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Bombesin, a tetradecapeptide, plays an important role in the release of gastrin and the activation of G-protein receptors [1]. Uses: Scientific research. Group: Peptides. CAS No. 31362-50-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0195.
Bombesin
Bombesin is a neuropeptide with many biological effects such as hormone release, activation of pancreatic enzyme secretion, inhibition of gastric emptying and modulation of gastric acid secretion. It binds to the gastrin-releasing peptide receptor (GRPR) in rat pancreatic acinar cells (Ki = 1.88 nM), and also to frog bombesin receptor subtype 4 (BB4) in CHO cells overexpressing the receptor (Ki = 1.7 nM). Uses: Neurotransmitter agents. Synonyms: H-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2; L-pyroglutamyl-L-glutaminyl-L-arginyl-L-leucyl-glycyl-L-asparagyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide; Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2. Grades: ≥95%. CAS No. 31362-50-2. Molecular formula: C71H110N24O18S. Mole weight: 1619.85.
[D-Phe12]-Bombesin is a bombesin receptor antagonist inhibiting bombesin-induced amylase release in guinea pig pancreas (IC50 = 4 mM). Synonyms: [D-Phe12]-Bombesin; 12-Phe-bombesin; Bombesin, phe(12)-; PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-MET-NH2; Bombesin, phenylalanine(12)-; (D-Phe12)-Bombesin; Bombesin, 12-D-phenylalanine; AKOS024456850; PD079209. CAS No. 108437-87-2. Molecular formula: C74H112N22O18S. Mole weight: 1629.9.
(d-Phe12,leu14)-bombesin
Heterocyclic Organic Compound. Alternative Names: (D-PHE12,LEU14)-BOMBESIN;GLP-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-DPHE-LEU-LEU-NH2;PGLU-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-LEU-NH2;PYR-QRLGNQWAVGFLL-NH2;PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-LEU-NH2;bombesin, Phe(12), Le. CAS No. 108437-88-3. Molecular formula: C75H114N22O18. Mole weight: 1611.84. Catalog: ACM108437883.
[D-Phe12,Leu14]-Bombesin
[D-Phe12,Leu14]-Bombesin is a bombesin receptor antagonist. It inhibits bombesin binding to rat brain (IC50 = 2 μM), inhibits amylase release in vitro (IC50 = 4 μM), and attenuates bombesin-mediated suppression of food intake in vivo. Synonyms: [D-Phe12,Leu14]-Bombesin; 108437-88-3; PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-LEU-NH2; (D-Phe12,Leu14)-Bombesin; AKOS024457621; PD079499; HY-103287; CS-0027153. CAS No. 108437-88-3. Molecular formula: C75H114N22O18. Mole weight: 1610.9.
(d-Phe6,leu-nhet13,des-met14)-bombesin(6-14)
Heterocyclic Organic Compound. Alternative Names: D-PHE-GLN-TRP-ALA-VAL-GLY-HIS-LEU-NHET;(D-PHE6,LEU-NHET13,DES-MET14)-BOMBESIN (6-14);H-D-PHE-GLN-TRP-ALA-VAL-GLY-HIS-LEU-NHET. CAS No. 124199-90-2. Molecular formula: C49H69N13O9. Mole weight: 984.15. Catalog: ACM124199902.
(LEU13-PSI(CH2NH)LEU14)-BOMBESIN
Heterocyclic Organic Compound. CAS No. 117016-31-6. Purity: 0.96. Catalog: ACM117016316.
PR-bombesin
PR-bombesin is an antimicrobial peptide found in Bombina maxima (Chinese red belly toad), and has antimicrobial activity as some neuropeptides. Synonyms: Glu-Lys-Lys-Pro-Pro-Arg-Pro-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met; proline rich bombesin-related peptide (PR-bombesin). Grades: ≥97%. Molecular formula: C89H133N25O20S. Mole weight: 1905.26.
Alytesin
Alytesin is an amphibian bombesin-like peptide originally isolated from the skin of the European amphibian, alytes obstetricans. It has biological activity very similar to bombesin. It could cause rat uterine contraction, intestinal contraction, gastric acid secretion and hypertension in vivo in the dog. It also adjusts thermoregulation following central administration in vivo. Synonyms: Alytesin; 31078-12-3; CID 16131139; XGRLGTQWAVGHLM; Alytesin (trifluoroacetate salt); BDBM85497; DTXSID40185027; Pgly-arg-leu-gly-thr-gln-trp-ala-val-gly-his-leu-met-NH2; AKOS024456835; AKOS040764257; CAS_31078-12-3; HY-103276; CS-0026803; J-018236. CAS No. 31078-12-3. Molecular formula: C68H106N22O17S. Mole weight: 1535.78.
BA 1
BA 1 is a potent bombesin receptor subtype 3 (BRS-3; BB3) agonist (IC50 = 2.52 nM), and also acts as a GRPR (BB1) and NMBR (BB2) agonist (IC50 = 0.26 and 1.55 nM, respectively). BA 1 enhances glucose transport in obese and diabetic primary myocytes. BA 1 was shown to stimulate NCI-H1299 lung cancer cell proliferation in vitro. Synonyms: BA 1; BA-1; BA1. CAS No. 183241-31-8. Molecular formula: C57H76N14O11. Mole weight: 1133.32.
Bag-1
Bag-1 is a novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist. Grades: 98%. CAS No. 1021937-07-4. Molecular formula: C22H27N3. Mole weight: 333.5.
Bag-2
Bag-2 is a new powerful non-peptide bombesin receptor subtype 3 (BRS-3) agonist. Synonyms: Bag-2; 1021936-34-4; CHEMBL1084942; 2-[4-[2-[5-(cyclopentylmethyl)-1H-imidazol-2-yl]ethyl]phenyl]benzoic acid[3H]bag-2. Grades: 98%. CAS No. 1021936-34-4. Molecular formula: C24H26N2O2. Mole weight: 374.5.
BIM 187
BIM 187 is a bombesin/GRP receptor agonist that reduces food intake following i.p. administration. Synonyms: BIM 187; BIM187; BIM-187. CAS No. 137734-88-4. Molecular formula: C53H76N14O10. Mole weight: 1069.27.
BIM 189
BIM 189 is a bombesin antagonist that reduces bombesin-induced satiety. Synonyms: [D-Phe6,Leu13,Cpa14]bombesin-(6-14)NH2. Grades: >96%. CAS No. 142062-55-3. Molecular formula: C56H73ClN14O10. Mole weight: 1137.73.
Boc-2-aminoindane-2-carboxylic acid
Boc-2-aminoindane-2-carboxylic acid is used to prepare thiol dipeptides as dual inhibitors of angiotensin-I-converting enzyme and neutral endopeptidase. It is also used in the synthesis of bombesin analogs. Synonyms: Boc-Aic-OH; 2-((tert-Butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid; N-BOC-2-AMINOINDANE-2-CARBOXYLIC ACID; 2-(BOC-AMINO)INDANE-2-CARBOXYLIC ACID; 2-[(tert-butoxy)carbonylamino]indane-2-carboxylic acid; BOC AIC OH. Grades: ≥ 98% (HPLC). CAS No. 71066-00-7. Molecular formula: C15H19NO4. Mole weight: 277.32.
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a broad spectrum neuropeptide inverse agonist and antagonist. It acts as a full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM) and antagonist at tachykinin, bradykinin, CCK and bombesin receptors. It induces apoptosis and inhibits cancer cell growth in vitro. Synonyms: 1-Arg-5-Phe-7,9-Trp-11-Leu-substance P; D-Arg(10)-D-Phe(5)-D-Trp(7,9)-Leu(11)-SP; substance P, phenylalanyl(5)-tryptophyl(7,9)-leucine(11)-. CAS No. 96736-12-8. Molecular formula: C79H109N19O12. Mole weight: 1516.85.
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate is a broad-spectrum neuropeptide inverse agonist and antagonist. It acts as a full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM) and antagonist at tachykinin, bradykinin, CCK, and bombesin receptors. It induces apoptosis and inhibits cancer cell growth in vitro. Synonyms: H-D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2.CH3CO2H; D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-leucinamide acetic acid; [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P acetate. Grades: ≥95%. CAS No. 2918771-49-8. Molecular formula: C81H113N19O14. Mole weight: 1576.91.
(D-ARG1,D-PRO2,D-TRP7,9,LEU11)-SUBSTANCE P
It is a potent antagonist for substance P and bombesin. Synonyms: Substance P, arg(1)-pro(2)-trp(7),(9)-leunh(2)(11)-; Argininyl(1)-prolyl(2)-tryptophyl-7,9-leucinamide(11)-substance P. CAS No. 84676-91-5. Molecular formula: C75H108N20O13. Mole weight: 1497.79.
Gastrin-Releasing Peptide, human
Gastrin-Releasing Peptide, human (GRP) belongs to the bombesin-like peptide family, and is not a classical hypothalamic-hypophyseal regulatory hormone since it plays only a perfunctory role in the mediation of pituitary hormone release. Uses: Scientific research. Group: Peptides. CAS No. 93755-85-2. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P0238.
Gastrin-Releasing Peptide, human
Gastrin-Releasing Peptide, human (GRP), one of the bombesin-like peptide family, is an agonist for the gastrin-releasing peptide receptor (GRPR) and it plays only a perfunctory role in the mediation of pituitary hormone release. Synonyms: Gastrin-Releasing Peptide, human; H-Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2. CAS No. 93755-85-2. Molecular formula: C130H204N38O31S2. Mole weight: 2859.38.
GRP (porcine)
GRP (porcine) is a mammalian bombesin-like peptide neurotransmitter that acts as an agonist for the gastrin-releasing peptide receptor (GRPR). It was shown to activate GABAergic interneurons in the amygdala resulting in an increase in GABA release and fear suppression in mice in vivo. Synonyms: Gastrin Releasing Peptide porcine. CAS No. 74815-57-9. Molecular formula: C126H198N38O31S2. Mole weight: 2805.31.
ICI 216140
ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC 50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 124001-41-8. Pack Sizes: 1 mg. Product ID: HY-P3112.
Kuwanon G
Kuwanon G is a flavonoid isolated from Morus alba, acts as a bombesin receptor antagonist, with potential antimicrobial activity. Group: Inhibitors. Alternative Names: kuwanon G;8-[(1S)-6α-(2,4-Dihydroxybenzoyl)-5β-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1β-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;Albanin F;Moracenin B;NSC 356888. CAS No. 75629-19-5. Molecular formula: C40H36O11. Mole weight: 692.71. Appearance: Solid. Purity: 0.95. Canonical SMILES: O=C1C (C/C=C (C)\C)=C (C2=CC=C (O)C=C2O)OC3=C ([C@H]4C=C (C)C[C@@H] (C5=CC=C (O)C=C5O)[C@@H]4C (C6=CC=C (O)C=C6O)=O)C (O)=CC (O)=C13. Catalog: ACM75629195.
Litorin
Litorin is an amphibian bombesin-like peptide. It can stimulate smooth muscle contraction, gastrin release, gastric acid and pancreatic secretion, and suppress food intake in vivo. Synonyms: L-pyroglutamyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-phenylalanyl-L-methioninamide. Grades: ≥95%. CAS No. 55749-97-8. Molecular formula: C51H68N14O11S. Mole weight: 1085.25.
MK7725 is a potent, selective bombesin receptor subtype-3 agonist. It is used for the treatment of obesity. Uses: Mk7725 is used for the treatment of obesity. Synonyms: MK7725; MK 7725; MK-7725; 2-[3-[6-[4-(trifluoromethoxy)phenyl]sulfonyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl]propan-2-ol. Grades: >98 %. CAS No. 1034152-95-8. Molecular formula: C25H19F6N5O5S. Mole weight: 615.50.
ML 18
ML 18 is a bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM) and binds GRPR (IC50 = 16 μM) with potential in combating lung cancer cells. Synonyms: ML-18; ML 18; ML18. 1H-Indole-3-propanamide, N-[[1- (4-methoxyphenyl) ?cyclohexyl]?methyl]?-α -[[[ (4-nitrophenyl) ?amino]?carbonyl]?amino]?-, (αS)?-; (αS)-N-[[1-(4-Methoxyphenyl)cyclohexyl]methyl]-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-1H-indole-3-propanamide. CAS No. 1422269-30-4. Molecular formula: C32H35N5O5. Mole weight: 569.65.
Nemifitide acetate
Nemifitide acetate is an antidepressant with a pentapeptide structure similar to melanocyte-inhibiting factor (MIF). It binds to several receptors, including 5-HT2A (as an antagonist), NPY1, bombesin, MC4, and MC5, although only in micromolar concentrations. Synonyms: INN 00835 acetate; H-Phe(4-F)-Hyp-Arg-Gly-Trp-NH2.CH3CO2H; 4-fluoro-L-phenylalanyl-(4R)-4-hydroxy-L-prolyl-L-arginyl-glycyl-L-tryptophanamide acetic acid; 4-F-Phe-4-OH-Pro-Arg-Gly-Trp-NH2.CH3CO2H. Grades: ≥95%. Molecular formula: C35H47FN10O8. Mole weight: 754.85.
Neuromedin B
Neuromedin B (NMB), an endogenous activator for the neuromedin B receptor (NMBR), is a member of Bombesin (BN)-like peptide family in mammals. Synonyms: H-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2; glycyl-L-asparagyl-L-leucyl-L-tryptophyl-L-alanyl-L-threonyl-glycyl-L-histidyl-L-phenylalanyl-L-methioninamide; Neuromedin B (porcine); [125I]-Bolton Hunter neuromedin B; [125I]BH-NMB (human, mouse, rat). Grades: ≥95%. CAS No. 87096-84-2. Molecular formula: C52H73N15O12S. Mole weight: 1132.29.
Neuromedin B
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals. Uses: Scientific research. Group: Peptides. CAS No. 87096-84-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0241.
Neuromedin C
Neuromedin C (NMC) is a decapeptide that acts as a growth factor in a variety of tumors. Synonyms: Neuromedin C (porcine); Gly-asn-his-trp-ala-val-gly-his-leu-met-NH2; GRP (18-27) (human, porcine, canine); Bombesin decapeptide; Grp-10; Gastrin releasing peptide 10; Canine gastrin-releasing peptide 10; Gastrin releasing peptide (18-27); glycyl-L-asparagyl-L-histidyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide. Grades: ≥95% by HPLC. CAS No. 81608-30-2. Molecular formula: C50H73N17O11S. Mole weight: 1120.29.
Neuromedin C (porcine)
Neuromedin C porcine (GRP, 18-27, porcine) is a bombesin-like neuropeptide that can be obtained from porcine spinal cord. Neuromedin C porcine exhibits a potent contractile activity on rat uterus in the characteristic manner of bombesin. Neuromedin C porcine has research potential for neurological-related diseases [1]. Uses: Scientific research. Group: Peptides. Alternative Names: GRP(18-27) (porcine). CAS No. 81608-30-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-103283.
PG-L
PG-L is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: H-Glu-Gly-Gly-Gly-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2; pGlu-Gly-Gly-Gly-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2; litorin-like peptide L (PG-L); Recombinant Pseudophryne guentheri Bombesin-like peptide L; L-alpha-glutamyl-glycyl-glycyl-glycyl-L-prolyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-phenylalanyl-L-methioninamide. Grades: ≥97%. Molecular formula: C62H86N18O16S. Mole weight: 1371.52.
Ranatensin
Ranatensin is a undecapeptide isolated from skin of Rana pipiens. It is a naturally occurring bombesin-like peptide. Synonyms: pGlu-Val-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2; 5-Oxo-L-Pro-L-Val-L-Pro-L-Glu(NH2)-L-Trp-L-Ala-L-Val-Gly-L-His-L-Phe-L-Met-NH2. CAS No. 29451-71-6. Molecular formula: C61H84N16O13S. Mole weight: 1281.48.
RC-3095
RC-3095 is a bombesin/gastrin-releasing peptide (BN/GRP) antagonist with potential anticancer activity. Synonyms: [D-Tpi6, Leu13 psi(CH2NH)-Leu14]bombesin-(6-14); (S)-N1-((2S,5S,8S,14S,17S,20S)-14-((1H-imidazol-5-yl)methyl)-20-carbamoyl-1-(1H-indol-3-yl)-17-isobutyl-8-isopropyl-5,22-dimethyl-3,6,9,12,15-pentaoxo-4,7,10,13,16,19-hexaazatricosan-2-yl)-2-((R)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamido)pentanediamide; N2-[(3R)-2,3,4,9-Tetrahydro-1H-β-carbolin-3-ylcarbonyl]-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-N-[(2S)-1-{[(2S)-1-amino-4-methyl-1-oxo-2-pentanyl]amino}-4-methyl-2-pentanyl]-L-histidina mide. Grades: ≥95%. CAS No. 138147-78-1. Molecular formula: C56H79N15O9. Mole weight: 1106.32.
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