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| Product | Description | |
|---|---|---|
| Bleomycin | Bleomycin. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3S,4S,5R,6R)-2-(((2R,3S,4S,5S,6S)-2-((1R,2S)-2-(6-amino-2-((S)-3-amino-1-(((S)-2,3-diamino-3-oxopropyl)amino)-3-oxopropyl)-5-methylpyrimidine-4-carboxamido)-3-(((2R,3S,4S)-5-(((2S,3R)-1-((2-(4-((3-((4-aminobutyl)amino)propyl)carbamoyl)-[2,4'-bithiazol]-2'-yl)ethyl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-3-hydroxy-4-methyl-5-oxopentan-2-yl)amino)-1-(1H-imidazol-4-yl)-3-oxopropoxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl carbamate. Molecular Formula: C57H89N19O21S2. Mole Weight: 1440.56. Catalog: APB03866. |  |
| Bleomycin a2 | Heterocyclic Organic Compound. Alternative Names: BLEOMYCIN A2;Bleomycinamide, N1-[3-(dimethylsulfonio)propyl]-; BLEMOYCIN AZ; Bleogin; N1-[3- (Dimethylsulfonio) propyl]bleomycinamide; Pingyangmycin A2;Zhengguangmycin A2;Einecs 234-356-5. CAS No. 11116-31-7. Molecular formula: C55H84N17O21S3+. Mole weight: 1415.55. Catalog: ACM11116317. |  |
| Bleomycin A2 | It is one of two components found in the glycopeptide antineoplastic antibiotic Bleomycin sulfate. Bleomycin sulfate is a chemotherapeutic agent used for the treatment of hodgkins lymphoma. It is isolated from the bacterium Streptomyces verticillus. Synonyms: Bleomycin a2; Bleomycinamide, N1-[3-(dimethylsulfonio)propyl]-; Bleogin; N1-[3- (Dimethylsulfonio) propyl]bleomycinamide; Pingyangmycin A2; Zhengguangmycin A2. Grades: ≥95.0%. CAS No. 11116-31-7. Molecular formula: C55H84N17O21S3. Mole weight: 1415.55. |  |
| Bleomycin a5 | Heterocyclic Organic Compound. Alternative Names: Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-; bleomycetin; Bleomycin A5; N1- (3- ( (4-Aminobutyl) amino) propyl) bleomycinamide; Pingyangmycin A5;Zhengguanmycin A5;Nsc350895. CAS No. 11116-32-8. Molecular formula: C57H89N19O21S2. Mole weight: 1440.56. Density: 1.56g/cm³. Catalog: ACM11116328. | |
| Bleomycin A5 hydrochloride | Bleomycin A5 hydrochloride is an antitumor antibiotic which induces apoptosis. Synonyms: Bleomycin A5 HCl; N1- (3- ( (4-Aminobutyl) amino) propyl) bleomycinamide hydrochloride; Bleomycinamide, N(sup 1)-(3-((4-aminobutyl)amino)propyl)-, hydrochloride. CAS No. 55658-47-4. Molecular formula: C57H89CuN19O21S2.3HCl. Mole weight: 1477.02. | |
| Bleomycin A5 Hydrochloride | Bleomycin A5 Hydrochloride. Group: Biochemicals. Alternative Names: N1- [3- [ (4-Aminobutyl) amino] propyl] bleomycinamide Hydrochloride. Grades: Highly Purified. CAS No. 55658-47-4. Pack Sizes: 5mg. Molecular Formula: C57H90ClN19O21S2, Molecular Weight: 1477.02. US Biological Life Sciences. |  Worldwide |
| Bleomycin A6 | Bleomycin is a glycopeptide anti-tumor antibiotic produced by Streptomyces verticillus B-80-Z2. It has anti-gram-positive bacteria, negative bacteria, and mycobacterial activity, and is particularly active against Mycobacterium phlei. Synonyms: zhengguangmycin A6. CAS No. 37293-17-7. Molecular formula: C60H96N20O21S2. Mole weight: 1497.65. | |
| Bleomycin B4 | Bleomycin B4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R, 3S, 4S, 5R, 6R) -2- ( ( (2R, 3S, 4S, 5S, 6S) -2- ( (1R, 2S) -2- (6-amino-2- ( (S) -3-amino-1- ( ( (S) -2, 3-diamino-3-oxopropyl) amino) -3-oxopropyl) -5-methylpyrimidine-4-carboxamido) -3- ( ( (2R, 3S, 4S) -5- ( ( (2S, 3R) -1- ( (2- (4- ( (4- (3- (4-guanidinobutyl) guanidino) butyl) carbamoyl) -[2, 4'-bithiazol]-2'-yl) ethyl) amino) -3-hydroxy-1-oxobutan-2-yl) amino) -3-hydroxy-4-methyl-5-oxopentan-2-yl) amino) -1- (1H-imidazol-4-yl) -3-oxopropoxy) -4, 5-dihydroxy-6- (hydroxymethyl) tetrahydro-2H-pyran-3-yl) oxy) -3, 5-dihydroxy-6- (hydroxymethyl) tetrahydro-2H-pyran-4-yl carbamate. CAS No. 9060-11-1. Molecular Formula: C60H95N23O21S2. Mole Weight: 1538.67. Catalog: APB9060111. | |
| Bleomycin complex (as sulfate salts) | Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2 and typically represent >90% of the total weight with the remainder comprising the minor analogues. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo- enzyme that induces DNA cleavage. Group: Biochemicals. Alternative Names: Blenoxane; Blexane; Bleo. Grades: Highly Purified. CAS No. 9041-93-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Bleomycin EP impurity B | Bleomycin EP impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 11116-32-8. Molecular Formula: C57H89N19O21S2. Mole Weight: 1440.57. Catalog: APB11116328. | |
| Bleomycin hydrochloride | Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 67763-87-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17565A. |  |
| Bleomycin hydrochloride | Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic. Group: Inhibitors. Alternative Names: Bleomycin, hydrochloride. CAS No. 67763-87-5. Molecular formula: C50H71N16O21S2R?x(HCl). Mole weight: Unspecified. Appearance: Solid. Purity: 0.9945. Canonical SMILES: O=C (C1=NC ([C@H] (CC (N)=O)NC[C@H] (N)C (N)=O)=NC (N)=C1C)N[C@H] (C (N[C@H] (C)[C@@H] (O)[C@H] (C)C (N[C@] ([C@H] (O)C) ([H])C (NCCC2=NC (C3=NC (C (N[R])=O)=CS3)=CS2)=O)=O)=O)[C@H] (C4=CN=CN4)O[C@H]5[C@H] ([C@H] ([C@@H] ([C@@H] (O5)CO)O)O)O[C@]6 ([H])[C@H] ([C@H] ([C@@H] ([C@H] (O6)CO)O)OC (N)=O)O. NC (NCCCC[R])=N. [R]CCC[S+] (C)C. [H]Cl. [R=]. [Bleomycin A2].[R=].[Bleomycin B2]. Catalog: ACM67763875. | |
| bleomycin hydrolase | The molecule is a homohexamer in which the monomers have a papain-like tertiary structure (in peptidase family C1). The active sites are on the walls of a central channel through the molecule, and access of substrate molecules to them is obstructed by this and by the C-terminus of each polypeptide chain. Bleomycin can scarcely be the natural substrate, and there are reports of limited endopeptidase activity. Known from bacteria as well as eukaryotic organisms. Hydrolase H from chicken muscle has many similarities to bleomycin hydrolase, but hydrolyses Ph-CO-Arg-2-naphthylamine as well as aminopeptidase substrates. Group: Enzymes. Synonyms: aminopeptidase C (Lactococcus lactis). Enzyme Commission Number: EC 3.4.22.40. CAS No. 53096-17-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4215; bleomycin hydrolase; EC 3.4.22.40; 53096-17-6; aminopeptidase C (Lactococcus lactis). Cat No: EXWM-4215. |  |
| Bleomycin impurity 2 | Bleomycin impurity 2. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C55H83N16O22S3+. Mole Weight: 1416.54. Catalog: APB10385. | |
| Bleomycin impurity 4 | Bleomycin impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2'-((3S,6R,7S,8S,11S)-1-(6-amino-2-((S)-3-amino-1-(((S)-2,3-diamino-3-oxopropyl)amino)-3-oxopropyl)-5-methylpyrimidin-4-yl)-3-((R)-(((2R,3S,4S,5S,6S)-3-(((2R,3S,4S,5R,6R)-4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)(1H-imidazol-4-yl)methyl)-7-hydroxy-11-((R)-1-hydroxyethyl)-6,8-dimethyl-1,4,9,12-tetraoxo-2,5,10,13-tetraazapentadecan-15-yl)-[2,4'-bithiazole]-4-carboxylic acid. CAS No. 37364-66-2. Molecular Formula: C50H72N16O22S2. Mole Weight: 1313.33. Catalog: APB37364662. | |
| Bleomycin Impurity 7 Sulfate | Bleomycin Impurity 7 Sulfate. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 9041-93-4 (unspecified sulfate content); N-[3- (dimethylsulfonio) propyl]bleomycinamide (bleomycin A2) and N-[4- (carbamimidoylamino) butyl]bleomycinamide (bleomycin B2), sulfate (1:1). Molecular Formula: C55H34N20O21S2· H2SO4. Mole Weight: 1513.62. Catalog: APB03864. | |
| Bleomycin Impurity 8 | Bleomycin Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3-(2'-((3S,6R,7S,8S,11S)-1-(6-amino-2-((S)-3-amino-1-(((S)-3-amino-3-oxo-2-(propan-2-ylideneamino)propyl)amino)-3-oxopropyl)-5-methylpyrimidin-4-yl)-3-((R)-(((2R,3S,4S,5S,6S)-3-(((2R,3S,4S,5R,6R)-4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)(1H-imidazol-4-yl)methyl)-7-hydroxy-11-((R)-1-hydroxyethyl)-6,8-dimethyl-1,4,9,12-tetraoxo-2,5,10,13-tetraazapentadecan-15-yl)-[2,4'-bithiazole]-4-carboxamido)propyl)dimethylsulfonium. Molecular Formula: C58H88N17O21S3. Mole Weight: 1455.62. Catalog: APB03865. | |
| Bleomycin impurity A5 HCl | Bleomycin impurity A5 HCl. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 11116-32-8 (free salt); (2R,3S,4S,5R,6R)-2-(((2R,3S,4S,5S,6S)-2-((1R,2S)-2-(6-amino-2-((S)-3-amino-1-(((S)-2,3-diamino-3-oxopropyl)amino)-3-oxopropyl)-5-methylpyrimidine-4-carboxamido)-3-(((2R,3S,4S)-5-(((2S,3R)-1-((2-(4-((3-((4-aminobutyl)amino)propyl)carbamoyl)-[2,4'-bithiazol]-2'-yl)ethyl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-3-hydroxy-4-methyl-5-oxopentan-2-yl)amino)-1-(1H-imidazol-4-yl)-3-oxopropoxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl carbamate hydrochloride. CAS No. 55658-47-4. Molecular Formula: C57H89N19O21S2·HCl. Mole Weight: 1477.03. Catalog: APB55658474. | |
| Bleomycin sulfate | Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Bleomycin sulfate. CAS No. 9041-93-4. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-17565. | |
| Bleomycin sulfate | Bleomycin Sulfate is part of a group of related glycopeptide antibiotics. Bleomycin A2 is the main component of the bleomycin employed clinically. Antineoplastic. Group: Inhibitors. Alternative Names: Blenmycins;BleoMycin Sufate;BLEMOYCIN SULFATE;Bleomycin (sulfate);BLENOXANE. CAS No. 9041-93-4. Molecular formula: C110H168N34O46S7. Appearance: White powder. Purity: 0.9853. Canonical SMILES: O=C (C1=NC ([C@H] (CC (N)=O)NC[C@H] (N)C (N)=O)=NC (N)=C1C)N[C@H] (C (N[C@H] (C)[C@@H] (O)[C@H] (C)C (N[C@] ([C@H] (O)C) ([H])C (NCCC2=NC (C3=NC (C (N[R])=O)=CS3)=CS2)=O)=O)=O)[C@H] (C4=CN=CN4)O[C@H]5[C@H] ([C@H] ([C@@H] ([C@@H] (O5)CO)O)O)O[C@]6 ([H])[C@H] ([C@H] ([C@@H] ([C@H] (O6)CO)O)OC (N)=O)O. NC (NCCCC[R])=N. [R]CCC[S+] (C)C. O=S (O) (O)=O. [R=]. [Bleomycin A2].[R=].[Bleomycin B2]. Catalog: ACM9041934. | |
| Bleomycin Sulfate | 10mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: N/A. CAS No. 9041-93-4. Prepack ID 25097489-10mg. See USA prepack pricing. |  |
| Bleomycin Sulfate (A2, B2) | A group of related glycopeptide antibiotics. Bleomycin A2 is the main component of the bleomycin employed clinically. Antineoplastic. Mixture of Bleomycin A2, B2 isolated from Streptomyces verticillus. Group: Biochemicals. Alternative Names: Blenoxane; Blexane; Bleo. Grades: Purified. CAS No. 9041-93-4. Pack Sizes: 10mg, 50mg. Molecular Formula: C55H84N17O21S3·xH2SO4, Molecular Weight: 1415.56 (free acid basis). US Biological Life Sciences. | Worldwide |
| Demethylbleomycin A2 sulfate | A demethylated form of bleomycin A2 which is a major component in standard grade bleomycin. It is formed by heating bleomycin A2. It has high antimicrobial activity against mycobacterium smegmatis compared to bleomycin A2. It has a lower toxicity. Synonyms: Bleomycin DM-A2 sulfate; N1-[3-(Methylthio)propyl]bleomycinamide sulfate. Grades: ≥90%. Molecular formula: C54H81N17O21S3.xH2SO4. Mole weight: 1400.51 (free base). | |
| acylagmatine amidase | Also acts on acetylagmatine, propanoylagmatine and bleomycin B2. Group: Enzymes. Synonyms: acylagmatine amidohydrolase; acylagmatine deacylase. Enzyme Commission Number: EC 3.5.1.40. CAS No. 39419-74-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4429; acylagmatine amidase; EC 3.5.1.40; 39419-74-4; acylagmatine amidohydrolase; acylagmatine deacylase. Cat No: EXWM-4429. | |
| AM095 | AM095, an effective LPA1 receptor antagonist, has been found to decrease dermal fibrosis caused by attenuates bleomycin. IC50: 0.98 uM and 0.73 uM for human and mouse LPA1 respectively. Synonyms: AM095 (free acid); AM-095; AM 095. Grades: 98%. CAS No. 1228690-36-5. Molecular formula: C27H24N2O5. Mole weight: 456.49. | |
| AS-605240 | AS605240 is a selective PI3Kgamma inhibitor, has been proved effective on several inflammatory diseases. Orally administration of AS605240 significantly prevented lung inflammation and reduced collagen deposition. AS605240 also inhibited augmented expression of TNF-alpha and IL-1beta induced by bleomycin instillation. AS605240 may be a useful in treating inflammation diseases. AS605240 may represent a promising novel agent for the future therapy of pulmonary fibrosis. Synonyms: AS 605240; AS605240; AS-605240. Grades: 0.98. CAS No. 648450-29-7. Molecular formula: C12H7N3O2S. Mole weight: 257.267. | |
| AUDA | AUDA is an inhibitor of soluble epoxide hydrolase with IC50 of 18 nM in mice. AUDA has been shown to demonstrate hypotensive effects, accompanied by an increase in urinary epoxide-to-diol ratios. AUDA can activate peroxisome proliferator-activated receptor α (PPARα) 3-fold, while showing no ability to affect PPARδ or PPAR&gamma. AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways. Synonyms: 12-(3-Adamantan-1-yl-ureido)dodecanoic Acid; 12-[[(Tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]dodecanoic Acid; A 003564556. Grades: >98%. CAS No. 479413-70-2. Molecular formula: C23H40N2O3. Mole weight: 392.6. | |
| Boanmycin Hydrochloride Liposome | Boanmycin hydrochloride has the same chemical structure as bleomycin A6 and has broad-spectrum anticancer effects. This product is a pre-formulated liposome with boanmycin hydrochloride. It is only for research purposes. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. |  |
| Boromycin (Antibiotic A 28829, Ivomycin, NSC216128) | Boron-containing macrolide antibiotic. Antibacterial. Antiprotozoal (Plasmodium, Babesia). Anti-HIV compound. Ca2+ homeostasis modulator. Potentiator of bleomycin-induced anti-tumor activity. Used as a chiral selector in capillary electrophoresis.CAS Number:34524-20-4. Group: Biochemicals. Grades: Highly Purified. CAS No. 34524-20-4. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| CCG 232601 | CCG 232601 is a selective and orally bioactive inhibitor of the Rho/MRTF/SRF signaling pathway (IC50 value of 0.55 μM (SRE.L assay)) as a potential antifibrotic therapeutic for systemic scleroderma. CCG-232601 inhibits the development of bleomycin-induced dermal fibrosis in mice when administered orally. Synonyms: N-(4-chlorophenyl)-5,5-difluoro-1-(3-pyridin-4-ylbenzoyl)piperidine-3-carboxamide; CCG-232601; CCG 232601; CCG232601. Grades: 99%. CAS No. 1922099-21-5. Molecular formula: C24H20ClF2N3O2. Mole weight: 455.88. | |
| cis-Diamineplatinum(II) dichloride | cis-Diamineplatinum(II) dichloride. Uses: Cisplatin is a cytostatic agent and it is used to treat various cancer types, including cancer of ovary, testis, lung, head, neck, bladder, neuroblastoma, and nephroblastoma, and hodgkin's disease and non-hodgkin lymphoma.cddp, also referred to as cisplatinum or cisplatin, is a yellow powder and has found widespread use a chemotherapeutic agent.cisplatin, combined with bleomycin and vinblastine or etoposide, produces cures in most patients with metastatic testicular cancer or germ cell cancer of the ovary. cisplatin also shows some activity against carcinomas of the head and neck, bladder, cervix, prostate, and lung. Group: Salt. Alternative Names: cis-Dichlorodiammine platinum(II). CAS No. 15663-27-1. Molecular formula: 300.05. Mole weight: Pt(NH3)2Cl2. Pt ≥65.0%. |  |
| cis-Diamineplatinum(II) dichloride | Cisplatin is a cytostatic agent and it is used to treat various cancer types, including cancer of ovary, testis, lung, head, neck, bladder, neuroblastoma, and nephroblastoma, and Hodgkin's disease and non-Hodgkin lymphoma.CDDP, also referred to as cisplatinum or cisplatin, is a yellow powder and has found widespread use a chemotherapeutic agent.Cisplatin, combined with bleomycin and vinblastine or etoposide, produces cures in most patients with metastatic testicular cancer or germ cell cancer of the ovary. Cisplatin also shows some activity against carcinomas of the head and neck, bladder, cervix, prostate, and lung. Group: Platinum series of catalysts. Alternative Names: cis-Dichlorodiammine platinum(II). CAS No. 15663-27-1. Molecular formula: Pt(NH3)2Cl2. Mole weight: 300.05. Appearance: yellow crystals. Purity: Pt ≥65.0%. Catalog: ACM15663271. | |
| Cleomycin A2 | It is produced by the strain of Streptomyces verticillus NK-68-144. It has anti-mycobacterial and HeLa cell activity. Synonyms: 3S, S-Dimethylmercaptopropyl aminocleomycin; Bleomycinamide, 16-de(1-hydroxyethyl)-N1-(3-(dimethylsulfonio)propyl)-16-(1-hydroxycyclopropyl)-. CAS No. 754137-61-6. Molecular formula: C56H84N17O21S3. Mole weight: 1427.56. | |
| Cleomycin B2 | It is produced by the strain of Streptomyces vericillus NK68-144. Cleomycin B2 has the same structure as the corresponding bleomycin. Synonyms: Bleomycinamide, N(1)-(4-((aminoiminomethyl)amino)butyl)-16-de(1-hydroxyethyl)-16-(1-hydroxycyclopropyl)-, (16S)-. CAS No. 76741-88-3. Molecular formula: C56H84N20O21S2. Mole weight: 1437.51. | |
| Dermatan sulphate sodium | Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 54328-33-5. Pack Sizes: 5 mg. Product ID: HY-N8278. | |
| Entrectinib | Entrectinib (NMS-E628) is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C , ROS1 and ALK , with IC 50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NMS-E628; RXDX-101. CAS No. 1108743-60-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12678. | |
| FR-167653 | FR-167653 is a p38 mitogen-activated protein kinase inhibitor, which suppresses the development of endometriosis in a murine model. FR-167653 meliorates murine bleomycin-induced pulmonary fibrosis. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: FR-167653; FR 167653; FR167653. CAS No. 158876-66-5. Molecular formula: C24H20FN5O6S. Mole weight: 525.51. | |
| H-Arg-Ala-OH | Arg-Ala inhibits angiotensin 1-converting enzyme (ACE) and yeast bleomycin hydrolase. Synonyms: Arginylalanine; Arg-Ala; L-arginyl-L-alanine; RA dipeptide; N-L-Arginyl-L-alanine; Arginine Alanine dipeptide; (S)-2-((S)-2-Amino-5-guanidinopentanamido)propanoic acid. CAS No. 40968-45-4. Molecular formula: C9H19N5O3. Mole weight: 245.28. | |
| Lactoquinomycin A | It is produced by the strain of Str. tanashiensis IM 8442T. It's a quinone antibiotic. It has the activity of anti-gram-positive bacteria and some gram-negative bacteria, but the effect of anti-gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A has stronger antibacterial activity than Lactoquinomycin B. It inhibits a variety of cell lines including lymphoma L5178Y progenitor, adriamycin resistant, bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.02, 0.006, 0.008, 0.033, 0.013 and 0.03, respectively. Synonyms: Lactoquinomycin A; Medermycin; [3aS,(-)]-3,3aβ,5,11bβ-Tetrahydro-7-hydroxy-5β-methyl-8-[3-(dimethylamino)-2,3,6-trideoxy-L-arabino-hexopyranosyl]-2H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11-trione; Antibiotic K 73A; 2H-Furo[3,2-b]naphtho[2,3-d]pyran-2,6,11-trione,3,3a,5,11b-tetrahydro-7-hydroxy-5-methyl-8-[2,3,6-trideoxy-3-(dimethylamino)-beta-D-arabino-hexopyranosyl]-, (3aR,5R,11bR)-. Grades: 95%. CAS No. 60227-09-0. Molecular formula: C24H27NO8. Mole weight: 457.48. | |
| Lactoquinomycin B | It is produced by the strain of Str. tanashiensis IM 8442T. It's a quinone antibiotic. It has the activity of anti-gram-positive bacteria and some gram-negative bacteria, but the effect of anti-gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A has stronger antibacterial activity than Lactoquinomycin B. It inhibits a variety of cell lines including lymphoma L5178Y progenitor, adriamycin resistant, bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.43, 0.21, 0.19, 0.16, 0.2 and 0.12, respectively. Synonyms: 3a,11b-Dihydro-7-hydroxy-5-methyl-8-[2,3,6-trideoxy-3-(dimethylamino)-β-D-arabino-hexopyranosyl]-5a,11a-epoxy-5H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11(3H)-trione; 5a,11a-Epoxy-5H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11(3H)-trione, 3a,11b-dihydro-7-hydroxy-5-methyl-8-[2,3,6-trideoxy-3-(dimethylamino)-b-D-arabino-hexopyranosyl]-. CAS No. 101342-94-3. Molecular formula: C24H27NO9. Mole weight: 473.48. | |
| LL D05139(beta) | LL D05139(beta) is produced by the strain of Glycomyces harbinensis. It has anti-gram-positive and anti-gram-negative bacteria activities, and its activity is stronger than that of nitroserine. And its antitumor activity is similar to that of diazoserine and lower than Bleomycin. Synonyms: N-(L-alanyl)-O-(2-diazoacetyl)-L-serine; N-l-alanyl-l-serine diazoacetate. CAS No. 95153-19-8. Molecular formula: C8H12N4O5. Mole weight: 244.20. | |
| Malformin C | Peptide antibiotic. Induces root curvature and malformation in plants. Antibacterial, antimalarial and antitrypanosomal. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents.Malformin C is a bicyclic pentapeptide containing L-leucine, D-isoleucine, L-valine, and two D-cysteines coupled with a disulfide-bond bridge. Malformins A1 and C, originally isolated from the culture broth of Aspergillus niger FKI-2342, were found to abrogate the bleomycin-induced G2 arrest in Jurkat cells with IC50 values of 480nM and 0.9nM, respectively. Malformins may be promising candidates as anti-cancer agents. Source:Synthetic. Originally isolated from Aspergillus niger FKI-2342. Group: Biochemicals. Grades: Highly Purified. CAS No. 59926-78-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C23H39N5O5S2. US Biological Life Sciences. | Worldwide |
| Methyl 2-(S)-[N-Carbobenzyloxy]amino-3-aminopropionate, Hydrochloride (Methyl 2- (S) -[N-[ (Benzyloxy) carbonyl]amino-3-aminopropionate, Hydrochloride) | Important building block for the synthesis of peptides containing DAP residues, e.g. bleomycins, edeines, tuberactinomycins. Group: Biochemicals. Alternative Names: Methyl 2- (S) -[N-[ (Benzyloxy) carbonyl]amino-3-aminopropionate, Hydrochloride. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Methyl 2- (S) - [N-Carbobenzyloxy] amino-3- [N-tert-butyloxycarbonyl] aminopropionate | Important building block for the synthesis of peptides containing DAP residues, e.g. bleomycins, edeines, tuberactinomycins. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Na-Carbobenzyloxy-b-amino-L-alanine (CBZ-L-b-Aminoalanine) | Important building block for the synthesis of peptides containing DAP residues, e.g. bleomycins, edeines, tuberactinomycins. Group: Biochemicals. Alternative Names: CBZ-L-b-Aminoalanine. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| N-α-Carbobenzoxy-L-α,β-diaminopropionic acid methyl ester hydrochloride | Important building block for the synthesis of peptides containing DAP residues, e.g. bleomycins, edeines, tuberactinomycins. Uses: Important building block for the synthesis of peptides containing dap residues, e.g. bleomycins, edeines, tuberactinomycins. Synonyms: Z-Dap-OMe HCl. Grades: ≥ 98.5% (HPLC). CAS No. 35761-27-4. Molecular formula: C12H17ClN2O4. Mole weight: 288.73. | |
| Nα-Z-L-2,3-diaminopropionic acid | . Uses: Important building block for the synthesis of peptides containing dap residues, e.g. bleomycins, edeines, tuberactinomycins. Synonyms: Z-L-Dap-OH. Grades: ≥ 98% (Assay). CAS No. 35761-26-3. Molecular formula: C11H14N2O4. Mole weight: 238.48. | |
| NCX 466 | NCX 466 is a cyclooxygenase inhibiting nitric oxide donors (CINODs). NCX 466 shows higher efficacy in reducing levels of profibrotic cytokine transforming growth factor-β and oxidative stress in a mouse model of bleomycin-induced lung fibrosis camparing to naproxen. Synonyms: (αS)-6-Methoxy-α-methyl-2-naphthaleneacetic acid (5S)-5,6-bis(nitrooxy)hexyl ester. Grades: ≥98% by HPLC. CAS No. 1262956-64-8. Molecular formula: C20H24N2O9. Mole weight: 436.41. | |
| NCX 466 ((aS)-6-Methoxy-a-methyl-2-naphthalene acetic acid (5S)-5,6-bis(nitrooxy)hexyl ester) | Cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor (CINOD). Inhibits COX-1 and COX-2 while releasing NO. Demonstrates higher efficacy than naproxen, its congener drug, in reducing levels of profibrotic cytokine transforming growth factor-beta and oxidative stress in a mouse model of bleomycin-induced lung fibrosis. Orally available. Group: Biochemicals. Grades: Highly Purified. CAS No. 1262956-64-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| NU1025 | NU1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. NU1025 enhanced the cytotoxicity of the DNA-methylating agent MTIC, gamma-irradiation and bleomycin 3.5-, 1.4- and 2-fold respectively. Synonyms: NU-1025; NU 1025; 8-Hydroxy-2-methylquinazoline-4-one; NSC 696807. Grades: ≥98%. CAS No. 90417-38-2. Molecular formula: C9H8N2O2. Mole weight: 176.17. | |
| PEPLEOMYCIN SULFATE | Peplomycin is a semisynthetic analog of Bleomycin. It is a mixture of several basic glycopeptide antineoplastic antibiotics that isolated from the fungus Streptomyces verticillus. Peplomycin can form complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals. This leads to single- and double-stranded breaks in DNA. Peplomycin is a DNA synthesis inhibitor and has been used for the treatment of a various of Malignancies. Uses: Malignancies. Synonyms: N1- [3- [ [ (1S) -1-phenylethyl] amino] propyl] bleomycinamide Sulfate; NK 631; NSC-276382. Grades: 98%. CAS No. 70384-29-1. Molecular formula: C61H90N18O25S3. Mole weight: 1571.67. | |
| Peplomycin | Peplomycin is an extensively-researched compound aiding in studying a wide spectrum of malignancies encompassing pulmonary, mammary and gastric carcinomas. Uses: Antibiotics, antineoplastic. Synonyms: Pepleo; Bleomycin PEP; N(sup 1) - (3- ( (1-Phenylethyl) amino) propyl) bleomycinamide. Grades: >98%. CAS No. 68247-85-8. Molecular formula: C61H88N18O21S2. Mole weight: 1473.59. | |
| Peplomycin sulfate | Peplomycin sulfate. Group: Biochemicals. Alternative Names: N1- [3- [ [ (1S) -1-phenylethyl] amino] propyl] bleomycinamide. Grades: Highly Purified. CAS No. 70384-29-1. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C61H90N18O25S3. US Biological Life Sciences. | Worldwide |
| Phleomycin | It is produced by the strain of Streptoverticillium verticillum 843-1. It's a heteropeptide antibiotic. It has anti-gram-positive bacteria, negative bacteria and mycobacterium effects. The therapeutic index of the complex for Solid Adenocarcinoma and Sarcoma-180 are 16. The therapeutic index of Ehrlician ascites cancer is 4-8. It acts an antibiotic originally, an anticancer agent and a selection agent for transformed algae, protista, animal and fungal cells. Synonyms: Bleomycin; phleomycin complex; Phleomycins. CAS No. 11006-33-0. Molecular formula: C51H75N17O21S2. Mole weight: 1326.37. | |
| Phleomycin | Phleomycin is an anticancer glycopeptide antibiotic found in Streptomyces verticillus , which cause DNA cleavage. Phleomycin binds and intercalates DNA to damage the integrity of the double helix, which is similar to Bleomycin (HY-17565A) [1]. Uses: Scientific research. Group: Natural products. CAS No. 11006-33-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126490. | |
| Phleomycin | Phleomycin is an anticancer glycopeptide antibiotic found in Streptomyces verticillus, which cause DNA cleavage. Phleomycin binds and intercalates DNA to damage the integrity of the double helix, which is similar to Bleomycin (HY-17565A). Group: Inhibitors. CAS No. 11006-33-0. Molecular formula: C55H86N20O21S2. Mole weight: 418.44. Purity: ≥97%. Catalog: ACM11006330. | |
| Phleomycin B2 | It is produced by the strain of Streptoverticillium verticillum 843-1. It's a heteropeptide antibiotic. It has anti-gram-positive bacteria, negative bacteria and mycobacterium effects. Synonyms: Epi-Bleomycin; Dehydrophleomycin D1; Zhengguanmycin B2; N1-[4-[[Amino (imino) methyl]amino]butyl]bleomycinamide; Bleomycin B2; Bleomycinamide, N1-(4-((aminoiminomethyl)amino)butyl)-. CAS No. 9060-10-0. Molecular formula: C55H84N20O21S2. Mole weight: 1425.51. | |
| Phleomycin D1 | It is produced by the strain of Streptoverticillium verticillum 843-1. It's a heteropeptide antibiotic. It has anti-gram-positive bacteria, negative bacteria and mycobacterium effects. It extends the survival time of mice transplanted with Ehrman's ascites cancer by 300 percent with MED of 12.5-25 μg/mL. It inhibits airy entity carcinoma in mice with IC50 of 0.31 μg/mL. Synonyms: Zeocin; Zeocine; (7R)-N1-[4-[[Amino(imino)methyl]amino]butyl]-7,8-dihydrobleomycinamide; Bleomycinamide, N1-[4-[(aminoiminomethyl)amino]butyl]-7,8-dihydro-. Grades: 95%. CAS No. 11031-11-1. Molecular formula: C55H86N20O21S2. Mole weight: 1427.52. | |
| Phleomycin E | It is produced by the strain of Streptoverticillium verticillum 843-1. It's a heteropeptide antibiotic. It has anti-gram-positive bacteria, negative bacteria and mycobacterium effects. It extends the survival time of mice transplanted with Ehrman's ascites cancer by 300 percent with MED of 12.5-25 μg/mL. It inhibits airy entity carcinoma in mice with IC50 of 0.31 μg/mL. Synonyms: N1- [4- [ [ [ [4- [ [Aminoiminomethyl]amino]butyl]amino] (imino) methyl]amino]butyl]-7, 8-dihydrobleomycinamide; Bleomycinamide, N1- [4- [ [ [ [4- [ (aminoiminomethyl) amino] butyl] amino] iminomethyl] amino] butyl] -7, 8-dihydro-. CAS No. 11031-13-3. Molecular formula: C60H97N23O21S2. Mole weight: 1540.68. | |
| Phleomycin F | It is produced by the strain of Streptoverticillium verticillum 843-1. It's a heteropeptide antibiotic. It has anti-gram-positive bacteria, negative bacteria and mycobacterium effects. It extends the survival time of mice transplanted with Ehrman's ascites cancer by 300 percent with MED of 25-50 μg/mL. Synonyms: Bleomycin B4; Dehydrophleomycin E; N1- [4- [ (Aminoiminomethyl) [4- [ (aminoiminomethyl) amino] butyl] amino] butyl] bleomycinamide; Bleomycinamide, N1-[4-[ (aminoiminomethyl) [4-[ (aminoiminomethyl) amino]butyl]amino]butyl]-. CAS No. 9060-11-1. Molecular formula: C60H95N23O21S2. Mole weight: 1538.67. | |
| SPL 334 | SPL 334 is an S-nitrosoglutathione reductase inhibitor that prevents weight loss, and alleviates lung inflammation and fibrosis in a bleomycin injury model of interstitial lung disease in mice. Synonyms: SPL-334; SPL334; SPL 334; 4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 688347-51-5. Molecular formula: C22H15N3O3S2. Mole weight: 433.5. | |
| Vesnarinone | Vesnarinone, a quinolinone derivative, is a cardiotonic agent. It has pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux. Its IC50 value is 1 μM and 300 μM for inhibition of HERG channels and PDE. It is a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. It is a new and novel inotropic drug that has unique and complex mechanisms of action. It inhibits phosphodiesterase, thereby leading to increased intracellular calcium, and also affects numerous myocardial ion channels, resulting in the prolongation of the open...eby leading to increased intracellular calcium, and also affects numerous myocardial ion channels, resulting in the prolongation of the opening time of sodium channels and the decrease in the delayed outward and inward rectifying potassium current. it improves ventricular performance most in patients with the worst degree of heart failure. Synonyms: RG-0210; RG 0210; RG0210; OPC-8212; OPC 8212; OPC8212; Piteranometozine; Vesnarinone; Arkin; Arkin-Z. OPC 8212;6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone;3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2(1h)-quinolinone. Grades: >98%. CAS No. 81840-15-5. Molecular formula: C22H25N3O4. Mole weight: 395.45. | |
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