
3,5-Dichloro-2-hydroxybenzenesulfonic acid, sodium salt (HDCBS-Na)
Chromogenic reagent for HDL cholesterol. HDL (High Density Lipoproteins) are responsible for the reverse transport of cholesterol from peripheral cells to the liver, where cholesterol is transformed to bileacids. These are excreted into the intestine via the biliary tract. Monitoring of HDL-cholesterol in serum is of clinical importance because there is an inverse correlation between serum HDL-cholesterol concentrations and the risk of atherosclerotic disease. It is believed that elevated HDL-cholesterol concentrations offer protection against coronary heart disease, while reduced HDL-cholesterol concentrations, particularly in conjunction with elevated triglycerides, increase cardiovascular risk. Group: Biochemicals. Grades: Highly Purified. CAS No. 54970-72-8. Pack Sizes: 50g, 100g. US Biological Life Sciences.
Worldwide
3α(17β)-hydroxysteroid dehydrogenase (NAD+)
Also acts on other 17β-hydroxysteroids and on the 3α-hydroxy group of pregnanes and bileacids. Different from EC 1.1.1.50 3α-hydroxysteroid dehydrogenase (Si-specific) or EC 1.1.1.213 3α-hydroxysteroid dehydrogenase (Re-specific). Group: Enzymes. Synonyms: 3α,17β-hydroxy steroid dehydrogenase; 3α(17β)-HSD; 17-ketoreductase (ambiguous); 17β-HSD (ambiguous); HSD17B6 (gene name); HSD17B8 (gene name). Enzyme Commission Number: EC 1.1.1.239. CAS No. 126469-82-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0146; 3α(17β)-hydroxysteroid dehydrogenase (NAD+); EC 1.1.1.239; 126469-82-7; 3α,17β-hydroxy steroid dehydrogenase; 3α(17β)-HSD; 17-ketoreductase (ambiguous); 17β-HSD (ambiguous); HSD17B6 (gene name); HSD17B8 (gene name). Cat No: EXWM-0146.
(3α,5 β)-3-(Benzoyloxy)-12-oxo-cholan-24-oic Acid Methyl Esteris an intermediate in the synthesis of 3α,12 β-Dihydroxycholanoic Acid is a bileacid that may decrease of the toxic effects of deoxycholic acid on lipid peroxidn. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C32H44O5. US Biological Life Sciences.
(3α,5 β)-3-[(Ethoxycarbonyl)oxy]-7-oxo-cholan-24-oic Acid Methyl Ester is an intermediate in the synthesis of α-Muricholic Acid (M732750), an bileacid metabolite found in urine. Group: Biochemicals. Grades: Highly Purified. CAS No. 96475-64-8. Pack Sizes: 25mg. US Biological Life Sciences.
(3α,5 β ) -3-[ (Ethoxycarbonyl) oxy]chol-6-en-24-oic Acid Methyl Ester is an intermediate in the synthesis of α-Muricholic Acid (M732750), an bileacid metabolite found in urine. Group: Biochemicals. Grades: Highly Purified. CAS No. 61252-26-4. Pack Sizes: 10mg. US Biological Life Sciences.
(3α,5 β,6α)-3,6-Dihydroxycholan-24-oic Acid 4-(1-Oxopropyl)phenyl Ester is an intermediate in the preparation of taurine-conjugated bileacids. Group: Biochemicals. Grades: Highly Purified. CAS No. 155587-60-3. Pack Sizes: 50mg. US Biological Life Sciences.
(3α,5 β,6α)-6-Bromo-3-[(ethoxycarbonyl)oxy]-7-oxo-cholan-24-oic Acid Methyl Ester is an intermediate in the synthesis of α-Muricholic Acid (M732750), an bileacid metabolite found in urine. Group: Biochemicals. Grades: Highly Purified. CAS No. 125112-73-4. Pack Sizes: 25mg. US Biological Life Sciences.
(3α,5 β , 6α , 7α ) -6, 7-Epoxy-3-[ (ethoxycarbonyl) oxy]cholan-24-oic Acid Methyl Ester is an intermediate in the synthesis of α-Muricholic Acid (M732750), an bileacid metabolite found in urine. Group: Biochemicals. Alternative Names: 6, 7-Epoxy-1H-cyclopenta [a]phenanthrene, Cholan-24-oic Acid Deriv. Grades: Highly Purified. CAS No. 125112-76-7. Pack Sizes: 10mg. US Biological Life Sciences.
(3α,5 β, 6α, 7α)-6-Bromo-3-[(ethoxycarbonyl)oxy]-7-hydroxycholan-24-oic Acid Methyl Ester is an intermediate in the synthesis of α-Muricholic Acid (M732750), an bileacid metabolite found in urine. Group: Biochemicals. Grades: Highly Purified. CAS No. 125112-74-5. Pack Sizes: 10mg. US Biological Life Sciences.
(3α,5 β,6 β,7α)-3-[(Ethoxycarbonyl)oxy]-6-(formyloxy)-7-hydroxycholan-24-oic Acid Methyl Ester is an intermediate in the synthesis of α-Muricholic Acid (M732750), an bileacid metabolite found in urine. Group: Biochemicals. Grades: Highly Purified. CAS No. 125112-77-8. Pack Sizes: 5mg. US Biological Life Sciences.
(3α,5 β,7α)-3-[(Ethoxycarbonyl)oxy]-7-hydroxycholan-24-oic Acid Methyl Ester is an intermediate in the synthesis of α-Muricholic Acid (M732750), an bileacid metabolite found in urine. Group: Biochemicals. Grades: Highly Purified. CAS No. 61252-49-1. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
3α,7α-dihydroxy-5β-cholestanate-CoA ligase
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. This enzyme participates in bileacid biosynthesis. Group: Enzymes. Synonyms: 3α,7α-dihydroxy-5β-cholestanoyl coenzyme A synthetase; DHCA-CoA ligase; 3α,7α-dihydroxy-5β-cholestanate:CoA ligase (AMP-forming). Enzyme Commission Number: EC 6.2.1.28. CAS No. 118732-03-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5686; 3α,7α-dihydroxy-5β-cholestanate-CoA ligase; EC 6.2.1.28; 118732-03-9; 3α,7α-dihydroxy-5β-cholestanoyl coenzyme A synthetase; DHCA-CoA ligase; 3α,7α-dihydroxy-5β-cholestanate:CoA ligase (AMP-forming). Cat No: EXWM-5686.
3α,7α-Dihydroxycoprostanic acid
3α, 7α-Dihydroxycoprostanic acid is an endogenous metabolite. 3α, 7α-Dihydroxycoprostanic acid, a bileacid, is the precursor to chenodeoxycholic acid [1]. Uses: Scientific research. Group: Natural products. CAS No. 17974-66-2. Pack Sizes: 1 mg. Product ID: HY-113097.
3α,7 β-Di-O-acetyl Ursodeoxycholic Acid Methyl Ester is a reactant used in the preparation of bileacids and their metabolites. Group: Biochemicals. Alternative Names: Methyl 3α,7 β-Diacetoxy-5 β-cholan-24-oate; Methyl Ursodeoxycholate Diacetate; 3α,7 β-Dihydroxy-5 β-cholanic Acid Methyl Ester Diacetate. Grades: Highly Purified. CAS No. 60384-30-7. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
3α-hydroxycholanate dehydrogenase (NADP+)
This bacterial enzyme is involved in the modification of secondary bileacids to form 3β-bileacids (also known as iso-bileacids) via a 3-oxo intermediate. The enzyme catalyses a reversible reaction in vitro. Also acts on related bileacids. cf. EC 1.1.1.52, 3α-hydroxycholanate dehydrogenase (NAD+). Group: Enzymes. Synonyms: α-hydroxy-cholanate dehydrogenase (ambiguous). Enzyme Commission Number: EC 1.1.1.392. CAS No. 9028-57-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0312; 3α-hydroxycholanate dehydrogenase (NADP+); EC 1.1.1.392; 9028-57-3; α-hydroxy-cholanate dehydrogenase (ambiguous). Cat No: EXWM-0312.
3α-Hydroxysteroid Dehydrogenase, Recombinant
In enzymology, a 3alpha-hydroxysteroid dehydrogenase (B-specific) (EC 1.1.1.50) is an enzyme that catalyzes the chemical reaction: androsterone + NAD (P)+ ? 5alpha-androstane-3,17-dione + NAD (P)H + H+. The 3 substRates of this enzyme are androsterone, NAD+, and NADP+, whereas its 4 products are 5alpha-androstane-3,17-dione, NADH, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor, more specifically it is part of the group of hydroxysteroid dehydrogenases. Applications: Bileacid is one of the substrates of 3α-hydroxy steroiddehydrogenase. 3α-hydroxy ste...3-dehydrogenase (B-specific); 3α-hydroxysteroid:NAD (P)+ 3-oxidoreductase (B-specific); EC 1.1.1.50. Enzyme Commission Number: EC 1.1.1.50. Purity: 90% (SDS-PAGE test). Mole weight: About 28 kDa (SDS-PAGE detection). Activity: About 50U/mg powder. Appearance: White powder, lyophilized. Storage: 4°C, store at -20°C for long-term preservation. Form: Freeze dried powder. hydroxyprostaglandin dehydrogenase; 3α-hydroxysteroid oxidoreductase; sterognost 3α; 3α-hydroxysteroid dehydrogenase (B-specific); 3α-hydroxysteroid 3-dehydrogenase (B-specific); 3α-hydroxysteroid:NAD (P)+ 3-oxidoreductase (B-specific); EC 1.1.1.50. Cat No: NATE-1138.
3 β-Hydroxychol-5-enoic Acid Methyl Ester
3 β-Hydroxychol-5-enoic Acid Methyl Ester is a derivative of 5-Cholenic acid-3 β-ol, an selective inhibition of cyclic AMP-dependent protein kinase. 3 β-Hydroxychol-5-enoic Acid Methyl Ester is a reactant used in the preparation of cholenoic acid based bileacids present in human biological fluids. Group: Biochemicals. Alternative Names: L 601920-0; Methyl 3 β-hydroxychol-5-en-24-oate; Methyl 3 β-hydroxychol-5-enoate; Methyl Δ5-3 β-Hydroxycholanoate; Methyl-3 β-hydroxycholenate; NSC 84140. Grades: Highly Purified. CAS No. 20231-57-6. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
3β-hydroxycholanate 3-dehydrogenase (NAD+)
This bacterial enzyme is involved, along with EC 1.1.1.52, 3α-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3α-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bileacids to form 3β-bileacids (also known as iso-bileacids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bileacids. cf. EC 1.1.1.393, 3β-hydroxycholanate 3-dehydrogenase (NADP+). Group: Enzymes. Synonyms: 3β-hydroxysteroid dehydrogenase. Enzyme Commission Number: EC 1.1.1.391. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0311; 3β-hydroxycholanate 3-dehydrogenase (NAD+); EC 1.1.1.391; 3β-hydroxysteroid dehydrogenase. Cat No: EXWM-0311.
3β-hydroxycholanate 3-dehydrogenase (NADP+)
This bacterial enzyme is involved, along with EC 1.1.1.52, 3α-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3α-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bileacids to form 3β-bileacids (also known as iso-bileacids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bileacids. cf. EC 1.1.1.391, 3β-hydroxycholanate 3-dehydrogenase (NAD+). Group: Enzymes. Synonyms: 3β-hydroxysteroid dehydrogenase (ambiguous). Enzyme Commission Number: EC 1.1.1.393. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0313; 3β-hydroxycholanate 3-dehydrogenase (NADP+); EC 1.1.1.393; 3β-hydroxysteroid dehydrogenase (ambiguous). Cat No: EXWM-0313.
3-Hydroxy-7,12-diketocholanoic Acid
3-Hydroxy-7,12-diketocholanoic Acid is a bileacid salt as biosurfactants. Group: Biochemicals. Grades: Highly Purified. CAS No. 517-33-9. Pack Sizes: 50mg, 250mg. Molecular Formula: C24H36O5, Molecular Weight: 404.54. US Biological Life Sciences.
Worldwide
3-oxo-5β-steroid 4-dehydrogenase
This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-CH group of donor with other acceptors. This enzyme participates in 3 metabolic pathways: bileacid biosynthesis, c21-steroid hormone metabolism, and androgen and estrogen metabolism. Group: Enzymes. Synonyms: 3-oxo-5β-steroid:(acceptor) Δ4-oxidoreductase. Enzyme Commission Number: EC 1.3.99.6. CAS No. 9067-97-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1440; 3-oxo-5β-steroid 4-dehydrogenase; EC 1.3.99.6; 9067-97-4; 3-oxo-5β-steroid:(acceptor) Δ4-oxidoreductase. Cat No: EXWM-1440.
3-?Oxocholic acid
3-Oxocholic acid is an oxo-bileacid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 3-Dehydrocholic acid. CAS No. 2304-89-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N7387.
3-Oxo deoxycholic acid
3-oxo Deoxycholic acid is a secondary bileacid and a metabolite of Deoxycholic acid (HY-N0593) in C. perfringens [1]. Uses: Scientific research. Group: Natural products. CAS No. 4185-1-7. Pack Sizes: 5 mg. Product ID: HY-W391635.
4β-Hydroxycholesterol
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bileacids that is found in human circulation [1]. Uses: Scientific research. Group: Natural products. CAS No. 17320-10-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-124265.
(5 β,6α)-6-Hydroxy-3-oxo-cholan-24-oic Acid
6α-Hydroxy bileacid analog. A receptor-specific activator of nuclear liver X receptor alpha. Group: Biochemicals. Alternative Names: 6α-Hydroxy-3-oxo-5 β-cholan-24-oic Acid. Grades: Highly Purified. CAS No. 67733-54-4. Pack Sizes: 10mg. US Biological Life Sciences.
6α-Hydroxy bileacid analog. Used in the preparation of progesterone and α-Hyodeoxycholic Acid. Group: Biochemicals. Alternative Names: Methyl-3-keto-6α-hydroxy-5 β-cholanoate; 6α-Hydroxy-3-oxo-5 β-cholan-24-oic Acid Methyl Ester. Grades: Highly Purified. CAS No. 3360-89-2. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
5β-cholestane-3α,7α-diol 12α-hydroxylase
A heme-thiolate protein (P-450). This is the key enzyme in the biosynthesis of the bileacid cholic acid (3α,7α,12α-trihydroxy-5β-cholanoic acid). The activity of this enzyme determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid. The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent. Group: Enzymes. Synonyms: 5β-cholestane-3α,7α-diol 12α-monooxygenase; sterol 12α-hydroxylase (ambiguous); CYP8B1; cytochrome P450 8B1. Enzyme Commission Number: EC 1.14.13.96. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0904; 5β-cholestane-3α,7α-diol 12α-hydroxylase; EC 1.14.13.96; 5β-cholestane-3α,7α-diol 12α-monooxygenase; sterol 12α-hydroxylase (ambiguous); CYP8B1; cytochrome P450 8B1. Cat No: EXWM-0904.
6-Oxolithocholic acid
6-Oxolithocholic acid is a bileacid metabolite derived from Lithocholic acid (HY-B0172). 6-Oxolithocholic acid has high cytotoxicity and can induce apoptosis , especially in hepatocytes. 6-Oxolithocholic acid can participate in the regulation of bileacid metabolism and synthesis and affect the metabolic pathway of cholesterol. 6-Oxolithocholic acid can be used to study the role of bileacids in health and disease, especially in the context of digestive and liver diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 6-Ketolithocholic acid. CAS No. 2393-61-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-W587530.
7,7-Azo-3-a,12-a-dihydroxytaurocholanic Acid, Sodium Salt
A photoaffinity probe for the hepatocyte bileacid transport system. Enquire about the radiolabelled compound. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
7α,12α-Dihydroxy-5 β-cholestan-3-one
Substrate for 3α-Hydroxysteroid Dehydrogenase in primary bileacid biosynthesis. Group: Biochemicals. Alternative Names: (5 β, 7α, 12α)-7, 12-Dihydroxy-cholestan-3-one. Grades: Highly Purified. CAS No. 547-97-7. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
7α-Hydroxy-4-cholesten-3-one
7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bileacids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bileacid loss, irritable bowel syndrome, and other diseases associated with defective bileacid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1 [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 3862-25-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-113259.
7α-Hydroxy-4-cholesten-3-one-d7
7α-Hydroxy-4-cholesten-3-one-d 7 is the deuterium labeled 7α-Hydroxy-4-cholesten-3-one. 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bileacids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bileacid loss, irritable bowel syndrome, and other diseases associated with defective bileacid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 2260669-17-6. Pack Sizes: 5 mg; 500 μg. Product ID: HY-113259S.
7α-hydroxycholest-4-en-3-one 12α-hydroxylase
A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH-hemoprotein reductase and cytochrome b5 for maximal activity. This enzyme is important in bileacid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid. Group: Enzymes. Synonyms: 7α-hydroxy-4-cholesten-3-one 12α-monooxygenase; CYP12; sterol 12α-hydroxylase (ambiguous); HCO 12α-hydroxylase. Enzyme Commission Number: EC 1.14.18.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0970; 7α-hydroxycholest-4-en-3-one 12α-hydroxylase; EC 1.14.18.8; 7α-hydroxy-4-cholesten-3-one 12α-monooxygenase; CYP12; sterol 12α-hydroxylase (ambiguous); HCO 12α-hydroxylase. Cat No: EXWM-0970.
7α-Hydroxy Cholesterol
7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bileacids cholic acid and chenodeoxycholic acid. 7α-Hydroxy Cholesterol is also a secondary metabolite of Cholesterol. 7α-hydroxy Cholesterol (40 μM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs). Synonyms: cholest-5-ene-3β,7α-diol; 7alpha-hydroxy-cholesterol; 7-alpha-OHC. Grades: > 95%. CAS No. 566-26-7. Molecular formula: C27H46O2. Mole weight: 402.65.
7α-hydroxysteroid dehydrogenase
Catalyses the oxidation of the 7α-hydroxy group of bileacids and alcohols both in their free and conjugated forms. The Bacteroides fragilis and Clostridium enzymes can also utilize NADP+. Group: Enzymes. Synonyms: 7α-hydroxy steroid dehydrogenase; 7α-HSDH. Enzyme Commission Number: EC 1.1.1.159. CAS No. 39361-64-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0062; 7α-hydroxysteroid dehydrogenase; EC 1.1.1.159; 39361-64-3; 7α-hydroxy steroid dehydrogenase; 7α-HSDH. Cat No: EXWM-0062.
7β-hydroxysteroid dehydrogenase (NADP+)
Catalyses the oxidation of the 7β-hydroxy group of bileacids such as ursodeoxycholate. Group: Enzymes. Synonyms: NADP-dependent 7β-hydroxysteroid dehydrogenase; 7β-hydroxysteroid dehydrogenase (NADP). Enzyme Commission Number: EC 1.1.1.201. CAS No. 79393-83-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0106; 7β-hydroxysteroid dehydrogenase (NADP+); EC 1.1.1.201; 79393-83-2; NADP-dependent 7β-hydroxysteroid dehydrogenase; 7β-hydroxysteroid dehydrogenase (NADP). Cat No: EXWM-0106.
7-Ketocholesterol
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bileacid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis ( apoptosis ) [1]. Uses: Scientific research. Group: Natural products. CAS No. 566-28-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113342.
7-keto-Deoxycholic acid
7-keto-Deoxycholic acid is a metabolite of bileacids in Clostridium absonum. 7-keto-Deoxycholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 911-40-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-41324.
7-Ketolithocholic acid
7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid), a bileacid, can be absorbed and suppresses endogenous bileacid production and biliary cholesterol secretion [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 3α-Hydroxy-7-oxo-5β-cholanic acid. CAS No. 4651-67-6. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-W018512.
7-O-Acetyl Ursodeoxycholic Acid Methyl Ester
7-O-Acetyl Ursodeoxycholic Acid Methyl Ester is a reactant used in the preparation of bileacids and 3 β-Ursodeoxycholic Acid. Group: Biochemicals. Alternative Names: (3α,5 β,7 β)-7-(Acetyloxy)-3-hydroxy-cholan-24-oic Acid Methyl Ester. Grades: Highly Purified. CAS No. 75672-24-1. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Alisol B 23-Acetate
Alisol B 23-acetate (23-Acetylalismol B), a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation.IC50 Value:Target: Anti-hepatotoxic natural product.In vitro: Alisol-B 23-acetate has an effect on FXR activation in a dose-dependent manner using luciferase reporter assay in HepG2 cells.In vivo: In alisol B 23-acetate-treated mice, the changes in transporters and enzymes, as well as ameliorative liver histology were abrogated by FXR antagonist guggulsterone. Alisol B 23-acetate treatment in a dose-dependent manner resulted in protection against hepatotoxicity induced by CCl4via FXR activation. Through FXR activation, alisol B 23-acetate promoted hepatocyte proliferation via an induction in hepatic levels of FoxM1b, Cyclin D1 and Cyclin B1. Alisol B 23-acetate also reduced hepatic bileacids through a decrease in hepatic uptake transporter Ntcp, bileacid synthetic enzymes Cyp7a1, Cyp8b1, and an increase in efflux transporter Bsep, Mrp2 expression. In addition, alisol B 23-acetate induced the expression of STAT3 phosphorylation, and STAT3 target genes Bcl-xl and SOCS3, resulting in decreased hepatocyte apoptosis. Group: Inhibitors. CAS No. 26575-95-1. Molecular formula: C32H50O5. Mole weight: 514.8. Appearance: White powder. Purity: 0.98. IUPACName: [1-(3,3-dimethyloxiran-2-yl)-3-[(8S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-3-oxo-1,2,5,6,7,9,11,12,15
Allocholic acid
Allocholic acid is a bileacid metabolized from animals. Allocholic acid is also a precursor to petromyzonol. Synonyms: 3alpha,7alpha,12alpha-Trihydroxy-5alpha-cholan-24-oic acid; 5alpha-cholic acid; 5α-cholanic acid-3α,7α,12α-triol. Grades: >99%. CAS No. 2464-18-8. Molecular formula: C24H40O5. Mole weight: 408.57.
Allocholic acid
Allocholic acid is a typically fetal bileacid found in vertebrates and reappears during liver regeneration and carcinogenesis, besides it is also a conjugate acid of allocholate and an isomer of cholic acid. Allocholic acid is a potent and specific stimulant of the adult olfactory system, it has a role as a marine metabolite, a rat metabolite and a human metabolite [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 2464-18-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-125934.
Allo-UDCA
Allo-UDCA is an impurity of ursodeoxycholic acid (UDCA), a naturally occurring hydrophilic bileacid. Synonyms: 3alpha,7beta-Dihydroxy-5alpha-cholan-24-oic Acid; Ursodesoxycholsaure; Alloursodeoxycholic acid. CAS No. 105227-28-9. Molecular formula: C24H40O4. Mole weight: 392.57.
α-Hyodeoxycholic Acid-d5
Labeled Hyodeoxycholic Acid. Unlabeled version is isolated from pig bile. Antitumor agent. Group: Biochemicals. Alternative Names: (3α,5 β,6α)-Dihydroxy-5 β-cholan-24-oic Acid-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
α-methylacyl-CoA racemase
α-methyl-branched acyl-CoA derivatives with chain lengths of more than C10 are substrates. Also active towards some aromatic compounds (e.g. ibuprofen) and bileacid intermediates, such as trihydroxycoprostanoyl-CoA. Not active towards free acids. Group: Enzymes. Enzyme Commission Number: EC 5.1.99.4. CAS No. 156681-44-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5436; α-methylacyl-CoA racemase; EC 5.1.99.4; 156681-44-6. Cat No: EXWM-5436.
α-Muricholic acid
α-Muricholic acid is the most abundant primary bileacid in rodents [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 2393-58-0. Pack Sizes: 1 mg. Product ID: HY-115433.
α-Muricholic Acid
α-Muricholic Acid is an bileacid found in urine. Studies have linked α-Muricholic in the understanding of the complex signaling pathways of hepatic lipid abnormalities with type 2 diabetes and a treatment target for this condition. Group: Biochemicals. Alternative Names: 5 β-Cholanic Acid-3α,6 β,7α-triol; 3α,6 β,7α-Trihydroxy-5 β-cholan-24-oic Acid; 3α,6 β,7α-Trihydroxy-5 β-cholanic Acid; 3α,6 β,7α-Trihydroxy-5 β-cholan-24-oic Acid; (3α,5 β,6 β,7α)-3,6,7-Trihydroxycholan-24-oic Acid. Grades: Highly Purified. CAS No. 2393-58-0. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
α-Phocaecholic acid
α-Phocaecholic acid is a bileacid. Synonyms: alpha-Phocaecholic acid; 3,7,12,23-Tetrahydroxycholan-24-oic acid. CAS No. 6879-45-4. Molecular formula: C24H40O6. Mole weight: 424.57.
β-Hyodeoxycholic Acid
A potential bileacid metabolite. Group: Biochemicals. Alternative Names: (3 β,5 β,6α)-. Grades: Highly Purified. CAS No. 570-84-3. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
β-Muricholic Acid
β-Muricholic Acid is an bileacid found in urine. β-Muricholic Acid has been used in studies of down regulation of transporter protein through ubiquitin dependent protein degradation. Group: Biochemicals. Alternative Names: 3α,6 β,7 β-Trihydroxy-5 β-cholan-24-oic Acid; 5 β-Cholanic Acid-3α,6 β,7 β-triol; 3α,6 β,7 β-Trihydroxy-5 β-cholanic Acid; 3α,6 β,7 β-Trihydroxy-5 β-cholan-24-oic Acid; (3α,5 β,6 β,7 β)-3,6,7-Trihydroxycholan-24-oic Acid. Grades: Highly Purified. CAS No. 2393-59-1. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
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